PT1180062E - Metodo para a producao de micro e nanoparticulas morfologicamente uniformes utilizando micromisturadores - Google Patents

Metodo para a producao de micro e nanoparticulas morfologicamente uniformes utilizando micromisturadores

Info

Publication number
PT1180062E
PT1180062E PT00943639T PT00943639T PT1180062E PT 1180062 E PT1180062 E PT 1180062E PT 00943639 T PT00943639 T PT 00943639T PT 00943639 T PT00943639 T PT 00943639T PT 1180062 E PT1180062 E PT 1180062E
Authority
PT
Portugal
Prior art keywords
nanoparticles
micro
micromisturers
uniforms
morphologically
Prior art date
Application number
PT00943639T
Other languages
English (en)
Inventor
Gesine Hildebrand
Johannes Tack
Stephan Harnisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT1180062E publication Critical patent/PT1180062E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B01F33/30121—Interdigital streams, e.g. lamellae the interdigital streams being concentric lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
PT00943639T 1999-05-26 2000-05-24 Metodo para a producao de micro e nanoparticulas morfologicamente uniformes utilizando micromisturadores PT1180062E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19925184A DE19925184A1 (de) 1999-05-26 1999-05-26 Kontinuierliches Verfahren zur Herstellung von morphologisch einheitlichen Mikro- und Nanopartikeln mittels Mikromischer sowie nach diesem Verfahren hergestellte Partikel

Publications (1)

Publication Number Publication Date
PT1180062E true PT1180062E (pt) 2004-08-31

Family

ID=7909952

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00943639T PT1180062E (pt) 1999-05-26 2000-05-24 Metodo para a producao de micro e nanoparticulas morfologicamente uniformes utilizando micromisturadores

Country Status (9)

Country Link
EP (1) EP1180062B1 (pt)
JP (1) JP2003500202A (pt)
AT (1) ATE261337T1 (pt)
AU (1) AU5804300A (pt)
DE (2) DE19925184A1 (pt)
DK (1) DK1180062T3 (pt)
ES (1) ES2216907T3 (pt)
PT (1) PT1180062E (pt)
WO (1) WO2000072955A1 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7771444B2 (en) 2000-12-20 2010-08-10 Fox Hollow Technologies, Inc. Methods and devices for removing material from a body lumen
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
DE10010194A1 (de) * 2000-03-02 2001-09-13 Henkel Kgaa Verfahren zur Herstellung von Mikrokapseln
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
DE10148615B4 (de) * 2001-09-26 2005-03-31 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren und Vorrichtung zur Durchführung chemischer Prozesse
DE10154045A1 (de) * 2001-11-02 2003-05-22 Basf Coatings Ag Verfahren zur Herstellung von (Co)Polymerisaten von olefinisch ungesättigten Monomeren
GB0200744D0 (en) * 2002-01-14 2002-02-27 Imperial College Preparation of nanoparticles
DE10205362A1 (de) * 2002-02-08 2003-08-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen
US20050271731A1 (en) * 2002-09-11 2005-12-08 Akira Suzuki Process for the production of microspheres and unit therefor
JP4527384B2 (ja) * 2002-12-06 2010-08-18 綜研化学株式会社 マイクロチャンネルを用いた着色球状粒子の製造方法、およびその製造方法に用いるマイクロチャンネル式製造装置
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
EP1633463B1 (en) 2003-05-16 2007-10-24 Velocys Inc. Process for forming an emulsion using microchannel process technology
US7485671B2 (en) 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
JP4431857B2 (ja) 2003-05-30 2010-03-17 富士フイルム株式会社 マイクロデバイス
JP2005068125A (ja) * 2003-08-21 2005-03-17 Rohm & Haas Co 殺生物剤配合物の調製方法
JP4461900B2 (ja) 2004-05-10 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
JP4461941B2 (ja) 2004-07-21 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
US7622509B2 (en) 2004-10-01 2009-11-24 Velocys, Inc. Multiphase mixing process using microchannel process technology
GB0516549D0 (en) 2005-08-12 2005-09-21 Sulaiman Brian Milling system
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008149192A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2240162A4 (en) 2007-12-06 2013-10-09 Bend Res Inc NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
US8414604B2 (en) 2008-10-13 2013-04-09 Covidien Lp Devices and methods for manipulating a catheter shaft
JP5107220B2 (ja) * 2008-12-11 2012-12-26 三菱重工業株式会社 燃料供給装置及びガスタービン
GB2469087A (en) 2009-04-02 2010-10-06 Ct Angewandte Nanotech Can Preparation of colloidal dispersion
ES2532407T3 (es) 2009-04-29 2015-03-26 Covidien Lp Dispositivos para cortar y raspar tejido
CN102458276B (zh) 2009-05-14 2014-05-21 泰科保健集团有限合伙公司 粥样斑块切除导管
BR112012013389A2 (pt) 2009-12-02 2018-03-06 Tyco Healthcare métodos e dispositivos para o corte de um tecido
WO2011072149A1 (en) 2009-12-11 2011-06-16 Fox Hollow Technologies, Inc. Material removal device having improved material capture efficiency and methods of use
BR112012031907A2 (pt) 2010-06-14 2020-08-04 Covidien Lp dispositivo de remoção de material.
JP5636114B2 (ja) 2010-10-28 2014-12-03 コヴィディエン リミテッド パートナーシップ 物質除去デバイスおよび使用方法
WO2012064966A2 (en) 2010-11-11 2012-05-18 Tyco Healthcare Group Lp Flexible debulking catheters with imaging and methods of use and manufacture
US8992717B2 (en) 2011-09-01 2015-03-31 Covidien Lp Catheter with helical drive shaft and methods of manufacture
JP5314794B2 (ja) * 2012-08-27 2013-10-16 三菱重工業株式会社 燃料供給装置及びガスタービン
US9579157B2 (en) 2012-09-13 2017-02-28 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015137289A1 (ja) * 2014-03-10 2015-09-17 国立大学法人 東京大学 水分散性非晶質粒子及びその調製方法
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
US10449155B2 (en) 2015-11-09 2019-10-22 Medical Corporation Ijunkai Drug introducing agent for administration into a living body and manufacturing method
JP6302531B2 (ja) * 2015-11-09 2018-03-28 医療法人 医潤会 生体投与を目的とした薬物導入剤および製造方法
DE102015226018A1 (de) * 2015-12-18 2017-06-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kontinuierliches Verfahren zur Herstellung von vesikulären oder scheibenförmigen, supramolekularen Nanopartikeln, und Verwendungen hiervon
CN109529692B (zh) * 2018-12-26 2021-04-20 大连理工大学 一种用于低扩散系数流体的被动式收敛-发散微混合器
US20230172252A1 (en) 2020-04-10 2023-06-08 Emulco Laboratories C.V.B.A. Method for producing emulsions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2172574T5 (es) * 1993-11-19 2012-11-29 Alkermes, Inc. Preparación de micropartículas biodegradables que contienen un agente biológicamente activo
EP0706821A1 (en) * 1994-10-06 1996-04-17 Centre De Microencapsulation Method of coating particles
DE19540292C1 (de) * 1995-10-28 1997-01-30 Karlsruhe Forschzent Statischer Mikrovermischer
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
JP2975943B2 (ja) * 1996-02-20 1999-11-10 農林水産省食品総合研究所長 エマルションの製造方法及びエマルションの製造装置
IE970801A1 (en) * 1997-11-11 1999-05-19 Helsinn Chemicals Ireland Ltd An apparatus for producing a pharmaceutical product
JP3081880B2 (ja) * 1998-03-30 2000-08-28 農林水産省食品総合研究所長 マイクロスフィアの連続製造装置

Also Published As

Publication number Publication date
WO2000072955A1 (de) 2000-12-07
ES2216907T3 (es) 2004-11-01
AU5804300A (en) 2000-12-18
EP1180062A1 (de) 2002-02-20
JP2003500202A (ja) 2003-01-07
DE19925184A1 (de) 2000-11-30
ATE261337T1 (de) 2004-03-15
DK1180062T3 (da) 2004-07-05
DE50005599D1 (de) 2004-04-15
EP1180062B1 (de) 2004-03-10

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