DE60103345D1 - Verfahren zur Herstellung von N-Carboxyanhydriden - Google Patents

Verfahren zur Herstellung von N-Carboxyanhydriden

Info

Publication number
DE60103345D1
DE60103345D1 DE60103345T DE60103345T DE60103345D1 DE 60103345 D1 DE60103345 D1 DE 60103345D1 DE 60103345 T DE60103345 T DE 60103345T DE 60103345 T DE60103345 T DE 60103345T DE 60103345 D1 DE60103345 D1 DE 60103345D1
Authority
DE
Germany
Prior art keywords
carboxyanhydrides
preparation
reaction
atoms
nca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103345T
Other languages
English (en)
Other versions
DE60103345T2 (de
Inventor
Fabrice Cornille
Jean-Luc Copier
Jean-Pierre Senet
Yves Robin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isochem SAS
Original Assignee
Isochem SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isochem SAS filed Critical Isochem SAS
Application granted granted Critical
Publication of DE60103345D1 publication Critical patent/DE60103345D1/de
Publication of DE60103345T2 publication Critical patent/DE60103345T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60103345T 2000-10-30 2001-10-19 Verfahren zur Herstellung von N-Carboxyanhydriden Expired - Lifetime DE60103345T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0013906 2000-10-30
FR0013906A FR2815962B1 (fr) 2000-10-30 2000-10-30 Procede de preparation des n-carboxyanhydrides

Publications (2)

Publication Number Publication Date
DE60103345D1 true DE60103345D1 (de) 2004-06-24
DE60103345T2 DE60103345T2 (de) 2005-06-16

Family

ID=8855887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103345T Expired - Lifetime DE60103345T2 (de) 2000-10-30 2001-10-19 Verfahren zur Herstellung von N-Carboxyanhydriden

Country Status (15)

Country Link
US (1) US6479665B2 (de)
EP (1) EP1201659B1 (de)
JP (1) JP4203786B2 (de)
KR (1) KR100772349B1 (de)
CN (1) CN1195746C (de)
AT (1) ATE267181T1 (de)
CA (1) CA2360033C (de)
DE (1) DE60103345T2 (de)
DK (1) DK1201659T3 (de)
ES (1) ES2220692T3 (de)
FR (1) FR2815962B1 (de)
HK (1) HK1046408B (de)
HU (1) HU228392B1 (de)
IL (1) IL146008A (de)
SG (1) SG101497A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2828195B1 (fr) * 2001-05-31 2003-12-26 Isochem Sa Procede de preparation des n-carboxyanhydrides
FR2846326A1 (fr) * 2002-10-29 2004-04-30 Isochem Sa Procede de purification des n-carboxyanhydrides
US7317070B1 (en) 2004-03-12 2008-01-08 Sigma-Aldrich Co. Process for the preparation of polyamino acids
WO2006027788A1 (en) * 2004-09-06 2006-03-16 Biocon Limited Process for the preparation of n-carboxyanhydrides
WO2006047703A2 (en) * 2004-10-26 2006-05-04 Sigma-Aldrich Co. Synthesis of amino acid, n-carboxyanhydrides
FR2928372B1 (fr) * 2008-03-10 2010-12-31 Solvay Procede de synthese peptidique
EP2307448B1 (de) * 2008-08-07 2015-04-22 Sigma-Aldrich Co. LLC Herstellung von polylysin und polyornithin mit geringem molekulargewicht und hohem ertrag
US20120071612A1 (en) 2009-03-10 2012-03-22 Sigma-Aldrich Co., Llc Method for the production of polyamino acid random copolymers
CN101684078B (zh) * 2009-08-24 2013-01-16 浙江工业大学 2-氨基丁酰胺盐酸盐的化学合成方法
CA2816964C (en) 2010-11-03 2019-02-05 Verbio Vereinigte Bioenergie Ag Method of obtaining phytosterols and/or tocopherols from residues of a distillation of the esters of vegetable oils, preferably from distillation residues from a transesterification of vegetable oils
WO2012067974A1 (en) * 2010-11-17 2012-05-24 Sigma-Aldrich Co. Llc. A greener method for the production of copolymer 1
JP5833635B2 (ja) * 2011-03-25 2015-12-16 日本曹達株式会社 グルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶、及びグルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶化方法。
CN103335873B (zh) * 2013-06-04 2017-04-19 深圳翰宇药业股份有限公司 测量氨基酸‑n‑甲酸酐中氯离子含量的方法
CN104777114A (zh) * 2015-04-10 2015-07-15 合肥安德生制药有限公司 一种氨基酸-n-甲酸酐中氯离子的测定方法
JP6995695B2 (ja) 2018-05-25 2022-01-17 信越化学工業株式会社 アミノ酸ｎ－カルボキシ無水物の精製方法
JP7042969B2 (ja) * 2018-09-28 2022-03-28 ロンザ リミテッド Ｎ－カルボキシ無水物の作製方法
CN114634460A (zh) * 2020-12-16 2022-06-17 北京大学 羧基环内酸酐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1012498A (en) * 1963-07-23 1965-12-08 Ajinomoto Kk A process for preparing ª†-methyl glutamate n-carboxy anhydride
GB1189261A (en) * 1967-01-21 1970-04-22 Kyowa Hakko Kogyo Kk Process for Producing N-Carboxy Anhydrides of Glutamic Acid-gamma-Esters
NL6808553A (de) * 1967-06-30 1968-12-31
GB1208251A (en) * 1968-01-12 1970-10-14 Kyowa Hakko Kogyo Kk PROCESS FOR THE PREPARATION OF N-CARBOXYLIC ACID ANHYDRIDES OF GLUTAMIC ACID-gamma-ESTERS
US4496541A (en) * 1983-01-12 1985-01-29 Usv Pharmaceutical Corporation Compounds for treating hypertension
JPH0543560A (ja) * 1991-08-09 1993-02-23 Ajinomoto Co Inc 新規ｎ−カルボキシアミノ酸無水物及びこれを原料とするポリペプチドの製造法
SI9200213A (en) * 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates
US6262274B1 (en) * 2000-10-13 2001-07-17 Everlight Usa, Inc. Process for preparing N-[1-(S)-ethyoxycarbonyl-3-phenylpropyl]-L-ananine N-carboxyanhydride

Also Published As

Publication number Publication date
KR20020034896A (ko) 2002-05-09
DE60103345T2 (de) 2005-06-16
EP1201659B1 (de) 2004-05-19
ATE267181T1 (de) 2004-06-15
ES2220692T3 (es) 2004-12-16
HK1046408B (zh) 2005-10-14
CN1195746C (zh) 2005-04-06
HU228392B1 (hu) 2013-03-28
CN1355166A (zh) 2002-06-26
HK1046408A1 (en) 2003-01-10
JP4203786B2 (ja) 2009-01-07
DK1201659T3 (da) 2004-09-13
KR100772349B1 (ko) 2007-11-02
IL146008A (en) 2006-12-31
HU0104566D0 (en) 2002-01-28
CA2360033A1 (en) 2002-04-30
US20020082431A1 (en) 2002-06-27
FR2815962B1 (fr) 2003-03-07
FR2815962A1 (fr) 2002-05-03
JP2002145871A (ja) 2002-05-22
HUP0104566A3 (en) 2002-12-28
US6479665B2 (en) 2002-11-12
CA2360033C (en) 2007-02-06
HUP0104566A2 (hu) 2002-07-29
EP1201659A1 (de) 2002-05-02
SG101497A1 (en) 2004-01-30

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