DE3688225T2 - Herstellung menschlichen somatomedins c. - Google Patents

Herstellung menschlichen somatomedins c.

Info

Publication number
DE3688225T2
DE3688225T2 DE8686902217T DE3688225T DE3688225T2 DE 3688225 T2 DE3688225 T2 DE 3688225T2 DE 8686902217 T DE8686902217 T DE 8686902217T DE 3688225 T DE3688225 T DE 3688225T DE 3688225 T2 DE3688225 T2 DE 3688225T2
Authority
DE
Germany
Prior art keywords
dna sequences
somatomedin
optimal
production
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686902217T
Other languages
German (de)
English (en)
Other versions
DE3688225D1 (de
Inventor
N Buell
Nageswararao Movva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen MA Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Application granted granted Critical
Publication of DE3688225D1 publication Critical patent/DE3688225D1/de
Publication of DE3688225T2 publication Critical patent/DE3688225T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE8686902217T 1985-03-26 1986-03-25 Herstellung menschlichen somatomedins c. Expired - Lifetime DE3688225T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858507833A GB8507833D0 (en) 1985-03-26 1985-03-26 Production of human somatomedin c
PCT/US1986/000579 WO1986005810A1 (en) 1985-03-26 1986-03-25 Production of human somatomedin c

Publications (2)

Publication Number Publication Date
DE3688225D1 DE3688225D1 (de) 1993-05-13
DE3688225T2 true DE3688225T2 (de) 1993-07-22

Family

ID=10576658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686902217T Expired - Lifetime DE3688225T2 (de) 1985-03-26 1986-03-25 Herstellung menschlichen somatomedins c.

Country Status (14)

Country Link
EP (1) EP0215110B1 (ja)
JP (4) JPH0691832B2 (ja)
CN (1) CN1034588C (ja)
AT (1) ATE87977T1 (ja)
AU (1) AU594950B2 (ja)
CA (1) CA1339305C (ja)
DE (1) DE3688225T2 (ja)
DK (1) DK175223B1 (ja)
ES (1) ES8705921A1 (ja)
GB (1) GB8507833D0 (ja)
IL (1) IL78278A0 (ja)
NO (1) NO302709B1 (ja)
WO (1) WO1986005810A1 (ja)
ZA (1) ZA862240B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ221789A (en) * 1986-09-12 1991-05-28 Genentech Inc Recombinant prorelaxin, its preparation and pharmaceutical compositions comprising it
GB8712540D0 (en) * 1987-05-28 1987-07-01 Ucb Sa Expression of human proapolipoprotein a-i
US4876242A (en) * 1987-09-21 1989-10-24 Merck & Co., Inc. Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
AUPP807899A0 (en) 1999-01-08 1999-02-04 University Of Queensland, The Codon utilization
JP6018719B1 (ja) * 2016-03-15 2016-11-02 Ｂｘ新生精機株式会社 シャッター開閉機の巻上装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207842A (en) * 1983-04-25 1988-02-12 Chiron Corp Production of human insulin-like growth factor (igf) using cdna
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
SE8303626D0 (sv) * 1983-06-23 1983-06-23 Kabigen Ab A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced
EP0151760A1 (en) * 1984-01-06 1985-08-21 Takeda Chemical Industries, Ltd. Novel DNA and use thereof
US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields

Also Published As

Publication number Publication date
AU594950B2 (en) 1990-03-22
ATE87977T1 (de) 1993-04-15
JPH07143896A (ja) 1995-06-06
JPH07145200A (ja) 1995-06-06
EP0215110A4 (en) 1987-07-09
ES553374A0 (es) 1987-05-16
JPH07102152B2 (ja) 1995-11-08
EP0215110A1 (en) 1987-03-25
NO864724L (no) 1987-01-23
ZA862240B (en) 1986-11-26
AU5665786A (en) 1986-10-23
CN1034588C (zh) 1997-04-16
JPH0691832B2 (ja) 1994-11-16
JPH07143885A (ja) 1995-06-06
DK175223B1 (da) 2004-07-12
CA1339305C (en) 1997-08-19
NO302709B1 (no) 1998-04-14
JP2602628B2 (ja) 1997-04-23
GB8507833D0 (en) 1985-05-01
IL78278A0 (en) 1986-07-31
ES8705921A1 (es) 1987-05-16
DK569886D0 (da) 1986-11-26
DK569886A (da) 1986-11-26
JPS62502305A (ja) 1987-09-10
EP0215110B1 (en) 1993-04-07
WO1986005810A1 (en) 1986-10-09
JP2568383B2 (ja) 1997-01-08
DE3688225D1 (de) 1993-05-13
CN86102889A (zh) 1986-11-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOGEN IDEC MA INC., CAMBRIDGE, MASS., US