JP2003507479A - Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体 - Google Patents

Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体

Info

Publication number
JP2003507479A
JP2003507479A JP2001518708A JP2001518708A JP2003507479A JP 2003507479 A JP2003507479 A JP 2003507479A JP 2001518708 A JP2001518708 A JP 2001518708A JP 2001518708 A JP2001518708 A JP 2001518708A JP 2003507479 A JP2003507479 A JP 2003507479A
Authority
JP
Japan
Prior art keywords
methyl
triazine
compound
ylmethoxy
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001518708A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003507479A5 (https=
Inventor
カーリング，ウイリアム・ロバート
ギブリン，アレクサンダー・リチヤード
ムーア，ケビン・ウイリアム
モイズ，クリストフアー・リチヤード
ローリー，マイケル
ストリート，レズリー・ジヨージフ
Original Assignee
メルク シャープ エンド ドーム リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク シャープ エンド ドーム リミテッド filed Critical メルク シャープ エンド ドーム リミテッド
Publication of JP2003507479A publication Critical patent/JP2003507479A/ja
Publication of JP2003507479A5 publication Critical patent/JP2003507479A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
JP2001518708A 1999-08-23 2000-08-17 Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体 Withdrawn JP2003507479A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9919957.2A GB9919957D0 (en) 1999-08-23 1999-08-23 Therapeutic agents
GB9919957.2 1999-08-23
PCT/GB2000/003199 WO2001014377A1 (en) 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
JP2003507479A true JP2003507479A (ja) 2003-02-25
JP2003507479A5 JP2003507479A5 (https=) 2007-10-11

Family

ID=10859670

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001518708A Withdrawn JP2003507479A (ja) 1999-08-23 2000-08-17 Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体

Country Status (10)

Country Link
US (1) US6608062B1 (https=)
EP (1) EP1212324B1 (https=)
JP (1) JP2003507479A (https=)
AT (1) ATE253066T1 (https=)
AU (1) AU775008B2 (https=)
CA (1) CA2380452C (https=)
DE (1) DE60006260T2 (https=)
ES (1) ES2208404T3 (https=)
GB (1) GB9919957D0 (https=)
WO (1) WO2001014377A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010509312A (ja) * 2006-11-10 2010-03-25 アデックス ファーマ ソシエテ アノニム Ｇａｂａｂ受容体調節因子としての新規トリアジンジオン誘導体
JP2024529839A (ja) * 2021-06-29 2024-08-14 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
AU2003252499B2 (en) * 2002-07-12 2007-11-08 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2006327300A1 (en) 2005-12-20 2007-06-28 Astrazeneca Ab Substituted Cinnoline derivatives as GABAa-receptor modulators and method for their synthesis
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
IL310992A (en) * 2021-08-25 2024-04-01 Ptc Therapeutics Inc NLRP3 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
ES2194205T3 (es) 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
CA2346289A1 (en) * 1998-10-16 2000-04-27 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for gaba receptors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010509312A (ja) * 2006-11-10 2010-03-25 アデックス ファーマ ソシエテ アノニム Ｇａｂａｂ受容体調節因子としての新規トリアジンジオン誘導体
JP2024529839A (ja) * 2021-06-29 2024-08-14 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター

Also Published As

Publication number Publication date
EP1212324A1 (en) 2002-06-12
ES2208404T3 (es) 2004-06-16
ATE253066T1 (de) 2003-11-15
GB9919957D0 (en) 1999-10-27
US6608062B1 (en) 2003-08-19
WO2001014377A1 (en) 2001-03-01
AU775008B2 (en) 2004-07-15
EP1212324B1 (en) 2003-10-29
CA2380452C (en) 2008-10-28
AU6707700A (en) 2001-03-19
DE60006260T2 (de) 2004-07-29
DE60006260D1 (de) 2003-12-04
CA2380452A1 (en) 2001-03-01

Similar Documents

Publication Publication Date Title
US6476030B1 (en) Pyrazolo-triazine derivatives as ligands for GABA receptors
EP1149102B1 (en) Triazolo-pyridazine derivatives as ligands for gaba receptors
US6541484B2 (en) Pyrazolo-pyridine derivatives as ligands for GABA receptors
JP2003507479A (ja) Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体
JP2002501066A (ja) Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体
US6593325B1 (en) Pyrido-pyridazine derivatives as ligands for GABA receptors
US6872720B2 (en) Pyrazolo-triazine derivatives as ligands for gaba receptors
JP2002518391A (ja) Ｇａｂａ受容体のリガンドとしてのトリアゾロ−ピリジン誘導体
JP2002501067A (ja) Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体
US6303597B1 (en) Triazolo-pyridazine derivatives as ligands for GABA receptors
US6730676B2 (en) Pyrazino-pyridazine derivatives as ligands for GABA receptors
JP2002518392A (ja) Ｇａｂａ受容体のリガンドとしてのトリアゾロピリミジン類
JP2002501071A (ja) Ｇａｂａ受容体のリガンドとしてのトリアゾロ−ピリダジン誘導体
WO2004014891A1 (en) Pyridazine derivatives as ligands for gaba receptors
US6699859B1 (en) Triazolo-pyridazine derivatives as ligands for GABA receptors
JP2002501069A (ja) Ｇａｂａ受容体のためのリガンドとしてのトリアゾロ−ピリダジン誘導体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070815

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070815

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20091210