DE60004377T2 - Oral wirksame 7-alpha-alkyl androgene - Google Patents

Oral wirksame 7-alpha-alkyl androgene Download PDF

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Publication number
DE60004377T2
DE60004377T2 DE60004377T DE60004377T DE60004377T2 DE 60004377 T2 DE60004377 T2 DE 60004377T2 DE 60004377 T DE60004377 T DE 60004377T DE 60004377 T DE60004377 T DE 60004377T DE 60004377 T2 DE60004377 T2 DE 60004377T2
Authority
DE
Germany
Prior art keywords
alkyl
ethyl
compound
ethenyl
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004377T
Other languages
German (de)
English (en)
Other versions
DE60004377D1 (de
Inventor
Jaap Louw Van Der
Dirk Leysen
Roberta Buma Bursi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE60004377D1 publication Critical patent/DE60004377D1/de
Application granted granted Critical
Publication of DE60004377T2 publication Critical patent/DE60004377T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60004377T 1999-04-06 2000-03-31 Oral wirksame 7-alpha-alkyl androgene Expired - Lifetime DE60004377T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201070 1999-04-06
EP99201070 1999-04-06
PCT/EP2000/002851 WO2000059920A2 (en) 1999-04-06 2000-03-31 Orally active 7.alpha.-alkyl androgens

Publications (2)

Publication Number Publication Date
DE60004377D1 DE60004377D1 (de) 2003-09-11
DE60004377T2 true DE60004377T2 (de) 2004-06-09

Family

ID=8240066

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004377T Expired - Lifetime DE60004377T2 (de) 1999-04-06 2000-03-31 Oral wirksame 7-alpha-alkyl androgene

Country Status (10)

Country Link
US (2) US6756366B1 (enExample)
EP (1) EP1212345B1 (enExample)
JP (1) JP2002541153A (enExample)
AT (1) ATE246703T1 (enExample)
AU (1) AU5209600A (enExample)
CO (1) CO5160345A1 (enExample)
DE (1) DE60004377T2 (enExample)
ES (1) ES2204613T3 (enExample)
PE (1) PE20010029A1 (enExample)
WO (1) WO2000059920A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
AU2003205604B8 (en) * 2002-01-21 2009-12-24 Merck Sharp & Dohme B.V. Process for the preparation of 7alpha-methylsteroids
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
KR101602802B1 (ko) * 2008-04-09 2016-03-11 페린 파마슈티칼즈, 인코포레이티드 고열 홍조에 대한 스테로이드 치료
EP2667876A2 (en) * 2010-12-15 2013-12-04 Harbor BioSciences, Inc. Methods and compounds for preparing 3alpha-oxygen substituted steroids

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755689A (fr) * 1969-09-03 1971-03-03 Upjohn Co Procede de fabrication de nouvelles 7 beta-alkyl-19- nortestosterones
US5342834A (en) * 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
US6037339A (en) * 1993-02-08 2000-03-14 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
DE69418744T2 (de) * 1993-03-05 1999-11-11 Akzo Nobel N.V., Arnheim/Arnhem Verwendung von Pregnanderivaten zur Behandlung von Tumoren
IL113816A (en) * 1994-06-08 1998-12-06 Akzo Nobel Nv Pharmaceutical compositions containing desogestrel their preparation and use
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
PT833642E (pt) * 1995-06-22 2002-08-30 Akzo Nobel Nv Comprimidos de desogestrel prensados por granulacao a seco
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
IL119468A (en) * 1995-11-06 2000-02-29 Akzo Nobel Nv Method of isomerisation of equilin or derivatives thereof
US5998639A (en) * 1995-11-06 1999-12-07 Akzo Nobel, N.V. Sulfatation of estrogen mixtures
CA2200423C (en) * 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
IL123195A (en) * 1997-02-21 2002-11-10 Akzo Nobel Nv Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them
CN1260802A (zh) * 1997-05-16 2000-07-19 阿克佐诺贝尔公司 20－芳烷基－5α－孕甾烷衍生物
ATE215555T1 (de) * 1997-06-04 2002-04-15 Akzo Nobel Nv 17-beta.-allyloxy(thio)alkyl-androstan derivative zur modulation von meiose
DK0927556T3 (da) * 1997-09-23 2000-11-20 Akzo Nobel Nv Coatede dosisenheder
US6080773A (en) * 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
HUP0100542A3 (en) * 1997-11-14 2001-10-29 Akzo Nobel Nv Progestogen and antiprogestogen containing kit, process for its preparation and use of the compounds for the preparation of contraseptives
ATE220686T1 (de) * 1997-12-18 2002-08-15 Akzo Nobel Nv 17beta-aryl(arylmethyl)oxy(thio)alkyl- androstanderivative
JP4422331B2 (ja) * 1998-02-26 2010-02-24 ナームローゼ・フエンノートチヤツプ・オルガノン アゼチジン誘導体およびピロリジン誘導体
AU756739B2 (en) * 1998-06-19 2003-01-23 N.V. Organon Testosterone derivative
US6528501B1 (en) * 1998-12-11 2003-03-04 Akzo Nobel N.V. 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
JP2002539134A (ja) * 1999-03-09 2002-11-19 アクゾ・ノベル・エヌ・ベー 減数分裂の阻害のための２２ｒ−ヒドロキシコレスタ−８，１４−ジエン誘導体
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
TW548277B (en) * 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
KR20020092907A (ko) * 1999-09-06 2002-12-12 악조 노벨 엔.브이. 11번 위치에 탄화수소 치환기를 보유한 비방향족에스트로겐 스테로이드
SK287095B6 (sk) * 1999-12-02 2009-12-07 N.V. Organon Androgénové zlúčeniny, použitie androgénových zlúčenín a súprava s ich obsahom
ATE374752T1 (de) * 2000-03-27 2007-10-15 Organon Nv Nicht-steroidale tetracyclische verbindungen für östrogen-verwandte behandlungen
JP2004506712A (ja) * 2000-08-23 2004-03-04 アクゾ・ノベル・エヌ・ベー 医療に使用するための１０−アリール−１１Ｈ−ベンゾ［ｂ］フルオレン誘導体および類似体

Also Published As

Publication number Publication date
WO2000059920A3 (en) 2001-02-15
CO5160345A1 (es) 2002-05-30
ES2204613T3 (es) 2004-05-01
EP1212345B1 (en) 2003-08-06
DE60004377D1 (de) 2003-09-11
JP2002541153A (ja) 2002-12-03
PE20010029A1 (es) 2001-01-26
WO2000059920A2 (en) 2000-10-12
AU5209600A (en) 2000-10-23
US6756366B1 (en) 2004-06-29
EP1212345A2 (en) 2002-06-12
US20040209853A1 (en) 2004-10-21
ATE246703T1 (de) 2003-08-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL