DE3867403D1 - L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung. - Google Patents

L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung.

Info

Publication number
DE3867403D1
DE3867403D1 DE8888115183T DE3867403T DE3867403D1 DE 3867403 D1 DE3867403 D1 DE 3867403D1 DE 8888115183 T DE8888115183 T DE 8888115183T DE 3867403 T DE3867403 T DE 3867403T DE 3867403 D1 DE3867403 D1 DE 3867403D1
Authority
DE
Germany
Prior art keywords
optionally substituted
acid addition
denotes
production
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888115183T
Other languages
German (de)
English (en)
Inventor
Yoshimi Tsuchiya
Masahiro Hayashi
Hiroshi Takehana
Akihiro Hisaka
Yoshio Sawasaki
Masaki Ihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of DE3867403D1 publication Critical patent/DE3867403D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8888115183T 1987-09-18 1988-09-16 L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung. Expired - Lifetime DE3867403D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23429987 1987-09-18
JP3126088 1988-02-13

Publications (1)

Publication Number Publication Date
DE3867403D1 true DE3867403D1 (de) 1992-02-13

Family

ID=26369718

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888115183T Expired - Lifetime DE3867403D1 (de) 1987-09-18 1988-09-16 L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung.

Country Status (12)

Country Link
US (1) US4966915A (enExample)
EP (1) EP0309827B1 (enExample)
JP (1) JPH02138A (enExample)
KR (1) KR890005031A (enExample)
CN (1) CN1032785A (enExample)
AT (1) ATE71083T1 (enExample)
AU (1) AU2234088A (enExample)
CA (1) CA1316180C (enExample)
DE (1) DE3867403D1 (enExample)
DK (1) DK517588A (enExample)
IL (1) IL87765A0 (enExample)
PT (1) PT88526B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003217430B2 (en) * 2002-02-15 2008-10-23 Darpharma, Inc. Mono-ester and asymmetrically substituted Di-ester pro-drugs of the dopamine D1 receptor agonists
AU2003293423A1 (en) 2002-12-06 2004-06-30 Xenoport, Inc. Carbidopa prodrugs and uses thereof
US6970629B2 (en) 2002-12-19 2005-11-29 Corning Cable Systems Llc Optical tube assembly having a dry insert and methods of making the same
US20090190890A1 (en) 2002-12-19 2009-07-30 Freeland Riley S Fiber optic cable having a dry insert and methods of making the same
US7471862B2 (en) 2002-12-19 2008-12-30 Corning Cable Systems, Llc Dry fiber optic cables and assemblies
IL154318A (en) * 2003-02-06 2010-05-31 Sarah Herzog Memorial Hospital Pharmaceutical compositions for the treatment of movement disorders
AU2005252220B2 (en) 2004-06-04 2011-06-02 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
WO2005121070A1 (en) 2004-06-04 2005-12-22 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
US7563821B2 (en) 2005-12-05 2009-07-21 Xenoport, Inc. Levodopa prodrug mesylate, compositions thereof, and uses thereof
TW200843731A (en) 2006-12-21 2008-11-16 Xenoport Inc Catechol protected levodopa diester prodrugs, compositions, and methods of use
CA2673336A1 (en) 2006-12-21 2008-06-26 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
US9290445B2 (en) 2008-10-20 2016-03-22 Xenoport, Inc. Methods of synthesizing a levodopa ester prodrug
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
KR101025612B1 (ko) * 2008-11-10 2011-03-30 한국해양연구원 신규 화합물인 Ｒａｍａｌｉｎ 및 그 용도
CA2789236C (en) 2009-11-09 2014-09-09 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
JP5774610B2 (ja) 2010-03-04 2015-09-09 オリオン コーポレーション パーキンソン病の治療方法
CN103694127B (zh) * 2013-12-30 2015-04-01 上海交通大学 链霉菌属菌种所产的化合物及该化合物的制备方法和应用
ES2739536T3 (es) 2014-10-21 2020-01-31 Abbvie Inc Profármacos de carbidopa y L-dopa y su uso para tratar la enfermedad de Parkinson
CN113197851A (zh) 2015-05-06 2021-08-03 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
TW202031265A (zh) 2018-11-15 2020-09-01 美商艾伯維有限公司 用於皮下投藥之醫藥調配物
US20220213128A1 (en) * 2021-01-03 2022-07-07 RockGen Therapeutics LLC L-Dopa Enhanced with a Neuroprotective Agent as a Therapy for Parkinson's Disease
US20240415800A1 (en) * 2021-10-11 2024-12-19 The Johns Hopkins University Dopa and caffeic acid analogs as novel gcpii inhibitors
EP4788310A1 (en) 2023-10-02 2026-08-12 Universiteit van Amsterdam Reducing dopamine feed-back inhibition in dopaminergic cells by tadalafil

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US393923A (en) * 1888-12-04 Samuel preston
US2868818A (en) * 1953-12-15 1959-01-13 Merck & Co Inc Alpha methyl phenylalanines
US3725470A (en) * 1969-05-14 1973-04-03 Hoffmann La Roche Amino acid derivatives
CH562199A5 (enExample) * 1970-10-30 1975-05-30 Hoffmann La Roche
BE793426A (fr) * 1971-12-28 1973-06-28 Lannacher Heilmittel G M B H Derives de phenylalanine
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
US4401676A (en) * 1977-06-01 1983-08-30 Merck & Co., Inc. Novel α-amino acids
US4311706A (en) * 1980-01-22 1982-01-19 Interx Research Corporation Novel dopa/dopamine prodrugs

Also Published As

Publication number Publication date
EP0309827A1 (en) 1989-04-05
US4966915A (en) 1990-10-30
DK517588A (da) 1989-03-19
PT88526A (pt) 1988-10-01
ATE71083T1 (de) 1992-01-15
DK517588D0 (da) 1988-09-16
AU2234088A (en) 1989-03-23
JPH0541626B2 (enExample) 1993-06-24
CA1316180C (en) 1993-04-13
PT88526B (pt) 1992-11-30
JPH02138A (ja) 1990-01-05
EP0309827B1 (en) 1992-01-02
CN1032785A (zh) 1989-05-10
IL87765A0 (en) 1989-02-28
KR890005031A (ko) 1989-05-11

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee