DE3875848T2 - Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen. - Google Patents

Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen.

Info

Publication number
DE3875848T2
DE3875848T2 DE8888307191T DE3875848T DE3875848T2 DE 3875848 T2 DE3875848 T2 DE 3875848T2 DE 8888307191 T DE8888307191 T DE 8888307191T DE 3875848 T DE3875848 T DE 3875848T DE 3875848 T2 DE3875848 T2 DE 3875848T2
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
compound
carbamoyl
vanadium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE8888307191T
Other languages
German (de)
English (en)
Other versions
DE3875848D1 (de
Inventor
Norio Iwano
Masayasu Kato
Yoshio Toyoshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16330618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3875848(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3875848D1 publication Critical patent/DE3875848D1/de
Publication of DE3875848T2 publication Critical patent/DE3875848T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8888307191T 1987-08-04 1988-08-03 Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen. Revoked DE3875848T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19480987 1987-08-04

Publications (2)

Publication Number Publication Date
DE3875848D1 DE3875848D1 (de) 1992-12-17
DE3875848T2 true DE3875848T2 (de) 1993-03-25

Family

ID=16330618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888307191T Revoked DE3875848T2 (de) 1987-08-04 1988-08-03 Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen.

Country Status (11)

Country Link
US (1) US5578732A (OSRAM)
EP (1) EP0302720B1 (OSRAM)
KR (1) KR960000047B1 (OSRAM)
AT (1) ATE82283T1 (OSRAM)
CA (1) CA1263119A (OSRAM)
DE (1) DE3875848T2 (OSRAM)
DK (1) DK171989B1 (OSRAM)
ES (1) ES2052728T3 (OSRAM)
GR (1) GR3006974T3 (OSRAM)
HU (1) HU199828B (OSRAM)
IE (1) IE61717B1 (OSRAM)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
DE69132082T2 (de) 1990-10-17 2000-08-31 Takeda Chemical Industries, Ltd. Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
CA2138787A1 (en) * 1992-07-08 1994-01-20 Clifton Augustus Baile Alleviating stomach ulcers in swine
ES2060541B1 (es) * 1993-02-26 1995-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
ES2063705B1 (es) * 1993-06-14 1995-07-16 S A L V A T Lab Sa Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion.
US5374730A (en) * 1993-11-04 1994-12-20 Torcan Chemical Ltd. Preparation of omeprazole and lansoprazole
TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100458170B1 (ko) * 1997-05-26 2005-05-03 동아제약주식회사 2-[3-메톡시-4-(2,2,2-트리플로로에톡시)2-피리딜]메틸설피닐-1h-벤즈이미다졸의신규제조방법
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
TWI289557B (en) 1999-06-17 2007-11-11 Takeda Chemical Industries Ltd A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
PL333847A1 (en) * 1999-06-18 2001-01-02 Inst Farmaceutyczny Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
WO2001002389A1 (en) 1999-06-30 2001-01-11 Takeda Chemical Industries, Ltd. Crystals of benzimidazole compounds
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
KR100362947B1 (ko) * 1999-09-21 2002-11-30 주식회사 대웅 설폭시드 화합물의 제조방법
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
AU2001256732A1 (en) * 2000-05-15 2001-11-26 Takeda Chemical Industries Ltd. Process for producing crystal
US7285668B2 (en) * 2000-12-01 2007-10-23 Takeda Pharmaceutical Company Limited Process for the crystallization of (R)- or (S)-lansoprazole
PL368563A1 (en) * 2001-02-02 2005-04-04 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
KR100430575B1 (ko) * 2001-02-21 2004-05-10 주식회사 씨트리 란소프라졸 및 그 중간체의 제조방법
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
US20040248941A1 (en) * 2001-09-25 2004-12-09 Keiji Kamiyama Benzimidazone compound, process for producing the same, and use thereof
EP1476442A2 (en) * 2002-03-27 2004-11-17 Teva Pharmaceutical Industries Ltd. Lansoprazole polymorphs and processes for preparation thereof
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
WO2004011455A1 (en) * 2002-07-26 2004-02-05 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
PT1501824E (pt) * 2002-08-21 2007-11-28 Teva Pharma Método para purificação de lansoprazole
EP1764364A1 (en) * 2002-08-21 2007-03-21 Teva Pharmaceutical Industries Ltd A method for the purification of lansoprazole
CA2771725C (en) * 2002-10-16 2015-08-18 Takeda Pharmaceutical Company Limited Solid preparation comprising a non-toxic base and a proton pump inhibitor
WO2004046135A1 (en) * 2002-11-18 2004-06-03 Teva Pharmaceutical Industries Ltd. Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
JP2006514108A (ja) 2002-12-19 2006-04-27 テバ ファーマシューティカル インダストリーズ リミティド パントプラゾールナトリウムの固体状態、それらの調製方法、及び公知のパントプラゾールナトリウム水和物の調製方法
JP2006516574A (ja) * 2003-02-05 2006-07-06 テバ ファーマシューティカル インダストリーズ リミティド ランソプラゾール安定化方法
JP2006523201A (ja) * 2003-03-28 2006-10-12 シデム ファーマ スルホキシド誘導体をエナンチオ選択的に調製する方法
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
WO2004111029A2 (en) 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
EP1768668A2 (en) 2004-06-16 2007-04-04 Tap Pharmaceutical Products, Inc. Multiple ppi dosage form
CA2787378C (en) 2004-09-13 2015-11-03 Takeda Pharmaceutical Company Limited Method for producing lansoprazole crystal
EP1681056A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
KR100758600B1 (ko) * 2006-01-05 2007-09-13 주식회사 대웅제약 란소프라졸 결정형 ａ의 제조방법
WO2008035189A1 (en) * 2006-09-22 2008-03-27 Orchid Chemicals & Pharmaceuticals Limited A method for the purification of lansoprazole
EP2114919A2 (en) 2007-01-31 2009-11-11 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic seperation
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
EP2203068A4 (en) 2007-10-12 2012-08-22 Takeda Pharmaceuticals Usa Inc METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES INDEPENDENT FROM FOOD STORAGE
CL2009000547A1 (es) 2008-03-10 2010-05-07 Takeda Pharmaceuticals Co Forma cristalina de (r)-2[[[3-metil-4-(2,2,2-trifluoroetoxi)-2-piridinil]metil]sulfinil]-1h-bencimidazol, metodo de preparacion; composicion farmaceutica y su uso para la profilaxis o tratamiento de ulcera peptica, gastritis, esofagitis erosiva, esofago de barret,dispepsia funcional, cancer gastrico.
ES2343935B1 (es) * 2008-12-29 2011-04-28 Laboratorios Viñas S.A. Intermedios utiles para la obtencion de 2-(2-piridinilmetilsulfinil)-1h-benzimidazoles y procedimientos correspondientes.
KR20100101405A (ko) * 2009-03-09 2010-09-17 한미홀딩스 주식회사 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102180865B (zh) * 2011-03-17 2013-01-16 浙江工业大学 一种兰索拉唑的合成方法
US9119769B2 (en) 2011-12-30 2015-09-01 The Curators Of The University Of Missouri Method for transforming pharmaceutical crystal forms
WO2013108068A1 (en) 2012-01-21 2013-07-25 Jubilant Life Sciences Limited Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers
CN103724325B (zh) * 2013-12-10 2016-04-13 南京工业大学 制备亚磺酰基-1-氢-苯并咪唑衍生物的方法
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺
CN116891458A (zh) * 2023-06-19 2023-10-17 南京唯创远医药科技有限公司 一种艾普拉唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

Also Published As

Publication number Publication date
CA1263119A (en) 1989-11-21
HU199828B (en) 1990-03-28
US5578732A (en) 1996-11-26
DK428188D0 (da) 1988-08-01
EP0302720A1 (en) 1989-02-08
EP0302720B1 (en) 1992-11-11
DK428188A (da) 1989-02-05
HUT49346A (en) 1989-09-28
KR960000047B1 (ko) 1996-01-03
KR890003738A (ko) 1989-04-17
ATE82283T1 (de) 1992-11-15
DE3875848D1 (de) 1992-12-17
ES2052728T3 (es) 1994-07-16
IE61717B1 (en) 1994-11-30
IE882376L (en) 1989-02-04
DK171989B1 (da) 1997-09-08
GR3006974T3 (OSRAM) 1993-06-30

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8363 Opposition against the patent
8331 Complete revocation