DE60027718D1 - Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
DE60027718D1
DE60027718D1 DE60027718T DE60027718T DE60027718D1 DE 60027718 D1 DE60027718 D1 DE 60027718D1 DE 60027718 T DE60027718 T DE 60027718T DE 60027718 T DE60027718 T DE 60027718T DE 60027718 D1 DE60027718 D1 DE 60027718D1
Authority
DE
Germany
Prior art keywords
optionally substituted
group
hydrogen
preparation
hydrocarbon group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60027718T
Other languages
English (en)
Other versions
DE60027718T2 (de
Inventor
Fumio Itoh
Hiroshi Hosono
Masaki Kawamura
Keiji Kubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of DE60027718D1 publication Critical patent/DE60027718D1/de
Application granted granted Critical
Publication of DE60027718T2 publication Critical patent/DE60027718T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60027718T 1999-06-22 2000-06-21 Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung Expired - Fee Related DE60027718T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP17605799 1999-06-22
JP17605799 1999-06-22
JP26628099 1999-09-20
JP26628099 1999-09-20
JP2000017956 2000-01-24
JP2000017956 2000-01-24
PCT/JP2000/004034 WO2000078747A1 (fr) 1999-06-22 2000-06-21 Derives acylhydrazine, procede d'elaboration et utilisation

Publications (2)

Publication Number Publication Date
DE60027718D1 true DE60027718D1 (de) 2006-06-08
DE60027718T2 DE60027718T2 (de) 2007-05-16

Family

ID=27324198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027718T Expired - Fee Related DE60027718T2 (de) 1999-06-22 2000-06-21 Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung

Country Status (7)

Country Link
US (1) US6723722B1 (de)
EP (1) EP1188755B1 (de)
AT (1) ATE325114T1 (de)
AU (1) AU5566300A (de)
CA (1) CA2383492A1 (de)
DE (1) DE60027718T2 (de)
WO (1) WO2000078747A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2416384A1 (en) * 2000-07-17 2003-01-16 Takeda Chemical Industries, Ltd. Sulfone derivatives, their production and use
CA2428123A1 (en) * 2000-11-08 2002-05-16 Shuji Kitamura Carbamate derivatives, their production and use
EP1486485A4 (de) 2002-03-15 2009-07-15 Kissei Pharmaceutical Neue kristalle eines 5-hydroxycarbamimidoyl-2-hydroxybenzolsulfonamidderivats
WO2003093245A1 (en) 2002-05-03 2003-11-13 Elan Pharmaceuticals, Inc. Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists
AU2003271185A1 (en) * 2002-10-15 2004-05-04 Takeda Pharmaceutical Company Limited Imidazopyridine derivative, process for producing the same, and use
CA2507026A1 (en) * 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited Imidazole derivatives, their production and use
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
UA84930C2 (ru) 2004-05-14 2008-12-10 Вертекс Фармасьютикалс Инкорпорейтед Пиррольные соединения как ингибиторы протеинкиназ erk, их синтез и соответствующие промежуточные соединения
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
RU2318818C1 (ru) * 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124610A (en) 1964-03-10 Preparation of intermediates
US3067237A (en) 1959-04-14 1962-12-04 Sterling Drug Inc Lower-alkyl mono-or bis-(alkanesulfonamido) benzoate esters
GB992961A (en) 1960-07-28 1965-05-26 Ciba Ltd Process for the manufacture of amino acid derivatives
US3441570A (en) 1966-01-20 1969-04-29 Parke Davis & Co 3-tertiary aminoalkylamino-3-phenyl oxindole compounds
JPS5216156B2 (de) 1972-08-16 1977-05-07
DE2602422A1 (de) 1976-01-23 1977-07-28 Thomae Gmbh Dr K Neue 6-aminopenicillansaeuren, ihre salze und derivate und verfahren zu ihrer herstellung und diese enthaltende arzneimittel
NZ207192A (en) 1983-02-18 1987-08-31 Wellcome Found Hydantoins and pharmaceutical compositions
JPH07119982B2 (ja) 1986-04-18 1995-12-20 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
GB8704158D0 (en) 1987-02-23 1987-04-01 Wellcome Found Substituted hydantoin compounds
JPH0782221B2 (ja) 1988-06-28 1995-09-06 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
GB9011589D0 (en) 1990-05-24 1990-07-11 Wellcome Found Amino bicyclic compounds
US5182272A (en) 1991-05-03 1993-01-26 G. D. Searle & Co. 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
DE4206858A1 (de) 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
DE4228717A1 (de) 1992-08-28 1994-03-03 Cassella Ag Imidazolidin-Derivate
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5612353A (en) 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JPH10161270A (ja) 1996-10-01 1998-06-19 Fuji Photo Film Co Ltd 熱現像記録材料
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
AR012374A1 (es) 1997-04-15 2000-10-18 Smithkline Beecham Corp Inhibidores de proteasas, composiones farmaceuticas y usos para la preparacion de medicamentos.
CA2287292A1 (en) * 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
JP3830060B2 (ja) 1997-06-09 2006-10-04 富士写真フイルム株式会社 熱現像記録材料
DE19728524A1 (de) * 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JPH11119373A (ja) 1997-10-14 1999-04-30 Fuji Photo Film Co Ltd 熱現像記録材料
JPH11133545A (ja) 1997-10-31 1999-05-21 Fuji Photo Film Co Ltd 熱現像記録材料
CA2318351A1 (en) 1997-12-26 1999-07-08 Hidemitsu Nishida Aromatic compounds having cyclic amino or salts thereof
ATE346050T1 (de) 1998-01-27 2006-12-15 Aventis Pharma Inc Substituierte oxoazaheterocyclyl faktor xa hemmer
US6403595B1 (en) 1998-02-05 2002-06-11 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, processes for producing the same and utilization thereof
JPH11327077A (ja) 1998-05-11 1999-11-26 Fuji Photo Film Co Ltd 熱現像記録材料
US6239151B1 (en) 1998-06-26 2001-05-29 Hoffmann-La Roche Inc. Compounds as inhibitor of tumor necrosis factor alpha release

Also Published As

Publication number Publication date
WO2000078747A1 (fr) 2000-12-28
CA2383492A1 (en) 2000-12-28
ATE325114T1 (de) 2006-06-15
AU5566300A (en) 2001-01-09
EP1188755A4 (de) 2003-01-08
EP1188755B1 (de) 2006-05-03
WO2000078747A8 (fr) 2001-03-29
US6723722B1 (en) 2004-04-20
DE60027718T2 (de) 2007-05-16
EP1188755A1 (de) 2002-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee