DE60045816D1 - Probenhalter für ein gasphaseionenspektrometer - Google Patents

Probenhalter für ein gasphaseionenspektrometer

Info

Publication number
DE60045816D1
DE60045816D1 DE60045816T DE60045816T DE60045816D1 DE 60045816 D1 DE60045816 D1 DE 60045816D1 DE 60045816 T DE60045816 T DE 60045816T DE 60045816 T DE60045816 T DE 60045816T DE 60045816 D1 DE60045816 D1 DE 60045816D1
Authority
DE
Germany
Prior art keywords
probe
analyte
gas phase
binding
phase ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60045816T
Other languages
English (en)
Inventor
William E Rich
Pil-Je Um
Kamen Voivodov
Tai-Tung Yip
Jody Beecher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Application granted granted Critical
Publication of DE60045816D1 publication Critical patent/DE60045816D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409Sample holders or containers
    • H01J49/0418Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/12Ion sources; Ion guns using an arc discharge, e.g. of the duoplasmatron type
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/26Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/261In terms of molecular thickness or light wave length
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE60045816T 1999-04-27 2000-04-27 Probenhalter für ein gasphaseionenspektrometer Expired - Lifetime DE60045816D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13165299P 1999-04-27 1999-04-27
US09/560,715 US6897072B1 (en) 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer
PCT/US2000/011452 WO2000066265A2 (en) 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer

Publications (1)

Publication Number Publication Date
DE60045816D1 true DE60045816D1 (de) 2011-05-19

Family

ID=26829688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60045816T Expired - Lifetime DE60045816D1 (de) 1999-04-27 2000-04-27 Probenhalter für ein gasphaseionenspektrometer

Country Status (10)

Country Link
US (3) US6897072B1 (de)
EP (1) EP1173878B1 (de)
JP (1) JP2003524772A (de)
KR (1) KR100713786B1 (de)
CN (1) CN1204592C (de)
AT (1) ATE504937T1 (de)
AU (1) AU774336B2 (de)
CA (1) CA2368247A1 (de)
DE (1) DE60045816D1 (de)
WO (1) WO2000066265A2 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69432791T2 (de) * 1993-05-28 2004-06-03 Baylor College Of Medicine, Houston Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
AU774336B2 (en) * 1999-04-27 2004-06-24 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
JP5048183B2 (ja) * 2001-01-22 2012-10-17 国立大学法人北海道大学 直鎖状高分子を有する低摩擦ハイドロゲルおよびその製造方法
US20030228639A1 (en) * 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
US20020192714A1 (en) * 2001-05-22 2002-12-19 University Of Vermont And State Agricultural College Single polymer matrix unit chromatography
JP4194370B2 (ja) 2001-05-25 2008-12-10 ウォーターズ・インヴェストメンツ・リミテッド Maldi質量分析用脱塩プレート
US20030032203A1 (en) * 2001-07-10 2003-02-13 Sabatini David M. Small molecule microarrays
GB0120131D0 (en) 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
US7842498B2 (en) * 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US20040018519A1 (en) * 2001-11-16 2004-01-29 Wright ,Jr. George L Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers
WO2003046144A2 (en) * 2001-11-26 2003-06-05 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
EP1478465A2 (de) * 2002-02-26 2004-11-24 Ciphergen Biosystems, Inc. Vorrichtung und verfahren zur automatisierung der übertragung von mehreren proben zu einem analysegerät
US20030218130A1 (en) * 2002-05-02 2003-11-27 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide-based hydrogels
FR2839723B1 (fr) * 2002-05-14 2004-07-23 Rhodia Chimie Sa Polymere obtenu par polymerisation radicalaire controlee comprenant au moins une fonction boronate, association avec un compose ligand et utilisations
CA2493817A1 (en) 2002-08-06 2004-02-12 The John Hopkins University Use of biomarkers for detecting ovarian cancer
EP1550862B1 (de) * 2002-10-04 2012-01-25 Protosera Inc. Verfahren zur identifizierung eines analyts durch gelelektrophorese - massenspektrometrie
WO2004076511A2 (en) * 2003-02-21 2004-09-10 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel surface coatings
US6977370B1 (en) 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
US7785769B2 (en) * 2003-07-25 2010-08-31 The United States of America as reprsented by the Secretary of the Navy Immobilization of oligonucleotides and proteins in sugar-containing hydrogels
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
US8012693B2 (en) * 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7183544B2 (en) * 2003-12-31 2007-02-27 Ciphergen Biosystems Inc. Bi-functional polymer chip
EP1751546A2 (de) * 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
KR100624452B1 (ko) * 2004-12-21 2006-09-18 삼성전자주식회사 고정화된 히드로겔 또는 peg-히드로겔 공중합체를이용한 핵산의 분리 및 정제 방법
JP2008527351A (ja) 2005-01-06 2008-07-24 イースタン バージニア メディカル スクール 前立腺癌のバイオマーカーとしてのアポリポタンパク質a−iiアイソフォーム
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
ATE548651T1 (de) * 2005-06-16 2012-03-15 3M Innovative Properties Co Verfahren zur klassifizierung chemisch quervernetzter zellulärer proben unter verwendung von massenspektren
EP2993474B1 (de) 2005-06-24 2019-06-12 Vermillion, Inc. Biomarker für ovarialkarzinom: beta-2-mikroglobulin
US20090215086A1 (en) * 2005-12-12 2009-08-27 Momar Ndao Biomarkers for Babesia
EP2469279A1 (de) 2006-03-11 2012-06-27 The Board Of Trustees Of The Leland Stanford Junior University Cystatin C, Lysozyme und Beta-2 Mikroglobulin als Biomarker für periphere Arterienerkrankung
JP4838639B2 (ja) * 2006-06-09 2011-12-14 キヤノン株式会社 質量分析用基板及び質量分析装置
US20080193772A1 (en) * 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
US8053247B2 (en) * 2006-10-11 2011-11-08 Phynexus, Inc. Method and device for preparing an analyte for analysis by mass spectrometry
US20080187928A1 (en) * 2006-12-29 2008-08-07 The Salk Institute For Biological Studies Methods for enhancing exercise performance
EP2639316A1 (de) 2007-05-11 2013-09-18 The Johns Hopkins University Biomarker für Melanome
EP2220506B1 (de) 2007-10-29 2013-10-02 Vermillion, Inc. Biomarker zum nachweis von ovarialkarzinom im frühstadium
JP2009121997A (ja) * 2007-11-15 2009-06-04 Tokyo Metropolitan Univ 質量分析における試料の調整方法
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
CA2735518A1 (en) * 2008-08-26 2010-03-04 Lance A. Liotta Hydrogel nanoparticle based immunoassay
EP2687609B1 (de) 2008-11-10 2017-01-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Behandlung von soliden Tumoren
US8715928B2 (en) 2009-02-13 2014-05-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
EP2498763A4 (de) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc Hydrogele auf polysaccharidbasis
WO2011120691A1 (en) * 2010-04-01 2011-10-06 Roche Diagnostics Gmbh Method for isolating an analyte from a sample fluid with a protein-repellent hydrogel
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
AU2013277971B2 (en) 2012-06-22 2018-11-15 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
US9360474B2 (en) * 2012-11-29 2016-06-07 Opti Medical Systems, Inc. Multi-layer device for selectively determining magnesium ion
US20160109455A1 (en) 2013-05-10 2016-04-21 Vermillion, Inc. Compositions for ovarian cancer assessment having improved specificty
EP3049560B1 (de) * 2013-09-24 2021-05-12 Entopsis, LLC Verwendung von nachweis-arrays zur diagnose
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
WO2015106003A1 (en) 2014-01-08 2015-07-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Ras pathways as markers of protection against hiv and methods to improve vaccine efficacy
WO2015127183A2 (en) * 2014-02-21 2015-08-27 Massachusetts Institute Of Technology Expansion microscopy
KR102656644B1 (ko) 2015-02-09 2024-04-09 슬링샷 바이오사이언시즈 인코포레이티드 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법
WO2016130548A1 (en) 2015-02-10 2016-08-18 Arcanum Alloy Design, Inc. Methods and systems for slurry coating
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
CA2994957A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Protein retention expansion microscopy
CN108474029B (zh) 2015-08-07 2021-07-23 麻省理工学院 通过扩展显微法的蛋白质和核酸的纳米级成像
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
WO2017099829A1 (en) 2015-12-11 2017-06-15 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
US11306362B2 (en) 2016-02-08 2022-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE)
WO2017201418A1 (en) 2016-05-20 2017-11-23 Arcanum Alloys, Inc. Methods and systems for coating a steel substrate
CN106323168B (zh) * 2016-08-30 2018-10-02 中航工业哈尔滨轴承有限公司 利用ogp光学测量仪测量圆弧切点的方法
WO2018136856A1 (en) 2017-01-23 2018-07-26 Massachusetts Institute Of Technology Multiplexed signal amplified fish via splinted ligation amplification and sequencing
WO2018144645A1 (en) * 2017-01-31 2018-08-09 Perkinelmer Health Sciences, Inc. Coiled wire sampler
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
FR3065652B1 (fr) * 2017-04-27 2021-07-23 Biomerieux Sa Plaque d'analyse maldi-tof a support papier et son utilisation
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
EP4060041B1 (de) 2017-09-25 2023-12-27 Fred Hutchinson Cancer Center Hocheffiziente gezielte genomweite in-situ-profilierung
JP7293219B2 (ja) * 2017-11-10 2023-06-19 パーキンエルマー・ヘルス・サイエンシーズ・カナダ・インコーポレイテッド 複数検体イオン源
WO2019156957A1 (en) 2018-02-06 2019-08-15 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
EP3867943A1 (de) * 2018-10-18 2021-08-25 DH Technologies Development Pte. Ltd. Funktionalisierung eines probennahmeelements zur verwendung mit einem massenspektrometriesystem
CN110672711B (zh) * 2019-10-22 2021-09-21 南通市第二人民医院 一种肿瘤分子的离子计数检测装置
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070348A (en) 1973-07-25 1978-01-24 Rohm Gmbh Water-swellable, bead copolymer
US3896661A (en) 1974-01-09 1975-07-29 Stanford Research Inst Method of coupling thin layer chromatograph with mass spectrometer
US4060678A (en) * 1975-02-11 1977-11-29 Plastomedical Sciences, Inc. Cationic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4154638A (en) 1977-08-04 1979-05-15 Ppg Industries, Inc. Coupling agent for bonding an organic polymer to an inorganic surface
GB2083827B (en) 1980-09-11 1984-03-28 Atomic Energy Authority Uk Biologically active composites
GB2088392B (en) 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57158209A (en) 1981-03-25 1982-09-30 Kao Corp Production of bead-form highly water-absorbing polymer
US4438239A (en) * 1981-03-30 1984-03-20 California Institute Of Technology Microsphere coated substrate containing reactive aldehyde groups
JPS57195105A (en) * 1981-05-26 1982-11-30 Kuraray Co Ltd Preparation of modified cis-1,4-polyisoprene rubber
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
JPS61275355A (ja) 1985-05-29 1986-12-05 Kao Corp 吸収性物品
US4908512A (en) * 1985-08-21 1990-03-13 Kratos Analytical Limited Apparatus and methods of use in the mass analysis of chemical samples
US5336742A (en) 1987-03-13 1994-08-09 Minnesota Mining And Manufacturing Company Polymeric supports
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
SE462408B (sv) 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE8804074D0 (sv) 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
GB2226032B (en) 1988-12-16 1993-08-18 Urs Heimgartner Detection of glycoproteins
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
GB2236185B (en) 1989-08-22 1994-03-23 Finnigan Mat Gmbh Process,specimen and device for making an analyte available for an investigation
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5532279A (en) 1990-05-03 1996-07-02 Dionex Corporation Ion-exchange composition employing resin attachment to dispersant and method for forming the same
US5196302A (en) 1990-08-29 1993-03-23 The United States Of America As Represented By The Sectetary Of The Navy Enzymatic assays using superabsorbent materials
US5639620A (en) 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
JP3217171B2 (ja) * 1992-04-14 2001-10-09 住友化学工業株式会社 樹脂組成物およびそれから作られた二次加工品
US5268097A (en) 1992-06-19 1993-12-07 Sepracor Inc. Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same
US5266097A (en) * 1992-12-31 1993-11-30 The Vigoro Corporation Aminoureaformaldehyde fertilizer method and composition
US5744306A (en) * 1993-04-19 1998-04-28 Emory University Methods for nucleic acid detection, sequencing, and cloning using exonuclease
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
DE69432791T2 (de) 1993-05-28 2004-06-03 Baylor College Of Medicine, Houston Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5438161A (en) * 1993-06-04 1995-08-01 S&C Electric Company Apparatus with interconnection arrangement
CA2131047A1 (en) 1993-09-01 1995-03-02 Takashi Sanada Thermoplastic resin composition
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
AU4102896A (en) 1994-11-29 1996-06-19 Analogic Corporation Particle agglutination assay system
US5786439A (en) 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6013855A (en) 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU2460399A (en) 1998-01-20 1999-08-02 Packard Bioscience Company Gel pad arrays and methods and systems for making them
WO2000056934A1 (en) 1999-03-24 2000-09-28 Packard Bioscience Company Continuous porous matrix arrays
AU774336B2 (en) * 1999-04-27 2004-06-24 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
US20030218130A1 (en) * 2002-05-02 2003-11-27 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide-based hydrogels

Also Published As

Publication number Publication date
US20070158547A1 (en) 2007-07-12
US7479631B2 (en) 2009-01-20
AU774336B2 (en) 2004-06-24
US20050090016A1 (en) 2005-04-28
ATE504937T1 (de) 2011-04-15
CN1360732A (zh) 2002-07-24
KR20020026427A (ko) 2002-04-10
EP1173878A2 (de) 2002-01-23
CA2368247A1 (en) 2000-11-09
WO2000066265A3 (en) 2001-08-09
AU4675000A (en) 2000-11-17
EP1173878B1 (de) 2011-04-06
US6897072B1 (en) 2005-05-24
CN1204592C (zh) 2005-06-01
US7205156B2 (en) 2007-04-17
WO2000066265A8 (en) 2001-03-15
WO2000066265A9 (en) 2001-09-07
JP2003524772A (ja) 2003-08-19
KR100713786B1 (ko) 2007-05-07
WO2000066265A2 (en) 2000-11-09

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