DE59712460D1 - Messvorrichtung mit einem planaren optischen wellenleiter - Google Patents

Messvorrichtung mit einem planaren optischen wellenleiter

Info

Publication number
DE59712460D1
DE59712460D1 DE59712460T DE59712460T DE59712460D1 DE 59712460 D1 DE59712460 D1 DE 59712460D1 DE 59712460 T DE59712460 T DE 59712460T DE 59712460 T DE59712460 T DE 59712460T DE 59712460 D1 DE59712460 D1 DE 59712460D1
Authority
DE
Germany
Prior art keywords
excitation radiation
wave
optical waveguide
planar optical
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59712460T
Other languages
German (de)
English (en)
Inventor
Gerolf Kraus
Michael Pawlak
Gert Ludwig Duveneck
Peter Oroszlan
Andreas Helg
Alfredo Emilio Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP96810808A external-priority patent/EP0843173A1/de
Priority claimed from EP96810807A external-priority patent/EP0843172A1/de
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE59712460D1 publication Critical patent/DE59712460D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Optical Integrated Circuits (AREA)
DE59712460T 1996-11-18 1997-11-18 Messvorrichtung mit einem planaren optischen wellenleiter Expired - Lifetime DE59712460D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96810808A EP0843173A1 (de) 1996-11-18 1996-11-18 Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
EP96810807A EP0843172A1 (de) 1996-11-18 1996-11-18 Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
PCT/EP1997/006443 WO1998022799A2 (de) 1996-11-18 1997-11-18 Messvorrichtung und deren verwendung

Publications (1)

Publication Number Publication Date
DE59712460D1 true DE59712460D1 (de) 2005-12-01

Family

ID=26144278

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59712460T Expired - Lifetime DE59712460D1 (de) 1996-11-18 1997-11-18 Messvorrichtung mit einem planaren optischen wellenleiter

Country Status (7)

Country Link
US (2) US6198869B1 (https=)
EP (1) EP0938656B1 (https=)
JP (1) JP3748571B2 (https=)
AT (1) ATE308039T1 (https=)
AU (1) AU6291498A (https=)
DE (1) DE59712460D1 (https=)
WO (1) WO1998022799A2 (https=)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2924399A (en) * 1998-02-05 1999-08-23 Novartis Ag Method and device for measuring luminescence
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
EP1131659A4 (en) * 1998-10-29 2005-02-02 Mark Stephen Braiman GERMANIUM, QUASI PLANAIRES, A DECREASING SECTION WAVEGUIDES FOR MEDIUM INFRARED DETECTION
DE19856041A1 (de) * 1998-12-04 2000-07-13 Inst Chemo Biosensorik Verfahren und Vorrichtung zur Durchführung von quantitativen Fluoreszenz markierten Affinitätstests
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
KR100883079B1 (ko) 1999-07-05 2009-02-10 노파르티스 아게 플랫폼, 플랫폼을 가지는 장치, 및 플랫폼을 사용하는 방법
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
ATE516492T1 (de) 1999-08-13 2011-07-15 Bayer Technology Services Gmbh Vorrichtung und verfahren zur multianalytbestimmung
DK1204856T3 (da) † 1999-08-20 2005-08-08 Diagnostische Forsch Stiftung Fremgangsmåde til bestemmelse af stoffer ved evanescensfelt-metoden
DE19948087B4 (de) * 1999-10-06 2008-04-17 Evotec Ag Verfahren zur Herstellung eines Reaktionssubstrats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6592733B1 (en) 1999-11-12 2003-07-15 Motorola, Inc. Capillary electrophoresis devices incorporating optical waveguides
AU2009401A (en) 1999-12-17 2001-06-25 Zeptosens Ag Flow cell array and the utilization thereof for multianalyte determination
US6580507B2 (en) * 2000-03-02 2003-06-17 Sd Acquisition Inc. Single source, single detector chip, multiple-longitudinal channel electromagnetic radiation absorbance and fluorescence monitoring system
AU2001226796A1 (en) * 2000-05-06 2001-11-26 Zeptosens Ag Grating optical waveguide structure for multi-analyte determinations and the usethereof
WO2001092870A2 (de) 2000-06-02 2001-12-06 Zeptosens Ag Kit und verfahren zur multianalytbestimmung
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
DE10058095C2 (de) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Vorrichtung zur Bestimmung von Analyten durch Chemilumineszenz
EP2169383A1 (de) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Körper für Durchflussküvetten und deren Verwendung
GB0207944D0 (en) * 2002-04-05 2002-05-15 Univ Cambridge Tech Method of detection
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
DE10307802A1 (de) * 2003-02-24 2004-09-09 Advalytix Ag Analyseverfahren und -Vorrichtung zur Analyse von spezifischen Bindungsreaktionen
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
DE102004039564B4 (de) * 2004-08-13 2006-06-29 Institut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm Vorrichtung zum optischen Screening von Oberflächen biologischer Proben in zweidimensionaler Anordnung
US7095941B2 (en) * 2004-10-27 2006-08-22 Schott Corporation Fused optical fiber optical device system
JP2006162538A (ja) * 2004-12-10 2006-06-22 Seiko Instruments Inc 微量質量測定装置
GB0501944D0 (en) 2005-01-31 2005-03-09 Univ Cambridge Tech Compounds for use in chemical detection and/or quantitation
JP4290128B2 (ja) * 2005-02-25 2009-07-01 キヤノン株式会社 センサ
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US7639355B2 (en) * 2007-06-26 2009-12-29 Hewlett-Packard Development Company, L.P. Electric-field-enhancement structure and detection apparatus using same
DE102007033124B4 (de) * 2007-07-16 2012-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium
US7860354B2 (en) * 2007-11-06 2010-12-28 Kabushiki Kaisha Toshiba Optical sensor
JP2009133836A (ja) * 2007-11-06 2009-06-18 Toshiba Corp 光学式センサ
EP2110694B1 (en) 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
JP2010151510A (ja) * 2008-12-24 2010-07-08 Tdk Corp 液性測定装置
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
AU2010241641B2 (en) * 2009-04-29 2015-05-14 Ldip, Llc Waveguide-based detection system with scanning light source
JP5272965B2 (ja) * 2009-08-19 2013-08-28 株式会社島津製作所 蛍光検出器
CN102985803A (zh) 2010-02-19 2013-03-20 加利福尼亚太平洋生物科学股份有限公司 集成的分析系统和方法
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
WO2012004735A1 (en) * 2010-07-09 2012-01-12 Koninklijke Philips Electronics N.V. Cartridge with large-scale manufacturing design
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
US8750652B2 (en) * 2010-10-12 2014-06-10 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic waveguide detector
CN103282766B (zh) 2010-11-19 2016-10-26 加利福尼亚大学董事会 混合型平面光流控集成
RU2014113337A (ru) * 2011-09-06 2015-10-20 Конинклейке Филипс Н.В. Способ и устройство для ввода светового пучка в пленку
WO2013108087A1 (en) * 2012-01-18 2013-07-25 Jawaharlal Nehru Centre For Advanced Scientific Research A system and a method to detect hydrogen leakage using nano-crystallised palladium gratings
CN105917003A (zh) 2013-11-17 2016-08-31 宽腾矽公司 用于生物和化学试样的快速分析的有源像素集成装置
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP2916125A1 (en) * 2014-03-07 2015-09-09 One Drop Diagnostics Sàrl Fluorescence-detected assays on microfluidic chips
CN106796175B (zh) 2014-08-08 2021-01-05 宽腾矽公司 用于探测、检测和分析分子的光学系统和检测芯片
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
KR102585730B1 (ko) 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
MX384725B (es) 2014-08-08 2025-03-14 Quantum Si Inc Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas.
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
AU2016259012C1 (en) 2015-05-07 2022-11-17 Pacific Biosciences Of California, Inc. Multiprocessor pipeline architecture
CA2991087C (en) * 2015-06-30 2019-12-03 Imec Vzw Radiation carrier and use thereof in an optical sensor
JP2019512090A (ja) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． 寿命イメージングおよび検出用途のためのセンサおよびデバイス
KR102560427B1 (ko) 2016-12-22 2023-07-28 퀀텀-에스아이 인코포레이티드 직접 비닝 픽셀을 갖는 집적 광검출기
WO2018160595A2 (en) 2017-02-28 2018-09-07 The Regents Of The University Of California Optofluidic analyte detection systems using multi-mode interference waveguides
WO2019023174A1 (en) 2017-07-24 2019-01-31 Quantum-Si Incorporated MASSIVELY PARALLEL BIO-OPTOELECTRONIC INSTRUMENT HAND-HELD
WO2019246328A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
US12399172B2 (en) 2020-09-18 2025-08-26 Salvus, Llc Interferometric detection and quantification system and methods of use in healthcare
US11994504B2 (en) 2020-09-18 2024-05-28 Salvus, Llc Interferometric detection and quantification system and methods of use in food processing and food supply chain
US11740177B2 (en) 2020-09-18 2023-08-29 Salvus, Llc Interferometric detection and quantification system and methods of use in aquatics
DE102020133924A1 (de) 2020-12-17 2022-06-23 Carl Zeiss Jena Gmbh Chiplabor-system mit funktionalisiertem wellenleiter

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184600B1 (en) * 1984-12-10 1990-03-14 Prutec Limited Method for optically ascertaining parameters of species in a liquid analyte
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5830766A (en) * 1990-05-23 1998-11-03 Ares-Serono Research & Development Ltd. Partnership Enhanced signal-to-noise ratio and sensitivity optical immunoassay
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
CN1149335A (zh) 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法
TW302435B (https=) * 1995-05-12 1997-04-11 Ciba Geigy Ag
AU6354796A (en) * 1995-06-23 1997-01-22 Novartis Ag Flow cell
EP0928416A4 (en) * 1996-03-19 2000-03-29 Univ Utah Res Found LENS AND RELATED FLOW CELL
JP3266041B2 (ja) * 1996-05-22 2002-03-18 株式会社島津製作所 部材接合法及びこの方法により製造した光学測定装置
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays

Also Published As

Publication number Publication date
US20010001021A1 (en) 2001-05-10
ATE308039T1 (de) 2005-11-15
US6384912B2 (en) 2002-05-07
EP0938656B1 (de) 2005-10-26
WO1998022799A2 (de) 1998-05-28
WO1998022799A3 (de) 1998-08-20
US6198869B1 (en) 2001-03-06
JP2001504230A (ja) 2001-03-27
AU6291498A (en) 1998-06-10
JP3748571B2 (ja) 2006-02-22
EP0938656A2 (de) 1999-09-01

Similar Documents

Publication Publication Date Title
DE59712460D1 (de) Messvorrichtung mit einem planaren optischen wellenleiter
DE59915078D1 (https=)
RU2158916C1 (ru) Устройство и способ проведения количественного анализа сродства с использованием флуоресцентных меток
DK219683A (da) Fremgangsmaade til bestemmelse af en analyt og apparat til maaling af kinetiske parametre
GB9212302D0 (en) Method for improving measurement precision in evanescent wave optical biosensor assays
NO176293C (no) Metode for å bestemme en ligand i en pröve ved bruk av en optisk bölgeleder og en anordning for utförelse av metoden
IL113854A0 (en) Process for detecting evanescently excited luminescence and a device for its use
NO971011L (no) Optisk lesbar remse for analyttdeteksjon
DE69031707D1 (de) Anordnung zur Neuorientierung und Fokussierung von Licht unter Verwendung eines optischen Wellenleiter-Bragg-Gitters
CA2231186A1 (en) Optical apparatus for performing an immunoassay
ATE394662T1 (de) Optisch basierte sensor-vorrichtungen
WO2002059253A3 (en) Fluorescence detection system including a photonic band gap structure
CA1339005C (en) Method of assay
DK0388872T3 (da) Fremgangsmåde til undersøgelse af overfladestrukturer
JP3968425B2 (ja) 光導波路への光導入方法及びそれを用いた光導波路分光測定装置
CA2283251A1 (en) Device and method for carrying out fluorescence immunoassays
EP0175585B1 (en) Dielectric waveguide sensors and their use in immunoassays
SE8901623D0 (sv) Einrichtung zur automatischen photometrischen analyse kleinster probenmengen
HK1049042A1 (zh) 檢測玻璃中內含物的方法
DE50011023D1 (de) Fluoreszenzkorrelationsspektroskopievorrichtung und -verfahren, insbesondere zur mehrfarbenfluoreszenzkorrelationsspektroskopie
SE9300231D0 (sv) Foerbaettrad metod foer brytningsindexdetektion i vaetska
JPH0372237A (ja) 光学的測定用のスラブ型光導波路
RU96124783A (ru) Способ определения люминесценции, обусловленной слабым возбуждением

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8328 Change in the person/name/address of the agent

Representative=s name: LUETJENS, H., DIPL.-CHEM. DR. RER. NAT., PAT.-ANW.