ATE116134T1 - Substituierte 2-aminobenzothiazole und derivate verwendbar als cerebrovasculare mittel. - Google Patents
Substituierte 2-aminobenzothiazole und derivate verwendbar als cerebrovasculare mittel.Info
- Publication number
- ATE116134T1 ATE116134T1 AT88104100T AT88104100T ATE116134T1 AT E116134 T1 ATE116134 T1 AT E116134T1 AT 88104100 T AT88104100 T AT 88104100T AT 88104100 T AT88104100 T AT 88104100T AT E116134 T1 ATE116134 T1 AT E116134T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- substituted
- alkyl
- phenyl
- aminobenzothiazoles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2642887A | 1987-03-16 | 1987-03-16 | |
US07/143,107 US4826860A (en) | 1987-03-16 | 1988-01-25 | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE116134T1 true ATE116134T1 (de) | 1995-01-15 |
Family
ID=26701234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88104100T ATE116134T1 (de) | 1987-03-16 | 1988-03-15 | Substituierte 2-aminobenzothiazole und derivate verwendbar als cerebrovasculare mittel. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4826860A (de) |
EP (1) | EP0282971B1 (de) |
JP (1) | JP2602275B2 (de) |
AT (1) | ATE116134T1 (de) |
CA (1) | CA1312287C (de) |
DE (1) | DE3852555T2 (de) |
ES (1) | ES2065895T3 (de) |
GR (1) | GR3015466T3 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2619712B1 (fr) * | 1987-08-25 | 1990-08-31 | Rhone Poulenc Sante | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la schizophrenie |
US5236940A (en) * | 1988-12-15 | 1993-08-17 | Rhone-Poulenc Sante | Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation |
FR2640624B1 (fr) * | 1988-12-15 | 1994-08-12 | Rhone Poulenc Sante | Medicaments a base de derives de la benzothiazolamine-2, nouveaux derives et leur preparation |
EP0374041B1 (de) * | 1988-12-15 | 1992-06-17 | Rhone-Poulenc Sante | 2-Benzothiazolamin-Derivate enthaltende Arzneimittel, Verbindungen und ihre Herstellung |
FR2649705B2 (fr) * | 1989-07-13 | 1994-09-23 | Rhone Poulenc Sante | Medicaments a base de derives de la benzothiazolamine-2, nouveaux derives et leur preparation |
FR2649701B2 (fr) * | 1988-12-15 | 1991-11-22 | Rhone Poulenc Sante | Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant |
EP0375510B1 (de) * | 1988-12-15 | 1992-11-11 | Rhone-Poulenc Sante | 2-Imino-6-polyfluoralkoxy-benzothiazol-Derivate, Verfahren zu deren Herstellung und Arzneimittel, die sie enthalten |
DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
FR2662160B1 (fr) * | 1990-05-18 | 1992-07-24 | Rhone Poulenc Sante | Derives d'alkylthio-3 propyl-3 benzothiazoline leur preparation et les medicaments les contenant. |
FR2662694A1 (fr) * | 1990-06-05 | 1991-12-06 | Rhone Poulenc Sante | Derives du benzoselenazole, leur preparation et les medicaments les contenant. |
FR2663030A1 (fr) * | 1990-06-05 | 1991-12-13 | Rhone Poulenc Sante | Derives selenies de benzothiazoline leur preparation et les medicaments les contenant. |
FR2662695A1 (fr) * | 1990-06-05 | 1991-12-06 | Rhone Poulenc Sante | Amino-2 polyfluoroalcoxy-6 benzoselenazoles, leur preparation et les medicaments les contenant. |
FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
CA2097458C (en) * | 1992-06-02 | 2004-07-20 | Tameichi Ochiai | Metal chelate compound and optical recording medium using the compound |
FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
FR2700116B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants comme radioprotecteurs. |
FR2702148B1 (fr) * | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
FR2714828B1 (fr) * | 1994-01-12 | 1996-02-02 | Rhone Poulenc Rorer Sa | Application du riluzole dans le traitement des maladies mitochondriales. |
FR2741803A1 (fr) * | 1995-12-01 | 1997-06-06 | Rhone Poulenc Rorer Sa | Application de 2-aminobenzothiazoles dans le traitement de la maladie de parkinson et des syndromes parkinsoniens |
SE9802360D0 (sv) * | 1998-07-01 | 1998-07-01 | Wikstroem Hakan Vilhelm | New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin |
FR2787028B1 (fr) | 1998-12-15 | 2002-10-18 | Aventis Pharma Sa | Utilisation du riluzole dans le traitement des traumatismes acoustiques |
WO2000069838A1 (en) * | 1999-05-12 | 2000-11-23 | Neurosearch A/S | Ion channel modulating agents |
DE60041365D1 (de) | 1999-06-04 | 2009-02-26 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von Riluzol zur Behandlung Multipler Sklerose |
US20070092450A1 (en) * | 2000-10-16 | 2007-04-26 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
US20040180809A1 (en) * | 2000-10-16 | 2004-09-16 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
US6716413B1 (en) * | 2000-10-16 | 2004-04-06 | Mallinckrodt, Inc. | Indole compounds as tissue-specific exogenous optical agents |
EP1416931B1 (de) * | 2001-08-13 | 2007-06-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Hemmer der aggregation von polyq |
EP2266590A3 (de) | 2002-02-22 | 2011-04-20 | Shire LLC | Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen |
AU2003257300B2 (en) * | 2002-08-07 | 2010-01-21 | Neuraxon Inc. | Amino benzothiazole compounds with NOS inhibitory activity |
US20040176430A1 (en) * | 2002-11-21 | 2004-09-09 | Jeffrey Sterling | Propargyl-trifluoromethoxy-amino-benzothiazole derivatives |
US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
WO2005037276A1 (en) * | 2003-10-09 | 2005-04-28 | Aventis Pharma S.A. | Use of riluzole for the treatment of essential tremor |
WO2005077343A2 (de) * | 2004-02-11 | 2005-08-25 | Max-Delbrück-Centrum für Molekulare Medizin | Neue arzneimittel und diagnostische zusammensetzungen für behandlung und diagnose von neurodegenerativen erkrankungen und amyloid-krankheiten |
US20050197365A1 (en) * | 2004-02-27 | 2005-09-08 | Jeffrey Sterling | Diamino thiazoloindan derivatives and their use |
US9629817B2 (en) | 2005-08-25 | 2017-04-25 | Steven Michael Weiss | Reducing myocardial damage and the incidence of arrhythmia arising from loss, reduction or interruption in coronary blood flow |
US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
EP2509596B1 (de) | 2009-12-08 | 2019-08-28 | Case Western Reserve University | Gamma aminosäure zur behandlung von augenerkrankungen |
WO2015057884A1 (en) | 2013-10-16 | 2015-04-23 | The Regents Of The University Of California | Methods for treating seizure disorders and pain |
CN110330450B (zh) * | 2019-06-12 | 2021-01-15 | 温州医科大学 | 一种不对称硫脲类化合物的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2019529A (en) * | 1935-11-05 | Aminobenzothiazole compound | ||
US1345552A (en) | 1917-12-03 | 1920-07-06 | Waldo A Rigal | Combination-lock |
GB1153648A (en) * | 1967-03-22 | 1969-05-29 | Twyford Lab Ltd | Substituted 2-Anilino Benzothiazole Basic Ethers |
LU63457A1 (de) * | 1970-07-06 | 1971-11-12 | ||
JPS5018463A (de) * | 1973-06-19 | 1975-02-26 | ||
DE2656468A1 (de) * | 1976-12-14 | 1978-06-15 | Boehringer Mannheim Gmbh | N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung |
DD149070A1 (de) * | 1980-02-14 | 1981-06-24 | Gerhard Kempter | Verfahren zur herstellung von basisch substituierten acylaminoheterocyclen |
DE3017976A1 (de) * | 1980-05-10 | 1981-11-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 2-amino-5-halogen-benzothiazole, verfahen zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
DE3328438A1 (de) * | 1982-08-10 | 1984-02-16 | Basf Ag, 6700 Ludwigshafen | Neue oxamidsaeure-derivaten, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
EP0186087B1 (de) * | 1984-12-22 | 1989-08-23 | Dr. Karl Thomae GmbH | Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel |
-
1988
- 1988-01-25 US US07/143,107 patent/US4826860A/en not_active Expired - Lifetime
- 1988-02-08 CA CA000558374A patent/CA1312287C/en not_active Expired - Lifetime
- 1988-03-15 AT AT88104100T patent/ATE116134T1/de not_active IP Right Cessation
- 1988-03-15 EP EP88104100A patent/EP0282971B1/de not_active Expired - Lifetime
- 1988-03-15 JP JP63059558A patent/JP2602275B2/ja not_active Expired - Lifetime
- 1988-03-15 ES ES88104100T patent/ES2065895T3/es not_active Expired - Lifetime
- 1988-03-15 DE DE3852555T patent/DE3852555T2/de not_active Expired - Lifetime
-
1995
- 1995-03-20 GR GR950400597T patent/GR3015466T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1312287C (en) | 1993-01-05 |
EP0282971A3 (de) | 1991-04-24 |
ES2065895T3 (es) | 1995-03-01 |
DE3852555D1 (de) | 1995-02-09 |
US4826860A (en) | 1989-05-02 |
GR3015466T3 (en) | 1995-06-30 |
JPS63313729A (ja) | 1988-12-21 |
EP0282971A2 (de) | 1988-09-21 |
DE3852555T2 (de) | 1995-05-04 |
JP2602275B2 (ja) | 1997-04-23 |
EP0282971B1 (de) | 1994-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |