DE3421735A1 - Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe - Google Patents
Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffeInfo
- Publication number
- DE3421735A1 DE3421735A1 DE19843421735 DE3421735A DE3421735A1 DE 3421735 A1 DE3421735 A1 DE 3421735A1 DE 19843421735 DE19843421735 DE 19843421735 DE 3421735 A DE3421735 A DE 3421735A DE 3421735 A1 DE3421735 A1 DE 3421735A1
- Authority
- DE
- Germany
- Prior art keywords
- hydrolysis
- weight
- parts
- preparation
- propylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 13
- 230000007062 hydrolysis Effects 0.000 title claims abstract description 12
- 239000008177 pharmaceutical agent Substances 0.000 title abstract 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 229960002622 triacetin Drugs 0.000 claims abstract description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 8
- 235000013773 glyceryl triacetate Nutrition 0.000 claims abstract description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 8
- 239000000829 suppository Substances 0.000 claims abstract description 8
- 239000012166 beeswax Substances 0.000 claims abstract description 7
- 239000012188 paraffin wax Substances 0.000 claims abstract description 7
- 239000000654 additive Substances 0.000 claims abstract description 6
- 235000013871 bee wax Nutrition 0.000 claims abstract description 6
- 239000000945 filler Substances 0.000 claims abstract description 5
- IUYIRQQAVVYNBK-UHFFFAOYSA-N propane-1,2-diol;tetradecanoic acid Chemical compound CC(O)CO.CCCCCCCCCCCCCC(O)=O IUYIRQQAVVYNBK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- -1 palmitic acid-1,2 propylene glycol ester Chemical class 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 abstract description 2
- JZGXQKWQIKFIBT-UHFFFAOYSA-N hexadecanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCCCCCCCCCC(O)=O JZGXQKWQIKFIBT-UHFFFAOYSA-N 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 6
- 229960001138 acetylsalicylic acid Drugs 0.000 description 6
- 229940116364 hard fat Drugs 0.000 description 6
- 239000000155 melt Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000010695 polyglycol Substances 0.000 description 3
- 229920000151 polyglycol Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 229940066675 ricinoleate Drugs 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843421735 DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843421735 DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3421735A1 true DE3421735A1 (de) | 1985-12-12 |
| DE3421735C2 DE3421735C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-11-16 |
Family
ID=6238145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843421735 Granted DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3421735A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0271882A1 (en) * | 1986-12-16 | 1988-06-22 | Schering Corporation | Novel vaginal suppository |
| EP0213761A3 (en) * | 1985-08-13 | 1988-10-05 | Pharmacontrol Corp. | Stable sodium aspirin tablet compositions |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2551446B2 (de) * | 1975-11-15 | 1977-09-15 | Karl Werner Schlüter GmbH, 2000 Ham burg | Verfahren zur herstellung von suppositorien |
| DE2802273A1 (de) * | 1977-01-21 | 1978-07-27 | Meiji Seika Kaisha | Verfahren zur herstellung von suppositorien aus aminoglycosid-antibiotica |
| DE2439538B2 (de) * | 1974-08-17 | 1979-10-31 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe |
-
1984
- 1984-06-12 DE DE19843421735 patent/DE3421735A1/de active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2439538B2 (de) * | 1974-08-17 | 1979-10-31 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe |
| DE2551446B2 (de) * | 1975-11-15 | 1977-09-15 | Karl Werner Schlüter GmbH, 2000 Ham burg | Verfahren zur herstellung von suppositorien |
| DE2802273A1 (de) * | 1977-01-21 | 1978-07-27 | Meiji Seika Kaisha | Verfahren zur herstellung von suppositorien aus aminoglycosid-antibiotica |
Non-Patent Citations (2)
| Title |
|---|
| DE-Z: chemie-Ingenieur-Technik, 55, 1983, Nr.6, S.476-478 * |
| Lexikon der Hilfsstoffe für Pharmazie, Kolsmetik und angrenzende Gebiete, H.P.FIEDLER, Aulendorf, 1981, S. 884 li Sp. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0213761A3 (en) * | 1985-08-13 | 1988-10-05 | Pharmacontrol Corp. | Stable sodium aspirin tablet compositions |
| EP0271882A1 (en) * | 1986-12-16 | 1988-06-22 | Schering Corporation | Novel vaginal suppository |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3421735C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8125 | Change of the main classification |
Ipc: A61K 31/60 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |