DE3927865A1 - T-pa-mutante gk1l - Google Patents

T-pa-mutante gk1l

Info

Publication number
DE3927865A1
DE3927865A1 DE3927865A DE3927865A DE3927865A1 DE 3927865 A1 DE3927865 A1 DE 3927865A1 DE 3927865 A DE3927865 A DE 3927865A DE 3927865 A DE3927865 A DE 3927865A DE 3927865 A1 DE3927865 A1 DE 3927865A1
Authority
DE
Germany
Prior art keywords
domains
protein
gk1l
dna
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3927865A
Other languages
German (de)
English (en)
Inventor
Anne Dipl Biol Dr Rer Na Stern
Ulrich Weidle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE3927865A priority Critical patent/DE3927865A1/de
Priority to US07/671,776 priority patent/US5223422A/en
Priority to EP90912217A priority patent/EP0440763B1/de
Priority to PCT/EP1990/001401 priority patent/WO1991002798A2/de
Priority to JP2511463A priority patent/JPH04500010A/ja
Priority to AT90912217T priority patent/ATE120236T1/de
Priority to DE59008764T priority patent/DE59008764D1/de
Publication of DE3927865A1 publication Critical patent/DE3927865A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
DE3927865A 1989-08-23 1989-08-23 T-pa-mutante gk1l Withdrawn DE3927865A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE3927865A DE3927865A1 (de) 1989-08-23 1989-08-23 T-pa-mutante gk1l
US07/671,776 US5223422A (en) 1989-08-23 1990-08-22 T-pa mutant gk1l
EP90912217A EP0440763B1 (de) 1989-08-23 1990-08-22 t-PA-MUTANTE GK1L
PCT/EP1990/001401 WO1991002798A2 (de) 1989-08-23 1990-08-22 t-PA-MUTANTE GK1L
JP2511463A JPH04500010A (ja) 1989-08-23 1990-08-22 ｔ―ＰＡ―変異体ＧＫ１Ｌ
AT90912217T ATE120236T1 (de) 1989-08-23 1990-08-22 T-pa-mutante gk1l.
DE59008764T DE59008764D1 (de) 1989-08-23 1990-08-22 t-PA-MUTANTE GK1L.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3927865A DE3927865A1 (de) 1989-08-23 1989-08-23 T-pa-mutante gk1l

Publications (1)

Publication Number Publication Date
DE3927865A1 true DE3927865A1 (de) 1991-02-28

Family

ID=6387718

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3927865A Withdrawn DE3927865A1 (de) 1989-08-23 1989-08-23 T-pa-mutante gk1l
DE59008764T Expired - Fee Related DE59008764D1 (de) 1989-08-23 1990-08-22 t-PA-MUTANTE GK1L.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59008764T Expired - Fee Related DE59008764D1 (de) 1989-08-23 1990-08-22 t-PA-MUTANTE GK1L.

Country Status (6)

Country Link
US (1) US5223422A (enExample)
EP (1) EP0440763B1 (enExample)
JP (1) JPH04500010A (enExample)
AT (1) ATE120236T1 (enExample)
DE (2) DE3927865A1 (enExample)
WO (1) WO1991002798A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000268170A1 (en) * 2000-09-04 2002-03-22 Hunan Royal Biotech A cell line expressing mutant human tissue-type plasminogen activator, constructing strategy and method of expressed protein preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0231624B1 (en) * 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs

Also Published As

Publication number Publication date
EP0440763B1 (de) 1995-03-22
ATE120236T1 (de) 1995-04-15
WO1991002798A3 (de) 1991-04-04
JPH0571228B2 (enExample) 1993-10-06
EP0440763A1 (de) 1991-08-14
WO1991002798A2 (de) 1991-03-07
JPH04500010A (ja) 1992-01-09
US5223422A (en) 1993-06-29
DE59008764D1 (de) 1995-04-27

Similar Documents

Publication Publication Date Title
DE3687584T4 (de) Vektoren und Verfahren zur Expression einer die Aktivität des menschlichen Proteins-C enthaltenden Substanz.
DE3885419T2 (de) Für die direkte Expression von aktiviertem menschlichen Protein-C verwendbare Vektoren und Zusammensetzungen.
DE69333727T2 (de) Protein-C-Derivat
DE3871798T2 (de) Modifizierter faktor vii/viia.
DE69434332T2 (de) Thrombin mutanten
DE69131292T2 (de) Antikoagulierende proteine
DE68923298T2 (de) Gewebe-plasminogenaktivator mit zymogenen oder fibrinspezifischen eigenschaften.
DE69004966T2 (de) Antikoagulierendes protein.
DE69034013T2 (de) Serpin-resistenter T-PA; Mutanten; Gene
DE69126205T2 (de) Oxidationsresistente analoga des thrombomodulins
DE3851613T2 (de) Co-Expression in eukaryontischen Zellen.
DE60217377T2 (de) Thrombin-spaltbare chimäre proteine
DE69432592T2 (de) Mutanten der pro-urokinase
DE3316297A1 (de) Humangewebe-plasminogen-aktivator
DE69126049T2 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
JPH05508664A (ja) リン脂質標的血栓溶解剤
DE69031271T2 (de) Varianten von pai-2
DE69024382T2 (de) Fledermausspeichel-Plasminogenaktivator vPA-alpha 1
DE3786317T2 (de) Proteinanaloge des gewebs-plasminogenaktivators.
DE60038312T2 (de) Faktor x-analog mit einer verbesserten fähigkeit, aktiviert zu werden
DE3688983T2 (de) Faktor IX-Protein.
DE3852625T2 (de) Vektoren und Verbindungen zur Expression von Zymogen-Formen von menschlichem Protein C.
Lijnen et al. Characterization of a chimeric plasminogen activator consisting of amino acids 1 to 274 of tissue-type plasminogen activator and amino acids 138 to 411 of single-chain urokinase-type plasminogen activator.
EP0440763B1 (de) t-PA-MUTANTE GK1L
DE3486023T2 (de) Verfahren zur herstellung von urokinase zymogen.

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee