BR0014057A - Processo para preparar ácido metileno bisfosfÈnico substituìdo ou não substituìdo, e, sal do mesmo - Google Patents
Processo para preparar ácido metileno bisfosfÈnico substituìdo ou não substituìdo, e, sal do mesmoInfo
- Publication number
- BR0014057A BR0014057A BR0014057-0A BR0014057A BR0014057A BR 0014057 A BR0014057 A BR 0014057A BR 0014057 A BR0014057 A BR 0014057A BR 0014057 A BR0014057 A BR 0014057A
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- acid
- unsubstituted methylene
- bisphosphonic acid
- preparing substituted
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO PARA PREPARAR áCIDO METILENO BISFOSFÈNICO SUBSTITUìDO OU NãO SUBSTITUìDO, E, SAL DO MESMO". Processo para a preparação de sais de ácidos metileno bisfosfónicos substituídos ou não substituídos através de hidrólise do éster de ácido correspondente com ácido clorídrico, remoção de água do ácido azeotropicamente antes da adição de amina ou base para produzir o sal resultante em bom rendimento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9903345A SE9903345D0 (sv) | 1999-09-17 | 1999-09-17 | Novel process |
PCT/GB2000/003473 WO2001021629A1 (en) | 1999-09-17 | 2000-09-11 | Process for preparing methylene bisphosphonic and salts |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014057A true BR0014057A (pt) | 2002-05-21 |
Family
ID=20417040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014057-0A BR0014057A (pt) | 1999-09-17 | 2000-09-11 | Processo para preparar ácido metileno bisfosfÈnico substituìdo ou não substituìdo, e, sal do mesmo |
Country Status (24)
Country | Link |
---|---|
US (2) | US6657076B1 (pt) |
EP (1) | EP1216253B1 (pt) |
JP (1) | JP4881524B2 (pt) |
KR (1) | KR100776105B1 (pt) |
CN (1) | CN1150200C (pt) |
AR (1) | AR029393A1 (pt) |
AT (1) | ATE242778T1 (pt) |
AU (1) | AU771628B2 (pt) |
BR (1) | BR0014057A (pt) |
CA (1) | CA2383829C (pt) |
CO (1) | CO5231228A1 (pt) |
DE (1) | DE60003323T2 (pt) |
DK (1) | DK1216253T3 (pt) |
ES (1) | ES2200921T3 (pt) |
HK (1) | HK1045696B (pt) |
IL (2) | IL148442A (pt) |
MY (1) | MY119965A (pt) |
NO (1) | NO331532B1 (pt) |
NZ (1) | NZ517552A (pt) |
PT (1) | PT1216253E (pt) |
SE (1) | SE9903345D0 (pt) |
TW (1) | TWI274057B (pt) |
WO (1) | WO2001021629A1 (pt) |
ZA (1) | ZA200201661B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
CN101282730A (zh) * | 2005-10-06 | 2008-10-08 | 依奈特制药公司 | 有机碱的磷酸抗原盐及其结晶方法 |
JP5363045B2 (ja) * | 2008-07-24 | 2013-12-11 | 大八化学工業株式会社 | ホスホン酸の製造方法 |
BR112017014996A2 (pt) | 2015-01-14 | 2018-03-20 | Chiesi Farm Spa | formulações farmacêuticas e recipientes selados |
CN111647016A (zh) * | 2020-07-10 | 2020-09-11 | 成都纽瑞特医疗科技股份有限公司 | 羟基亚甲基二膦酸盐的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3251907A (en) * | 1962-08-23 | 1966-05-17 | Procter & Gamble | Method for preparing tetra-secondary alkyl methylenediphosphonates |
CA777769A (en) | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
JPS54125777A (en) | 1978-03-20 | 1979-09-29 | Kao Corp | Bleaching composition |
IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
US4478763A (en) * | 1982-10-20 | 1984-10-23 | Univ. Of Southern California | Process for preparing alpha-fluorinated alkanediphosphonates |
JPS61123709A (ja) * | 1984-11-19 | 1986-06-11 | Nippon Soken Inc | 排気ガス微粒子浄化機能を有する内燃機関の制御装置 |
US4689123A (en) * | 1986-12-23 | 1987-08-25 | The Dow Chemical Company | Novel tetraphosphonic acid compounds, intermediates and a process for their production |
FI83421C (fi) * | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
FI83657C (fi) * | 1989-09-08 | 1991-08-12 | Huhtamaeki Oy | Foerfarande foer framstaellning av metylenbisfosfonsyror. |
FI89366C (fi) | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
HU221501B (en) | 1993-02-10 | 2002-10-28 | Astrazeneca Ab | N-alkyl-2-substituted atp analogues |
EP0742279A1 (en) | 1995-05-10 | 1996-11-13 | The Procter & Gamble Company | Acidic aqueous liquid compositions |
SE9701219D0 (sv) | 1997-04-04 | 1997-04-04 | Astra Pharma Prod | New compounds |
FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
-
1999
- 1999-09-17 SE SE9903345A patent/SE9903345D0/xx unknown
-
2000
- 2000-09-11 BR BR0014057-0A patent/BR0014057A/pt not_active Application Discontinuation
- 2000-09-11 DE DE60003323T patent/DE60003323T2/de not_active Expired - Lifetime
- 2000-09-11 AU AU70270/00A patent/AU771628B2/en not_active Expired
- 2000-09-11 PT PT00958856T patent/PT1216253E/pt unknown
- 2000-09-11 KR KR1020027003519A patent/KR100776105B1/ko active IP Right Grant
- 2000-09-11 WO PCT/GB2000/003473 patent/WO2001021629A1/en active Application Filing
- 2000-09-11 CA CA002383829A patent/CA2383829C/en not_active Expired - Lifetime
- 2000-09-11 AT AT00958856T patent/ATE242778T1/de active
- 2000-09-11 IL IL14844200A patent/IL148442A/xx active IP Right Grant
- 2000-09-11 EP EP00958856A patent/EP1216253B1/en not_active Expired - Lifetime
- 2000-09-11 NZ NZ517552A patent/NZ517552A/en not_active IP Right Cessation
- 2000-09-11 DK DK00958856T patent/DK1216253T3/da active
- 2000-09-11 JP JP2001525004A patent/JP4881524B2/ja not_active Expired - Lifetime
- 2000-09-11 ES ES00958856T patent/ES2200921T3/es not_active Expired - Lifetime
- 2000-09-11 US US10/088,177 patent/US6657076B1/en not_active Expired - Lifetime
- 2000-09-11 CN CNB008121826A patent/CN1150200C/zh not_active Expired - Lifetime
- 2000-09-14 TW TW089118778A patent/TWI274057B/zh not_active IP Right Cessation
- 2000-09-15 MY MYPI20004298A patent/MY119965A/en unknown
- 2000-09-15 AR ARP000104849A patent/AR029393A1/es active IP Right Grant
- 2000-09-18 CO CO00070530A patent/CO5231228A1/es active IP Right Grant
-
2002
- 2002-02-27 ZA ZA200201661A patent/ZA200201661B/en unknown
- 2002-03-14 NO NO20021269A patent/NO331532B1/no not_active IP Right Cessation
- 2002-10-07 HK HK02107336.6A patent/HK1045696B/zh not_active IP Right Cessation
-
2003
- 2003-12-01 US US10/725,820 patent/US7288673B2/en not_active Expired - Lifetime
-
2005
- 2005-04-26 IL IL168246A patent/IL168246A/en active IP Right Grant
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |