AU775008B2 - Imidazo-triazine derivatives as ligands for gaba receptors - Google Patents

Imidazo-triazine derivatives as ligands for gaba receptors Download PDF

Info

Publication number
AU775008B2
AU775008B2 AU67077/00A AU6707700A AU775008B2 AU 775008 B2 AU775008 B2 AU 775008B2 AU 67077/00 A AU67077/00 A AU 67077/00A AU 6707700 A AU6707700 A AU 6707700A AU 775008 B2 AU775008 B2 AU 775008B2
Authority
AU
Australia
Prior art keywords
methyl
triazine
triazol
ylmethoxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU67077/00A
Other languages
English (en)
Other versions
AU6707700A (en
Inventor
William Robert Carling
Alexander Richard Guiblin
Kevin William Moore
Christopher Richard Moyes
Michael Rowley
Leslie Joseph Street
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU6707700A publication Critical patent/AU6707700A/en
Application granted granted Critical
Publication of AU775008B2 publication Critical patent/AU775008B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AU67077/00A 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors Ceased AU775008B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9919957.2A GB9919957D0 (en) 1999-08-23 1999-08-23 Therapeutic agents
GB9919957 1999-08-23
PCT/GB2000/003199 WO2001014377A1 (en) 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
AU6707700A AU6707700A (en) 2001-03-19
AU775008B2 true AU775008B2 (en) 2004-07-15

Family

ID=10859670

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67077/00A Ceased AU775008B2 (en) 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors

Country Status (10)

Country Link
US (1) US6608062B1 (https=)
EP (1) EP1212324B1 (https=)
JP (1) JP2003507479A (https=)
AT (1) ATE253066T1 (https=)
AU (1) AU775008B2 (https=)
CA (1) CA2380452C (https=)
DE (1) DE60006260T2 (https=)
ES (1) ES2208404T3 (https=)
GB (1) GB9919957D0 (https=)
WO (1) WO2001014377A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0210127D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
AU2003252499B2 (en) * 2002-07-12 2007-11-08 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US7425556B2 (en) 2005-12-20 2008-09-16 Astrazeneca Ab Compounds and uses thereof
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
GB0622472D0 (en) 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP4362946A4 (en) * 2021-06-29 2025-05-21 Zomagen Biosciences Ltd Nlrp3 modulators
CR20240093A (es) * 2021-08-25 2024-05-23 Ptc Therapeutics Inc Inhibidores de NLRP3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422194A (en) 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
KR20000029548A (ko) * 1996-07-25 2000-05-25 더블유. 지. 콜 가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체
ATE371659T1 (de) 1998-10-16 2007-09-15 Merck Sharp & Dohme Pyrazolotriazinderivate als gaba-rezeptorliganden

Also Published As

Publication number Publication date
CA2380452C (en) 2008-10-28
US6608062B1 (en) 2003-08-19
AU6707700A (en) 2001-03-19
GB9919957D0 (en) 1999-10-27
WO2001014377A1 (en) 2001-03-01
ES2208404T3 (es) 2004-06-16
ATE253066T1 (de) 2003-11-15
DE60006260D1 (de) 2003-12-04
EP1212324B1 (en) 2003-10-29
CA2380452A1 (en) 2001-03-01
EP1212324A1 (en) 2002-06-12
DE60006260T2 (de) 2004-07-29
JP2003507479A (ja) 2003-02-25

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