DE60018186T2 - Arzneimittel zur vorbeugung / behandlung / inhibierung des fortschritts für einfache oder preproliferative retinopathie - Google Patents
Arzneimittel zur vorbeugung / behandlung / inhibierung des fortschritts für einfache oder preproliferative retinopathie Download PDFInfo
- Publication number
- DE60018186T2 DE60018186T2 DE60018186T DE60018186T DE60018186T2 DE 60018186 T2 DE60018186 T2 DE 60018186T2 DE 60018186 T DE60018186 T DE 60018186T DE 60018186 T DE60018186 T DE 60018186T DE 60018186 T2 DE60018186 T2 DE 60018186T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- compound
- angiotensin
- antagonist activity
- retinopathy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000008512 pyrimidinediones Chemical class 0.000 description 1
- 150000008318 pyrimidones Chemical class 0.000 description 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
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- 238000012827 research and development Methods 0.000 description 1
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- 239000004208 shellac Substances 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000011630 spontaneously hypertensive stroke prone rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- QIQCZROILFZKAT-UHFFFAOYSA-N tetracarbon dioxide Chemical group O=C=C=C=C=O QIQCZROILFZKAT-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- XWMXMWHHTIEXRE-UHFFFAOYSA-N thiadiazole 1-oxide Chemical group O=S1C=CN=N1 XWMXMWHHTIEXRE-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
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- 230000001131 transforming effect Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- KAKQVSNHTBLJCH-UHFFFAOYSA-N trifluoromethanesulfonimidic acid Chemical group NS(=O)(=O)C(F)(F)F KAKQVSNHTBLJCH-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- 230000007998 vessel formation Effects 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
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- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12149899 | 1999-04-28 | ||
| JP12149899 | 1999-04-28 | ||
| PCT/JP2000/002766 WO2000066161A1 (en) | 1999-04-28 | 2000-04-27 | Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60018186D1 DE60018186D1 (de) | 2005-03-24 |
| DE60018186T2 true DE60018186T2 (de) | 2005-12-29 |
Family
ID=14812676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60018186T Expired - Lifetime DE60018186T2 (de) | 1999-04-28 | 2000-04-27 | Arzneimittel zur vorbeugung / behandlung / inhibierung des fortschritts für einfache oder preproliferative retinopathie |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7064141B1 (https=) |
| EP (1) | EP1197223B1 (https=) |
| KR (1) | KR100865059B1 (https=) |
| CN (1) | CN1172719C (https=) |
| AT (1) | ATE289204T1 (https=) |
| AU (1) | AU774799B2 (https=) |
| BR (1) | BR0010084A (https=) |
| CA (1) | CA2371554C (https=) |
| CZ (1) | CZ301913B6 (https=) |
| DE (1) | DE60018186T2 (https=) |
| DK (1) | DK1197223T3 (https=) |
| ES (1) | ES2233362T3 (https=) |
| HU (1) | HU226948B1 (https=) |
| MX (1) | MXPA01010923A (https=) |
| NO (1) | NO327446B1 (https=) |
| NZ (1) | NZ514855A (https=) |
| PL (1) | PL196895B1 (https=) |
| PT (1) | PT1197223E (https=) |
| RU (1) | RU2239454C2 (https=) |
| SI (1) | SI1197223T1 (https=) |
| SK (1) | SK286859B6 (https=) |
| WO (1) | WO2000066161A1 (https=) |
| ZA (1) | ZA200108527B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452176A4 (en) * | 2001-12-03 | 2009-01-21 | Takeda Pharmaceutical | AGENTS FOR IMPROVING THE STATE OF RESISTANCE OF INSULIN |
| JP4484427B2 (ja) * | 2001-12-03 | 2010-06-16 | 武田薬品工業株式会社 | インスリン抵抗性改善剤 |
| TW200304812A (en) * | 2002-03-08 | 2003-10-16 | Sankyo Co | An eye drop containing a tetrazole derivative |
| US8980870B2 (en) | 2002-09-24 | 2015-03-17 | Boehringer Ingelheim International Gmbh | Solid telmisartan pharmaceutical formulations |
| DE10335027A1 (de) * | 2003-07-31 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Angiotensin II Rezeptor Antagonisten |
| KR101087519B1 (ko) * | 2003-04-15 | 2011-11-28 | 상꾜 가부시키가이샤 | 안구 내 혈관 신생성 질환의 예방 또는 치료를 위한 의약 |
| US20050038093A1 (en) * | 2003-05-02 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Treating diabetic retinopathy with angiotensin II receptor blockers |
| ES2425750T3 (es) * | 2004-08-31 | 2013-10-17 | Newsouth Innovations Pty Limited | Inhibición del VEGF |
| ME01615B (me) * | 2004-11-05 | 2014-09-20 | Boehringer Ingelheim Int | Dvoslojna tableta koja sadrži telmisartan i amlodipin |
| PL1872783T3 (pl) * | 2005-04-21 | 2012-05-31 | Santen Pharmaceutical Co Ltd | Środek leczniczy w schorzeniach rogówkowo-spojówkowych |
| CN101312962A (zh) * | 2005-12-06 | 2008-11-26 | 参天制药株式会社 | 角膜结膜病变的治疗剂 |
| WO2008123536A1 (en) * | 2007-03-28 | 2008-10-16 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027211D0 (en) | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
| DE4201554A1 (de) * | 1992-01-22 | 1993-07-29 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5591762A (en) | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
| GB9110635D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| IL104755A0 (en) * | 1992-02-17 | 1993-06-10 | Ciba Geigy Ag | Treatment of glaucoma |
| GB9223860D0 (en) * | 1992-11-13 | 1993-01-06 | Glaxo Group Ltd | Chemical compounds |
| CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
| JPH0789957A (ja) * | 1993-09-22 | 1995-04-04 | Nissan Chem Ind Ltd | ビフェニルメチルアミン誘導体 |
| ATE300287T1 (de) | 1994-02-08 | 2005-08-15 | Novartis Pharma Gmbh | Behandlung von normaldruckglaukom mit valsartan |
| JPH09210183A (ja) * | 1996-01-31 | 1997-08-12 | Suzuki Motor Corp | 動力伝達装置 |
| BR9708336A (pt) * | 1996-03-29 | 1999-08-03 | Smithkline Beecham Corp | Diidrato de eprosartan e processo para sua produção e formulação |
| EP0914158B2 (en) * | 1996-04-05 | 2006-01-25 | Takeda Chemical Industries, Ltd. | Pharmaceutical combination containing a compound having angiotensin ii antagonistic activity and a compound which increases the insulin-sensitivity |
| TW416953B (en) * | 1996-09-25 | 2001-01-01 | Takeda Chemical Industries Ltd | Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use |
| EP0855392A3 (de) * | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6262102B1 (en) * | 1997-06-27 | 2001-07-17 | Smithkline Beecham Corporation | Eprosartan monohydrate |
| IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
| DK1027047T3 (da) * | 1997-08-06 | 2007-01-29 | Smithkline Beecham Corp | Eprosartan-arginyl-ladningsneutraliseringskompleks og fremgangsmåde til dets fremstilling og formulering |
| AU2745199A (en) | 1998-03-04 | 1999-09-20 | Takeda Chemical Industries Ltd. | Sustained-release preparation for aii antagonist, production and use thereof |
| TR200100062T2 (tr) * | 1998-07-10 | 2001-06-21 | Novartis Ag | Valsartan ve kalsiyum kanalı bloklayıcısının anti-hipertensif kombinasyonu |
| FR2783422A1 (fr) * | 1998-09-21 | 2000-03-24 | Sanofi Sa | Composition pharmaceutique contenant un antagoniste des recepteurs at1 de l'angiotensine ii et un antiagregant plaquettaire |
| JP2000159671A (ja) * | 1998-12-01 | 2000-06-13 | Takeda Chem Ind Ltd | 血管新生阻害剤 |
-
2000
- 2000-04-27 AT AT00921056T patent/ATE289204T1/de not_active IP Right Cessation
- 2000-04-27 BR BR0010084-6A patent/BR0010084A/pt not_active Application Discontinuation
- 2000-04-27 CA CA002371554A patent/CA2371554C/en not_active Expired - Fee Related
- 2000-04-27 KR KR1020017013765A patent/KR100865059B1/ko not_active Expired - Fee Related
- 2000-04-27 RU RU2001132073/15A patent/RU2239454C2/ru not_active IP Right Cessation
- 2000-04-27 EP EP00921056A patent/EP1197223B1/en not_active Expired - Lifetime
- 2000-04-27 US US09/958,740 patent/US7064141B1/en not_active Expired - Fee Related
- 2000-04-27 SK SK1545-2001A patent/SK286859B6/sk not_active IP Right Cessation
- 2000-04-27 PT PT00921056T patent/PT1197223E/pt unknown
- 2000-04-27 PL PL350554A patent/PL196895B1/pl not_active IP Right Cessation
- 2000-04-27 MX MXPA01010923A patent/MXPA01010923A/es active IP Right Grant
- 2000-04-27 SI SI200030651T patent/SI1197223T1/xx unknown
- 2000-04-27 DE DE60018186T patent/DE60018186T2/de not_active Expired - Lifetime
- 2000-04-27 HU HU0200890A patent/HU226948B1/hu not_active IP Right Cessation
- 2000-04-27 CN CNB008067783A patent/CN1172719C/zh not_active Expired - Fee Related
- 2000-04-27 NZ NZ514855A patent/NZ514855A/xx not_active IP Right Cessation
- 2000-04-27 WO PCT/JP2000/002766 patent/WO2000066161A1/ja not_active Ceased
- 2000-04-27 ES ES00921056T patent/ES2233362T3/es not_active Expired - Lifetime
- 2000-04-27 CZ CZ20013804A patent/CZ301913B6/cs not_active IP Right Cessation
- 2000-04-27 DK DK00921056T patent/DK1197223T3/da active
- 2000-04-27 AU AU41434/00A patent/AU774799B2/en not_active Ceased
-
2001
- 2001-10-17 ZA ZA200108527A patent/ZA200108527B/en unknown
- 2001-10-26 NO NO20015257A patent/NO327446B1/no not_active IP Right Cessation
-
2006
- 2006-04-19 US US11/406,345 patent/US20060189669A1/en not_active Abandoned
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