DE60037578T2 - Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen - Google Patents
Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen Download PDFInfo
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- DE60037578T2 DE60037578T2 DE60037578T DE60037578T DE60037578T2 DE 60037578 T2 DE60037578 T2 DE 60037578T2 DE 60037578 T DE60037578 T DE 60037578T DE 60037578 T DE60037578 T DE 60037578T DE 60037578 T2 DE60037578 T2 DE 60037578T2
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- syndrome
- mitochondrial
- deficiency
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| CA2339008C (en) * | 1998-07-31 | 2009-12-15 | Massachusetts Institute Of Technology | Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases |
| US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
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| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| ES2298130T3 (es) | 1999-02-23 | 2008-05-16 | The Regents Of The University Of California | Uso de triacetiluridina para el tratamiento de trastornos mitocondriales. |
| US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
| DE10110355A1 (de) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
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| EP1395681B1 (en) * | 2001-05-29 | 2006-07-26 | The University of British Columbia | Pharmacological applications of mitochondrial dna assays |
| JP2004182705A (ja) * | 2002-10-11 | 2004-07-02 | Yasutoshi Koga | ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物 |
| JP2006515891A (ja) * | 2003-01-17 | 2006-06-08 | シーブイ・セラピューティクス・インコーポレイテッド | 循環器疾患の処置に有効な置換ヘテロ環化合物 |
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| ES2823728T3 (es) * | 2005-09-15 | 2021-05-10 | Ptc Therapeutics Inc | Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| BRPI0817387A2 (pt) | 2007-11-02 | 2015-09-08 | Massachusetts Inst Technology | métodos de conformidade de suplementação dietária de uridina e uso dos mesmos |
| CN101612110B (zh) * | 2008-06-23 | 2012-07-25 | 欣凯医药化工中间体（上海）有限公司 | 三乙酰尿苷缓释制剂及其制备方法 |
| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| RU2400221C2 (ru) * | 2008-11-11 | 2010-09-27 | ФГУ "Московский НИИ педиатрии и детской хирургии Росмедтехнологий" | Способ лечения врожденных структурных миопатий и врожденных мышечных дистрофий путем коррекции вторичных митохондриальных изменений |
| ES2640485T3 (es) * | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
| WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
| EP3182980B1 (en) * | 2014-08-19 | 2020-10-14 | Wellstat Therapeutics Corporation | Treatment of glycosylation deficiency diseases |
| FR3027804A1 (fr) | 2014-10-31 | 2016-05-06 | Centre Nat Rech Scient | Utilisation d'un inhibiteur de transcriptase inverse dans la prevention et le traitement des maladies degeneratives |
| US10675293B2 (en) | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| IL289747B2 (en) | 2015-06-05 | 2025-10-01 | Fundacio Hospital Univ Vall Dhebron Institut De Recerca | Combination of deoxyribonucleosides for the treatment of mitochondrial DNA depletion syndrome and/or deletion syndrome |
| LT3505174T (lt) * | 2015-06-17 | 2020-09-10 | The Trustees Of Columbia University In The City Of New York | Deoksinukleozidų terapija, skirta gydyti ligas, kurias sukelia nesubalansuoti nukleotidų kiekiai, įskaitant mitochondrinės dnr išsekimo sindromus |
| CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| KR101981843B1 (ko) | 2016-09-13 | 2019-05-23 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 미토콘드리아 기능 개선용 조성물 |
| AU2019242628A1 (en) | 2018-03-26 | 2020-09-24 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
| JP2022546611A (ja) * | 2019-09-05 | 2022-11-04 | ミトレインボー セラピューティクス，インコーポレーテッド | ミトコンドリアｄｎａ枯渇障害の処置 |
| US20210315880A1 (en) | 2020-03-20 | 2021-10-14 | Clear Creek Bio, Inc. | Methods of treating viral infections using inhibitors of nucleotide synthesis pathways |
| KR102290596B1 (ko) | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도 |
| US20230357304A1 (en) * | 2020-09-14 | 2023-11-09 | Wellstat Therapeutics Corporation | 2′,3′-Diacetyluridine Substituted With Acetoacetyl at the 5′ Position |
| EP3970713A1 (en) | 2020-09-16 | 2022-03-23 | GV Squared S.r.l. | Pharmaceutical composition comprising uridine and pyruvate for regulating the profileration, activity and survival of immune cells |
| CN113116900B (zh) * | 2021-04-14 | 2022-07-08 | 兰州大学 | 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用 |
| BE1030026B1 (fr) * | 2022-06-14 | 2023-07-07 | Dendrogenix | Composés dérivés de stérols et composition pharmaceutique les comprenant pour leur utilisation dans la prévention, l’amélioration et/ou le traitement d’une pathologie liée à un déficit mitochondrial |
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| JPH10273469A (ja) * | 1997-02-03 | 1998-10-13 | Takeda Chem Ind Ltd | ２環性キノン誘導体、製造法および剤 |
| US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| ES2298130T3 (es) | 1999-02-23 | 2008-05-16 | The Regents Of The University Of California | Uso de triacetiluridina para el tratamiento de trastornos mitocondriales. |
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2000
- 2000-02-23 ES ES00910321T patent/ES2298130T3/es not_active Expired - Lifetime
- 2000-02-23 EP EP07008953.7A patent/EP1808177B1/en not_active Expired - Lifetime
- 2000-02-23 IL IL14496400A patent/IL144964A0/xx unknown
- 2000-02-23 AT AT00910321T patent/ATE381935T1/de active
- 2000-02-23 AU AU32434/00A patent/AU776437B2/en not_active Ceased
- 2000-02-23 RU RU2001125913/14A patent/RU2268732C2/ru not_active IP Right Cessation
- 2000-02-23 WO PCT/US2000/004663 patent/WO2000050043A1/en not_active Ceased
- 2000-02-23 KR KR1020017010801A patent/KR100758712B1/ko not_active Expired - Fee Related
- 2000-02-23 CN CNB008041032A patent/CN1191835C/zh not_active Expired - Fee Related
- 2000-02-23 RU RU2005121711/14A patent/RU2394580C2/ru not_active IP Right Cessation
- 2000-02-23 JP JP2000600654A patent/JP4776780B2/ja not_active Expired - Lifetime
- 2000-02-23 US US09/889,251 patent/US7638501B1/en not_active Expired - Fee Related
- 2000-02-23 HU HU0400914A patent/HU230191B1/hu not_active IP Right Cessation
- 2000-02-23 BR BR0008447-6A patent/BR0008447A/pt not_active Application Discontinuation
- 2000-02-23 MX MXPA01008549A patent/MXPA01008549A/es active IP Right Grant
- 2000-02-23 PT PT00910321T patent/PT1171137E/pt unknown
- 2000-02-23 NZ NZ513926A patent/NZ513926A/en not_active IP Right Cessation
- 2000-02-23 DE DE60037578T patent/DE60037578T2/de not_active Expired - Lifetime
- 2000-02-23 KR KR1020077012846A patent/KR100879559B1/ko not_active Expired - Fee Related
- 2000-02-23 CN CNB2004100784053A patent/CN100379426C/zh not_active Expired - Fee Related
- 2000-02-23 DK DK00910321T patent/DK1171137T3/da active
- 2000-02-23 EP EP00910321A patent/EP1171137B1/en not_active Expired - Lifetime
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2001
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2009
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