DE3421789A1 - Arzneimittel aus dem thymus und verfahren zu dessen herstellung - Google Patents
Arzneimittel aus dem thymus und verfahren zu dessen herstellungInfo
- Publication number
- DE3421789A1 DE3421789A1 DE19843421789 DE3421789A DE3421789A1 DE 3421789 A1 DE3421789 A1 DE 3421789A1 DE 19843421789 DE19843421789 DE 19843421789 DE 3421789 A DE3421789 A DE 3421789A DE 3421789 A1 DE3421789 A1 DE 3421789A1
- Authority
- DE
- Germany
- Prior art keywords
- thymus
- polypeptides
- acetic acid
- tissue
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 90
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 39
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 39
- 229920001184 polypeptide Polymers 0.000 claims abstract description 38
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims abstract description 24
- 239000002244 precipitate Substances 0.000 claims abstract description 22
- 238000000605 extraction Methods 0.000 claims abstract description 20
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- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000011592 zinc chloride Substances 0.000 claims abstract description 12
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- 238000000926 separation method Methods 0.000 claims abstract description 5
- 239000003960 organic solvent Substances 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 45
- 229940079593 drug Drugs 0.000 claims description 30
- 210000001519 tissue Anatomy 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 238000002955 isolation Methods 0.000 claims description 5
- 229940126601 medicinal product Drugs 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 abstract description 3
- 239000012467 final product Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 24
- 239000000843 powder Substances 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
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- 239000013543 active substance Substances 0.000 description 10
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08516697A GB2177402A (en) | 1985-07-02 | 1985-07-02 | Thymus-gland preparation and method for producing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3421789A1 true DE3421789A1 (de) | 1985-12-12 |
| DE3421789C2 DE3421789C2 (enrdf_load_stackoverflow) | 1988-10-06 |
Family
ID=10581651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843421789 Granted DE3421789A1 (de) | 1985-07-02 | 1984-06-12 | Arzneimittel aus dem thymus und verfahren zu dessen herstellung |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS60258120A (enrdf_load_stackoverflow) |
| CH (1) | CH659586A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3421789A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2583982B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2177402A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3633651A1 (de) * | 1986-10-03 | 1988-04-14 | Alfred Dr Dick | Verwendung von fraktionen aus thymus- und milzextrakten zur behandlung der psoriasis |
| EP0259564A3 (en) * | 1986-07-10 | 1989-09-27 | ELLEM INDUSTRIA FARMACEUTICA S.p.A. | A thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions |
| US5811399A (en) * | 1988-12-14 | 1998-09-22 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants |
| US6066622A (en) * | 1991-10-28 | 2000-05-23 | Cytran, Inc. | Immunomodulating peptides and methods of use |
| US6100380A (en) * | 1991-10-28 | 2000-08-08 | Cytran, Inc. | Immunomodulating peptides and methods of use |
| US6368788B1 (en) | 1987-12-30 | 2002-04-09 | Cytran, Inc. | Method of treating complications in immunodepressed states resulting from HIV infection |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0365161A (ja) * | 1989-08-01 | 1991-03-20 | Marudai Shokuhin Kk | 機能性食品 |
| RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| RU2107691C1 (ru) | 1995-03-02 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| RU2121480C1 (ru) * | 1996-02-28 | 1998-11-10 | Закрытое акционерное общество Центр "Пептос" | Пептид, обладающий влиянием на регенерацию кроветворной и иммунной систем, и фармацевтическая композиция на его основе |
| RU2149006C1 (ru) * | 1998-06-19 | 2000-05-20 | Внуков Владислав Анатольевич | Способ получения иммуномодуляторов |
| RU2295963C1 (ru) * | 2005-10-18 | 2007-03-27 | Закрытое акционерное общество Научно-производственное предприятие "Тринита" | Способ получения иммуностимулятора |
| RU2320354C2 (ru) * | 2005-12-15 | 2008-03-27 | Общество с ограниченной ответственностью "ЛАЙФЭЛИКСИР" | Способ получения иммуностимулирующих тимусных полипептидов, влияющих на гемопоэз |
| RU2290936C1 (ru) * | 2006-01-31 | 2007-01-10 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Способ получения средства для поддерживающей терапии, обладающего тканеспецифической активностью |
| RU2327475C1 (ru) * | 2006-11-28 | 2008-06-27 | Общество с ограниченной ответственностью Научно-производственное предприятие "ЭргоБио" | Способ получения иммуноактивных полипептидов/пептидов, обладающих иммунокорригирующими свойствами |
| RU2648466C1 (ru) * | 2016-11-01 | 2018-03-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Способ получения биогенного стимулятора для лечения и профилактики заболеваний сельскохозяйственных животных |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3040427A1 (de) * | 1980-10-24 | 1982-05-06 | Vtoroj moskovskij gosudarstvennyj medicinskij institut imeni N.I. Pirogova, Moskva | Das t-system der immunitaet regulierendes praeparat und verfahren zu seiner herstellung |
| WO1984001090A1 (en) * | 1982-09-20 | 1984-03-29 | Endorphin Inc | Immune stimulator |
| EP0080518B1 (de) * | 1981-11-26 | 1986-10-15 | Ollendiek, Heinrich, Dr. med. | Verfahren zur Extraktion der Thymusdrüse |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU934589A1 (ru) * | 1980-06-16 | 1985-06-30 | Военно-Медицинская Ордена Ленина Краснознаменная Академия Им.С.М.Кирова | Способ получени полипептидов |
-
1984
- 1984-05-24 CH CH2550/84A patent/CH659586A5/de not_active IP Right Cessation
- 1984-06-04 JP JP59113234A patent/JPS60258120A/ja active Granted
- 1984-06-12 DE DE19843421789 patent/DE3421789A1/de active Granted
-
1985
- 1985-07-01 FR FR858510002A patent/FR2583982B1/fr not_active Expired
- 1985-07-02 GB GB08516697A patent/GB2177402A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3040427A1 (de) * | 1980-10-24 | 1982-05-06 | Vtoroj moskovskij gosudarstvennyj medicinskij institut imeni N.I. Pirogova, Moskva | Das t-system der immunitaet regulierendes praeparat und verfahren zu seiner herstellung |
| EP0080518B1 (de) * | 1981-11-26 | 1986-10-15 | Ollendiek, Heinrich, Dr. med. | Verfahren zur Extraktion der Thymusdrüse |
| WO1984001090A1 (en) * | 1982-09-20 | 1984-03-29 | Endorphin Inc | Immune stimulator |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0259564A3 (en) * | 1986-07-10 | 1989-09-27 | ELLEM INDUSTRIA FARMACEUTICA S.p.A. | A thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions |
| DE3633651A1 (de) * | 1986-10-03 | 1988-04-14 | Alfred Dr Dick | Verwendung von fraktionen aus thymus- und milzextrakten zur behandlung der psoriasis |
| US6368788B1 (en) | 1987-12-30 | 2002-04-09 | Cytran, Inc. | Method of treating complications in immunodepressed states resulting from HIV infection |
| US6777195B2 (en) | 1987-12-30 | 2004-08-17 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: immunostimulants |
| US5811399A (en) * | 1988-12-14 | 1998-09-22 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants |
| US6066622A (en) * | 1991-10-28 | 2000-05-23 | Cytran, Inc. | Immunomodulating peptides and methods of use |
| US6100380A (en) * | 1991-10-28 | 2000-08-08 | Cytran, Inc. | Immunomodulating peptides and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8516697D0 (en) | 1985-08-07 |
| JPH0247966B2 (enrdf_load_stackoverflow) | 1990-10-23 |
| JPS60258120A (ja) | 1985-12-20 |
| DE3421789C2 (enrdf_load_stackoverflow) | 1988-10-06 |
| CH659586A5 (de) | 1987-02-13 |
| GB2177402A (en) | 1987-01-21 |
| FR2583982B1 (fr) | 1989-02-24 |
| FR2583982A1 (fr) | 1987-01-02 |
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