CA1258426A - Synergistic mixtures of interferons and tumor necrosis-factor - Google Patents
Synergistic mixtures of interferons and tumor necrosis-factorInfo
- Publication number
- CA1258426A CA1258426A CA000484739A CA484739A CA1258426A CA 1258426 A CA1258426 A CA 1258426A CA 000484739 A CA000484739 A CA 000484739A CA 484739 A CA484739 A CA 484739A CA 1258426 A CA1258426 A CA 1258426A
- Authority
- CA
- Canada
- Prior art keywords
- interferon
- type
- necrosis factor
- tumour necrosis
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 69
- 102000014150 Interferons Human genes 0.000 title claims abstract description 48
- 108010050904 Interferons Proteins 0.000 title claims abstract description 48
- 229940047124 interferons Drugs 0.000 title claims description 24
- 230000002195 synergetic effect Effects 0.000 title claims description 12
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000003390 tumor necrosis factor Human genes 0.000 title 1
- 102000018594 Tumour necrosis factor Human genes 0.000 claims abstract description 65
- 108050007852 Tumour necrosis factor Proteins 0.000 claims abstract description 65
- 229940079322 interferon Drugs 0.000 claims abstract description 26
- 239000000824 cytostatic agent Substances 0.000 claims abstract description 14
- 230000001085 cytostatic effect Effects 0.000 claims abstract description 14
- 241000282414 Homo sapiens Species 0.000 claims description 53
- 108010074328 Interferon-gamma Proteins 0.000 claims description 39
- 102000008070 Interferon-gamma Human genes 0.000 claims description 32
- 102000002227 Interferon Type I Human genes 0.000 claims description 30
- 108010014726 Interferon Type I Proteins 0.000 claims description 27
- 239000012535 impurity Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 3
- 238000010353 genetic engineering Methods 0.000 claims 11
- 101000959794 Homo sapiens Interferon alpha-2 Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 29
- 230000001472 cytotoxic effect Effects 0.000 abstract description 6
- 231100000433 cytotoxic Toxicity 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 description 31
- 108090000623 proteins and genes Proteins 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 12
- 102100037850 Interferon gamma Human genes 0.000 description 7
- 108010047761 Interferon-alpha Proteins 0.000 description 7
- 102000006992 Interferon-alpha Human genes 0.000 description 7
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 7
- 239000002609 medium Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 239000005289 controlled pore glass Substances 0.000 description 2
- 102000057041 human TNF Human genes 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 230000017066 negative regulation of growth Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
- 101000999325 Homo sapiens Cobalamin binding intrinsic factor Proteins 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101001054328 Mus musculus Interferon beta Proteins 0.000 description 1
- 101001044384 Mus musculus Interferon gamma Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- DLEDLHFNQDHEOJ-UDTOXTEMSA-N mezerein Chemical compound O([C@@H]1[C@H]([C@@]23[C@H]4[C@](C(C(C)=C4)=O)(O)[C@H](O)[C@@]4(CO)O[C@H]4[C@H]3[C@H]3O[C@@](O2)(O[C@]31C(C)=C)C=1C=CC=CC=1)C)C(=O)\C=C\C=C\C1=CC=CC=C1 DLEDLHFNQDHEOJ-UDTOXTEMSA-N 0.000 description 1
- DLEDLHFNQDHEOJ-KVZAMRGJSA-N mezerein Natural products CC1C(OC(=O)C=C/C=C/c2ccccc2)C3(OC4(OC3C5C6OC6(CO)C(O)C7(O)C(C=C(C)C7=O)C15O4)c8ccccc8)C(=C)C DLEDLHFNQDHEOJ-KVZAMRGJSA-N 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 108700029353 mouse Ifna Proteins 0.000 description 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843423234 DE3423234A1 (de) | 1984-06-23 | 1984-06-23 | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| DEP3423234.6 | 1984-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1258426A true CA1258426A (en) | 1989-08-15 |
Family
ID=6238998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000484739A Expired CA1258426A (en) | 1984-06-23 | 1985-06-21 | Synergistic mixtures of interferons and tumor necrosis-factor |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4791101A (enExample) |
| EP (1) | EP0170843B1 (enExample) |
| JP (1) | JPS6115842A (enExample) |
| AT (1) | ATE82508T1 (enExample) |
| AU (2) | AU593212B2 (enExample) |
| CA (1) | CA1258426A (enExample) |
| DD (2) | DD238725A5 (enExample) |
| DE (2) | DE3423234A1 (enExample) |
| DK (1) | DK282585A (enExample) |
| GR (1) | GR851492B (enExample) |
| HU (1) | HU206270B (enExample) |
| IE (1) | IE59289B1 (enExample) |
| IL (1) | IL75597A (enExample) |
| NZ (1) | NZ212513A (enExample) |
| PH (1) | PH24406A (enExample) |
| ZA (1) | ZA854682B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| DE3423234A1 (de) * | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| ATE73856T1 (de) * | 1984-12-21 | 1992-04-15 | Biogen Inc | Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren. |
| US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
| NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
| US4822605A (en) * | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
| CA1291706C (en) * | 1986-04-03 | 1991-11-05 | Alfred Rudolph | COMBINATION THERAPY USING INTERFERON-.beta. AND INTERLEUKIN-2 |
| CA1290249C (en) * | 1986-04-09 | 1991-10-08 | Cetus Corporation | COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| PT85076B (pt) * | 1986-06-16 | 1990-07-31 | Genentech Inc | Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa |
| US5362490A (en) * | 1986-07-25 | 1994-11-08 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Human myelomonocyte interferon-gamma, and process for preparation and use thereof |
| IL80005A (en) * | 1986-09-10 | 1992-11-15 | Yeda Res & Dev | Compositions for modulating the effect of tnf and il-1 |
| US4929442A (en) * | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
| US4980160A (en) * | 1986-10-16 | 1990-12-25 | Biogen, Inc. | Combinations of tumor necrosis factors and anti-inflammatory agents and methods for treating malignant and non-malignant diseases |
| US4963354A (en) * | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
| ES2034790T3 (es) * | 1989-04-11 | 1993-04-01 | Boehringer Ingelheim International Gmbh | Empleo de al menos una citroquina para la preparacion de un medicamento para el tratamiento sistematico de lesiones preneoplasticas. |
| US6042837A (en) * | 1989-09-20 | 2000-03-28 | Kalland; Terje | Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC) |
| US6126945A (en) * | 1989-10-03 | 2000-10-03 | Pharmacia Ab | Tumor killing effects of enterotoxins, superantigens, and related compounds |
| US5676942A (en) * | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| EP0625991B1 (en) * | 1992-02-10 | 1999-04-28 | Interferon Sciences, Inc. | Improved alpha interferon composition and method for its production from human peripheral blood leukocytes |
| EP1416282A3 (en) * | 1995-07-25 | 2004-06-23 | Toray Industries, Inc. | Method for screening compounds for treating bone disorders |
| US6617171B2 (en) * | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| US6599710B1 (en) | 1999-03-10 | 2003-07-29 | The General Hospital Corporation | Treatment of autoimmune disease |
| CZ20022372A3 (cs) * | 1999-12-13 | 2002-11-13 | Bioniche Life Sciences Inc. | Terapeuticky pouľitelné syntetické oligonukleotidy |
| US20020091095A1 (en) * | 1999-12-13 | 2002-07-11 | Phillips Nigel C. | Modulation of Fas and FasL expression |
| US7309694B2 (en) * | 2000-02-15 | 2007-12-18 | Fondazione Centro San Raffaele Del Monte Tabor | Modified cytokines for use in cancer therapy |
| IT1317835B1 (it) * | 2000-02-15 | 2003-07-15 | San Raffaele Centro Fond | Citochine modificate per uso nella terapia del cancro. |
| US7109303B2 (en) * | 2000-02-15 | 2006-09-19 | Fondazione Centro San Raffaele Del Monte Tabor | Modified cytokines for use in cancer therapy |
| US20030129162A1 (en) * | 2000-09-12 | 2003-07-10 | Lau Allan S. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| CN1527721A (zh) * | 2000-09-12 | 2004-09-08 | 基因特罗生物治疗公司 | 含治疗性蛋白混合物的组合物及其生产方法 |
| US7674453B2 (en) * | 2002-02-06 | 2010-03-09 | Ares Trading Sa | Tumor necrosis factor combined with interferon in demyelinating diseases |
| GB0209896D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| GB0209893D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| US7628988B2 (en) | 2002-06-27 | 2009-12-08 | The General Hospital Corporation | Methods and compositions for treating type 1 diabetes |
| US7582313B2 (en) * | 2002-06-27 | 2009-09-01 | The General Hospital Corporation | Methods of organ regeneration using Hox 11-expressing pluripotent cells |
| WO2004045376A2 (en) * | 2002-11-15 | 2004-06-03 | The General Hospital Corporation | Screening methods to identify treatments for autoimmune disease |
| US7285269B2 (en) | 2002-12-02 | 2007-10-23 | Amgen Fremont, Inc. | Antibodies directed to tumor necrosis factor |
| CA2536041A1 (en) * | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| US20080102054A1 (en) * | 2005-01-18 | 2008-05-01 | Faustman Denise L | Compositions Containing Agm Cells And Methods Of Use Thereof |
| DE102012024749A1 (de) | 2012-12-11 | 2014-06-26 | Martin Röcken | Tumorprävention und -therapie durch Induktion einer Tumorseneszenz |
| PT2953634T (pt) | 2013-02-07 | 2021-09-02 | Massachusetts Gen Hospital | Métodos de expansão ou depleção das células t reguladoras |
| CN111239415B (zh) | 2013-10-17 | 2024-03-26 | 综合医院公司 | 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物 |
| AU2016263198C1 (en) | 2015-05-15 | 2023-10-05 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| EP3340999A4 (en) | 2015-08-28 | 2019-06-12 | The General Hospital Corporation | AGONISTIC ANTI-TUMOR NECROSIS RECEPTOR 2 ANTIBODIES |
| EP3355914B1 (en) | 2015-09-29 | 2024-03-06 | The General Hospital Corporation | A composition comprising bcg for reducing cholesterol. |
| EP3455262A4 (en) | 2016-05-13 | 2020-04-08 | The General Hospital Corporation | ANTAGONISTIC ANTI-TUMOR NECROSE FACTOR RECEPTOR SUPER FAMILY ANTIBODIES |
| CN112105632A (zh) * | 2018-01-24 | 2020-12-18 | 北京智康博药肿瘤医学研究有限公司 | 细胞因子融合蛋白 |
| CN113302205B (zh) | 2018-11-15 | 2024-12-06 | 综合医院公司 | 激动性肿瘤坏死因子受体超家族多肽 |
| CN114436088A (zh) * | 2020-11-02 | 2022-05-06 | 奥的斯电梯公司 | 用于电梯轿厢的安全出口组件及电梯系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513124B1 (fr) * | 1981-07-21 | 1989-11-17 | Hayashibara Biochem Lab | Production et applications du facteur de lyse des cellules-cibles |
| JPH0764744B2 (ja) * | 1981-11-21 | 1995-07-12 | 株式会社林原生物化学研究所 | 標的細胞障害性因子とヒトインタ−フェロンとを有効成分として含有する悪性腫瘍治療剤 |
| ZA844070B (en) * | 1983-06-01 | 1984-12-24 | Genentech Inc | Gamma interferon-lymphotoxin synergism |
| CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
| DE3421731A1 (de) * | 1984-06-12 | 1985-12-12 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Humaner-tumor-nekrose-faktor |
| DE3423234A1 (de) * | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
-
1984
- 1984-06-23 DE DE19843423234 patent/DE3423234A1/de not_active Ceased
-
1985
- 1985-06-19 GR GR851492A patent/GR851492B/el unknown
- 1985-06-20 US US06/746,793 patent/US4791101A/en not_active Expired - Fee Related
- 1985-06-20 EP EP85107618A patent/EP0170843B1/de not_active Expired - Lifetime
- 1985-06-20 DE DE8585107618T patent/DE3586833D1/de not_active Expired - Fee Related
- 1985-06-20 PH PH32429A patent/PH24406A/en unknown
- 1985-06-20 AT AT85107618T patent/ATE82508T1/de not_active IP Right Cessation
- 1985-06-21 DK DK282585A patent/DK282585A/da not_active Application Discontinuation
- 1985-06-21 IE IE154785A patent/IE59289B1/en not_active IP Right Cessation
- 1985-06-21 IL IL75597A patent/IL75597A/xx not_active IP Right Cessation
- 1985-06-21 JP JP60135823A patent/JPS6115842A/ja active Pending
- 1985-06-21 CA CA000484739A patent/CA1258426A/en not_active Expired
- 1985-06-21 DD DD85277633A patent/DD238725A5/de not_active IP Right Cessation
- 1985-06-21 DD DD85295292A patent/DD250053A5/de not_active IP Right Cessation
- 1985-06-21 NZ NZ212513A patent/NZ212513A/xx unknown
- 1985-06-21 ZA ZA854682A patent/ZA854682B/xx unknown
- 1985-06-21 AU AU43931/85A patent/AU593212B2/en not_active Ceased
- 1985-06-21 HU HU852456A patent/HU206270B/hu unknown
- 1985-06-24 AU AU44167/85A patent/AU4416785A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ATE82508T1 (de) | 1992-12-15 |
| IL75597A0 (en) | 1985-10-31 |
| EP0170843B1 (de) | 1992-11-19 |
| IE59289B1 (en) | 1994-02-09 |
| AU4393185A (en) | 1986-01-02 |
| JPS6115842A (ja) | 1986-01-23 |
| HUT37891A (en) | 1986-03-28 |
| US4791101A (en) | 1988-12-13 |
| DD250053A5 (de) | 1987-09-30 |
| DK282585A (da) | 1985-12-24 |
| DD238725A5 (de) | 1986-09-03 |
| DE3423234A1 (de) | 1986-02-06 |
| NZ212513A (en) | 1988-08-30 |
| AU593212B2 (en) | 1990-02-08 |
| IL75597A (en) | 1991-11-21 |
| IE851547L (en) | 1985-12-23 |
| ZA854682B (en) | 1987-02-25 |
| HU206270B (en) | 1992-10-28 |
| EP0170843A1 (de) | 1986-02-12 |
| DE3586833D1 (de) | 1992-12-24 |
| AU4416785A (en) | 1986-01-02 |
| PH24406A (en) | 1990-06-13 |
| GR851492B (enExample) | 1985-11-25 |
| DK282585D0 (da) | 1985-06-21 |
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