DE3588249D1 - Methode zur Herstellung von menschlichen Wachstumshormonen - Google Patents

Methode zur Herstellung von menschlichen Wachstumshormonen

Info

Publication number
DE3588249D1
DE3588249D1 DE3588249T DE3588249T DE3588249D1 DE 3588249 D1 DE3588249 D1 DE 3588249D1 DE 3588249 T DE3588249 T DE 3588249T DE 3588249 T DE3588249 T DE 3588249T DE 3588249 D1 DE3588249 D1 DE 3588249D1
Authority
DE
Germany
Prior art keywords
human growth
polypeptide
growth hormone
acid sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3588249T
Other languages
English (en)
Other versions
DE3588249T2 (de
DE122004000009I2 (de
Inventor
Shmaryahu Blumberg
Meir Daniela Ben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3588249D1 publication Critical patent/DE3588249D1/de
Publication of DE3588249T2 publication Critical patent/DE3588249T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3588249T 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen Expired - Lifetime DE3588249T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64148884A 1984-08-16 1984-08-16
US641488 1984-08-16

Publications (2)

Publication Number Publication Date
DE3588249D1 true DE3588249D1 (de) 2003-11-06
DE3588249T2 DE3588249T2 (de) 2004-05-06

Family

ID=24572607

Family Applications (4)

Application Number Title Priority Date Filing Date
DE200412000009 Pending DE122004000009I1 (de) 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen.
DE19853588249 Active DE122004000009I2 (de) 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen
DE8585904198T Expired - Lifetime DE3586773T2 (de) 1984-08-16 1985-08-09 Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
DE3588249T Expired - Lifetime DE3588249T2 (de) 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE200412000009 Pending DE122004000009I1 (de) 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen.
DE19853588249 Active DE122004000009I2 (de) 1984-08-16 1985-08-09 Methode zur Herstellung von menschlichen Wachstumshormonen
DE8585904198T Expired - Lifetime DE3586773T2 (de) 1984-08-16 1985-08-09 Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.

Country Status (11)

Country Link
EP (2) EP0191827B1 (de)
JP (1) JPH0822240B2 (de)
AT (2) ATE251217T1 (de)
AU (1) AU591464B2 (de)
CA (1) CA1318869C (de)
DE (4) DE122004000009I1 (de)
HK (1) HK143096A (de)
IL (1) IL76107A (de)
LU (1) LU91064I2 (de)
WO (1) WO1986001229A1 (de)
ZA (1) ZA856194B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
IL76360A0 (en) * 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
WO1986007380A1 (en) * 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Process for preparing polypeptide
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
US5013662A (en) * 1985-09-20 1991-05-07 Cetus Corporation Bacterial methionine n-terminal peptidase
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB8703015D0 (en) * 1987-02-10 1987-03-18 Biogen Nv Aminopeptidase
US5032573A (en) * 1987-03-23 1991-07-16 Bayer Aktiengesellschaft Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
DE3811921A1 (de) * 1988-04-09 1989-10-19 Hoechst Ag Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen
US5079345A (en) * 1988-08-19 1992-01-07 Eli Lilly And Company Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
ATE196548T1 (de) 1991-05-10 2000-10-15 Genentech Inc Auswählen von agonisten und antagonisten von liganden
US6429186B1 (en) 1991-05-10 2002-08-06 Genentech, Inc. Ligand antagonists for treatment of breast cancer
GB9225021D0 (en) * 1992-11-30 1993-01-20 Sandoz Ltd Organic compounds
KR970010135B1 (ko) * 1993-06-17 1997-06-21 주식회사 엘지화학 신규 아미노펩티다제
AU2445495A (en) * 1994-05-09 1995-11-29 Unizyme Laboratories A/S An enzymatic process for producing a desired protein from an amino terminal extended protein
KR100369839B1 (ko) * 1997-02-28 2003-06-12 주식회사 엘지생명과학 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법
KR20010080015A (ko) * 1998-10-05 2001-08-22 다케다 야쿠힌 고교 가부시키가이샤 Ｎ-말단 메티오닌의 제거방법
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
KR100956907B1 (ko) 2001-09-13 2010-05-11 제넨테크, 인크. 아미노펩티다아제
ATE502957T1 (de) 2004-06-23 2011-04-15 Usv Ltd Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
WO2009057533A1 (ja) 2007-10-29 2009-05-07 Jcr Pharmaceuticals Co., Ltd. アミノペプチダーゼの製造方法
KR20090124204A (ko) * 2008-05-29 2009-12-03 (주)바이오큐어팜 아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
ATE30246T1 (de) * 1982-12-10 1987-10-15 Nordisk Gentofte Verfahren zur herstellung reifer proteine aus schmelzproteinen hergestellt in pro- oder eukaryotischen zellen.
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
WO1986007380A1 (en) * 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Process for preparing polypeptide

Also Published As

Publication number Publication date
EP0489711B1 (de) 2003-10-01
DE3588249T2 (de) 2004-05-06
ZA856194B (en) 1986-04-30
JPS62500003A (ja) 1987-01-08
IL76107A (en) 1991-03-10
DE3586773T2 (de) 1993-03-18
LU91064I2 (en) 2004-05-26
EP0191827A1 (de) 1986-08-27
DE122004000009I1 (de) 2004-11-18
EP0191827B1 (de) 1992-10-21
WO1986001229A1 (en) 1986-02-27
EP0489711A2 (de) 1992-06-10
DE122004000009I2 (de) 2006-09-07
AU4773985A (en) 1986-03-07
EP0489711A3 (en) 1992-10-07
HK143096A (en) 1996-08-09
CA1318869C (en) 1993-06-08
JPH0822240B2 (ja) 1996-03-06
IL76107A0 (en) 1985-12-31
ATE81673T1 (de) 1992-11-15
ATE251217T1 (de) 2003-10-15
AU591464B2 (en) 1989-12-07
DE3586773D1 (de) 1992-11-26
EP0191827A4 (de) 1988-09-28

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Legal Events

Date Code Title Description
V448 Application of spc

Free format text: PRODUCT NAME: SOMATROPIN, GENTECHNISCH AUS E. COLI (A 4255/A 4600); REGISTRATION NO/DATE: 23770.00.00, 23770.01.00, 23770.02.00, 23773.00.00, 23773.01.00, 23773.02.00; 19920331

Spc suppl protection certif: 12 2004 000 009

Filing date: 20040329

8364 No opposition during term of opposition
V484 Delivery of the decision of grant

Free format text: PRODUCT NAME: SOMATROPIN, GENTECHNISCH AUS E. COLI (A 4255/A 4600); REGISTRATION NO/DATE: 23770.00.00, 23770.01.00, 23770.02.00, 23773.00.00, 23773.01.00, 23773.02.00; 19920331

Spc suppl protection certif: 12 2004 000 009

Filing date: 20040329

V457 Spc granted

Free format text: PRODUCT NAME: SOMATROPIN, GENTECHNISCH AUS E. COLI (A 4255/A 4600); REGISTRATION NO/DATE: 23770.00.00, 23770.01.00, 23770.02.00, 23773.00.00, 23773.01.00, 23773.02.00; 19920331

Spc suppl protection certif: 12 2004 000 009

Filing date: 20040329

V464 Spc expired

Free format text: PRODUCT NAME: SOMATROPIN, GENTECHNISCH AUS E. COLI (A 4255/A 4600); REGISTRATION NO/DATE: 23770.00.00, 23770.01.00, 23770.02.00, 23773.00.00, 23773.01.00, 23773.02.00; 19920331

Spc suppl protection certif: 12 2004 000 009

Filing date: 20040329