DE3888821D1 - Tricyclische Verbindungen. - Google Patents
Tricyclische Verbindungen.Info
- Publication number
- DE3888821D1 DE3888821D1 DE88120889T DE3888821T DE3888821D1 DE 3888821 D1 DE3888821 D1 DE 3888821D1 DE 88120889 T DE88120889 T DE 88120889T DE 3888821 T DE3888821 T DE 3888821T DE 3888821 D1 DE3888821 D1 DE 3888821D1
- Authority
- DE
- Germany
- Prior art keywords
- tricyclic compounds
- tricyclic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31576987 | 1987-12-14 | ||
JP2354388 | 1988-02-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3888821D1 true DE3888821D1 (de) | 1994-05-05 |
DE3888821T2 DE3888821T2 (de) | 1994-08-11 |
Family
ID=26360920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3888821T Expired - Fee Related DE3888821T2 (de) | 1987-12-14 | 1988-12-14 | Tricyclische Verbindungen. |
Country Status (5)
Country | Link |
---|---|
US (3) | US4994463A (de) |
EP (1) | EP0325755B1 (de) |
AU (1) | AU612437B2 (de) |
DE (1) | DE3888821T2 (de) |
ES (1) | ES2053692T3 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8502099A1 (es) * | 1983-08-02 | 1984-12-16 | Espanola Farma Therapeut | Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina. |
AU605501B2 (en) * | 1987-08-25 | 1991-01-17 | Kyowa Hakko Kirin Co., Ltd. | Dibenz(b,e)oxepin derivative and antiallergic agent |
CA1338625C (en) * | 1988-06-09 | 1996-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
US5703088A (en) * | 1989-08-21 | 1997-12-30 | Beth Israel Deaconess Medical Center, Inc. | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
US5508280A (en) * | 1990-05-18 | 1996-04-16 | Merrell Pharmaceuticals, Inc. | 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists |
US5693645A (en) * | 1992-12-23 | 1997-12-02 | Beth Israel Deaconess Medical Center, Inc. | Use of spiperone or spiperone derivatives as immunosuppressant agents |
WO1996031503A1 (en) * | 1995-04-07 | 1996-10-10 | Novo Nordisk A/S | Novel heterocyclic compounds |
US5952352A (en) * | 1995-04-07 | 1999-09-14 | Novo Nordisk A/S | Heterocyclic compounds |
JPH11503132A (ja) * | 1995-04-07 | 1999-03-23 | ノボ ノルディスク アクティーゼルスカブ | 新規の複素環化合物 |
ATE238996T1 (de) * | 1995-06-29 | 2003-05-15 | Smithkline Beecham Corp | Integrin-rezeptor-antagonisten |
US6008213A (en) * | 1995-06-29 | 1999-12-28 | Smithkline Beecham Corporation | Integrin receptor antagonists |
ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
US6281212B1 (en) | 1996-07-12 | 2001-08-28 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
DK0934312T3 (da) * | 1996-10-04 | 2003-07-21 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
CN1099416C (zh) * | 1996-12-28 | 2003-01-22 | 史密丝克莱恩比彻姆公司 | 整联蛋白受体拮抗剂 |
CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
IL137266A0 (en) | 1998-01-21 | 2001-07-24 | Millennium Pharm Inc | Heterocyclic chemokine receptor antagonists and pharmaceutical compositions containing the same |
US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
CA2318088A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US7541365B2 (en) * | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO2004017994A1 (ja) * | 2002-08-22 | 2004-03-04 | Kyowa Hakko Kogyo Co., Ltd. | 喘息の予防および/または治療剤 |
EP1547616A1 (de) * | 2002-08-22 | 2005-06-29 | Kyowa Hakko Kogyo Co., Ltd. | Arzneimittel zur prävention und/oder behandlung von juckreiz |
TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
WO2004093912A1 (ja) * | 2003-04-23 | 2004-11-04 | Kyowa Hakko Kogyo Co. Ltd. | 好中球性炎症疾患の予防および/または治療剤 |
EP3233077A4 (de) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamin-d2-rezeptor-liganden |
US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
CN117677386A (zh) * | 2021-07-23 | 2024-03-08 | 瓦伦塔有限责任公司 | 具有亲溶酶体和抗病毒活性的化合物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3420851A (en) * | 1962-12-19 | 1969-01-07 | Pfizer & Co C | Novel dibenzoxepines |
US3354155A (en) * | 1963-10-14 | 1967-11-21 | Pfizer & Co C | Aminoalkylphosphonium compounds and process for the use thereof |
JPS4830064B1 (de) * | 1968-12-23 | 1973-09-17 | ||
GB1330966A (en) * | 1970-12-22 | 1973-09-19 | Yoshitomi Pharmaceutical | N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them |
GB1323659A (en) * | 1971-04-10 | 1973-07-18 | Yoshitomi Pharmaceutical | Piperazine derivatives methods for their production and pharmaceuticl compositions containing them |
JPS5250634B2 (de) * | 1971-08-23 | 1977-12-26 | ||
FR2218100A1 (en) * | 1973-02-20 | 1974-09-13 | Janssen Pharmaceutica Nv | Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones |
US4585788A (en) * | 1973-09-06 | 1986-04-29 | American Hoechst Corporation | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives |
US4282365A (en) * | 1978-11-24 | 1981-08-04 | Merck & Co., Inc. | Dibenz[b,e]oxepin compounds |
JPS58126883A (ja) * | 1982-01-25 | 1983-07-28 | Kyowa Hakko Kogyo Co Ltd | ジベンゾ〔b,e〕オキセピン誘導体を含有してなる抗喘息剤 |
JPS6028972A (ja) * | 1983-06-29 | 1985-02-14 | Kyowa Hakko Kogyo Co Ltd | ジベンゾ[b,e]オキセピン誘導体 |
JPS6147466A (ja) * | 1984-08-10 | 1986-03-07 | Dainippon Pharmaceut Co Ltd | アミン誘導体 |
JPS61152674A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔b,e〕オキセピン誘導体の製造法 |
JPS61152673A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔b,e〕オキセピン誘導体の製造法 |
EP0188802A3 (de) * | 1984-12-26 | 1986-08-20 | Kyowa Hakko Kogyo Co., Ltd. | Dibenz(b,e)oxepin-Derivat und antiallergisches Mittel |
JPS61152676A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔b,e〕オキセピン誘導体の製造法 |
JPS61152675A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔b,e〕オキセピン誘導体の製造法 |
US4596809A (en) * | 1985-03-25 | 1986-06-24 | Schering Corporation | Substituted 1,8-naphthyridinones, useful as anti-allergic agents |
JPS61257981A (ja) * | 1985-05-09 | 1986-11-15 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔b,e〕オキセピン誘導体および抗アレルギ−剤 |
GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
JPH0645600B2 (ja) * | 1985-12-25 | 1994-06-15 | 大日本製薬株式会社 | 1,4−ジアザシクロアルカン誘導体 |
JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
US4912222A (en) * | 1988-06-17 | 1990-03-27 | Fisons Corporation | Antihistamines related to cyproheptadine |
-
1988
- 1988-12-08 US US07/281,545 patent/US4994463A/en not_active Expired - Fee Related
- 1988-12-08 AU AU26711/88A patent/AU612437B2/en not_active Ceased
- 1988-12-14 ES ES88120889T patent/ES2053692T3/es not_active Expired - Lifetime
- 1988-12-14 DE DE3888821T patent/DE3888821T2/de not_active Expired - Fee Related
- 1988-12-14 EP EP88120889A patent/EP0325755B1/de not_active Expired - Lifetime
-
1990
- 1990-11-20 US US07/616,095 patent/US5143922A/en not_active Expired - Fee Related
-
1992
- 1992-05-18 US US07/884,208 patent/US5302602A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5302602A (en) | 1994-04-12 |
EP0325755A1 (de) | 1989-08-02 |
US4994463A (en) | 1991-02-19 |
EP0325755B1 (de) | 1994-03-30 |
DE3888821T2 (de) | 1994-08-11 |
AU612437B2 (en) | 1991-07-11 |
ES2053692T3 (es) | 1994-08-01 |
US5143922A (en) | 1992-09-01 |
AU2671188A (en) | 1989-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3888821D1 (de) | Tricyclische Verbindungen. | |
DE3873936D1 (de) | Lipoxygenasehemmende verbindungen. | |
DE3881970D1 (de) | Heterocyclische verbindungen. | |
ATE62227T1 (de) | Heterocyclische verbindungen. | |
FI891029A0 (fi) | Upprivbart lock. | |
DE3675422D1 (de) | Lipoxygenasehemmende verbindungen. | |
DE3851114D1 (de) | Trizyklische Verbindungen. | |
DE3873192D1 (de) | Benzo-anellierte cyclische verbindungen. | |
DE3675421D1 (de) | Lypoxygenasehemmende verbindungen. | |
DE68904874D1 (de) | Organische verbindungen. | |
NO880809L (no) | Antihyperkolesterolemiske tetrazolforbindelser. | |
DE68921298D1 (de) | Herzschützende tocopherolähnliche Verbindungen. | |
NO880736D0 (no) | Tyverisikring. | |
ATE94537T1 (de) | Arylpiperazinylalkylenphenylheterocyclische verbindungen. | |
FI882750A (fi) | Tricykliska pyridonderivat. | |
NO873816L (no) | Tricykliske forbindelser. | |
DE69105834D1 (de) | Bicyclische Verbindungen. | |
DE3861252D1 (de) | Antihypercholesterinaemische verbindungen. | |
DE3578424D1 (de) | Quino-benzothiazin-antibakterielle verbindungen. | |
ATE126217T1 (de) | Phenoxyheterozyklische verbindungen. | |
DE3866858D1 (de) | Tricyclische verbindungen. | |
ATE93512T1 (de) | Oximino-aether-verbindungen. | |
DE3854544D1 (de) | Pestizide Verbindungen. | |
FI891099A0 (fi) | Tricykliska aminderivat. | |
DE3878192D1 (de) | N-phenyltetrahydrophthalimidverbindungen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |