DE3435156A1 - Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren - Google Patents

Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren

Info

Publication number
DE3435156A1
DE3435156A1 DE19843435156 DE3435156A DE3435156A1 DE 3435156 A1 DE3435156 A1 DE 3435156A1 DE 19843435156 DE19843435156 DE 19843435156 DE 3435156 A DE3435156 A DE 3435156A DE 3435156 A1 DE3435156 A1 DE 3435156A1
Authority
DE
Germany
Prior art keywords
acid
acids
cleavage
penicillin
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843435156
Other languages
German (de)
English (en)
Inventor
Manfred Dr.rer.nat. 8120 Weilheim Gloger
Josef Maier
Gerd Dr.rer.nat. 6800 Mannheim Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19843435156 priority Critical patent/DE3435156A1/de
Priority to US06/774,140 priority patent/US4859602A/en
Priority to EP85112018A priority patent/EP0176068B1/de
Priority to DE8585112018T priority patent/DE3581994D1/de
Priority to AT85112018T priority patent/ATE61413T1/de
Priority to JP60210368A priority patent/JPS6188895A/ja
Publication of DE3435156A1 publication Critical patent/DE3435156A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19843435156 1984-09-25 1984-09-25 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren Withdrawn DE3435156A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE19843435156 DE3435156A1 (de) 1984-09-25 1984-09-25 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
US06/774,140 US4859602A (en) 1984-09-25 1985-09-09 Process for the preparation of stereoisomers of 1-aminoalkylphosphonic and phosphinic acids
EP85112018A EP0176068B1 (de) 1984-09-25 1985-09-23 Verfahren zur Herstellung der Stereoisomeren von 1-Amino-alkylphosphonsäuren oder 1-Amino-alkylphosphinsäuren
DE8585112018T DE3581994D1 (de) 1984-09-25 1985-09-23 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-amino-alkylphosphinsaeuren.
AT85112018T ATE61413T1 (de) 1984-09-25 1985-09-23 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphins|uren.
JP60210368A JPS6188895A (ja) 1984-09-25 1985-09-25 １‐アミノ‐アルキルホスホン酸又は１‐アミノ‐アルキルホスフイン酸の立体異性体の製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843435156 DE3435156A1 (de) 1984-09-25 1984-09-25 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren

Publications (1)

Publication Number Publication Date
DE3435156A1 true DE3435156A1 (de) 1986-04-03

Family

ID=6246309

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19843435156 Withdrawn DE3435156A1 (de) 1984-09-25 1984-09-25 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
DE8585112018T Expired - Lifetime DE3581994D1 (de) 1984-09-25 1985-09-23 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-amino-alkylphosphinsaeuren.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585112018T Expired - Lifetime DE3581994D1 (de) 1984-09-25 1985-09-23 Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-amino-alkylphosphinsaeuren.

Country Status (5)

Country Link
US (1) US4859602A (https=)
EP (1) EP0176068B1 (https=)
JP (1) JPS6188895A (https=)
AT (1) ATE61413T1 (https=)
DE (2) DE3435156A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3516114A1 (de) * 1985-05-04 1986-11-06 Heiss, Bernhard R., 8000 München 1-acylamido-alkylphosphonsaeuren und ihre salze, verfahren zu deren herstellung und ihre verwendung als tenside

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
GB8728121D0 (en) * 1987-12-01 1988-01-06 Ciba Geigy Ag Resolution process
DE3903446A1 (de) * 1989-02-06 1990-10-18 Hoechst Ag Verfahren zur enzymatischen trennung von 2-amino-4-methylphosphinobuttersaeurederivaten
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.
US5057607A (en) * 1990-06-08 1991-10-15 Eli Lilly And Company Enantiomerically selective biocatalyzed acylation
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
EP0923555B1 (en) * 1996-05-01 2005-06-15 Ortho-McNeil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
ATE227295T1 (de) 1998-07-16 2002-11-15 Aventis Pharma Gmbh Phosphin- und phosphonsäurederivate als arzneimittel
EP1315827A1 (en) * 2000-09-08 2003-06-04 Dsm N.V. Method for the preparation of enantiomerically enriched amines
WO2002020821A2 (en) * 2000-09-08 2002-03-14 Dsm N.V. Process for the preparation of enantiomerically enriched amines
CN102171185A (zh) 2008-08-01 2011-08-31 拜奥西尼斯医药股份有限公司 甲硫氨酸类似物及其使用方法
WO2020169822A1 (en) * 2019-02-21 2020-08-27 Universite Claude Bernard Lyon 1 Structured molecular vectors for anti-inflammatory compounds and uses thereof
CN118994613A (zh) * 2024-08-01 2024-11-22 中国计量大学 一种外消旋镍有机膦酸聚合物的手性拆分和放大的新方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1369462A (en) * 1971-11-23 1974-10-09 Beecham Group Ltd Enzymic resolution of racemic n-acyl-dl-amino acids
US4151229A (en) * 1973-11-14 1979-04-24 Ciba-Geigy Corporation Process for the manufacture of aminoalkyl-phosponic acid esters
DE2732301C3 (de) * 1977-07-16 1980-12-11 Roehm Gmbh, 6100 Darmstadt Verfahren zur Herstellung von stabilisierten trägergebundenen Proteinen
DE2834539A1 (de) * 1978-08-07 1980-02-21 Basf Ag Makroporoese polymere als traegermaterial zur kovalenten bindung von proteinen
US4226941A (en) * 1979-09-27 1980-10-07 Meiji Seika Kaisha, Ltd. Process for the optical resolution of d,l-2-amino-4-methylphosphinobutyric acid
DE3048612C2 (de) * 1980-12-23 1982-12-02 Hoechst Ag, 6000 Frankfurt "Verfahren zur enzymatischen Trennung von L-2-Ami no-4-methylphosphinobuttersäure"
DE3334846A1 (de) * 1983-09-27 1985-04-04 Hoechst Ag, 6230 Frankfurt Immobilisierte acylase, verfahren zu ihrer herstellung und ihre verwendung
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3516114A1 (de) * 1985-05-04 1986-11-06 Heiss, Bernhard R., 8000 München 1-acylamido-alkylphosphonsaeuren und ihre salze, verfahren zu deren herstellung und ihre verwendung als tenside

Also Published As

Publication number Publication date
EP0176068A2 (de) 1986-04-02
US4859602A (en) 1989-08-22
JPS6227800B2 (https=) 1987-06-16
EP0176068A3 (en) 1988-06-01
EP0176068B1 (de) 1991-03-06
DE3581994D1 (de) 1991-04-11
ATE61413T1 (de) 1991-03-15
JPS6188895A (ja) 1986-05-07

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination