DE60002042D1 - Neue kristallinische form des kaliumsalzes des (s)-omeprazols - Google Patents

Neue kristallinische form des kaliumsalzes des (s)-omeprazols

Info

Publication number
DE60002042D1
DE60002042D1 DE60002042T DE60002042T DE60002042D1 DE 60002042 D1 DE60002042 D1 DE 60002042D1 DE 60002042 T DE60002042 T DE 60002042T DE 60002042 T DE60002042 T DE 60002042T DE 60002042 D1 DE60002042 D1 DE 60002042D1
Authority
DE
Germany
Prior art keywords
omeprazol
crystaline
new
shape
potassium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60002042T
Other languages
English (en)
Other versions
DE60002042T2 (de
Inventor
Maths Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60002042D1 publication Critical patent/DE60002042D1/de
Application granted granted Critical
Publication of DE60002042T2 publication Critical patent/DE60002042T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60002042T 1999-01-28 2000-01-18 Neue kristallinische form des kaliumsalzes des (s)-omeprazols Expired - Lifetime DE60002042T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9900274A SE9900274D0 (sv) 1999-01-28 1999-01-28 New compound
PCT/SE2000/000087 WO2000044744A1 (en) 1999-01-28 2000-01-18 Potassium salt of ($i(s))-omeprazole

Publications (2)

Publication Number Publication Date
DE60002042D1 true DE60002042D1 (de) 2003-05-15
DE60002042T2 DE60002042T2 (de) 2003-12-18

Family

ID=20414267

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002042T Expired - Lifetime DE60002042T2 (de) 1999-01-28 2000-01-18 Neue kristallinische form des kaliumsalzes des (s)-omeprazols

Country Status (40)

Country Link
US (1) US6511996B1 (de)
EP (1) EP1149090B1 (de)
JP (1) JP2002535401A (de)
KR (1) KR100624054B1 (de)
CN (1) CN1231477C (de)
AR (1) AR022425A1 (de)
AT (1) ATE236899T1 (de)
AU (1) AU768676B2 (de)
BG (1) BG65060B1 (de)
BR (1) BR0007647A (de)
CA (1) CA2357744C (de)
CZ (1) CZ300504B6 (de)
DE (1) DE60002042T2 (de)
DK (1) DK1149090T3 (de)
DZ (1) DZ3001A1 (de)
EE (1) EE04240B1 (de)
EG (1) EG23980A (de)
ES (1) ES2193937T3 (de)
HK (1) HK1041259B (de)
HU (1) HU226766B1 (de)
ID (1) ID30095A (de)
IL (1) IL144107A0 (de)
IS (1) IS2019B (de)
MY (1) MY119095A (de)
NO (1) NO319719B1 (de)
NZ (1) NZ512804A (de)
PL (1) PL197881B1 (de)
PT (1) PT1149090E (de)
RS (1) RS50200B (de)
RU (1) RU2237666C2 (de)
SA (1) SA00200895B1 (de)
SE (1) SE9900274D0 (de)
SI (1) SI1149090T1 (de)
SK (1) SK285626B6 (de)
TN (1) TNSN00017A1 (de)
TR (1) TR200102138T2 (de)
TW (1) TWI269795B (de)
UA (1) UA71594C2 (de)
WO (1) WO2000044744A1 (de)
ZA (1) ZA200105526B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US6875872B1 (en) * 1993-05-28 2005-04-05 Astrazeneca Compounds
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
CN1842525A (zh) 2003-05-05 2006-10-04 兰贝克赛实验室有限公司 苯并咪唑衍生物的钡盐
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP2007532677A (ja) * 2004-04-16 2007-11-15 サンタラス インコーポレイティッド プロトンポンプ阻害剤、緩衝剤、および運動促進薬の組み合わせ
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
NZ551970A (en) * 2004-06-24 2010-01-29 Astrazeneca Ab New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt
WO2006073779A1 (en) * 2004-12-30 2006-07-13 Transform Phamaceuticals, Inc. Novel omeprazole forms and related methods
ES2259269B1 (es) 2005-03-03 2007-11-01 Esteve Quimica, S.A. Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos.
US7576219B2 (en) 2005-10-26 2009-08-18 Hanmi Pharm. Co., Ltd Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
CN100384839C (zh) * 2006-02-17 2008-04-30 中国科学院上海有机化学研究所 [(取代的吡啶基)甲基]亚磺酰基-1h-苯并咪唑类化合物及其对映体的锌盐的制备方法
WO2007148213A2 (en) * 2006-06-21 2007-12-27 Glenmark Pharmaceuticals Limited Novel polymorph of esomeprazole potassium and process for its preparation
GB2444593B (en) 2006-10-05 2010-06-09 Santarus Inc Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
US7906678B2 (en) 2006-12-04 2011-03-15 Bayer Schering Pharma Aktiengesellschaft Crystalline potassium salt of lipoxin A4 analogs
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
WO2009074997A2 (en) * 2007-12-10 2009-06-18 Lee Pharma Ltd. A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate
EP2143722A1 (de) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Verfahren zur Herstellung von Esomeprazol-Natrium von hoher chemischer Reinheit und neue Formen von Esomeprazol-Natrium
WO2010097583A1 (en) 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
WO2010122583A2 (en) 2009-04-24 2010-10-28 Rubicon Research Private Limited Oral pharmaceutical compositions of acid labile substances
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
CN102319223B (zh) * 2011-09-21 2013-06-19 石药集团欧意药业有限公司 一种埃索美拉唑冻干制剂及其制备方法
CN102633776B (zh) * 2012-03-28 2014-06-18 中山市仁合药业有限公司 一种埃索美拉唑及其钠盐的制备方法
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE4035455A1 (de) 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
US5877192A (en) 1993-05-28 1999-03-02 Astra Aktiebolag Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
UA41946C2 (uk) 1994-07-08 2001-10-15 Астра Актієболаг Оральна фармацевтична складова одинична дозована форма у вигляді таблетки, спосіб її одержання, упаковка у вигляді блістера та спосіб інгібування секреції шлункової кислоти і/або лікування шлунково-кишкових запальних захворювань
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) 1994-11-28 1995-01-11 Astra Ab Oxidation
HRP960232A2 (en) 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
SE510643C2 (sv) * 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B

Also Published As

Publication number Publication date
AU768676B2 (en) 2003-12-18
PL197881B1 (pl) 2008-05-30
IS2019B (is) 2005-06-15
EP1149090B1 (de) 2003-04-09
SK10372001A3 (sk) 2002-02-05
BG65060B1 (bg) 2007-01-31
EG23980A (en) 2008-02-27
HUP0105313A2 (hu) 2002-05-29
CA2357744A1 (en) 2000-08-03
RS50200B (sr) 2009-07-15
CZ20012730A3 (cs) 2002-02-13
TNSN00017A1 (fr) 2005-11-10
DZ3001A1 (fr) 2004-03-27
NO20013665D0 (no) 2001-07-26
HK1041259A1 (en) 2002-07-05
JP2002535401A (ja) 2002-10-22
CN1339034A (zh) 2002-03-06
SE9900274D0 (sv) 1999-01-28
ZA200105526B (en) 2002-10-04
AR022425A1 (es) 2002-09-04
MY119095A (en) 2005-03-31
KR100624054B1 (ko) 2006-09-18
IS5989A (is) 2001-07-05
BR0007647A (pt) 2001-10-16
HK1041259B (zh) 2003-10-24
SA00200895B1 (ar) 2006-11-11
TR200102138T2 (tr) 2001-12-21
RU2237666C2 (ru) 2004-10-10
BG105841A (en) 2002-04-30
ID30095A (id) 2001-11-01
ES2193937T3 (es) 2003-11-16
DK1149090T3 (da) 2003-06-30
CN1231477C (zh) 2005-12-14
HU226766B1 (en) 2009-09-28
DE60002042T2 (de) 2003-12-18
NO20013665L (no) 2001-07-26
WO2000044744A1 (en) 2000-08-03
CA2357744C (en) 2009-06-16
CZ300504B6 (cs) 2009-06-03
US6511996B1 (en) 2003-01-28
NZ512804A (en) 2003-07-25
KR20010101699A (ko) 2001-11-14
TWI269795B (en) 2007-01-01
EP1149090A1 (de) 2001-10-31
EE200100395A (et) 2002-10-15
IL144107A0 (en) 2002-05-23
EE04240B1 (et) 2004-02-16
SI1149090T1 (en) 2003-10-31
ATE236899T1 (de) 2003-04-15
NO319719B1 (no) 2005-09-05
AU2469400A (en) 2000-08-18
HUP0105313A3 (en) 2003-01-28
PT1149090E (pt) 2003-07-31
UA71594C2 (uk) 2004-12-15
SK285626B6 (sk) 2007-05-03
YU53801A (sh) 2004-07-15

Similar Documents

Publication Publication Date Title
DE60002042T2 (de) Neue kristallinische form des kaliumsalzes des (s)-omeprazols
ATE258918T1 (de) Kristallform alpha des perindopril-tert- butylaminsalzes
ID25792A (id) Antibodi-antibodi terhadap cd40 manusia
ID24829A (id) Garam natrium omeprazola
EE200200403A (et) Pregabaliini asümmeetriline süntees
AR028567A1 (es) Nuevos derivados de fenil-propargileter
MA27126A1 (fr) 3'PROMEDICAMENTS DE 2'-DESOXY- β-L-NUCLEOSIDES
EP1503795A4 (de) Verwendung von hitzschockproteinen zur verstärkung der wirksamkeit von antikörper-therapeutika
PT1250321E (pt) Composicao de gliburida
ID30226A (id) Komposisi penat rambut
DE60107074D1 (de) Kristallin form ii von cabergolin
PT1322592E (pt) Derivados substituidos de 1-aminobutan-3-ol
AR028070A1 (es) Sintesis de compuestos de ciclohexendimetanol o ciclohexandimetanol
DE60019461D1 (de) Neue polymorphe formen von olanzapin
ID21715A (id) Fungsionalisasi selektif natrium glisinat
PT1230212E (pt) Metodo de embalar elementos de construcao de brinquedo
ID30381A (id) Penggunaan arilalkanoilpiridazina
ID25524A (id) Komposisi pasta natrium sianida
PT1232141E (pt) Eteres de o-desmetil-venlafaxina
AR028007A1 (es) Procedimiento para preparar eteres de oxima
FR2774984B1 (fr) Purification du thiophene
GB0031030D0 (en) Use of salt water
ES1046338Y (es) Salero pefeccionado
DE60124221D1 (de) MONOHYDRAT DES CIS-LITHIUM-CYANO-4-i3-(CYCLOPENTYLOY)-4-METHOXYPHENYLöCYCLOHEXANCARBOXYLATS
EP1210591A4 (de) Abgeschlossene salzbrücke

Legal Events

Date Code Title Description
8364 No opposition during term of opposition