DE3726381A1 - Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3726381A1
DE3726381A1 DE19873726381 DE3726381A DE3726381A1 DE 3726381 A1 DE3726381 A1 DE 3726381A1 DE 19873726381 DE19873726381 DE 19873726381 DE 3726381 A DE3726381 A DE 3726381A DE 3726381 A1 DE3726381 A1 DE 3726381A1
Authority
DE
Germany
Prior art keywords
group
grouping
hydrogen atom
linear
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873726381
Other languages
German (de)
English (en)
Inventor
Peter Dipl Chem Dr Moersdorf
Helmut Dipl Chem Schickaneder
Volker Dr Pfahlert
Geb Hintermayer Engler
Armin Dr Buschauer
Walter Prof Dr Dr Schunack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Priority to DE19873726381 priority Critical patent/DE3726381A1/de
Priority to ES88102371T priority patent/ES2053595T3/es
Priority to AT88102371T priority patent/ATE84531T1/de
Priority to EP88102371A priority patent/EP0302164B1/de
Priority to DE8888102371T priority patent/DE3877454D1/de
Priority to IL85542A priority patent/IL85542A0/xx
Priority to ZA881271A priority patent/ZA881271B/xx
Priority to AU12320/88A priority patent/AU599752B2/en
Priority to NZ223684A priority patent/NZ223684A/xx
Priority to CA000560361A priority patent/CA1304086C/en
Priority to AR88310486A priority patent/AR243873A1/es
Priority to PT87184A priority patent/PT87184B/pt
Priority to IE105088A priority patent/IE63297B1/en
Priority to HU881444A priority patent/HUT49604A/hu
Priority to HU881777A priority patent/HU201053B/hu
Priority to DK194388A priority patent/DK194388A/da
Priority to JP63088017A priority patent/JPS6442470A/ja
Priority to US07/180,135 priority patent/US4948802A/en
Priority to KR1019880004088A priority patent/KR890003737A/ko
Publication of DE3726381A1 publication Critical patent/DE3726381A1/de
Priority to GR930400045T priority patent/GR3006790T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19873726381 1987-08-07 1987-08-07 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE3726381A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE19873726381 DE3726381A1 (de) 1987-08-07 1987-08-07 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES88102371T ES2053595T3 (es) 1987-08-07 1988-02-18 Ester de acido de carbonato de guanidina, procedimiento para su produccion y remedios contenidos en esta union.
AT88102371T ATE84531T1 (de) 1987-08-07 1988-02-18 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
EP88102371A EP0302164B1 (de) 1987-08-07 1988-02-18 Guanidincarbonsäureester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE8888102371T DE3877454D1 (de) 1987-08-07 1988-02-18 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
IL85542A IL85542A0 (en) 1987-08-07 1988-02-24 Guanidine carboxylic acid esters,processes for their preparation and pharmaceutical preparations containing these compounds
ZA881271A ZA881271B (en) 1987-08-07 1988-02-24 Guanidine carboxylic acid esters,processes for their preparation and pharmaceutical preparations containing these compounds
AU12320/88A AU599752B2 (en) 1987-08-07 1988-02-26 Guanidine carboxylic acid esters, processes for their preparation and pharmaceutical preparations containing these compounds
NZ223684A NZ223684A (en) 1987-08-07 1988-02-29 Guanidine carboxylic acid esters and pharmaceutical compositions
CA000560361A CA1304086C (en) 1987-08-07 1988-03-02 Guanidine carboxylic acid esters, processes for their preparation and pharmaceutical preparations containing these compounds
AR88310486A AR243873A1 (es) 1987-08-07 1988-04-05 Procedimiento de preparacion de derivados de guanidina.
PT87184A PT87184B (pt) 1987-08-07 1988-04-07 Processo para a preparacao de derivados de guanidina e de composicoes farmaceuticas que os contem
IE105088A IE63297B1 (en) 1987-08-07 1988-04-08 Guanidine carboxylic acid esters,processes for their preparation and pharmaceutical preparations containing these compounds
HU881444A HUT49604A (en) 1987-08-07 1988-04-08 Process for producing guanidinecarboxylic acid esters and pharmaceutical compositions comprising same
HU881777A HU201053B (en) 1987-08-07 1988-04-08 Process for production of guanidin carbonic acid esthers and medical compositions containing them
DK194388A DK194388A (da) 1987-08-07 1988-04-08 Guanidincarboxylsyreestere, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse forbindelser
JP63088017A JPS6442470A (en) 1987-08-07 1988-04-08 Guanidinecarboxylic acid esters, manufacture and medicinal composition
US07/180,135 US4948802A (en) 1987-08-07 1988-04-11 Guanidine carboxylic acid esters and pharmaceutical preparations containing these compounds
KR1019880004088A KR890003737A (ko) 1987-08-07 1988-04-11 구아니딘 카르복실산 에스테르와 그 제법 및 이를 함유하는 약학적 제제
GR930400045T GR3006790T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-08-07 1993-01-14

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873726381 DE3726381A1 (de) 1987-08-07 1987-08-07 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE3726381A1 true DE3726381A1 (de) 1989-02-16

Family

ID=6333331

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873726381 Withdrawn DE3726381A1 (de) 1987-08-07 1987-08-07 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE8888102371T Expired - Fee Related DE3877454D1 (de) 1987-08-07 1988-02-18 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888102371T Expired - Fee Related DE3877454D1 (de) 1987-08-07 1988-02-18 Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.

Country Status (18)

Country Link
US (1) US4948802A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0302164B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6442470A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890003737A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR243873A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE84531T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU599752B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1304086C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3726381A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK194388A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2053595T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006790T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HU201053B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE63297B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL85542A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ223684A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT87184B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA881271B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0437645A1 (de) * 1990-01-15 1991-07-24 HEUMANN PHARMA GMBH & CO Imidazolylpropylguanidinderivat, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968216A (en) * 1969-10-29 1976-07-06 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
GB1305547A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1969-10-29 1973-02-07
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
DE2630847A1 (de) * 1976-07-09 1978-01-19 Bayer Ag Methoxycarbonyl-phenyl-guanidine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3528214A1 (de) * 1985-08-06 1987-02-12 Heumann Ludwig & Co Gmbh Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0199845B1 (de) * 1985-04-02 1990-08-01 HEUMANN PHARMA GMBH & CO Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3512084A1 (de) * 1985-04-02 1986-10-09 Ludwig Heumann & Co GmbH, 8500 Nürnberg Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3528215A1 (de) * 1985-08-06 1987-02-12 Heumann Ludwig & Co Gmbh Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0437645A1 (de) * 1990-01-15 1991-07-24 HEUMANN PHARMA GMBH & CO Imidazolylpropylguanidinderivat, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
AU624757B2 (en) * 1990-01-15 1992-06-18 Heumann Pharma Gmbh & Co. Imidazilyl propyl guanidine derivative, a process for its preparation and a pharmaceutical composition containing this compound

Also Published As

Publication number Publication date
EP0302164B1 (de) 1993-01-13
DE3877454D1 (de) 1993-02-25
AU599752B2 (en) 1990-07-26
IE63297B1 (en) 1995-04-05
ATE84531T1 (de) 1993-01-15
PT87184B (pt) 1995-03-01
CA1304086C (en) 1992-06-23
DK194388D0 (da) 1988-04-08
ZA881271B (en) 1988-08-22
KR890003737A (ko) 1989-04-17
IL85542A0 (en) 1988-08-31
HUT49604A (en) 1989-10-30
GR3006790T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-30
NZ223684A (en) 1989-11-28
EP0302164A1 (de) 1989-02-08
JPS6442470A (en) 1989-02-14
ES2053595T3 (es) 1994-08-01
AU1232088A (en) 1989-02-09
AR243873A1 (es) 1993-09-30
US4948802A (en) 1990-08-14
DK194388A (da) 1989-02-08
IE881050L (en) 1989-02-07
PT87184A (pt) 1989-06-30
HU201053B (en) 1990-09-28

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination