DE60012785T2 - Rekonstruktion gereinigter membranproteine in vorgefertigten liposomen - Google Patents

Rekonstruktion gereinigter membranproteine in vorgefertigten liposomen Download PDF

Info

Publication number
DE60012785T2
DE60012785T2 DE60012785T DE60012785T DE60012785T2 DE 60012785 T2 DE60012785 T2 DE 60012785T2 DE 60012785 T DE60012785 T DE 60012785T DE 60012785 T DE60012785 T DE 60012785T DE 60012785 T2 DE60012785 T2 DE 60012785T2
Authority
DE
Germany
Prior art keywords
liposomes
solution
tissue factor
phospholipids
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60012785T
Other languages
German (de)
English (en)
Other versions
DE60012785D1 (de
Inventor
Pratap Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Publication of DE60012785D1 publication Critical patent/DE60012785D1/de
Application granted granted Critical
Publication of DE60012785T2 publication Critical patent/DE60012785T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE60012785T 1999-12-10 2000-11-20 Rekonstruktion gereinigter membranproteine in vorgefertigten liposomen Expired - Lifetime DE60012785T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US459137 1999-12-10
US09/459,137 US6248353B1 (en) 1999-12-10 1999-12-10 Reconstitution of purified membrane proteins into preformed liposomes
PCT/US2000/031927 WO2001041740A2 (en) 1999-12-10 2000-11-20 Reconstitution of purified membrane proteins into preformed liposomes

Publications (2)

Publication Number Publication Date
DE60012785D1 DE60012785D1 (de) 2004-09-09
DE60012785T2 true DE60012785T2 (de) 2005-08-11

Family

ID=23823557

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60012785T Expired - Lifetime DE60012785T2 (de) 1999-12-10 2000-11-20 Rekonstruktion gereinigter membranproteine in vorgefertigten liposomen

Country Status (7)

Country Link
US (2) US6248353B1 (https=)
EP (1) EP1239833B1 (https=)
JP (1) JP4612261B2 (https=)
AT (1) ATE272393T1 (https=)
DE (1) DE60012785T2 (https=)
ES (1) ES2225271T3 (https=)
WO (1) WO2001041740A2 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
PT1031347E (pt) 1999-01-27 2002-09-30 Idea Ag Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis
ATE216875T1 (de) 1999-01-27 2002-05-15 Idea Ag Nichtinvasive impfung durch die haut
WO2001001962A1 (en) * 1999-07-05 2001-01-11 Idea Ag. A method for the improvement of transport across adaptable semi-permeable barriers
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
DK1345959T3 (da) * 2000-11-20 2011-09-05 Univ Illinois Membranscaffoldproteiner
US7592008B2 (en) * 2000-11-20 2009-09-22 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Membrane scaffold proteins
US7622437B2 (en) * 2000-11-20 2009-11-24 The Board Of Trustees Of The University Of Illinois Tissue factor compositions and methods
US7083958B2 (en) * 2000-11-20 2006-08-01 The Board Of Trustees Of The University Of Illinois Membrane scaffold proteins
US6596543B2 (en) * 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
US7015193B2 (en) * 2001-04-20 2006-03-21 University Of Vermont Compositions and methods to control bleeding
WO2003075889A1 (en) * 2002-03-05 2003-09-18 Transave, Inc. An inhalation system for prevention and treatment of intracellular infections
US20040105881A1 (en) * 2002-10-11 2004-06-03 Gregor Cevc Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
US20050032113A1 (en) * 2003-07-17 2005-02-10 Mitsubishi Pharma Corporation Membrane protein library for proteome analysis and method for preparing same
KR101076578B1 (ko) 2004-06-23 2011-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
JP2008519784A (ja) * 2004-11-12 2008-06-12 イデア アクチェンゲゼルシャフト 皮膚状態の治療における拡張表面凝集体
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
AT501650A1 (de) * 2005-02-22 2006-10-15 Technoclone Ges M B H Verfahren zur bestimmung der gerinnungsaktivierung sowie gerät zur durchführung des verfahrens
JP2008531692A (ja) * 2005-03-04 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 凝固及び線維素溶解カスケードのモジュレーター
US20080248565A1 (en) * 2007-03-01 2008-10-09 Invitrogen Corporation Isolated phospholipid-protein particles
US20070117179A1 (en) * 2005-09-27 2007-05-24 Invitrogen Corporation In vitro protein synthesis systems for membrane proteins that include adolipoproteins and phospholipid-adolipoprotein particles
JP2007106679A (ja) * 2005-10-11 2007-04-26 Shino Test Corp 血液凝固反応促進剤
EP1939218A1 (en) * 2006-12-29 2008-07-02 Thrombotargets Europe, S.L. Microvesicles derived from recombinant yeast having haemostatic activities and uses thereof
US7943168B2 (en) 2007-03-05 2011-05-17 Washington University Nanoparticle delivery systems comprising a hydrophobic core and a lipid/surfactant layer comprising a membrane-lytic peptide
CA2700808C (en) 2007-09-27 2017-11-14 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
EP2062661A1 (en) * 2007-09-28 2009-05-27 Proviron Holding Organic de-icer removal
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
US20090220588A1 (en) * 2008-02-21 2009-09-03 Massachusetts Institute Of Technology Simultaneous Delivery of Receptors and/or Co-Receptors for Growth Factor Stability and Activity
ES2524699T3 (es) 2008-06-05 2014-12-11 Immunovaccine Technologies Inc. Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba
US8956600B2 (en) 2009-08-10 2015-02-17 Taiwan Liposome Co. Ltd. Ophthalmic drug delivery system containing phospholipid and cholesterol
US10525152B2 (en) 2009-10-09 2020-01-07 Signablok, Inc. Methods and compositions for targeted imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
US12419839B2 (en) 2009-10-09 2025-09-23 Signablok, Inc. Methods and compositions for targeted delivery of protein fragments
KR101458315B1 (ko) 2013-07-19 2014-11-04 전북대학교산학협력단 표면 개질된 리포좀 및 그 제조방법
JP6626761B2 (ja) 2016-03-30 2019-12-25 シスメックス株式会社 プロトロンビン時間測定用試薬およびその製造方法
JP6652873B2 (ja) * 2016-03-30 2020-02-26 シスメックス株式会社 プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
WO2019200240A1 (en) 2018-04-13 2019-10-17 Board Of Regents, The University Of Texas System Transmembrane stem cell factor (tm-scf) lipid nanocarriers and methods of use thereof
EP3819640B1 (en) * 2018-07-06 2025-06-18 PHC Corporation Liposome-containing liquid reagent for measuring blood coagulation ability
JP7153519B2 (ja) 2018-09-28 2022-10-14 シスメックス株式会社 凝固時間測定用試薬及びその製造方法、試薬キット及び凝固時間の測定方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL238873A (https=) 1958-05-16
JPS56129859A (en) * 1980-03-14 1981-10-12 Sekisui Chem Co Ltd Plastic container for blood inspection
US4873089A (en) * 1985-07-12 1989-10-10 Cornell Research Foundation Inc., Cornell University Proteoliposomes as drug carriers
IL79114A (en) * 1985-08-07 1990-09-17 Allergan Pharma Method and composition for making liposomes
JPH0650999B2 (ja) 1988-09-12 1994-07-06 日本商事株式会社 血液凝固因子安定化法
US5472850A (en) 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
ES2120949T4 (es) 1990-06-28 2011-12-29 Sanofi-Aventis Deutschland Gmbh 50% Proteinas de fusión con porciones de inmunoglobulinas, su preparación y empleo.
US5314695A (en) 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
US5248590A (en) 1991-07-22 1993-09-28 Becton, Dickinson And Company Surface modified liposomes
ATE163768T1 (de) * 1991-10-04 1998-03-15 Dade Int Inc Herstellung von prothrombinzeit-reagenzien aus rekombinantem menschlichem gewebefaktor und sythetischen phospholipiden
AU674139B2 (en) 1992-04-13 1996-12-12 Ortho Diagnostic Systems Inc. Synthetic phospholipid reagent
US5358853A (en) 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
DE4243729A1 (de) 1992-12-23 1994-06-30 Behringwerke Ag Verfahren zur Reaktivierung von gereinigten Membranproteinen
DE69530914T2 (de) 1994-02-17 2004-03-11 New York Blood Center, Inc. Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
DE4416166C2 (de) 1994-05-06 1997-11-20 Immuno Ag Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen
EP1015890B1 (en) * 1997-04-23 2005-11-30 INSTRUMENTATION LABORATORY S.p.A. Recombinant rabbit tissue factor based prothrombin time reagent
JP4039722B2 (ja) * 1997-12-01 2008-01-30 シスメックス株式会社 複合因子測定試薬
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes

Also Published As

Publication number Publication date
ES2225271T3 (es) 2005-03-16
DE60012785D1 (de) 2004-09-09
US6706861B2 (en) 2004-03-16
EP1239833B1 (en) 2004-08-04
WO2001041740A3 (en) 2002-01-17
WO2001041740A2 (en) 2001-06-14
JP2003516525A (ja) 2003-05-13
ATE272393T1 (de) 2004-08-15
EP1239833A2 (en) 2002-09-18
US20020012699A1 (en) 2002-01-31
JP4612261B2 (ja) 2011-01-12
US6248353B1 (en) 2001-06-19

Similar Documents

Publication Publication Date Title
DE60012785T2 (de) Rekonstruktion gereinigter membranproteine in vorgefertigten liposomen
DE69224622T2 (de) Herstellung von prothrombinzeit-reagenzien aus rekombinantem menschlichem gewebefaktor und sythetischen phospholipiden
DE69131204T3 (de) Prothrombinzeitreagenz basierend auf gewebefaktor
Kinsky [47] Preparation of liposomes and a spectrophotometric assay for release of trapped glucose marker
DE69521470T2 (de) Kalibrator für prothrombin-zeit-assays
US6596543B2 (en) Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
Tang et al. Influence of cholesterol on the interaction of α-crystallin with phospholipids
EP0603671B1 (de) Verfahren zur Reaktivierung von gereinigten Membranproteinen
JP6652873B2 (ja) プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
EP0826965B1 (de) Verfahren zur Herstellung von Faktor V-Mangelplasma und ein so erhaltenes Mangelplasma
DE19734648A1 (de) Verwendung von Annexinen als Lupus Antikoagulans Kontrolle oder Standard in Gerinnungstesten
AT403437B (de) Physiologisch aktive gewebefaktor-präparation
DE69027936T2 (de) Lipid-abhängige diagnostische analysenverfahren
Schroeder Phospholipid polar head group manipulation modulates concanavalin A agglutinability of LM fibroblasts
Kowalska et al. Fluorescence studies of the blood platelet membranes associated with fibrinogen
JP7376478B2 (ja) リポソームを含有する液状血液凝固能測定試薬
Diizguneg et al. N-[2, 3-(Dioleyloxy) propyl]-N, N, N-trimethylammonium: Induction by Multivalent
DE4407386A1 (de) Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren
Gobbi et al. Physical factors in the thromboplastic activity of phospholipids

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC., DEERFIELD, US

8328 Change in the person/name/address of the agent

Representative=s name: PLATE SCHWEITZER ZOUNEK PATENTANWAELTE, 65203 WIES