DE60003323D1 - Verfahren für die herstellung von methylenbisphosphonsäure und deren salze - Google Patents
Verfahren für die herstellung von methylenbisphosphonsäure und deren salzeInfo
- Publication number
- DE60003323D1 DE60003323D1 DE60003323T DE60003323T DE60003323D1 DE 60003323 D1 DE60003323 D1 DE 60003323D1 DE 60003323 T DE60003323 T DE 60003323T DE 60003323 T DE60003323 T DE 60003323T DE 60003323 D1 DE60003323 D1 DE 60003323D1
- Authority
- DE
- Germany
- Prior art keywords
- salts
- production
- bisphosphonic acid
- methylene bisphosphonic
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903345 | 1999-09-17 | ||
| SE9903345A SE9903345D0 (sv) | 1999-09-17 | 1999-09-17 | Novel process |
| PCT/GB2000/003473 WO2001021629A1 (en) | 1999-09-17 | 2000-09-11 | Process for preparing methylene bisphosphonic and salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60003323D1 true DE60003323D1 (de) | 2003-07-17 |
| DE60003323T2 DE60003323T2 (de) | 2004-04-29 |
Family
ID=20417040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60003323T Expired - Lifetime DE60003323T2 (de) | 1999-09-17 | 2000-09-11 | Verfahren für die herstellung von methylenbisphosphonsäure und deren salze |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6657076B1 (de) |
| EP (1) | EP1216253B1 (de) |
| JP (1) | JP4881524B2 (de) |
| KR (1) | KR100776105B1 (de) |
| CN (1) | CN1150200C (de) |
| AR (1) | AR029393A1 (de) |
| AT (1) | ATE242778T1 (de) |
| AU (1) | AU771628B2 (de) |
| BR (1) | BR0014057A (de) |
| CA (1) | CA2383829C (de) |
| CO (1) | CO5231228A1 (de) |
| DE (1) | DE60003323T2 (de) |
| DK (1) | DK1216253T3 (de) |
| ES (1) | ES2200921T3 (de) |
| HK (1) | HK1045696B (de) |
| IL (2) | IL148442A (de) |
| MY (1) | MY119965A (de) |
| NO (1) | NO331532B1 (de) |
| NZ (1) | NZ517552A (de) |
| PT (1) | PT1216253E (de) |
| SE (1) | SE9903345D0 (de) |
| TW (1) | TWI274057B (de) |
| WO (1) | WO2001021629A1 (de) |
| ZA (1) | ZA200201661B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
| CN101282730A (zh) * | 2005-10-06 | 2008-10-08 | 依奈特制药公司 | 有机碱的磷酸抗原盐及其结晶方法 |
| JP5363045B2 (ja) * | 2008-07-24 | 2013-12-11 | 大八化学工業株式会社 | ホスホン酸の製造方法 |
| BR112017014996A2 (pt) | 2015-01-14 | 2018-03-20 | Chiesi Farm Spa | formulações farmacêuticas e recipientes selados |
| CN111647016A (zh) * | 2020-07-10 | 2020-09-11 | 成都纽瑞特医疗科技股份有限公司 | 羟基亚甲基二膦酸盐的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3251907A (en) * | 1962-08-23 | 1966-05-17 | Procter & Gamble | Method for preparing tetra-secondary alkyl methylenediphosphonates |
| CA777769A (en) | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
| JPS54125777A (en) | 1978-03-20 | 1979-09-29 | Kao Corp | Bleaching composition |
| IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| US4478763A (en) * | 1982-10-20 | 1984-10-23 | Univ. Of Southern California | Process for preparing alpha-fluorinated alkanediphosphonates |
| JPS61123709A (ja) * | 1984-11-19 | 1986-06-11 | Nippon Soken Inc | 排気ガス微粒子浄化機能を有する内燃機関の制御装置 |
| US4689123A (en) * | 1986-12-23 | 1987-08-25 | The Dow Chemical Company | Novel tetraphosphonic acid compounds, intermediates and a process for their production |
| FI83421C (fi) * | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
| FI83657C (fi) * | 1989-09-08 | 1991-08-12 | Huhtamaeki Oy | Foerfarande foer framstaellning av metylenbisfosfonsyror. |
| FI89366C (fi) | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
| HU221501B (en) | 1993-02-10 | 2002-10-28 | Astrazeneca Ab | N-alkyl-2-substituted atp analogues |
| EP0742279A1 (de) | 1995-05-10 | 1996-11-13 | The Procter & Gamble Company | Saure wässrige flüssige Zusammensetzungen |
| SE9701219D0 (sv) | 1997-04-04 | 1997-04-04 | Astra Pharma Prod | New compounds |
| FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
| SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
-
1999
- 1999-09-17 SE SE9903345A patent/SE9903345D0/xx unknown
-
2000
- 2000-09-11 BR BR0014057-0A patent/BR0014057A/pt not_active Application Discontinuation
- 2000-09-11 DE DE60003323T patent/DE60003323T2/de not_active Expired - Lifetime
- 2000-09-11 AU AU70270/00A patent/AU771628B2/en not_active Expired
- 2000-09-11 PT PT00958856T patent/PT1216253E/pt unknown
- 2000-09-11 KR KR1020027003519A patent/KR100776105B1/ko active IP Right Grant
- 2000-09-11 WO PCT/GB2000/003473 patent/WO2001021629A1/en active Application Filing
- 2000-09-11 CA CA002383829A patent/CA2383829C/en not_active Expired - Lifetime
- 2000-09-11 AT AT00958856T patent/ATE242778T1/de active
- 2000-09-11 IL IL14844200A patent/IL148442A/xx active IP Right Grant
- 2000-09-11 EP EP00958856A patent/EP1216253B1/de not_active Expired - Lifetime
- 2000-09-11 NZ NZ517552A patent/NZ517552A/en not_active IP Right Cessation
- 2000-09-11 DK DK00958856T patent/DK1216253T3/da active
- 2000-09-11 JP JP2001525004A patent/JP4881524B2/ja not_active Expired - Lifetime
- 2000-09-11 ES ES00958856T patent/ES2200921T3/es not_active Expired - Lifetime
- 2000-09-11 US US10/088,177 patent/US6657076B1/en not_active Expired - Lifetime
- 2000-09-11 CN CNB008121826A patent/CN1150200C/zh not_active Expired - Lifetime
- 2000-09-14 TW TW089118778A patent/TWI274057B/zh not_active IP Right Cessation
- 2000-09-15 MY MYPI20004298A patent/MY119965A/en unknown
- 2000-09-15 AR ARP000104849A patent/AR029393A1/es active IP Right Grant
- 2000-09-18 CO CO00070530A patent/CO5231228A1/es active IP Right Grant
-
2002
- 2002-02-27 ZA ZA200201661A patent/ZA200201661B/en unknown
- 2002-03-14 NO NO20021269A patent/NO331532B1/no not_active IP Right Cessation
- 2002-10-07 HK HK02107336.6A patent/HK1045696B/zh not_active IP Right Cessation
-
2003
- 2003-12-01 US US10/725,820 patent/US7288673B2/en not_active Expired - Lifetime
-
2005
- 2005-04-26 IL IL168246A patent/IL168246A/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |