DE3686888T2 - Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen. - Google Patents
Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen.Info
- Publication number
- DE3686888T2 DE3686888T2 DE8686308568T DE3686888T DE3686888T2 DE 3686888 T2 DE3686888 T2 DE 3686888T2 DE 8686308568 T DE8686308568 T DE 8686308568T DE 3686888 T DE3686888 T DE 3686888T DE 3686888 T2 DE3686888 T2 DE 3686888T2
- Authority
- DE
- Germany
- Prior art keywords
- radiation
- speckle
- pattern
- substance
- immunological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000126 substance Substances 0.000 title claims abstract description 71
- 238000000034 method Methods 0.000 title claims abstract description 55
- 230000001900 immune effect Effects 0.000 title claims abstract description 39
- 230000005855 radiation Effects 0.000 claims abstract description 88
- 230000001427 coherent effect Effects 0.000 claims abstract description 38
- 239000000463 material Substances 0.000 claims abstract description 16
- 238000001514 detection method Methods 0.000 claims description 22
- 230000008859 change Effects 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 230000010287 polarization Effects 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 238000001429 visible spectrum Methods 0.000 claims description 5
- 239000013566 allergen Substances 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- -1 antibody Proteins 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 6
- 230000004069 differentiation Effects 0.000 abstract description 6
- 238000005259 measurement Methods 0.000 abstract description 6
- 239000000376 reactant Substances 0.000 abstract description 2
- 238000012545 processing Methods 0.000 description 8
- 238000011002 quantification Methods 0.000 description 8
- 238000001914 filtration Methods 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 239000011859 microparticle Substances 0.000 description 4
- 238000004451 qualitative analysis Methods 0.000 description 4
- 238000004445 quantitative analysis Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 238000009739 binding Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000003570 air Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 231100001261 hazardous Toxicity 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000003909 pattern recognition Methods 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 235000003403 Limnocharis flava Nutrition 0.000 description 1
- 244000278243 Limnocharis flava Species 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 238000005162 X-ray Laue diffraction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007705 chemical test Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000004777 protein coat Anatomy 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4788—Diffraction
- G01N2021/479—Speckle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86308568A EP0266461B1 (en) | 1986-11-03 | 1986-11-03 | Methods for the detection and quantitation of immunological substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3686888D1 DE3686888D1 (OSRAM) | 1992-11-05 |
| DE3686888T2 true DE3686888T2 (de) | 1993-03-04 |
Family
ID=8196201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686308568T Expired - Fee Related DE3686888T2 (de) | 1986-11-03 | 1986-11-03 | Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4621063A (OSRAM) |
| EP (1) | EP0266461B1 (OSRAM) |
| AT (1) | ATE81208T1 (OSRAM) |
| DE (1) | DE3686888T2 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009057078A1 (de) * | 2009-12-04 | 2011-06-09 | Abb Ag | Photometrischer Gasanalysator |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
| US4737464A (en) * | 1985-09-26 | 1988-04-12 | Molecular Devices Corporation | Solid-state optical assay imaging apparatus |
| US5730937A (en) * | 1986-06-05 | 1998-03-24 | Pardikes; Dennis G. | Module for automatically controlling a polymer processing system |
| US5403552A (en) * | 1986-06-05 | 1995-04-04 | Pardikes; Dennis | Module for automatically controlling a polymer processing system |
| IL85137A (en) * | 1987-01-21 | 1992-02-16 | Ares Serono Res & Dev Ltd | Method of assaying for a ligand using surface plasmon resonance effect |
| CA1305921C (en) * | 1987-01-30 | 1992-08-04 | Eric K. Gustafson | Diffraction immunoassay and reagents |
| US4928153A (en) * | 1987-04-06 | 1990-05-22 | Kms Fusion, Inc. | Optical measurement of particle concentration |
| US5089387A (en) * | 1988-07-07 | 1992-02-18 | Adeza Biomedical Corporation | Dna probe diffraction assay and reagents |
| JPH02108968A (ja) * | 1988-10-19 | 1990-04-20 | Hitachi Ltd | 免疫分析方法 |
| US5268305A (en) * | 1989-06-15 | 1993-12-07 | Biocircuits Corporation | Multi-optical detection system |
| IL98150A0 (en) * | 1990-05-17 | 1992-08-18 | Adeza Biomedical Corp | Highly reflective biogratings and method for theirhighly reflective biogratings and method production |
| US5196350A (en) * | 1991-05-29 | 1993-03-23 | Omnigene, Inc. | Ligand assay using interference modulation |
| JPH08503552A (ja) * | 1991-05-29 | 1996-04-16 | オムニジェネ・インコーポレーテッド | 干渉モジュレーションを用いたリガンド検定 |
| US5225890A (en) * | 1991-10-28 | 1993-07-06 | Gencorp Inc. | Surface inspection apparatus and method |
| US5453841A (en) * | 1993-05-03 | 1995-09-26 | The United States Of America As Represented By The Secretary Of Commerce | Method for the dynamic measurement of the progress of a chemical reaction of an electrochemical interface |
| US5701176A (en) * | 1995-07-28 | 1997-12-23 | Precision Detectors, Inc. | High temperature light scattering measurement device comprising a rigid extension tube |
| WO1997008554A1 (en) * | 1995-08-22 | 1997-03-06 | Philips Electronics N.V. | Method and device for investigating non-linear optical behavior of a layer formed from first and second reactants e.g. antibody and antigen |
| US20040106167A1 (en) * | 1999-05-03 | 2004-06-03 | Icf Technologies, Inc. | Methods for evaluating sterilization procedures using a biological indicator |
| US7326562B2 (en) * | 1999-05-03 | 2008-02-05 | Icf Technologies, Inc. | Biological indicator system to detect effectiveness of sterilization |
| US6942989B2 (en) | 1999-05-03 | 2005-09-13 | Icf Technologies, Inc. | Methods, compositions and kits for biological indicator of sterilization |
| JP2001304816A (ja) * | 2000-04-26 | 2001-10-31 | Kenichiro Kobayashi | レーザ反射光による粒状斑点模様を利用した移動量測定方式とその装置 |
| JP2002162355A (ja) * | 2000-11-27 | 2002-06-07 | Hiroyuki Konno | レーザ反射光による粒状斑点模様の直接撮像方法とその装置 |
| WO2002078906A2 (en) * | 2001-03-29 | 2002-10-10 | Cellect Technologies Corp. | Methods devices and systems for sorting and separating particles |
| WO2006046183A1 (en) * | 2004-10-27 | 2006-05-04 | Koninklijke Philips Electronics N.V. | Optical identifier comprising an identification layer and a sensor layer |
| WO2007030748A2 (en) * | 2005-09-09 | 2007-03-15 | The University Of Chicago | Methods and compositions for diagnosis and immunotherapy of pollen allergy |
| US10012589B2 (en) * | 2013-08-16 | 2018-07-03 | The General Hospital Corporation | Portable diffraction-based imaging and diagnostic systems and methods |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US3804521A (en) * | 1972-02-22 | 1974-04-16 | Itek Corp | Optical device for measuring surface roughness |
| US3905767A (en) * | 1974-01-30 | 1975-09-16 | Miles Lab | Process for qualitative analysis or quantitation of antigens or antibodies |
| US4011044A (en) * | 1976-07-06 | 1977-03-08 | General Electric Company | Use of laser speckle patterns for measurement of electrophoretic mobilities |
| US4208185A (en) * | 1976-08-16 | 1980-06-17 | Mitsubishi Chemical Industries Limited | Method and apparatus for the measurement of antigens and antibodies |
| JPS5925460B2 (ja) * | 1978-05-19 | 1984-06-18 | 株式会社日立製作所 | ネフェロメトリック・イムノアッセイ法及び装置 |
| DE3135196A1 (de) * | 1981-09-05 | 1983-03-17 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren, mittel und vorrichtung zur bestimmung biologischer komponenten |
| EP0112721B1 (en) * | 1982-12-21 | 1988-05-18 | Ares-Serono N.V. | Assay technique |
| US4487839A (en) * | 1983-01-05 | 1984-12-11 | Ortho Diagnostic Systems Inc. | Immunoassay methods employing patterns for the detection of soluble and cell surface antigens |
| JP2527933B2 (ja) * | 1984-06-13 | 1996-08-28 | ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ | 特異的反応性サンプルの収集及び試験デバイス並びにその製造方法 |
| US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
| GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
| DE3481644D1 (de) * | 1984-12-10 | 1990-04-19 | Prutec Ltd | Verfahren zum optischen nachweis von parametern von substanzen in einem fluessigen analyt. |
-
1982
- 1982-10-12 US US06/433,732 patent/US4621063A/en not_active Expired - Fee Related
-
1986
- 1986-11-03 EP EP86308568A patent/EP0266461B1/en not_active Expired
- 1986-11-03 DE DE8686308568T patent/DE3686888T2/de not_active Expired - Fee Related
- 1986-11-03 AT AT86308568T patent/ATE81208T1/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009057078A1 (de) * | 2009-12-04 | 2011-06-09 | Abb Ag | Photometrischer Gasanalysator |
| DE102009057078B4 (de) * | 2009-12-04 | 2013-03-14 | Abb Ag | Photometrischer Gasanalysator |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3686888D1 (OSRAM) | 1992-11-05 |
| US4621063A (en) | 1986-11-04 |
| EP0266461B1 (en) | 1992-09-30 |
| ATE81208T1 (de) | 1992-10-15 |
| EP0266461A1 (en) | 1988-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |