DE60006260T2 - Imidazotriazinderivate als gaba rezeptor-liganden - Google Patents

Imidazotriazinderivate als gaba rezeptor-liganden Download PDF

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Publication number
DE60006260T2
DE60006260T2 DE60006260T DE60006260T DE60006260T2 DE 60006260 T2 DE60006260 T2 DE 60006260T2 DE 60006260 T DE60006260 T DE 60006260T DE 60006260 T DE60006260 T DE 60006260T DE 60006260 T2 DE60006260 T2 DE 60006260T2
Authority
DE
Germany
Prior art keywords
methyl
triazine
triazol
ylmethoxy
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60006260T
Other languages
German (de)
English (en)
Other versions
DE60006260D1 (de
Inventor
William Robert Harlow CARLING
Alexander Richard Harlow GUIBLIN
Kevin William Harlow MOORE
Christopher Richard Harlow MOYES
Michael Harlow ROWLEY
Leslie Joseph Harlow STREET
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE60006260D1 publication Critical patent/DE60006260D1/de
Publication of DE60006260T2 publication Critical patent/DE60006260T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE60006260T 1999-08-23 2000-08-17 Imidazotriazinderivate als gaba rezeptor-liganden Expired - Lifetime DE60006260T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9919957.2A GB9919957D0 (en) 1999-08-23 1999-08-23 Therapeutic agents
GB9919957 1999-08-23
PCT/GB2000/003199 WO2001014377A1 (en) 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
DE60006260D1 DE60006260D1 (de) 2003-12-04
DE60006260T2 true DE60006260T2 (de) 2004-07-29

Family

ID=10859670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60006260T Expired - Lifetime DE60006260T2 (de) 1999-08-23 2000-08-17 Imidazotriazinderivate als gaba rezeptor-liganden

Country Status (10)

Country Link
US (1) US6608062B1 (https=)
EP (1) EP1212324B1 (https=)
JP (1) JP2003507479A (https=)
AT (1) ATE253066T1 (https=)
AU (1) AU775008B2 (https=)
CA (1) CA2380452C (https=)
DE (1) DE60006260T2 (https=)
ES (1) ES2208404T3 (https=)
GB (1) GB9919957D0 (https=)
WO (1) WO2001014377A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
AU2003252499B2 (en) * 2002-07-12 2007-11-08 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2006327300A1 (en) 2005-12-20 2007-06-28 Astrazeneca Ab Substituted Cinnoline derivatives as GABAa-receptor modulators and method for their synthesis
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20240327413A1 (en) * 2021-06-29 2024-10-03 Zomagen Biosciences Ltd Nlrp3 modulators
IL310992A (en) * 2021-08-25 2024-04-01 Ptc Therapeutics Inc NLRP3 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
ES2194205T3 (es) 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
CA2346289A1 (en) * 1998-10-16 2000-04-27 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
EP1212324A1 (en) 2002-06-12
ES2208404T3 (es) 2004-06-16
ATE253066T1 (de) 2003-11-15
GB9919957D0 (en) 1999-10-27
US6608062B1 (en) 2003-08-19
WO2001014377A1 (en) 2001-03-01
AU775008B2 (en) 2004-07-15
EP1212324B1 (en) 2003-10-29
CA2380452C (en) 2008-10-28
AU6707700A (en) 2001-03-19
DE60006260D1 (de) 2003-12-04
JP2003507479A (ja) 2003-02-25
CA2380452A1 (en) 2001-03-01

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