GB1153648A - Substituted 2-Anilino Benzothiazole Basic Ethers - Google Patents

Substituted 2-Anilino Benzothiazole Basic Ethers

Info

Publication number
GB1153648A
GB1153648A GB1335867A GB1335867A GB1153648A GB 1153648 A GB1153648 A GB 1153648A GB 1335867 A GB1335867 A GB 1335867A GB 1335867 A GB1335867 A GB 1335867A GB 1153648 A GB1153648 A GB 1153648A
Authority
GB
United Kingdom
Prior art keywords
alkyl
benzothiazole
halobenzothiazole
trifluoromethylbenzothiazole
chloroethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1335867A
Inventor
Francis Frederick Stephens
Christopher James Sharpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TWYFORD LAB Ltd
Original Assignee
TWYFORD LAB Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TWYFORD LAB Ltd filed Critical TWYFORD LAB Ltd
Priority to GB1335867A priority Critical patent/GB1153648A/en
Publication of GB1153648A publication Critical patent/GB1153648A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

1,153,648. Benzothiazole derivatives. TWYFORD LABORATORIES Ltd. 20 March, 1968 [22 March, 1967], No. 13358/67. Heading C2C. Compounds of the general formula (R 1 = H, halogen, C 1-4 alkyl, CF 3 , alkoxy or NO 2 , R 2 , 3 = H, C 1-4 alkyl, #-hydroxyethyl or benzyl or -NR 2 R 3 = heterocyclic group, provided that R 1 is not H when R 2 , 3 are both alkyl) and their salts are prepared by reacting an appropriate 2-halobenzothiazole with the appropriate substituted aniline, optionally followed by salt formation. The 2-halobenzothiazole may be reacted with 4-(#-chloroethoxy)-aniline and the resulting 2 - [4 - (# - chloroethoxy)- anilino]benzothiazole condensed with R 2 R 3 NH. The preparation of bis-(2-nitro-4-trifluoromethylphenyl) disulphide, 2 - amino - 4 - trifluoromethylbenzenethiol, 2 - mercapto - 5 - trifluoromethylbenzothiazole and 2 - chloro - 5 - trifluoromethylbenzothiazole is described. The compounds of the invention are antidepressants, anticonvulsants, anticholinergic agents, potentiate the central action of amphetamine and reverse the effects of reserpine. They may be administered in the form of pharmaceutical preparations containing them together with a carrier.
GB1335867A 1967-03-22 1967-03-22 Substituted 2-Anilino Benzothiazole Basic Ethers Expired GB1153648A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1335867A GB1153648A (en) 1967-03-22 1967-03-22 Substituted 2-Anilino Benzothiazole Basic Ethers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1335867A GB1153648A (en) 1967-03-22 1967-03-22 Substituted 2-Anilino Benzothiazole Basic Ethers

Publications (1)

Publication Number Publication Date
GB1153648A true GB1153648A (en) 1969-05-29

Family

ID=10021513

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1335867A Expired GB1153648A (en) 1967-03-22 1967-03-22 Substituted 2-Anilino Benzothiazole Basic Ethers

Country Status (1)

Country Link
GB (1) GB1153648A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2182910A1 (en) * 1972-03-30 1973-12-14 Boots Co Ltd
EP0018080A1 (en) * 1979-03-19 1980-10-29 Ici Australia Limited Herbicidal compounds, their preparation, compositions and process for the use thereof
EP0282971A2 (en) * 1987-03-16 1988-09-21 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2182910A1 (en) * 1972-03-30 1973-12-14 Boots Co Ltd
EP0018080A1 (en) * 1979-03-19 1980-10-29 Ici Australia Limited Herbicidal compounds, their preparation, compositions and process for the use thereof
US4314065A (en) 1979-03-19 1982-02-02 Ici Australia Limited Phenylamine substituted on amine with a benzo(oxa, thia or di) azole group
EP0282971A2 (en) * 1987-03-16 1988-09-21 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
EP0282971A3 (en) * 1987-03-16 1991-04-24 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents

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