KR890003737A - 구아니딘 카르복실산 에스테르와 그 제법 및 이를 함유하는 약학적 제제 - Google Patents
구아니딘 카르복실산 에스테르와 그 제법 및 이를 함유하는 약학적 제제 Download PDFInfo
- Publication number
- KR890003737A KR890003737A KR1019880004088A KR880004088A KR890003737A KR 890003737 A KR890003737 A KR 890003737A KR 1019880004088 A KR1019880004088 A KR 1019880004088A KR 880004088 A KR880004088 A KR 880004088A KR 890003737 A KR890003737 A KR 890003737A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- hydrogen atom
- alkyl
- unsubstituted
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title claims 18
- -1 Guanidine carboxylic acid ester Chemical class 0.000 title claims 17
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title claims 17
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title claims 17
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 61
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 35
- 125000005843 halogen group Chemical group 0.000 claims 32
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 22
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 11
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- DPTRIXAWYKXUCX-UHFFFAOYSA-N methyl n-[n'-[3-(1h-imidazol-5-yl)propyl]-n-(4-pyridin-2-ylbutyl)carbamimidoyl]carbamate Chemical compound C=1C=CC=NC=1CCCCN=C(NC(=O)OC)NCCCC1=CNC=N1 DPTRIXAWYKXUCX-UHFFFAOYSA-N 0.000 claims 2
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002357 guanidines Chemical class 0.000 claims 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873726381 DE3726381A1 (de) | 1987-08-07 | 1987-08-07 | Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DEP3726381.7 | 1987-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890003737A true KR890003737A (ko) | 1989-04-17 |
Family
ID=6333331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880004088A Ceased KR890003737A (ko) | 1987-08-07 | 1988-04-11 | 구아니딘 카르복실산 에스테르와 그 제법 및 이를 함유하는 약학적 제제 |
Country Status (18)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| ES2070932T3 (es) * | 1990-01-15 | 1995-06-16 | Heumann Pharma Gmbh & Co | Derivado de imidazolilpropilguanidina, procedimiento para su preparacion y medicamentos que lo contienen. |
| USRE37303E1 (en) * | 1992-01-10 | 2001-07-31 | Institut National Del La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
| FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3968216A (en) * | 1969-10-29 | 1976-07-06 | Smith Kline & French Laboratories Limited | Method of inhibiting histamine activity with guanidine compounds |
| GB1305547A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1969-10-29 | 1973-02-07 | ||
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| DE2630847A1 (de) * | 1976-07-09 | 1978-01-19 | Bayer Ag | Methoxycarbonyl-phenyl-guanidine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3528214A1 (de) * | 1985-08-06 | 1987-02-12 | Heumann Ludwig & Co Gmbh | Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3579000D1 (de) * | 1985-04-02 | 1990-09-06 | Heumann Pharma Gmbh & Co | Imidazolylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
| DE3528215A1 (de) * | 1985-08-06 | 1987-02-12 | Heumann Ludwig & Co Gmbh | Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3512084A1 (de) * | 1985-04-02 | 1986-10-09 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1987
- 1987-08-07 DE DE19873726381 patent/DE3726381A1/de not_active Withdrawn
-
1988
- 1988-02-18 DE DE8888102371T patent/DE3877454D1/de not_active Expired - Fee Related
- 1988-02-18 AT AT88102371T patent/ATE84531T1/de not_active IP Right Cessation
- 1988-02-18 EP EP88102371A patent/EP0302164B1/de not_active Expired - Lifetime
- 1988-02-18 ES ES88102371T patent/ES2053595T3/es not_active Expired - Lifetime
- 1988-02-24 ZA ZA881271A patent/ZA881271B/xx unknown
- 1988-02-24 IL IL85542A patent/IL85542A0/xx not_active IP Right Cessation
- 1988-02-26 AU AU12320/88A patent/AU599752B2/en not_active Ceased
- 1988-02-29 NZ NZ223684A patent/NZ223684A/xx unknown
- 1988-03-02 CA CA000560361A patent/CA1304086C/en not_active Expired - Lifetime
- 1988-04-05 AR AR88310486A patent/AR243873A1/es active
- 1988-04-07 PT PT87184A patent/PT87184B/pt not_active IP Right Cessation
- 1988-04-08 DK DK194388A patent/DK194388A/da not_active Application Discontinuation
- 1988-04-08 JP JP63088017A patent/JPS6442470A/ja active Pending
- 1988-04-08 HU HU881777A patent/HU201053B/hu not_active IP Right Cessation
- 1988-04-08 IE IE105088A patent/IE63297B1/en not_active IP Right Cessation
- 1988-04-08 HU HU881444A patent/HUT49604A/hu unknown
- 1988-04-11 KR KR1019880004088A patent/KR890003737A/ko not_active Ceased
- 1988-04-11 US US07/180,135 patent/US4948802A/en not_active Expired - Fee Related
-
1993
- 1993-01-14 GR GR930400045T patent/GR3006790T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT49604A (en) | 1989-10-30 |
| ES2053595T3 (es) | 1994-08-01 |
| DK194388D0 (da) | 1988-04-08 |
| CA1304086C (en) | 1992-06-23 |
| PT87184A (pt) | 1989-06-30 |
| HU201053B (en) | 1990-09-28 |
| ATE84531T1 (de) | 1993-01-15 |
| GR3006790T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-06-30 |
| IE63297B1 (en) | 1995-04-05 |
| US4948802A (en) | 1990-08-14 |
| IE881050L (en) | 1989-02-07 |
| AR243873A1 (es) | 1993-09-30 |
| ZA881271B (en) | 1988-08-22 |
| AU599752B2 (en) | 1990-07-26 |
| DE3877454D1 (de) | 1993-02-25 |
| NZ223684A (en) | 1989-11-28 |
| EP0302164A1 (de) | 1989-02-08 |
| DE3726381A1 (de) | 1989-02-16 |
| AU1232088A (en) | 1989-02-09 |
| IL85542A0 (en) | 1988-08-31 |
| JPS6442470A (en) | 1989-02-14 |
| PT87184B (pt) | 1995-03-01 |
| EP0302164B1 (de) | 1993-01-13 |
| DK194388A (da) | 1989-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19880411 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19920303 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19880411 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19950522 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19960215 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19950522 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |