IL76107A - Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby - Google Patents
Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced therebyInfo
- Publication number
- IL76107A IL76107A IL76107A IL7610785A IL76107A IL 76107 A IL76107 A IL 76107A IL 76107 A IL76107 A IL 76107A IL 7610785 A IL7610785 A IL 7610785A IL 76107 A IL76107 A IL 76107A
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- acid residues
- terminal amino
- polypeptide
- polypeptides produced
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 125000000729 N-terminal amino-acid group Chemical group 0.000 title 1
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 4
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 4
- 239000000854 Human Growth Hormone Substances 0.000 abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 230000000813 microbial effect Effects 0.000 abstract 2
- 102000004400 Aminopeptidases Human genes 0.000 abstract 1
- 108090000915 Aminopeptidases Proteins 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/400,544 US5763215A (en) | 1984-08-16 | 1995-03-08 | Method of removing N-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64148884A | 1984-08-16 | 1984-08-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL76107A0 IL76107A0 (en) | 1985-12-31 |
| IL76107A true IL76107A (en) | 1991-03-10 |
Family
ID=24572607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL76107A IL76107A (en) | 1984-08-16 | 1985-08-15 | Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0489711B1 (de) |
| JP (1) | JPH0822240B2 (de) |
| AT (2) | ATE81673T1 (de) |
| AU (1) | AU591464B2 (de) |
| CA (1) | CA1318869C (de) |
| DE (4) | DE122004000009I2 (de) |
| HK (1) | HK143096A (de) |
| IL (1) | IL76107A (de) |
| LU (1) | LU91064I2 (de) |
| WO (1) | WO1986001229A1 (de) |
| ZA (1) | ZA856194B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK55685A (da) * | 1985-02-07 | 1986-08-08 | Nordisk Gentofte | Enzym eller enzymkompleks med proteolytisk aktivitet |
| IL76360A0 (en) * | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
| WO1986002068A1 (fr) * | 1984-09-26 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Separation mutuelle de proteines |
| US4861868A (en) | 1985-02-22 | 1989-08-29 | Monsanto Company | Production of proteins in procaryotes |
| WO1986007380A1 (fr) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Procede de preparation de polypeptides |
| US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
| US5013662A (en) * | 1985-09-20 | 1991-05-07 | Cetus Corporation | Bacterial methionine n-terminal peptidase |
| GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
| GB8703015D0 (en) * | 1987-02-10 | 1987-03-18 | Biogen Nv | Aminopeptidase |
| US5032573A (en) * | 1987-03-23 | 1991-07-16 | Bayer Aktiengesellschaft | Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof |
| DE3811921A1 (de) * | 1988-04-09 | 1989-10-19 | Hoechst Ag | Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen |
| US5079345A (en) * | 1988-08-19 | 1992-01-07 | Eli Lilly And Company | Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism |
| US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
| US6429186B1 (en) | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
| DE69231467T2 (de) | 1991-05-10 | 2001-01-25 | Genentech, Inc. | Auswählen von agonisten und antagonisten von liganden |
| GB9225021D0 (en) * | 1992-11-30 | 1993-01-20 | Sandoz Ltd | Organic compounds |
| KR970010135B1 (ko) * | 1993-06-17 | 1997-06-21 | 주식회사 엘지화학 | 신규 아미노펩티다제 |
| AU2445495A (en) * | 1994-05-09 | 1995-11-29 | Unizyme Laboratories A/S | An enzymatic process for producing a desired protein from an amino terminal extended protein |
| KR100369839B1 (ko) * | 1997-02-28 | 2003-06-12 | 주식회사 엘지생명과학 | 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법 |
| CA2346064A1 (en) * | 1998-10-05 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Method for removing n-terminal methionine |
| US6743600B1 (en) | 1999-04-30 | 2004-06-01 | Monsanto Technologies Llc | Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase |
| US6794159B1 (en) | 1999-04-30 | 2004-09-21 | Pharmacia Corporation | Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase |
| PL206286B1 (pl) | 2001-09-13 | 2010-07-30 | Genentech Incgenentech Inc | Komórka Gram-ujemnej bakterii, sposób wytwarzania heterologicznego peptydu, sposób zapobiegania odcinaniu N-końcowego aminokwasu, sposób odcinania N-końcowego aminokwasu i sposób wytwarzania skróconego polipeptydu |
| RU2241543C1 (ru) * | 2003-04-18 | 2004-12-10 | Институт проблем комплексного освоения недр РАН | Мельница для сухого измельчения растиранием |
| CN1953992A (zh) | 2004-06-23 | 2007-04-25 | Usv有限公司 | 源自胎盘和脑垂体同种型的嵌合体人生长激素和获得所述嵌合体的方法 |
| CN101868541A (zh) | 2007-10-29 | 2010-10-20 | 日本化学研究株式会社 | 生产氨肽酶的方法 |
| KR20090124204A (ko) * | 2008-05-29 | 2009-12-03 | (주)바이오큐어팜 | 아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
| DK55685A (da) * | 1985-02-07 | 1986-08-08 | Nordisk Gentofte | Enzym eller enzymkompleks med proteolytisk aktivitet |
| EP0127658B1 (de) * | 1982-12-10 | 1987-10-14 | Nordisk Gentofte A/S | Verfahren zur herstellung reifer proteine aus schmelzproteinen hergestellt in pro- oder eukaryotischen zellen |
| US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| WO1986007380A1 (fr) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Procede de preparation de polypeptides |
-
1985
- 1985-08-09 EP EP92101249A patent/EP0489711B1/de not_active Expired - Lifetime
- 1985-08-09 AU AU47739/85A patent/AU591464B2/en not_active Expired
- 1985-08-09 DE DE19853588249 patent/DE122004000009I2/de active Active
- 1985-08-09 WO PCT/US1985/001531 patent/WO1986001229A1/en not_active Ceased
- 1985-08-09 DE DE3588249T patent/DE3588249T2/de not_active Expired - Lifetime
- 1985-08-09 AT AT85904198T patent/ATE81673T1/de not_active IP Right Cessation
- 1985-08-09 EP EP85904198A patent/EP0191827B1/de not_active Expired - Lifetime
- 1985-08-09 AT AT92101249T patent/ATE251217T1/de active
- 1985-08-09 DE DE200412000009 patent/DE122004000009I1/de active Pending
- 1985-08-09 JP JP60503686A patent/JPH0822240B2/ja not_active Expired - Lifetime
- 1985-08-09 DE DE8585904198T patent/DE3586773T2/de not_active Expired - Lifetime
- 1985-08-15 ZA ZA856194A patent/ZA856194B/xx unknown
- 1985-08-15 IL IL76107A patent/IL76107A/xx active IP Right Revival
- 1985-08-15 CA CA000488771A patent/CA1318869C/en not_active Expired - Lifetime
-
1996
- 1996-08-01 HK HK143096A patent/HK143096A/en not_active IP Right Cessation
-
2004
- 2004-03-26 LU LU91064C patent/LU91064I2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1986001229A1 (en) | 1986-02-27 |
| EP0489711B1 (de) | 2003-10-01 |
| IL76107A0 (en) | 1985-12-31 |
| HK143096A (en) | 1996-08-09 |
| DE122004000009I1 (de) | 2004-11-18 |
| ATE81673T1 (de) | 1992-11-15 |
| EP0489711A3 (en) | 1992-10-07 |
| LU91064I2 (en) | 2004-05-26 |
| DE3586773D1 (de) | 1992-11-26 |
| ATE251217T1 (de) | 2003-10-15 |
| AU4773985A (en) | 1986-03-07 |
| AU591464B2 (en) | 1989-12-07 |
| DE3586773T2 (de) | 1993-03-18 |
| EP0191827B1 (de) | 1992-10-21 |
| EP0489711A2 (de) | 1992-06-10 |
| JPH0822240B2 (ja) | 1996-03-06 |
| EP0191827A4 (de) | 1988-09-28 |
| DE122004000009I2 (de) | 2006-09-07 |
| CA1318869C (en) | 1993-06-08 |
| DE3588249D1 (de) | 2003-11-06 |
| ZA856194B (en) | 1986-04-30 |
| JPS62500003A (ja) | 1987-01-08 |
| EP0191827A1 (de) | 1986-08-27 |
| DE3588249T2 (de) | 2004-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL76107A0 (en) | Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby | |
| HU902697D0 (en) | Process for the enzymatic removal of the n-terminal sequence of proteins | |
| NZ232742A (en) | Yeast heterologous protein production method, vectors, dna constructs and proteins so produced and aprotinin (1-58) so produced | |
| NZ510385A (en) | E. coli enterotoxin II signal peptide and a microorganism expressing a fusion protein of the MST peptide and a heterologous protein, such as human growth hormone | |
| CA2032153A1 (fr) | Application de nouveaux fragments d'adn en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant | |
| DE69112611D1 (de) | Proteinhydrolysate. | |
| EP0722461A4 (de) | Expression eines fusionspolypeptides, das ohne leadersequenz aus dem cytoplasma transportiert wird | |
| EP0499990A3 (en) | Method for producing cysteine-free peptides | |
| FI88398B (fi) | Foerfarande foer framstaellning av peptidanaloger | |
| ZA8860B (en) | Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof | |
| ES2009588A6 (es) | Un metodo para la preparacion de un polipeptido. | |
| EP0232107A3 (de) | Derivat des menschlichen Lymphotoxin-Polypeptids | |
| EP0330700A4 (de) | Menschlicher Prourokinase ähnliches Polypeptid. | |
| CA2198966A1 (en) | Method for cleaving chimeric protein using processing enzyme | |
| EP0300459A3 (de) | Menschlicher pankreatischer sekretorischer Trypsininhibitor | |
| DE69028935D1 (de) | Methode zur Produktion von Glukagon | |
| AU7542187A (en) | Light inducible promoter | |
| ATE81675T1 (de) | Produktion eines proteins. | |
| EP0750040A3 (de) | Varianten des Makrophagen-stimulierendes-Proteins und Verfahren zur ihrer Herstellung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NF | Patent restored | ||
| KB | Patent renewed | ||
| KB | Patent renewed |