DE3423234A1 - Synergistische mischungen von interferonen und tumor-nekrose-faktor - Google Patents
Synergistische mischungen von interferonen und tumor-nekrose-faktorInfo
- Publication number
- DE3423234A1 DE3423234A1 DE19843423234 DE3423234A DE3423234A1 DE 3423234 A1 DE3423234 A1 DE 3423234A1 DE 19843423234 DE19843423234 DE 19843423234 DE 3423234 A DE3423234 A DE 3423234A DE 3423234 A1 DE3423234 A1 DE 3423234A1
- Authority
- DE
- Germany
- Prior art keywords
- interferon
- tumor necrosis
- human
- mixture according
- interferons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000014150 Interferons Human genes 0.000 title claims abstract description 33
- 108010050904 Interferons Proteins 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 229940079322 interferon Drugs 0.000 title claims abstract description 13
- 230000002195 synergetic effect Effects 0.000 title abstract description 7
- 206010028980 Neoplasm Diseases 0.000 title abstract description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract description 19
- 102000003390 tumor necrosis factor Human genes 0.000 claims abstract description 6
- 229940047124 interferons Drugs 0.000 claims description 21
- 108010074328 Interferon-gamma Proteins 0.000 claims description 9
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 8
- 102000057041 human TNF Human genes 0.000 claims description 8
- 108010047761 Interferon-alpha Proteins 0.000 claims description 5
- 102000006992 Interferon-alpha Human genes 0.000 claims description 5
- 102000008070 Interferon-gamma Human genes 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000001613 neoplastic effect Effects 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 2
- 206010054094 Tumour necrosis Diseases 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 29
- 230000001028 anti-proliverative effect Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 30
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 6
- 241000282412 Homo Species 0.000 description 5
- 102100037850 Interferon gamma Human genes 0.000 description 5
- 230000001085 cytostatic effect Effects 0.000 description 5
- 231100000433 cytotoxic Toxicity 0.000 description 5
- 230000001472 cytotoxic effect Effects 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000824 cytostatic agent Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 102100026720 Interferon beta Human genes 0.000 description 2
- 108090000467 Interferon-beta Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 208000019065 cervical carcinoma Diseases 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
- 241001446459 Heia Species 0.000 description 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
- 102000002227 Interferon Type I Human genes 0.000 description 1
- 108010014726 Interferon Type I Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101001054328 Mus musculus Interferon beta Proteins 0.000 description 1
- 101001044384 Mus musculus Interferon gamma Proteins 0.000 description 1
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- DLEDLHFNQDHEOJ-UDTOXTEMSA-N mezerein Chemical compound O([C@@H]1[C@H]([C@@]23[C@H]4[C@](C(C(C)=C4)=O)(O)[C@H](O)[C@@]4(CO)O[C@H]4[C@H]3[C@H]3O[C@@](O2)(O[C@]31C(C)=C)C=1C=CC=CC=1)C)C(=O)\C=C\C=C\C1=CC=CC=C1 DLEDLHFNQDHEOJ-UDTOXTEMSA-N 0.000 description 1
- DLEDLHFNQDHEOJ-KVZAMRGJSA-N mezerein Natural products CC1C(OC(=O)C=C/C=C/c2ccccc2)C3(OC4(OC3C5C6OC6(CO)C(O)C7(O)C(C=C(C)C7=O)C15O4)c8ccccc8)C(=C)C DLEDLHFNQDHEOJ-KVZAMRGJSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 108700029353 mouse Ifna Proteins 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000000717 tumor promoter Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843423234 DE3423234A1 (de) | 1984-06-23 | 1984-06-23 | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| GR851492A GR851492B (enExample) | 1984-06-23 | 1985-06-19 | |
| AT85107618T ATE82508T1 (de) | 1984-06-23 | 1985-06-20 | Synergistische mischungen von interferonen und tumor-nekrose-faktor. |
| US06/746,793 US4791101A (en) | 1984-06-23 | 1985-06-20 | Synergistic mixtures of interferons and tumor necrosis factor |
| DE8585107618T DE3586833D1 (de) | 1984-06-23 | 1985-06-20 | Synergistische mischungen von interferonen und tumor-nekrose-faktor. |
| PH32429A PH24406A (en) | 1984-06-23 | 1985-06-20 | Synergistic mixtures of interferons and tumor necrosis factor |
| EP85107618A EP0170843B1 (de) | 1984-06-23 | 1985-06-20 | Synergistische Mischungen von Interferonen und Tumor-Nekrose-Faktor |
| JP60135823A JPS6115842A (ja) | 1984-06-23 | 1985-06-21 | インターフエロンと腫瘍壊死因子の相剰作用混合物 |
| HU852456A HU206270B (en) | 1984-06-23 | 1985-06-21 | Process for producing pharmaceutical compositions comprising synergic mixtures of interferons and tumour-necrosis factor |
| IE154785A IE59289B1 (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumour necrosis factor |
| DK282585A DK282585A (da) | 1984-06-23 | 1985-06-21 | Synergistiske blandinger af interferoner og tumor-nekrose-faktor |
| DD85295292A DD250053A5 (de) | 1984-06-23 | 1985-06-21 | Verfahren zur herstellung einer synergistischen mischung von interferonen und tumor-nekrose-faktor |
| AU43931/85A AU593212B2 (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumor necrosis factor |
| CA000484739A CA1258426A (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumor necrosis-factor |
| NZ212513A NZ212513A (en) | 1984-06-23 | 1985-06-21 | Synergistic composition containing an interferon and tissue necrosis factor |
| DD85277633A DD238725A5 (de) | 1984-06-23 | 1985-06-21 | Verfahren zur herstellung eine synergistischen mischung von interferonen und tumor-nekrose-faktor |
| IL75597A IL75597A (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumour necrosis factor |
| ZA854682A ZA854682B (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumour necrosis factor |
| AU44167/85A AU4416785A (en) | 1984-06-23 | 1985-06-24 | Synergistic mixtures of interferons and tumor necrosis factor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843423234 DE3423234A1 (de) | 1984-06-23 | 1984-06-23 | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3423234A1 true DE3423234A1 (de) | 1986-02-06 |
Family
ID=6238998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843423234 Ceased DE3423234A1 (de) | 1984-06-23 | 1984-06-23 | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| DE8585107618T Expired - Fee Related DE3586833D1 (de) | 1984-06-23 | 1985-06-20 | Synergistische mischungen von interferonen und tumor-nekrose-faktor. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585107618T Expired - Fee Related DE3586833D1 (de) | 1984-06-23 | 1985-06-20 | Synergistische mischungen von interferonen und tumor-nekrose-faktor. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4791101A (enExample) |
| EP (1) | EP0170843B1 (enExample) |
| JP (1) | JPS6115842A (enExample) |
| AT (1) | ATE82508T1 (enExample) |
| AU (2) | AU593212B2 (enExample) |
| CA (1) | CA1258426A (enExample) |
| DD (2) | DD250053A5 (enExample) |
| DE (2) | DE3423234A1 (enExample) |
| DK (1) | DK282585A (enExample) |
| GR (1) | GR851492B (enExample) |
| HU (1) | HU206270B (enExample) |
| IE (1) | IE59289B1 (enExample) |
| IL (1) | IL75597A (enExample) |
| NZ (1) | NZ212513A (enExample) |
| PH (1) | PH24406A (enExample) |
| ZA (1) | ZA854682B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362490A (en) * | 1986-07-25 | 1994-11-08 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Human myelomonocyte interferon-gamma, and process for preparation and use thereof |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| DE3423234A1 (de) * | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| EP0313104A3 (en) * | 1984-12-21 | 1989-07-12 | Biogen, Inc. | Purification, production and use of tumor necrosis factors |
| US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
| NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
| US4822605A (en) * | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
| CA1291706C (en) * | 1986-04-03 | 1991-11-05 | Alfred Rudolph | COMBINATION THERAPY USING INTERFERON-.beta. AND INTERLEUKIN-2 |
| CA1290249C (en) * | 1986-04-09 | 1991-10-08 | Cetus Corporation | COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| PT85076B (pt) * | 1986-06-16 | 1990-07-31 | Genentech Inc | Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa |
| IL80005A (en) * | 1986-09-10 | 1992-11-15 | Yeda Res & Dev | Compositions for modulating the effect of tnf and il-1 |
| US4929442A (en) * | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
| US4980160A (en) * | 1986-10-16 | 1990-12-25 | Biogen, Inc. | Combinations of tumor necrosis factors and anti-inflammatory agents and methods for treating malignant and non-malignant diseases |
| US4963354A (en) * | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
| DE59000270D1 (de) * | 1989-04-11 | 1992-10-01 | Boehringer Ingelheim Int | Verwendung von mindestens ein cytokin zur herstellung eines arzneimittels zur systemischen behandlung von praeneoplastischen laesionen. |
| US6042837A (en) * | 1989-09-20 | 2000-03-28 | Kalland; Terje | Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC) |
| US6126945A (en) * | 1989-10-03 | 2000-10-03 | Pharmacia Ab | Tumor killing effects of enterotoxins, superantigens, and related compounds |
| US5676942A (en) * | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| KR100223255B1 (ko) * | 1992-02-10 | 1999-10-15 | 더글라스 테스타 | 개량된 알파 인터페론 조성물 및 인간 말초혈 백혈구로 부터의 제조 방법 |
| EP1416282A3 (en) * | 1995-07-25 | 2004-06-23 | Toray Industries, Inc. | Method for screening compounds for treating bone disorders |
| US6617171B2 (en) * | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| US6599710B1 (en) | 1999-03-10 | 2003-07-29 | The General Hospital Corporation | Treatment of autoimmune disease |
| HUP0300627A3 (en) * | 1999-12-13 | 2005-11-28 | Bioniche Life Sciences Inc Bel | Therapeutically useful synthetic oligonucleotides |
| US20020091095A1 (en) * | 1999-12-13 | 2002-07-11 | Phillips Nigel C. | Modulation of Fas and FasL expression |
| US7109303B2 (en) * | 2000-02-15 | 2006-09-19 | Fondazione Centro San Raffaele Del Monte Tabor | Modified cytokines for use in cancer therapy |
| US7309694B2 (en) * | 2000-02-15 | 2007-12-18 | Fondazione Centro San Raffaele Del Monte Tabor | Modified cytokines for use in cancer therapy |
| IT1317835B1 (it) * | 2000-02-15 | 2003-07-15 | San Raffaele Centro Fond | Citochine modificate per uso nella terapia del cancro. |
| US20030129162A1 (en) * | 2000-09-12 | 2003-07-10 | Lau Allan S. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| CN1527721A (zh) * | 2000-09-12 | 2004-09-08 | 基因特罗生物治疗公司 | 含治疗性蛋白混合物的组合物及其生产方法 |
| SI1471974T1 (sl) * | 2002-02-06 | 2007-12-31 | Ares Trading Sa | Tumorje nekrotizirajoäśi faktor, kombiniran z interferonom, pri demielinizirajoäśih boleznih |
| GB0209893D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| GB0209896D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| US7582313B2 (en) * | 2002-06-27 | 2009-09-01 | The General Hospital Corporation | Methods of organ regeneration using Hox 11-expressing pluripotent cells |
| US7628988B2 (en) | 2002-06-27 | 2009-12-08 | The General Hospital Corporation | Methods and compositions for treating type 1 diabetes |
| US20040229785A1 (en) * | 2002-11-15 | 2004-11-18 | Denise Faustman | Screening methods to identify treatments for autoimmune disease |
| JP4754219B2 (ja) | 2002-12-02 | 2011-08-24 | アムジエン・フレモント・インコーポレイテツド | 腫瘍壊死因子を対象とする抗体、およびそれらの使用 |
| WO2005046746A2 (en) * | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| US20080102054A1 (en) * | 2005-01-18 | 2008-05-01 | Faustman Denise L | Compositions Containing Agm Cells And Methods Of Use Thereof |
| DE102012024749A1 (de) | 2012-12-11 | 2014-06-26 | Martin Röcken | Tumorprävention und -therapie durch Induktion einer Tumorseneszenz |
| EP2953634B1 (en) | 2013-02-07 | 2021-05-26 | The General Hospital Corporation | Methods for expansion or depletion of t-regulatory cells |
| KR102393711B1 (ko) | 2013-10-17 | 2022-05-04 | 더 제너럴 하스피탈 코포레이션 | 자가면역 질환의 치료에 반응하는 대상체의 식별 방법 및 그의 치료를 위한 조성물 |
| ES2962885T3 (es) | 2015-05-15 | 2024-03-21 | Massachusetts Gen Hospital | Anticuerpos antagonistas de la superfamilia del receptor del factor de necrosis tumoral |
| EP3340999A4 (en) | 2015-08-28 | 2019-06-12 | The General Hospital Corporation | AGONISTIC ANTI-TUMOR NECROSIS RECEPTOR 2 ANTIBODIES |
| US11266730B2 (en) | 2015-09-29 | 2022-03-08 | The General Hospital Corporation | Methods of treating and diagnosing disease using biomarkers for BCG therapy |
| CN116715767A (zh) | 2016-05-13 | 2023-09-08 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
| JP7534215B2 (ja) * | 2018-01-24 | 2024-08-14 | ベイジン パーカンズ オンコロジー カンパニー リミテッド | サイトカイン融合タンパク質 |
| CN114436088A (zh) * | 2020-11-02 | 2022-05-06 | 奥的斯电梯公司 | 用于电梯轿厢的安全出口组件及电梯系统 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3227262A1 (de) * | 1981-07-21 | 1983-03-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Verfahren zur herstellung von target-zellen-lysis-faktor und dessen verwendung |
| EP0128009A2 (en) * | 1983-06-01 | 1984-12-12 | Genentech, Inc. | Synergistic composition comprising gamma interferon and lymphotoxin, and its preparation |
| EP0131789A2 (en) * | 1983-06-27 | 1985-01-23 | Sloan-Kettering Institute For Cancer Research | Composition comprising purified human tumour necrosis factor in conjunction with human interferon and its use |
| DE3421731A1 (de) * | 1984-06-12 | 1985-12-12 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Humaner-tumor-nekrose-faktor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0764744B2 (ja) * | 1981-11-21 | 1995-07-12 | 株式会社林原生物化学研究所 | 標的細胞障害性因子とヒトインタ−フェロンとを有効成分として含有する悪性腫瘍治療剤 |
| DE3423234A1 (de) * | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
-
1984
- 1984-06-23 DE DE19843423234 patent/DE3423234A1/de not_active Ceased
-
1985
- 1985-06-19 GR GR851492A patent/GR851492B/el unknown
- 1985-06-20 PH PH32429A patent/PH24406A/en unknown
- 1985-06-20 AT AT85107618T patent/ATE82508T1/de not_active IP Right Cessation
- 1985-06-20 US US06/746,793 patent/US4791101A/en not_active Expired - Fee Related
- 1985-06-20 DE DE8585107618T patent/DE3586833D1/de not_active Expired - Fee Related
- 1985-06-20 EP EP85107618A patent/EP0170843B1/de not_active Expired - Lifetime
- 1985-06-21 NZ NZ212513A patent/NZ212513A/xx unknown
- 1985-06-21 JP JP60135823A patent/JPS6115842A/ja active Pending
- 1985-06-21 HU HU852456A patent/HU206270B/hu unknown
- 1985-06-21 AU AU43931/85A patent/AU593212B2/en not_active Ceased
- 1985-06-21 DK DK282585A patent/DK282585A/da not_active Application Discontinuation
- 1985-06-21 DD DD85295292A patent/DD250053A5/de not_active IP Right Cessation
- 1985-06-21 IL IL75597A patent/IL75597A/xx not_active IP Right Cessation
- 1985-06-21 ZA ZA854682A patent/ZA854682B/xx unknown
- 1985-06-21 CA CA000484739A patent/CA1258426A/en not_active Expired
- 1985-06-21 IE IE154785A patent/IE59289B1/en not_active IP Right Cessation
- 1985-06-21 DD DD85277633A patent/DD238725A5/de not_active IP Right Cessation
- 1985-06-24 AU AU44167/85A patent/AU4416785A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3227262A1 (de) * | 1981-07-21 | 1983-03-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Verfahren zur herstellung von target-zellen-lysis-faktor und dessen verwendung |
| EP0128009A2 (en) * | 1983-06-01 | 1984-12-12 | Genentech, Inc. | Synergistic composition comprising gamma interferon and lymphotoxin, and its preparation |
| EP0131789A2 (en) * | 1983-06-27 | 1985-01-23 | Sloan-Kettering Institute For Cancer Research | Composition comprising purified human tumour necrosis factor in conjunction with human interferon and its use |
| DE3421731A1 (de) * | 1984-06-12 | 1985-12-12 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Humaner-tumor-nekrose-faktor |
Non-Patent Citations (4)
| Title |
|---|
| 5397-5401 |
| CZARNIECKI, C.W. et.al.: J. Virology 49 (1984) 490-496 * |
| WILLIAMSON, B.D. et.al.: Proc. Natl. Acad. Sci. USA 80 (1983) |
| WILLIAMSON, B.D. et.al.: Proc. Natl. Acad. Sci. USA 80 (1983) 5397-5401 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362490A (en) * | 1986-07-25 | 1994-11-08 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Human myelomonocyte interferon-gamma, and process for preparation and use thereof |
| US5518899A (en) * | 1986-07-25 | 1996-05-21 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Preparation of human myelomonocyte interferon-gamma |
| US5554515A (en) * | 1986-07-25 | 1996-09-10 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Preparation of a monoclonal antibody specific to human myelomonocyte interferon-gamma |
| US5672692A (en) * | 1986-07-25 | 1997-09-30 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Purification of human myelomonocyte interferon gamma with an immobilized antibody |
Also Published As
| Publication number | Publication date |
|---|---|
| DK282585D0 (da) | 1985-06-21 |
| JPS6115842A (ja) | 1986-01-23 |
| IE59289B1 (en) | 1994-02-09 |
| NZ212513A (en) | 1988-08-30 |
| HU206270B (en) | 1992-10-28 |
| AU4416785A (en) | 1986-01-02 |
| EP0170843A1 (de) | 1986-02-12 |
| IE851547L (en) | 1985-12-23 |
| CA1258426A (en) | 1989-08-15 |
| IL75597A (en) | 1991-11-21 |
| DK282585A (da) | 1985-12-24 |
| DD238725A5 (de) | 1986-09-03 |
| ATE82508T1 (de) | 1992-12-15 |
| EP0170843B1 (de) | 1992-11-19 |
| DD250053A5 (de) | 1987-09-30 |
| DE3586833D1 (de) | 1992-12-24 |
| AU4393185A (en) | 1986-01-02 |
| US4791101A (en) | 1988-12-13 |
| HUT37891A (en) | 1986-03-28 |
| GR851492B (enExample) | 1985-11-25 |
| ZA854682B (en) | 1987-02-25 |
| AU593212B2 (en) | 1990-02-08 |
| IL75597A0 (en) | 1985-10-31 |
| PH24406A (en) | 1990-06-13 |
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| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
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| 8131 | Rejection |