DE60045324D1 - Impfstoffzusammensetzung - Google Patents
ImpfstoffzusammensetzungInfo
- Publication number
- DE60045324D1 DE60045324D1 DE60045324T DE60045324T DE60045324D1 DE 60045324 D1 DE60045324 D1 DE 60045324D1 DE 60045324 T DE60045324 T DE 60045324T DE 60045324 T DE60045324 T DE 60045324T DE 60045324 D1 DE60045324 D1 DE 60045324D1
- Authority
- DE
- Germany
- Prior art keywords
- vaccine composition
- vaccine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9918319.6A GB9918319D0 (en) | 1999-08-03 | 1999-08-03 | Vaccine composition |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60045324D1 true DE60045324D1 (de) | 2011-01-13 |
Family
ID=10858521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60031859T Expired - Lifetime DE60031859T2 (de) | 1999-08-03 | 2000-07-31 | Genetisch manipulierter bleb impfstoff |
DE60045324T Expired - Lifetime DE60045324D1 (de) | 1999-08-03 | 2000-07-31 | Impfstoffzusammensetzung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60031859T Expired - Lifetime DE60031859T2 (de) | 1999-08-03 | 2000-07-31 | Genetisch manipulierter bleb impfstoff |
Country Status (31)
Country | Link |
---|---|
US (4) | US20060216307A1 (de) |
EP (6) | EP1797894B1 (de) |
JP (3) | JP5524437B2 (de) |
KR (2) | KR20130083491A (de) |
CN (1) | CN1377415B (de) |
AR (1) | AR025218A1 (de) |
AT (2) | ATE490327T1 (de) |
AU (1) | AU770360C (de) |
BR (1) | BR0012974A (de) |
CA (3) | CA2820271A1 (de) |
CO (1) | CO5280150A1 (de) |
CY (1) | CY1107553T1 (de) |
CZ (1) | CZ2002403A3 (de) |
DE (2) | DE60031859T2 (de) |
DK (1) | DK1208214T3 (de) |
ES (3) | ES2399057T3 (de) |
GB (1) | GB9918319D0 (de) |
GC (1) | GC0000258A (de) |
HK (2) | HK1048493B (de) |
HU (1) | HUP0203056A3 (de) |
IL (2) | IL147647A0 (de) |
MX (1) | MXPA02001205A (de) |
MY (1) | MY129006A (de) |
NO (1) | NO332230B1 (de) |
NZ (3) | NZ530336A (de) |
PL (2) | PL211037B1 (de) |
PT (1) | PT1208214E (de) |
SI (1) | SI1208214T1 (de) |
TR (2) | TR200200275T2 (de) |
WO (1) | WO2001009350A2 (de) |
ZA (1) | ZA200200824B (de) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
US10967045B2 (en) | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
NO20002828D0 (no) * | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
BRPI0112928B1 (pt) | 2000-07-27 | 2017-08-29 | Children's Hospital & Research Center At Oakland | A composition comprising preparations comprising outer membrane vesicles (OMV), microvesicles (MV) or both MVO and MV |
GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
GB0025169D0 (en) | 2000-10-13 | 2000-11-29 | Smithkline Beecham Biolog | Novel compounds |
ES2892316T3 (es) | 2001-01-23 | 2022-02-03 | Sanofi Pasteur Inc | Vacuna meningocócica polivalente preparada con un conjugado de polisacárido y proteína |
GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
GB0103169D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
NZ530527A (en) | 2001-06-11 | 2006-06-30 | Applied Nanosystems B | Methods for binding AcmA-type protein anchor fusions to cell-wall material of micro-organisms |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
CN102552895B (zh) * | 2002-08-02 | 2014-07-23 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
GB0220197D0 (en) * | 2002-08-30 | 2002-10-09 | Univ Utrecht | Refolding method |
RU2317106C2 (ru) * | 2002-08-02 | 2008-02-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | Нейссериальные вакцинные композиции, содержащие комбинацию антигенов |
WO2004014419A1 (en) | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals S.A. | Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria |
CN103007263A (zh) * | 2002-08-02 | 2013-04-03 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
US7438918B2 (en) | 2002-08-30 | 2008-10-21 | University Of Iowa Research Foundation | Lipid A deficient mutants of Neisseria meningitidis |
GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
DK2351579T3 (en) | 2002-10-11 | 2017-01-09 | Novartis Vaccines And Diagnostics S R L | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages. |
EP2279746B1 (de) | 2002-11-15 | 2013-10-02 | Novartis Vaccines and Diagnostics S.r.l. | Oberflächenproteine in neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
CU23313A1 (es) | 2002-11-27 | 2008-09-25 | Inst Finlay Ct De Investigacia | Mã0/00todo de obtenciã"n de estructuras cocleares. composiciones vacunales y adyuvantes basados en estructuras cocleares y sus intermediarios |
EP2289546A3 (de) | 2003-01-30 | 2011-03-30 | Novartis Vaccines and Diagnostics S.r.l. | Injizierbarer Impfstoff gegen multiple Meningokokken-Serogruppen |
GB0308691D0 (en) * | 2003-04-07 | 2003-05-21 | Xenova Res Ltd | Vaccine preparations |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
CU23377A1 (es) * | 2003-11-04 | 2009-05-28 | Ct De Ingenieria Genetica Y Biotecnologia | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0416120D0 (en) | 2004-07-19 | 2004-08-18 | Health Prot Agency | Stable compositions containing OMV's |
AU2005203202C1 (en) * | 2004-07-30 | 2009-02-19 | Intervet International B.V. | Novel bacterium and vaccine |
GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
EP2433647A3 (de) | 2005-01-27 | 2012-06-06 | Children's Hospital & Research Center at Oakland | Gna1870-basierte vesikelimpfstoffe für breitbandschutz gegen neisseria meningitidis-bedingte erkrankungen |
JP2008530245A (ja) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 尿路病原性菌株由来の抗原 |
WO2006089264A2 (en) | 2005-02-18 | 2006-08-24 | Novartis Vaccines And Diagnostics Inc. | Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli |
EP1896064A2 (de) | 2005-06-27 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Immunogene zusammensetzung |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
UA92782C2 (ru) | 2006-01-17 | 2010-12-10 | Арне Форсгрен | Новый поверхностный белок haemophilus influenzae (белок е; ре) |
EP2032161B1 (de) | 2006-06-12 | 2012-07-11 | GlaxoSmithKline Biologicals S.A. | L3v los impfstoffe |
US20100166788A1 (en) | 2006-08-16 | 2010-07-01 | Novartis Vaccines And Diagnostics | Immunogens from uropathogenic escherichia coli |
NZ575273A (en) | 2006-09-07 | 2012-02-24 | Glaxosmithkline Biolog Sa | Method for making combination vaccine comprising inactivated poliovirus type 1, diptheria toxoid and tetanus toxoid |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
CN110872587A (zh) * | 2007-05-22 | 2020-03-10 | 康乃尔研究基金会有限公司 | 蛋白质在细菌及其衍生小泡表面展示的组合物和方法及其用途 |
WO2009038889A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital And Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
PT2200642E (pt) | 2007-10-19 | 2012-05-30 | Novartis Ag | Formulações de vacinas meningocócicas |
CA2716212A1 (en) | 2008-02-21 | 2009-08-27 | Novartis Ag | Meningococcal fhbp polypeptides |
WO2009111337A1 (en) | 2008-03-03 | 2009-09-11 | Irm Llc | Compounds and compositions as tlr activity modulators |
CA2726465A1 (en) | 2008-05-30 | 2009-12-30 | Wendell David Zollinger | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
KR101042541B1 (ko) * | 2008-07-25 | 2011-06-17 | 한국생명공학연구원 | 외막소체를 생산하는 재조합 g(-) 박테리아 및 이를이용한 다가항원이 실린 외막소체의 제조방법 |
GB0816447D0 (en) * | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
TWI548746B (zh) * | 2009-08-06 | 2016-09-11 | 英特威特國際股份有限公司 | 防備豬胸膜肺炎之疫苗及製備該疫苗之方法 |
NZ598458A (en) | 2009-08-27 | 2014-03-28 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
CN102740882A (zh) | 2009-08-27 | 2012-10-17 | 诺华有限公司 | 含有铝、寡核苷酸和聚阳离子的佐剂 |
CN102480932B (zh) | 2009-09-01 | 2015-01-14 | 阿昂梅迪克斯公司 | 源于肠道共生细菌的细胞外小泡及利用其的疫苗、备选药物筛选方法 |
WO2011027956A2 (ko) | 2009-09-04 | 2011-03-10 | 주식회사이언메딕스 | 그람 양성 박테리아에서 유래한 세포밖 소포체 및 이를 이용한 질병 모델 |
CN102844047B (zh) | 2009-09-02 | 2017-04-05 | 诺华股份有限公司 | 含tlr活性调节剂的免疫原性组合物 |
CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
JP5960055B2 (ja) | 2009-10-27 | 2016-08-02 | ノバルティス アーゲー | 改変髄膜炎菌fHBPポリペプチド |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
US20130004530A1 (en) | 2010-03-10 | 2013-01-03 | Jan Poolman | Vaccine composition |
WO2012020326A1 (en) | 2010-03-18 | 2012-02-16 | Novartis Ag | Adjuvanted vaccines for serogroup b meningococcus |
EP4324526A2 (de) * | 2010-07-26 | 2024-02-21 | Qu Biologics Inc. | Immunogene entzündungshemmende zusammensetzungen |
CA2810971C (en) | 2010-09-10 | 2020-11-03 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
JP5957443B2 (ja) * | 2011-03-28 | 2016-07-27 | 長瀬産業株式会社 | フェリチンの製造方法 |
EP2505208A1 (de) * | 2011-04-01 | 2012-10-03 | University of Graz | Impfstoff gegen Pasteurellaceae |
WO2012153302A1 (en) | 2011-05-12 | 2012-11-15 | Novartis Ag | Antipyretics to enhance tolerability of vesicle-based vaccines |
GB201110980D0 (en) | 2011-06-28 | 2011-08-10 | Health Prot Agency | Neisserial compositions and expression constructs |
AU2013214105A1 (en) | 2012-02-02 | 2014-07-24 | Novartis Ag | Promoters for increased protein expression in meningococcus |
EP3693010A1 (de) * | 2012-04-06 | 2020-08-12 | Cornell University | Untereinheiten-impfstoffabgabeplattform für robuste humorale und zelluläre immunantworten |
RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
CN103656631B (zh) * | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
ES2656510T3 (es) | 2012-11-30 | 2018-02-27 | Glaxosmithkline Biologicals S.A. | Antígenos de Pseudomonas y combinación de antigenos |
WO2015128480A1 (en) | 2014-02-28 | 2015-09-03 | Novartis Ag | Modified meningococcal fhbp polypeptides |
CA2972635A1 (en) | 2015-01-06 | 2016-07-14 | Immunovaccine Technologies Inc. | Lipid a mimics, methods of preparation, and uses thereof |
US11464845B2 (en) | 2017-07-21 | 2022-10-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neisseria meningitidis immunogenic compositions |
EP3607967A1 (de) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modifizierte meningokokken fhbp polypeptide |
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