DE60037938T2 - Antisense-therapie für trpm-2 - Google Patents
Antisense-therapie für trpm-2 Download PDFInfo
- Publication number
- DE60037938T2 DE60037938T2 DE60037938T DE60037938T DE60037938T2 DE 60037938 T2 DE60037938 T2 DE 60037938T2 DE 60037938 T DE60037938 T DE 60037938T DE 60037938 T DE60037938 T DE 60037938T DE 60037938 T2 DE60037938 T2 DE 60037938T2
- Authority
- DE
- Germany
- Prior art keywords
- trpm
- antisense
- composition
- antisense oligonucleotide
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12172699P | 1999-02-26 | 1999-02-26 | |
| US121726P | 1999-02-26 | ||
| PCT/US2000/004875 WO2000049937A2 (en) | 1999-02-26 | 2000-02-25 | Trpm-2 antisense therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60037938D1 DE60037938D1 (de) | 2008-03-20 |
| DE60037938T2 true DE60037938T2 (de) | 2009-01-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60037938T Expired - Lifetime DE60037938T2 (de) | 1999-02-26 | 2000-02-25 | Antisense-therapie für trpm-2 |
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| JP (1) | JP4785252B2 (enExample) |
| KR (2) | KR100820266B1 (enExample) |
| AT (1) | ATE385237T1 (enExample) |
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| CA (2) | CA2371814C (enExample) |
| DE (1) | DE60037938T2 (enExample) |
| DK (1) | DK1163254T3 (enExample) |
| ES (1) | ES2300257T3 (enExample) |
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| IL (2) | IL144975A0 (enExample) |
| NO (1) | NO330799B1 (enExample) |
| NZ (1) | NZ513757A (enExample) |
| WO (1) | WO2000049937A2 (enExample) |
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| US5417978A (en) | 1993-07-29 | 1995-05-23 | Board Of Regents, The University Of Texas System | Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use |
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| WO1995017507A1 (en) | 1993-12-23 | 1995-06-29 | Biognostik Gesellschaft für Biomolekulare Diagnostik mbH | ANTISENSE NUCLEIC ACIDS FOR THE PREVENTION AND TREATMENT OF DISORDERS IN WHICH EXPRESSION OF c-erbB PLAYS A ROLE |
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| AUPM672594A0 (en) | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
| US5789389A (en) | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
| US5855911A (en) | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| DK0882061T3 (da) | 1996-02-14 | 2004-09-27 | Isis Pharmaceuticals Inc | Sukkermodificerede gapped oligonukleotider |
| US5910583A (en) | 1996-11-04 | 1999-06-08 | Duke University | Antisense oligonucleotides against ERBB-2 |
| US6383808B1 (en) | 2000-09-11 | 2002-05-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of clusterin expression |
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| US6218371B1 (en) | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
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| US6335194B1 (en) | 1998-09-29 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Antisense modulation of survivin expression |
| US6172216B1 (en) | 1998-10-07 | 2001-01-09 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL-X expression |
| WO2000034469A1 (en) | 1998-12-11 | 2000-06-15 | The Research Foundation Of State University Of New York At Albany | Compositions and methods for altering cell migration |
| NZ513757A (en) | 1999-02-26 | 2004-12-24 | Univ British Columbia | Antisense oligonucleotides to inhibit TRPM-2 expression and delay androgen independance in prostatic tumour cells |
| US6900187B2 (en) | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| US5998148A (en) | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| JP2003529554A (ja) | 1999-12-21 | 2003-10-07 | エール ユニヴァーシティ | サバイビンによる血管形成の促進 |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| GB0031080D0 (en) | 2000-12-20 | 2001-01-31 | Novartis Ag | Organic compounds |
| WO2002097114A2 (en) | 2001-05-29 | 2002-12-05 | Sirna Therapeutics, Inc. | Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv |
| WO2003062421A1 (en) | 2002-01-17 | 2003-07-31 | The University Of British Columbia | Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| AU2003237790A1 (en) | 2002-05-14 | 2003-12-02 | Baylor College Of Medicine | Small molecule inhibitors of her2 expression |
| KR101117673B1 (ko) | 2002-08-21 | 2012-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 |
| US7285541B2 (en) | 2002-08-21 | 2007-10-23 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| CA2520518A1 (en) | 2003-04-18 | 2004-10-28 | The University Of British Columbia | Method for treatment of angiogenic disorders |
| US20040220131A1 (en) | 2003-04-18 | 2004-11-04 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| US8710020B2 (en) | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| US7285511B2 (en) | 2004-04-23 | 2007-10-23 | Saudi Basic Industries Corporation | Method of modifying zeolite catalyst |
| WO2006029023A2 (en) | 2004-09-02 | 2006-03-16 | Isis Pharmaceuticals, Inc. | Polymeric beads for oligonucleotide synthesis |
| SI1814595T1 (sl) | 2004-11-23 | 2014-06-30 | The University Of British Columbia | Zdravljenje raka s kombinacijo sredstva, ki moti EGF signalno pot, in oligonukleotida, ki zniĹľuje nivoje klusterina |
| CA2728449A1 (en) | 2008-06-18 | 2009-12-23 | Abbott Laboratories | P/gf-1 companion diagnostic methods and products |
| WO2012123820A1 (en) | 2011-03-14 | 2012-09-20 | The University Of British Columbia | Combination of anti-clusterin oligonucleotide with androgen receptor antagonist for the treatment of prostate cancer |
| RU2013145869A (ru) | 2011-03-15 | 2015-04-20 | Дзе Юниверсити Оф Бритиш Коламбиа | КОМБИНАЦИЯ ОЛИГОНУКЛЕОТИДА АНТИ-КЛАСТЕРИНА С ИНГИБИТОРОМ Hsp90 ДЛЯ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ |
| CA2836676A1 (en) | 2011-05-19 | 2012-11-22 | Teva Pharmaceutical Industries Ltd. | Method for treating non-small cell lung cancer |
| UY34812A (es) | 2012-05-18 | 2013-12-31 | Teva Pharma | Método para el tratamiento del cáncer de pulmón de células no pequeñas |
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| WO2014159775A1 (en) | 2013-03-14 | 2014-10-02 | Teva Pharmaceutical Industries Ltd. | Anti-clusterin monotherapy for cancer treatment |
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2000
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- 2000-02-25 ES ES00914710T patent/ES2300257T3/es not_active Expired - Lifetime
- 2000-02-25 WO PCT/US2000/004875 patent/WO2000049937A2/en not_active Ceased
- 2000-02-25 EP EP00914710A patent/EP1163254B1/en not_active Expired - Lifetime
- 2000-02-25 CA CA2371814A patent/CA2371814C/en not_active Expired - Fee Related
- 2000-02-25 DE DE60037938T patent/DE60037938T2/de not_active Expired - Lifetime
- 2000-02-25 JP JP2000600553A patent/JP4785252B2/ja not_active Expired - Fee Related
- 2000-02-25 CA CA2850318A patent/CA2850318A1/en not_active Abandoned
- 2000-02-25 DK DK00914710T patent/DK1163254T3/da active
- 2000-02-25 HU HU0200093A patent/HU227190B1/hu not_active IP Right Cessation
- 2000-02-25 AU AU36064/00A patent/AU767133B2/en not_active Ceased
- 2000-02-25 KR KR1020077004243A patent/KR100820266B1/ko not_active Expired - Fee Related
- 2000-02-25 AT AT00914710T patent/ATE385237T1/de active
- 2000-02-25 US US09/913,325 patent/US7534773B1/en not_active Expired - Fee Related
- 2000-02-25 KR KR1020017010946A patent/KR100768109B1/ko not_active Expired - Fee Related
- 2000-02-25 IL IL14497500A patent/IL144975A0/xx active IP Right Grant
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2001
- 2001-08-19 IL IL144975A patent/IL144975A/en not_active IP Right Cessation
- 2001-08-21 NO NO20014058A patent/NO330799B1/no not_active IP Right Cessation
- 2001-08-30 US US09/944,326 patent/US7368436B2/en not_active Expired - Fee Related
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2006
- 2006-03-06 US US11/276,581 patent/US7592323B1/en not_active Expired - Fee Related
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2007
- 2007-10-19 US US11/875,226 patent/US7732422B2/en not_active Expired - Fee Related
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- 2010-04-05 US US12/753,995 patent/US8173615B2/en not_active Expired - Fee Related
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2012
- 2012-05-04 US US13/464,670 patent/US8536149B2/en not_active Expired - Fee Related
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