DE3782686T2 - Zusammensetzungen zur vorbeugung von plastik-abstossung. - Google Patents
Zusammensetzungen zur vorbeugung von plastik-abstossung.Info
- Publication number
- DE3782686T2 DE3782686T2 DE8787108976T DE3782686T DE3782686T2 DE 3782686 T2 DE3782686 T2 DE 3782686T2 DE 8787108976 T DE8787108976 T DE 8787108976T DE 3782686 T DE3782686 T DE 3782686T DE 3782686 T2 DE3782686 T2 DE 3782686T2
- Authority
- DE
- Germany
- Prior art keywords
- heparin
- desulfated
- dose
- acetylated
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 132
- 229920000669 heparin Polymers 0.000 claims abstract description 128
- 229960002897 heparin Drugs 0.000 claims abstract description 128
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract description 16
- 230000002429 anti-coagulating effect Effects 0.000 claims abstract description 10
- 241000124008 Mammalia Species 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims description 25
- 206010003246 arthritis Diseases 0.000 claims description 22
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 31
- 241000700159 Rattus Species 0.000 description 27
- 241000699670 Mus sp. Species 0.000 description 24
- 108010037536 heparanase Proteins 0.000 description 23
- 230000000694 effects Effects 0.000 description 22
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- 208000009386 Experimental Arthritis Diseases 0.000 description 19
- 102100024025 Heparanase Human genes 0.000 description 17
- 210000003491 skin Anatomy 0.000 description 13
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- 238000006243 chemical reaction Methods 0.000 description 7
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 102100027378 Prothrombin Human genes 0.000 description 5
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- 238000011694 lewis rat Methods 0.000 description 5
- 201000006417 multiple sclerosis Diseases 0.000 description 5
- 229940039716 prothrombin Drugs 0.000 description 5
- 206010014025 Ear swelling Diseases 0.000 description 4
- 229920002971 Heparan sulfate Polymers 0.000 description 4
- 206010033799 Paralysis Diseases 0.000 description 4
- 238000011161 development Methods 0.000 description 4
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- 230000002265 prevention Effects 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 206010052779 Transplant rejections Diseases 0.000 description 3
- 230000000735 allogeneic effect Effects 0.000 description 3
- 230000001363 autoimmune Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000010432 diamond Substances 0.000 description 3
- 231100000673 dose–response relationship Toxicity 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 230000008105 immune reaction Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
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- 230000004044 response Effects 0.000 description 3
- 201000008827 tuberculosis Diseases 0.000 description 3
- SJHPCNCNNSSLPL-NTMALXAHSA-N (4z)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical compound O1C(=O)C(=C/OCC)/N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-NTMALXAHSA-N 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 238000011740 C57BL/6 mouse Methods 0.000 description 2
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 2
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 206010034464 Periarthritis Diseases 0.000 description 2
- 208000006735 Periostitis Diseases 0.000 description 2
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- 238000011803 SJL/J (JAX™ mice strain) Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000005784 autoimmunity Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000004957 immunoregulator effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
- 206010071155 Autoimmune arthritis Diseases 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 102000047918 Myelin Basic Human genes 0.000 description 1
- 101710107068 Myelin basic protein Proteins 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229960005097 diphtheria vaccines Drugs 0.000 description 1
- 230000002905 effect on arthritis Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000003194 forelimb Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000010726 hind limb paralysis Diseases 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000037231 joint health Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000004999 sex organ Anatomy 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- PXLIDIMHPNPGMH-UHFFFAOYSA-N sodium chromate Chemical compound [Na+].[Na+].[O-][Cr]([O-])(=O)=O PXLIDIMHPNPGMH-UHFFFAOYSA-N 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000011421 subcutaneous treatment Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000026492 vascular transport Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Soil Working Implements (AREA)
- Paper (AREA)
- Fertilizers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL79254A IL79254A0 (en) | 1986-06-26 | 1986-06-26 | Compositions for preventing graft rejection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3782686D1 DE3782686D1 (de) | 1992-12-24 |
| DE3782686T2 true DE3782686T2 (de) | 1993-06-09 |
Family
ID=11056896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787108976T Expired - Fee Related DE3782686T2 (de) | 1986-06-26 | 1987-06-23 | Zusammensetzungen zur vorbeugung von plastik-abstossung. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0251134B1 (enExample) |
| JP (1) | JP2527749B2 (enExample) |
| AT (1) | ATE82502T1 (enExample) |
| AU (1) | AU608228B2 (enExample) |
| DE (1) | DE3782686T2 (enExample) |
| DK (1) | DK169422B1 (enExample) |
| ES (1) | ES2052514T3 (enExample) |
| GR (1) | GR3006814T3 (enExample) |
| IL (1) | IL79254A0 (enExample) |
| NO (1) | NO872675L (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85145A (en) * | 1987-01-23 | 1994-08-26 | Univ Australian | Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity |
| US5541166A (en) * | 1987-01-23 | 1996-07-30 | The Australian National University | Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity |
| GB8808810D0 (en) * | 1988-04-14 | 1988-05-18 | Biopharm Clinical Research Ltd | Heparin-containing formulations |
| IL86753A0 (en) * | 1988-06-15 | 1988-11-30 | Hadassah Med Org | Pharmaceutical compositions for treatment of lupus |
| DE3821271A1 (de) * | 1988-06-23 | 1989-12-28 | Solco Basel Ag | Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt |
| IL88554A0 (en) * | 1988-12-01 | 1989-07-31 | Hadassah Med Org | Compositions containing a compound binding to a heparin receptor |
| US5158940A (en) * | 1990-02-14 | 1992-10-27 | The United States Government As Represented By The Secretary, Dhhs | Use of suramin to treat rheumatologic diseases |
| KR100571010B1 (ko) * | 1997-07-14 | 2006-04-13 | 무라마쯔 다카시 | 미드카인 또는 그 저해제를 유효성분으로 하는 약제 |
| US6538028B1 (en) | 2000-02-01 | 2003-03-25 | Vanderbilt University | Method for inhibiting complement activation |
| CN1197587C (zh) * | 2000-06-09 | 2005-04-20 | 中国科学院上海细胞生物学研究所 | N－位脱硫酸肝素在预防和治疗炎症中的应用 |
| CA2457719C (en) | 2001-09-12 | 2012-01-03 | Benito Casu | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| PT1748781E (pt) | 2004-05-27 | 2013-01-22 | Baxter Int | Processos para o tratamento de distúrbios de hemorragias utilizando polissacarídeos sulfatados |
| CA2731304C (en) | 2008-08-22 | 2017-06-06 | Baxter Healthcare S.A. | Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides |
| AU2011205271B2 (en) | 2010-01-14 | 2014-01-30 | Baxalta GmbH | Methods and compositions for treating bleeding disorders |
| US8846620B2 (en) | 2011-07-19 | 2014-09-30 | Baxter International Inc. | Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides |
| EP3594686A3 (en) | 2012-08-14 | 2020-04-08 | Baxalta GmbH | Methods and systems for screening compositions comprising non-anticoagulant sulfated polysaccharides |
| JP6377121B2 (ja) | 2013-03-12 | 2018-08-22 | バクサルタ インコーポレイテッド | 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ |
| SE538503C2 (en) | 2014-11-11 | 2016-08-16 | Tx Medic Ab | New dextran sulfate |
| CA2986974C (en) * | 2015-06-11 | 2023-08-15 | Universiteit Maastricht | Method for preventing transplant failure in a host |
-
1986
- 1986-06-26 IL IL79254A patent/IL79254A0/xx unknown
-
1987
- 1987-06-23 AT AT87108976T patent/ATE82502T1/de not_active IP Right Cessation
- 1987-06-23 ES ES87108976T patent/ES2052514T3/es not_active Expired - Lifetime
- 1987-06-23 DE DE8787108976T patent/DE3782686T2/de not_active Expired - Fee Related
- 1987-06-23 EP EP87108976A patent/EP0251134B1/en not_active Expired - Lifetime
- 1987-06-25 AU AU74706/87A patent/AU608228B2/en not_active Ceased
- 1987-06-25 NO NO872675A patent/NO872675L/no unknown
- 1987-06-26 DK DK331287A patent/DK169422B1/da not_active IP Right Cessation
- 1987-06-26 JP JP62159514A patent/JP2527749B2/ja not_active Expired - Lifetime
-
1993
- 1993-01-14 GR GR930400069T patent/GR3006814T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK331287D0 (da) | 1987-06-26 |
| ATE82502T1 (de) | 1992-12-15 |
| JPS6388127A (ja) | 1988-04-19 |
| DK331287A (da) | 1987-12-27 |
| IL79254A0 (en) | 1986-09-30 |
| AU608228B2 (en) | 1991-03-28 |
| EP0251134B1 (en) | 1992-11-19 |
| EP0251134A2 (en) | 1988-01-07 |
| JP2527749B2 (ja) | 1996-08-28 |
| EP0251134A3 (en) | 1989-05-03 |
| NO872675D0 (no) | 1987-06-25 |
| DE3782686D1 (de) | 1992-12-24 |
| AU7470687A (en) | 1988-01-07 |
| NO872675L (no) | 1987-12-28 |
| DK169422B1 (da) | 1994-10-31 |
| GR3006814T3 (enExample) | 1993-06-30 |
| ES2052514T3 (es) | 1994-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8380 | Miscellaneous part iii |
Free format text: DER PATENTINHABER LAUTET RICHTIG: YEDA RESEARCH AND DEVELOPMENT CO., LTD., REHOVOT, IL |
|
| 8364 | No opposition during term of opposition | ||
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