DE60142259D1 - Herstellungsverfahren für Wirkstoffträgerteilchen - Google Patents

Herstellungsverfahren für Wirkstoffträgerteilchen

Info

Publication number
DE60142259D1
DE60142259D1 DE60142259T DE60142259T DE60142259D1 DE 60142259 D1 DE60142259 D1 DE 60142259D1 DE 60142259 T DE60142259 T DE 60142259T DE 60142259 T DE60142259 T DE 60142259T DE 60142259 D1 DE60142259 D1 DE 60142259D1
Authority
DE
Germany
Prior art keywords
drug carrier
manufacturing process
carrier particles
physiologically tolerable
spay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142259T
Other languages
English (en)
Inventor
Eva Lynenskjold
Lone Norgaard Jorgensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Alpharma ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma ApS filed Critical Alpharma ApS
Application granted granted Critical
Publication of DE60142259D1 publication Critical patent/DE60142259D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
DE60142259T 2000-02-17 2001-02-19 Herstellungsverfahren für Wirkstoffträgerteilchen Expired - Lifetime DE60142259D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0003782.0A GB0003782D0 (en) 2000-02-17 2000-02-17 Process

Publications (1)

Publication Number Publication Date
DE60142259D1 true DE60142259D1 (de) 2010-07-08

Family

ID=9885881

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60113509T Expired - Lifetime DE60113509T2 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für wirkstoffträgerteilchen
DE60142259T Expired - Lifetime DE60142259D1 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für Wirkstoffträgerteilchen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60113509T Expired - Lifetime DE60113509T2 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für wirkstoffträgerteilchen

Country Status (9)

Country Link
US (2) US7338668B2 (de)
EP (2) EP1257256B1 (de)
AT (2) ATE468843T1 (de)
AU (1) AU784105B2 (de)
CA (1) CA2396376C (de)
DE (2) DE60113509T2 (de)
DK (2) DK1579852T3 (de)
GB (1) GB0003782D0 (de)
WO (1) WO2001060338A1 (de)

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GB9825033D0 (en) * 1998-11-13 1999-01-13 Nycomed Pharma As Process
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8071133B2 (en) * 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
US20040091528A1 (en) * 2002-11-12 2004-05-13 Yamanouchi Pharma Technologies, Inc. Soluble drug extended release system
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
CZ20032854A3 (cs) * 2003-10-17 2005-05-18 Pliva - Lachema A.S. Způsob přípravy dávkových jednotek pevné lékové formy obsahujících jako účinnou látku sodnou sůl warfarinu
EP1753403B1 (de) * 2004-05-24 2014-08-13 Takeda Nycomed AS Partikel mit einer calciumhaltigen verbindung und einem zuckeralkohol
US8846088B2 (en) 2005-02-03 2014-09-30 Takeda Nycomed As Melt granulation of a composition containing a calcium-containing compound
WO2006092727A2 (en) † 2005-03-04 2006-09-08 Nycomed Pharma As Process for the production of calcium compositions in a continuous fluid bed
UA92052C2 (ru) * 2005-12-07 2010-09-27 Нікомед Фарма Ас Предварительно уплотненные кальциесодержащие композиции
UA95093C2 (uk) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
TR200605624A2 (tr) * 2006-10-10 2008-05-21 Nobel İlaç Sanayi̇ Ve Ti̇caret Aş. Farmasötik dozaj şekli
EP2223702B1 (de) * 2007-12-03 2019-05-08 Tomita Pharmaceutical Co., Ltd. Kernteilchen für eine pharmazeutische zubereitung
DE102008004893A1 (de) * 2008-01-17 2009-07-23 Add Technologies Ltd. Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung
CN101980697A (zh) * 2008-03-28 2011-02-23 贝林格尔.英格海姆国际有限公司 制备口服给药的达比加群制剂的方法
KR20110039261A (ko) * 2008-07-14 2011-04-15 베링거 인겔하임 인터내셔날 게엠베하 다비가트란을 함유하는 의료용 화합물의 제조 방법
KR101258336B1 (ko) 2008-10-02 2013-04-25 밀란 인크. 다층 접착제 라미네이트를 제조하는 방법
MX2011004614A (es) 2008-11-11 2011-05-31 Boehringer Ingelheim Int Metodo para tratar o prevenir la trombosis usando etexilato de dabigatran o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional.
CN102215823A (zh) * 2008-11-20 2011-10-12 安万托特性材料股份有限公司 直接可压制的基于高功能性颗粒磷酸氢钙的共处理的赋形剂
WO2012027222A1 (en) * 2010-08-24 2012-03-01 Rutgers, The State University Of New Jersey Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
JP5917964B2 (ja) * 2012-03-19 2016-05-18 富士ゼロックス株式会社 錠剤、錠剤の製造方法、錠剤管理装置、錠剤照合装置及びプログラム
WO2014011830A1 (en) 2012-07-12 2014-01-16 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
MX2022014216A (es) 2020-05-18 2022-12-07 Orexo Ab Nueva composicion farmaceutica para administracion de farmacos.
WO2022241159A1 (en) * 2021-05-12 2022-11-17 Spectrix Therapeutics, LLC Compositions and methods
AR127780A1 (es) 2021-11-25 2024-02-28 Orexo Ab Nueva composición farmacéutica que comprende adrenalina

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US3833392A (en) * 1971-08-09 1974-09-03 Westinghouse Electric Corp Coating composition and method for preparing water-soluble cellulosic polymer coating compositions for coating fluorescent tubes
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
EP0028796B1 (de) * 1979-11-13 1983-07-13 Bayer Ag Beschichtete magnetische Metall- und Legierungspigmente, Verfahren zu ihrer Herstellung und ihre Verwendung
US4622057A (en) * 1983-03-02 1986-11-11 Corning Glass Works Process for making thick-walled ceramic bodies from synthetic micas
EP0439373A1 (de) 1990-01-26 1991-07-31 Pfizer Inc. Agglomerat von niedriger Dichte unter Verwendung eines Kohlenhydrats als Bindemittel
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms
US5397576A (en) * 1992-09-23 1995-03-14 Hoffmann-La Roche Inc. Spray triturated micronutrient compositions
JP2700141B2 (ja) * 1993-09-17 1998-01-19 富士化学工業株式会社 リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤
US5486507A (en) * 1994-01-14 1996-01-23 Fuisz Technologies Ltd. Porous particle aggregate and method therefor
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
DK0765157T3 (da) * 1994-06-15 1999-10-25 Dumex Ltd As Pellets
EP0797987B1 (de) * 1994-12-19 2003-10-15 Daiichi Pharmaceutical Co., Ltd. Granulat-präparate mit kontinuierlicher freisetzung und verfahren zur herstellung
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
GB9519094D0 (en) * 1995-09-19 1995-11-22 Warwick Int Group Granulated active with controlled release
JP4027535B2 (ja) * 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂溶性薬物を含有した粉末

Also Published As

Publication number Publication date
EP1579852A3 (de) 2007-07-25
WO2001060338A1 (en) 2001-08-23
AU3390001A (en) 2001-08-27
DE60113509D1 (de) 2005-10-27
ATE304843T1 (de) 2005-10-15
AU784105B2 (en) 2006-02-02
CA2396376A1 (en) 2001-08-23
DE60113509T2 (de) 2006-06-22
EP1257256A1 (de) 2002-11-20
ATE468843T1 (de) 2010-06-15
US20030211168A1 (en) 2003-11-13
DK1579852T3 (da) 2010-09-27
EP1257256B1 (de) 2005-09-21
US20090017125A1 (en) 2009-01-15
CA2396376C (en) 2010-04-27
GB0003782D0 (en) 2000-04-05
EP1579852A2 (de) 2005-09-28
DK1257256T3 (da) 2005-12-19
EP1579852B1 (de) 2010-05-26
US7338668B2 (en) 2008-03-04

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Legal Events

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