DE3852555T2 - Substituierte 2-Aminobenzothiazole und Derivate verwendbar als cerebrovasculare Mittel. - Google Patents

Substituierte 2-Aminobenzothiazole und Derivate verwendbar als cerebrovasculare Mittel.

Info

Publication number
DE3852555T2
DE3852555T2 DE3852555T DE3852555T DE3852555T2 DE 3852555 T2 DE3852555 T2 DE 3852555T2 DE 3852555 T DE3852555 T DE 3852555T DE 3852555 T DE3852555 T DE 3852555T DE 3852555 T2 DE3852555 T2 DE 3852555T2
Authority
DE
Germany
Prior art keywords
hydrogen
substituted
alkyl
phenyl
aminobenzothiazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852555T
Other languages
English (en)
Other versions
DE3852555D1 (de
Inventor
Graham Johnson
Michael Raymond Pavia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE3852555D1 publication Critical patent/DE3852555D1/de
Application granted granted Critical
Publication of DE3852555T2 publication Critical patent/DE3852555T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
DE3852555T 1987-03-16 1988-03-15 Substituierte 2-Aminobenzothiazole und Derivate verwendbar als cerebrovasculare Mittel. Expired - Lifetime DE3852555T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2642887A 1987-03-16 1987-03-16
US07/143,107 US4826860A (en) 1987-03-16 1988-01-25 Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents

Publications (2)

Publication Number Publication Date
DE3852555D1 DE3852555D1 (de) 1995-02-09
DE3852555T2 true DE3852555T2 (de) 1995-05-04

Family

ID=26701234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852555T Expired - Lifetime DE3852555T2 (de) 1987-03-16 1988-03-15 Substituierte 2-Aminobenzothiazole und Derivate verwendbar als cerebrovasculare Mittel.

Country Status (8)

Country Link
US (1) US4826860A (de)
EP (1) EP0282971B1 (de)
JP (1) JP2602275B2 (de)
AT (1) ATE116134T1 (de)
CA (1) CA1312287C (de)
DE (1) DE3852555T2 (de)
ES (1) ES2065895T3 (de)
GR (1) GR3015466T3 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2619712B1 (fr) * 1987-08-25 1990-08-31 Rhone Poulenc Sante Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la schizophrenie
US5236940A (en) * 1988-12-15 1993-08-17 Rhone-Poulenc Sante Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation
DE68901859T2 (de) * 1988-12-15 1993-01-14 Rhone Poulenc Sante 2-benzothiazolamin-derivate enthaltende arzneimittel, verbindungen und ihre herstellung.
FR2640624B1 (fr) * 1988-12-15 1994-08-12 Rhone Poulenc Sante Medicaments a base de derives de la benzothiazolamine-2, nouveaux derives et leur preparation
FR2649705B2 (fr) * 1989-07-13 1994-09-23 Rhone Poulenc Sante Medicaments a base de derives de la benzothiazolamine-2, nouveaux derives et leur preparation
EP0375510B1 (de) * 1988-12-15 1992-11-11 Rhone-Poulenc Sante 2-Imino-6-polyfluoralkoxy-benzothiazol-Derivate, Verfahren zu deren Herstellung und Arzneimittel, die sie enthalten
FR2649701B2 (fr) * 1988-12-15 1991-11-22 Rhone Poulenc Sante Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
DE3937271A1 (de) * 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
FR2662160B1 (fr) * 1990-05-18 1992-07-24 Rhone Poulenc Sante Derives d'alkylthio-3 propyl-3 benzothiazoline leur preparation et les medicaments les contenant.
FR2663030A1 (fr) * 1990-06-05 1991-12-13 Rhone Poulenc Sante Derives selenies de benzothiazoline leur preparation et les medicaments les contenant.
FR2662694A1 (fr) * 1990-06-05 1991-12-06 Rhone Poulenc Sante Derives du benzoselenazole, leur preparation et les medicaments les contenant.
FR2662695A1 (fr) * 1990-06-05 1991-12-06 Rhone Poulenc Sante Amino-2 polyfluoroalcoxy-6 benzoselenazoles, leur preparation et les medicaments les contenant.
FR2688138B1 (fr) * 1992-03-06 1995-05-05 Rhone Poulenc Rorer Sa Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique.
CA2097458C (en) * 1992-06-02 2004-07-20 Tameichi Ochiai Metal chelate compound and optical recording medium using the compound
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700116B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Application d'anticonvulsivants comme radioprotecteurs.
FR2702148B1 (fr) * 1993-03-05 1995-04-07 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement du neuro-sida.
FR2714828B1 (fr) * 1994-01-12 1996-02-02 Rhone Poulenc Rorer Sa Application du riluzole dans le traitement des maladies mitochondriales.
FR2741803A1 (fr) * 1995-12-01 1997-06-06 Rhone Poulenc Rorer Sa Application de 2-aminobenzothiazoles dans le traitement de la maladie de parkinson et des syndromes parkinsoniens
SE9802360D0 (sv) * 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
FR2787028B1 (fr) 1998-12-15 2002-10-18 Aventis Pharma Sa Utilisation du riluzole dans le traitement des traumatismes acoustiques
EP1178977B1 (de) * 1999-05-12 2005-06-01 Neurosearch A/S Ionenkanal modulierende mittel
US6872739B1 (en) * 1999-06-04 2005-03-29 Vereniging Voor Christelijk Wetenshappelikjk Onderwijs Use of riluzole for the treatment of multiple sclerosis
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
WO2003015772A1 (en) * 2001-08-13 2003-02-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of polyq-aggregation
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
ES2295672T3 (es) 2002-08-07 2008-04-16 Neuraxon Inc. Compuestos de aminobenzotiazol con actividad inhibitoria de la oxido nitrico sintasa (nos).
US20040176430A1 (en) * 2002-11-21 2004-09-09 Jeffrey Sterling Propargyl-trifluoromethoxy-amino-benzothiazole derivatives
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2005037276A1 (en) * 2003-10-09 2005-04-28 Aventis Pharma S.A. Use of riluzole for the treatment of essential tremor
US8710088B2 (en) * 2004-02-11 2014-04-29 Max-Delbruck-Centrum Fur Molekulare Medizin Pharmaceutical and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases
US20050197365A1 (en) * 2004-02-27 2005-09-08 Jeffrey Sterling Diamino thiazoloindan derivatives and their use
WO2007022568A1 (en) 2005-08-25 2007-03-01 Steven Michael Weiss Reducing myocardial damage and the incidence of arrhythmia arising from loss, reduction or interruption in coronary blood flow
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
CA2783699C (en) 2009-12-08 2019-01-15 Case Western Reserve University Primary amine compounds for treating ocular disorders
WO2015057884A1 (en) 2013-10-16 2015-04-23 The Regents Of The University Of California Methods for treating seizure disorders and pain
CN110330450B (zh) * 2019-06-12 2021-01-15 温州医科大学 一种不对称硫脲类化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2019529A (en) * 1935-11-05 Aminobenzothiazole compound
US1345552A (en) 1917-12-03 1920-07-06 Waldo A Rigal Combination-lock
GB1153648A (en) * 1967-03-22 1969-05-29 Twyford Lab Ltd Substituted 2-Anilino Benzothiazole Basic Ethers
LU63457A1 (de) * 1970-07-06 1971-11-12
JPS5018463A (de) * 1973-06-19 1975-02-26
DE2656468A1 (de) * 1976-12-14 1978-06-15 Boehringer Mannheim Gmbh N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung
DD149070A1 (de) * 1980-02-14 1981-06-24 Gerhard Kempter Verfahren zur herstellung von basisch substituierten acylaminoheterocyclen
DE3017976A1 (de) * 1980-05-10 1981-11-19 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte 2-amino-5-halogen-benzothiazole, verfahen zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
DE3328438A1 (de) * 1982-08-10 1984-02-16 Basf Ag, 6700 Ludwigshafen Neue oxamidsaeure-derivaten, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3572485D1 (en) * 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs

Also Published As

Publication number Publication date
ES2065895T3 (es) 1995-03-01
JPS63313729A (ja) 1988-12-21
ATE116134T1 (de) 1995-01-15
GR3015466T3 (en) 1995-06-30
EP0282971A3 (de) 1991-04-24
DE3852555D1 (de) 1995-02-09
EP0282971A2 (de) 1988-09-21
CA1312287C (en) 1993-01-05
EP0282971B1 (de) 1994-12-28
US4826860A (en) 1989-05-02
JP2602275B2 (ja) 1997-04-23

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Legal Events

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