WO1999057098A3 - Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 - Google Patents

Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 Download PDF

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Publication number
WO1999057098A3
WO1999057098A3 PCT/US1999/009641 US9909641W WO9957098A3 WO 1999057098 A3 WO1999057098 A3 WO 1999057098A3 US 9909641 W US9909641 W US 9909641W WO 9957098 A3 WO9957098 A3 WO 9957098A3
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WO
WIPO (PCT)
Prior art keywords
methionine aminopeptidase
amino acid
acid inhibitors
substituted beta
angiogenesis
Prior art date
Application number
PCT/US1999/009641
Other languages
French (fr)
Other versions
WO1999057098A2 (en
Inventor
Richard A Craig
Jack Henkin
Megumi Kawai
Linda Lijewski Lynch
Jyoti Patel
George S Sheppard
Jieyi Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL99346444A priority Critical patent/PL346444A1/en
Priority to BR9910092-4A priority patent/BR9910092A/en
Priority to CA002329704A priority patent/CA2329704A1/en
Priority to SK1628-2000A priority patent/SK16282000A3/en
Priority to EP99921611A priority patent/EP1073633A2/en
Priority to AU38778/99A priority patent/AU3877899A/en
Priority to JP2000547068A priority patent/JP2002513781A/en
Priority to IL13913999A priority patent/IL139139A0/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to KR1020007012124A priority patent/KR20010043198A/en
Priority claimed from US09/303,807 external-priority patent/US6242494B1/en
Publication of WO1999057098A2 publication Critical patent/WO1999057098A2/en
Publication of WO1999057098A3 publication Critical patent/WO1999057098A3/en
Priority to NO20005506A priority patent/NO20005506L/en
Priority to BG104981A priority patent/BG104981A/en

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A class of substituted β-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
PCT/US1999/009641 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 WO1999057098A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2000547068A JP2002513781A (en) 1998-05-01 1999-04-30 Substituted β-amino acid inhibitors of methionine aminopeptidase-2
CA002329704A CA2329704A1 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
SK1628-2000A SK16282000A3 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
EP99921611A EP1073633A2 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
AU38778/99A AU3877899A (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
PL99346444A PL346444A1 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
IL13913999A IL139139A0 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
BR9910092-4A BR9910092A (en) 1998-05-01 1999-04-30 Beta-amino acid inhibitors substituted for methionine aminopeptidase-2
KR1020007012124A KR20010043198A (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
NO20005506A NO20005506L (en) 1998-05-01 2000-11-01 Substituted beta-amino acid inhibitors for methionine aminopeptidase-2
BG104981A BG104981A (en) 1998-05-01 2000-11-24 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7171498A 1998-05-01 1998-05-01
US09/071,714 1998-05-01
US09/303,807 US6242494B1 (en) 1998-05-01 1999-04-30 Substituted β-amino acid inhibitors of methionine aminopeptidase-2

Publications (2)

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WO1999057098A2 WO1999057098A2 (en) 1999-11-11
WO1999057098A3 true WO1999057098A3 (en) 2000-07-27

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BR (1) BR9910092A (en)
NO (1) NO20005506L (en)
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GB9929297D0 (en) * 1999-12-11 2000-02-02 Glaxo Group Ltd Process
US20020002152A1 (en) 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
CN100357283C (en) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 Methionyl aminopeptidase inhibitor
US7030262B2 (en) 2002-08-06 2006-04-18 Abbott Laboratories 3-Amino-2-hydroxyalkanoic acids and their prodrugs
CA2494632A1 (en) * 2002-08-06 2004-02-12 Abbott Laboratories 3-amino-2-hrydroxyalkanoic acids and their prodrugs
CN1688557A (en) * 2002-10-09 2005-10-26 辉瑞产品公司 Thiazole compounds for treatment of neurodegenerative disorders
WO2005009344A2 (en) 2003-06-05 2005-02-03 Elan Pharmaceuticals, Inc. Acylated amino acid amidyl pyrazoles and related compounds
CA3008960A1 (en) 2016-01-11 2017-07-20 Syndevrx, Inc. Treatment for tumors driven by metabolic dysfunction
CN113453721A (en) 2018-10-26 2021-09-28 辛德弗雷克斯公司 Biomarkers of METAP2 inhibitor and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1510477A (en) * 1975-07-22 1978-05-10 Microbial Chem Res Found Peptides and to amino acid intermediates thereof
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1510477A (en) * 1975-07-22 1978-05-10 Microbial Chem Res Found Peptides and to amino acid intermediates thereof
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NISHIZAWA R ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF BESTATIN ANALOGUES, INHIBITORS OF AMINOPEPTIDASE B", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 20, no. 4, 1977, pages 510 - 515, XP000891249, ISSN: 0022-2623 *

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BR9910092A (en) 2002-01-22
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WO1999057098A2 (en) 1999-11-11
NO20005506D0 (en) 2000-11-01
NO20005506L (en) 2000-12-29

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