DE69525620T2 - Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung - Google Patents

Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung

Info

Publication number
DE69525620T2
DE69525620T2 DE69525620T DE69525620T DE69525620T2 DE 69525620 T2 DE69525620 T2 DE 69525620T2 DE 69525620 T DE69525620 T DE 69525620T DE 69525620 T DE69525620 T DE 69525620T DE 69525620 T2 DE69525620 T2 DE 69525620T2
Authority
DE
Germany
Prior art keywords
sucralfate
preparation
particles
sucral
fate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69525620T
Other languages
English (en)
Other versions
DE69525620D1 (de
Inventor
Katsuya Matsuda
Koichi Ozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69525620D1 publication Critical patent/DE69525620D1/de
Publication of DE69525620T2 publication Critical patent/DE69525620T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
DE69525620T 1994-04-26 1995-04-18 Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung Expired - Lifetime DE69525620T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8885594 1994-04-26
JP18952094 1994-08-11
PCT/JP1995/000753 WO1995028938A1 (fr) 1994-04-26 1995-04-18 Preparation de sucralfate granulee et fondue et son procede de production

Publications (2)

Publication Number Publication Date
DE69525620D1 DE69525620D1 (de) 2002-04-04
DE69525620T2 true DE69525620T2 (de) 2002-10-17

Family

ID=26430198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69525620T Expired - Lifetime DE69525620T2 (de) 1994-04-26 1995-04-18 Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung

Country Status (12)

Country Link
US (1) US5718923A (de)
EP (2) EP1110540A1 (de)
KR (1) KR100264547B1 (de)
CN (1) CN1081921C (de)
AT (1) ATE213635T1 (de)
AU (1) AU693545B2 (de)
BR (1) BR9507533A (de)
CA (1) CA2188785C (de)
DE (1) DE69525620T2 (de)
ES (1) ES2173183T3 (de)
TW (1) TW350773B (de)
WO (1) WO1995028938A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0833934T2 (sl) 1995-06-15 2013-04-30 Crucell Holland B.V. Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji
EP1128817A1 (de) * 1998-10-27 2001-09-05 Biovail Technologies Ltd Mikropartikel enthaltend peg und/oder peg glycerylestern
FR2838647B1 (fr) * 2002-04-23 2006-02-17 Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant
WO2014151565A1 (en) 2013-03-15 2014-09-25 The Brigham And Women's Hospital, Inc. Compounds to modulate intestinal absorption of nutrients
KR101583452B1 (ko) * 2015-01-30 2016-01-11 주식회사 대웅제약 위장질환 치료용 의약 조성물
US10973846B2 (en) 2015-09-24 2021-04-13 The Brigham And Women's Hospital, Inc. Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
KR101837104B1 (ko) * 2017-04-14 2018-03-09 한국프라임제약주식회사 수크랄페이트 합성 방법 및 이에 의한 수크랄페이트

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714159C2 (de) * 1986-04-30 1996-09-19 Chugai Pharmaceutical Co Ltd Sucralfat-Zubereitung
IT1203901B (it) * 1987-04-15 1989-02-23 Lisapharma Spa Composizioni farmaceutiche sotto forma di sospensioni stabili di sucralfato esenti da agenti sospendenti
US4940465A (en) * 1987-05-27 1990-07-10 Felix Theeuwes Dispenser comprising displaceable matrix with solid state properties
US5196405A (en) * 1987-07-08 1993-03-23 Norman H. Oskman Compositions and methods of treating hemorrhoids and wounds
DK505488D0 (da) * 1987-12-21 1988-09-09 Bar Shalom Daniel Middel og anvendelse af samme
DE4022944A1 (de) * 1990-07-19 1992-01-23 Merck Patent Gmbh Sucralfat-kautablette
CA2090479C (en) * 1990-08-31 2002-01-15 Kiyoshige Ochi Stock solution of sucralfate suspended in water and production thereof
JPH0539223A (ja) * 1990-11-26 1993-02-19 Chugai Pharmaceut Co Ltd スクラルフエート水性懸濁原液の工業的製造方法
US5417682A (en) * 1991-01-30 1995-05-23 Alza Corporation Device for administering active agent to biological environment
US5422108A (en) * 1991-09-19 1995-06-06 Smart Plants International Inc. Protection of plants against plant pathogens
JPH05238938A (ja) * 1992-02-28 1993-09-17 Teikoku Seiyaku Co Ltd スクラルファート懸濁液剤およびスクラルファートの投与方法

Also Published As

Publication number Publication date
AU693545B2 (en) 1998-07-02
CA2188785C (en) 2004-05-11
TW350773B (en) 1999-01-21
WO1995028938A1 (fr) 1995-11-02
AU2224695A (en) 1995-11-16
ES2173183T3 (es) 2002-10-16
BR9507533A (pt) 1997-09-02
CN1081921C (zh) 2002-04-03
ATE213635T1 (de) 2002-03-15
MX9604994A (es) 1998-05-31
CA2188785A1 (en) 1995-11-02
KR100264547B1 (ko) 2000-12-01
EP0759300A4 (de) 1997-07-16
EP1110540A1 (de) 2001-06-27
CN1147203A (zh) 1997-04-09
EP0759300B1 (de) 2002-02-27
KR970702053A (ko) 1997-05-13
DE69525620D1 (de) 2002-04-04
EP0759300A1 (de) 1997-02-26
US5718923A (en) 1998-02-17

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