DE60011391T2 - Verfahren und zusammensetzungen zur erhöhung der anzahl weisser blutzellen - Google Patents
Verfahren und zusammensetzungen zur erhöhung der anzahl weisser blutzellen Download PDFInfo
- Publication number
- DE60011391T2 DE60011391T2 DE60011391T DE60011391T DE60011391T2 DE 60011391 T2 DE60011391 T2 DE 60011391T2 DE 60011391 T DE60011391 T DE 60011391T DE 60011391 T DE60011391 T DE 60011391T DE 60011391 T2 DE60011391 T2 DE 60011391T2
- Authority
- DE
- Germany
- Prior art keywords
- methylene
- phenylenebis
- bis
- use according
- tetraazacyclotetradecane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11825599P | 1999-02-02 | 1999-02-02 | |
| US118225P | 1999-02-02 | ||
| PCT/CA2000/000104 WO2000045814A1 (en) | 1999-02-02 | 2000-02-02 | Methods and compositions to enhance white blood cell count |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60011391D1 DE60011391D1 (de) | 2004-07-15 |
| DE60011391T2 true DE60011391T2 (de) | 2005-07-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60011391T Expired - Lifetime DE60011391T2 (de) | 1999-02-02 | 2000-02-02 | Verfahren und zusammensetzungen zur erhöhung der anzahl weisser blutzellen |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6365583B1 (https=) |
| EP (1) | EP1148875B1 (https=) |
| JP (2) | JP4968868B2 (https=) |
| KR (1) | KR100643553B1 (https=) |
| CN (1) | CN1310642C (https=) |
| AP (1) | AP1497A (https=) |
| AT (1) | ATE268597T1 (https=) |
| AU (2) | AU772979B2 (https=) |
| BR (1) | BR0007924A (https=) |
| CA (1) | CA2361587C (https=) |
| CZ (1) | CZ20012698A3 (https=) |
| DE (1) | DE60011391T2 (https=) |
| DK (1) | DK1148875T3 (https=) |
| ES (1) | ES2222174T3 (https=) |
| HK (1) | HK1038319B (https=) |
| HU (1) | HUP0200100A3 (https=) |
| IL (1) | IL144400A (https=) |
| MX (1) | MXPA01007801A (https=) |
| NO (1) | NO20013770L (https=) |
| NZ (1) | NZ513602A (https=) |
| PT (1) | PT1148875E (https=) |
| SI (1) | SI1148875T1 (https=) |
| TR (1) | TR200102239T2 (https=) |
| WO (1) | WO2000045814A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| DE60042030D1 (de) * | 1999-12-17 | 2009-05-28 | Genzyme Corp | Chemokinrezeptor-bindende heterocyclische verbindungen |
| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| PT1317451E (pt) * | 2000-09-15 | 2006-12-29 | Anormed Inc | Compostos heterocíclicos que se ligam a receptores de quimioquinas |
| US6835731B2 (en) * | 2000-09-15 | 2004-12-28 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| AU2002211393B2 (en) | 2000-09-29 | 2007-06-28 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| ES2380009T3 (es) * | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
| WO2003022785A2 (en) * | 2001-09-12 | 2003-03-20 | Anormed Inc. | Synthesis of enantiomerically pure amino-substituted fused bicyclic rings |
| CA2467718C (en) * | 2001-12-21 | 2011-04-26 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| WO2004020462A1 (ja) | 2002-08-27 | 2004-03-11 | Fujii, Nobutaka | Ｃｘｃｒ４拮抗薬およびその用途 |
| EP1613613B1 (en) * | 2003-04-11 | 2021-06-02 | Genzyme Corporation | Cxcr4 chemokine receptor binding compounds |
| AU2004232361A1 (en) | 2003-04-22 | 2004-11-04 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US7501518B2 (en) * | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
| US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| EP1708703A4 (en) * | 2003-12-11 | 2008-04-09 | Anormed Inc | CHEMOKIN RECEPTOR BINDING COMPOUNDS |
| JP2008509928A (ja) * | 2004-08-13 | 2008-04-03 | アノーメド インコーポレイテッド | 前駆／幹細胞を動員するためのケモカインの組み合わせ |
| EP1942890A4 (en) * | 2005-06-15 | 2009-08-26 | Genzyme Corp | CHEMOKINE RECEPTOR BINDING COMPOUNDS |
| EP1924265A4 (en) * | 2005-08-16 | 2010-06-02 | Genzyme Corp | COMPOUNDS BINDING TO CHEMOKINE RECEPTORS |
| MX2008010895A (es) * | 2006-02-24 | 2008-09-03 | Genzyme Corp | Metodos para aumentar el flujo sanguineo y/o promover la regeneracion de tejidos. |
| AU2007281090A1 (en) * | 2006-08-02 | 2008-02-07 | Genzyme Corporation | Combination therapy |
| JP2010507567A (ja) * | 2006-08-07 | 2010-03-11 | ジェンザイム・コーポレーション | 併用療法 |
| CA2673719C (en) * | 2006-12-21 | 2018-07-24 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for bone marrow recovery |
| US9155780B2 (en) | 2009-02-11 | 2015-10-13 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
| US9427456B2 (en) | 2009-06-14 | 2016-08-30 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2638802C2 (ru) * | 2011-05-16 | 2017-12-15 | Джензим Корпорейшн | Применение антагонистов cxcr4 |
| US9439942B2 (en) | 2012-04-24 | 2016-09-13 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| IL274572B2 (en) | 2015-07-16 | 2024-01-01 | Biolinerx Ltd | Compositions and methods for treating cancer |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| PL3393468T3 (pl) | 2015-12-22 | 2023-01-23 | X4 Pharmaceuticals, Inc. | Metody leczenia niedoboru odporności |
| CN109310733A (zh) | 2016-02-23 | 2019-02-05 | 百欧林纳克斯有限公司 | 治疗急性骨髓性白血病的方法 |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| CN109187337A (zh) * | 2018-09-10 | 2019-01-11 | 南京工业职业技术学院 | 一种筛选强韧性FeAl晶界的方法 |
| CA3171250A1 (en) | 2020-03-10 | 2021-09-16 | E. Lynne KELLEY | Methods for treating neutropenia |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5612478A (en) | 1995-03-30 | 1997-03-18 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US5606053A (en) | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| JP2002529502A (ja) * | 1998-11-17 | 2002-09-10 | スミスクライン・ビーチャム・コーポレイション | 血小板減少症の治療法 |
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2000
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- 2000-02-02 DK DK00903441T patent/DK1148875T3/da active
- 2000-02-02 IL IL144400A patent/IL144400A/en not_active IP Right Cessation
- 2000-02-02 CN CNB008033285A patent/CN1310642C/zh not_active Expired - Fee Related
- 2000-02-02 BR BR0007924-3A patent/BR0007924A/pt not_active Application Discontinuation
- 2000-02-02 EP EP00903441A patent/EP1148875B1/en not_active Expired - Lifetime
- 2000-02-02 CA CA2361587A patent/CA2361587C/en not_active Expired - Fee Related
- 2000-02-02 AT AT00903441T patent/ATE268597T1/de not_active IP Right Cessation
- 2000-02-02 HK HK02100103.2A patent/HK1038319B/en not_active IP Right Cessation
- 2000-02-02 ES ES00903441T patent/ES2222174T3/es not_active Expired - Lifetime
- 2000-02-02 AU AU25278/00A patent/AU772979B2/en not_active Ceased
- 2000-02-02 AP APAP/P/2001/002221A patent/AP1497A/en active
- 2000-02-02 PT PT00903441T patent/PT1148875E/pt unknown
- 2000-02-02 JP JP2000596934A patent/JP4968868B2/ja not_active Expired - Fee Related
- 2000-02-02 DE DE60011391T patent/DE60011391T2/de not_active Expired - Lifetime
- 2000-02-02 NZ NZ513602A patent/NZ513602A/en unknown
- 2000-02-02 TR TR2001/02239T patent/TR200102239T2/xx unknown
- 2000-02-02 KR KR1020017009649A patent/KR100643553B1/ko not_active Expired - Fee Related
- 2000-02-02 CZ CZ20012698A patent/CZ20012698A3/cs unknown
- 2000-02-02 WO PCT/CA2000/000104 patent/WO2000045814A1/en not_active Ceased
- 2000-02-02 MX MXPA01007801A patent/MXPA01007801A/es not_active IP Right Cessation
- 2000-02-02 HU HU0200100A patent/HUP0200100A3/hu unknown
- 2000-02-02 SI SI200030444T patent/SI1148875T1/xx unknown
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2001
- 2001-08-01 NO NO20013770A patent/NO20013770L/no not_active Application Discontinuation
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2002
- 2002-01-04 US US10/039,150 patent/US6670354B2/en not_active Expired - Lifetime
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2004
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2011
- 2011-02-04 JP JP2011023235A patent/JP2011088937A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
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| 8381 | Inventor (new situation) |
Inventor name: MACFARLAND, TREVOR, RONALD, VANCOUVER, CA Inventor name: MILLER, W., ANDREW, WALLINGFORD OX10 9EF, GB Inventor name: BRIDGER, GARY J., BELLINGHAM, WASH., US Inventor name: ABRAMS, MICHAEL J., CUSTER, WASH., US Inventor name: HENSON, GEOFFREY W., FERNDALE, WASH., US |