ATE213635T1 - Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung - Google Patents
Verfahren für die herstellung schmelz-granulierte sucralfatzubereitungInfo
- Publication number
- ATE213635T1 ATE213635T1 AT95915338T AT95915338T ATE213635T1 AT E213635 T1 ATE213635 T1 AT E213635T1 AT 95915338 T AT95915338 T AT 95915338T AT 95915338 T AT95915338 T AT 95915338T AT E213635 T1 ATE213635 T1 AT E213635T1
- Authority
- AT
- Austria
- Prior art keywords
- sucralfate
- preparation
- particles
- melt
- melting point
- Prior art date
Links
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 title abstract 8
- 229960004291 sucralfate Drugs 0.000 title abstract 8
- 238000002360 preparation method Methods 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- 238000002844 melting Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8885594 | 1994-04-26 | ||
| JP18952094 | 1994-08-11 | ||
| PCT/JP1995/000753 WO1995028938A1 (en) | 1994-04-26 | 1995-04-18 | Molten granulated sucralfate preparation and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE213635T1 true ATE213635T1 (de) | 2002-03-15 |
Family
ID=26430198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95915338T ATE213635T1 (de) | 1994-04-26 | 1995-04-18 | Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5718923A (de) |
| EP (2) | EP1110540A1 (de) |
| KR (1) | KR100264547B1 (de) |
| CN (1) | CN1081921C (de) |
| AT (1) | ATE213635T1 (de) |
| AU (1) | AU693545B2 (de) |
| BR (1) | BR9507533A (de) |
| CA (1) | CA2188785C (de) |
| DE (1) | DE69525620T2 (de) |
| ES (1) | ES2173183T3 (de) |
| TW (1) | TW350773B (de) |
| WO (1) | WO1995028938A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000326A1 (en) | 1995-06-15 | 1997-01-03 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| AU1323400A (en) * | 1998-10-27 | 2000-05-15 | Fuisz Technologies Ltd. | Microparticles containing peg and/or peg glyceryl esters |
| FR2838647B1 (fr) * | 2002-04-23 | 2006-02-17 | Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant | |
| WO2014151565A1 (en) | 2013-03-15 | 2014-09-25 | The Brigham And Women's Hospital, Inc. | Compounds to modulate intestinal absorption of nutrients |
| KR101583452B1 (ko) * | 2015-01-30 | 2016-01-11 | 주식회사 대웅제약 | 위장질환 치료용 의약 조성물 |
| EP3352738B1 (de) | 2015-09-24 | 2024-01-17 | The Brigham and Women's Hospital, Inc. | Wasseraktivierte mukoadhäsive zusammensetzungen zur verringerung der intestinalen absorption von nährstoffen |
| KR101837104B1 (ko) * | 2017-04-14 | 2018-03-09 | 한국프라임제약주식회사 | 수크랄페이트 합성 방법 및 이에 의한 수크랄페이트 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO174085C (no) * | 1986-04-30 | 1994-03-16 | Chugai Pharmaceutical Co Ltd | Fremgangsmåte for fremstilling av sukralfatpreparater |
| IT1203901B (it) * | 1987-04-15 | 1989-02-23 | Lisapharma Spa | Composizioni farmaceutiche sotto forma di sospensioni stabili di sucralfato esenti da agenti sospendenti |
| US4940465A (en) * | 1987-05-27 | 1990-07-10 | Felix Theeuwes | Dispenser comprising displaceable matrix with solid state properties |
| US5196405A (en) * | 1987-07-08 | 1993-03-23 | Norman H. Oskman | Compositions and methods of treating hemorrhoids and wounds |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| DE4022944A1 (de) * | 1990-07-19 | 1992-01-23 | Merck Patent Gmbh | Sucralfat-kautablette |
| AU658576B2 (en) * | 1990-08-31 | 1995-04-27 | Chugai Seiyaku Kabushiki Kaisha | Stock solution of sucralfate suspended in water and production thereof |
| JPH0539223A (ja) * | 1990-11-26 | 1993-02-19 | Chugai Pharmaceut Co Ltd | スクラルフエート水性懸濁原液の工業的製造方法 |
| US5417682A (en) * | 1991-01-30 | 1995-05-23 | Alza Corporation | Device for administering active agent to biological environment |
| US5422108A (en) * | 1991-09-19 | 1995-06-06 | Smart Plants International Inc. | Protection of plants against plant pathogens |
| JPH05238938A (ja) * | 1992-02-28 | 1993-09-17 | Teikoku Seiyaku Co Ltd | スクラルファート懸濁液剤およびスクラルファートの投与方法 |
-
1995
- 1995-04-18 BR BR9507533A patent/BR9507533A/pt not_active Application Discontinuation
- 1995-04-18 EP EP01105293A patent/EP1110540A1/de not_active Withdrawn
- 1995-04-18 EP EP95915338A patent/EP0759300B1/de not_active Expired - Lifetime
- 1995-04-18 US US08/727,643 patent/US5718923A/en not_active Expired - Lifetime
- 1995-04-18 WO PCT/JP1995/000753 patent/WO1995028938A1/ja not_active Ceased
- 1995-04-18 KR KR1019960705975A patent/KR100264547B1/ko not_active Expired - Fee Related
- 1995-04-18 DE DE69525620T patent/DE69525620T2/de not_active Expired - Lifetime
- 1995-04-18 AU AU22246/95A patent/AU693545B2/en not_active Ceased
- 1995-04-18 AT AT95915338T patent/ATE213635T1/de not_active IP Right Cessation
- 1995-04-18 CA CA002188785A patent/CA2188785C/en not_active Expired - Fee Related
- 1995-04-18 CN CN95192805A patent/CN1081921C/zh not_active Expired - Fee Related
- 1995-04-18 ES ES95915338T patent/ES2173183T3/es not_active Expired - Lifetime
- 1995-04-21 TW TW084103954A patent/TW350773B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69525620D1 (de) | 2002-04-04 |
| AU693545B2 (en) | 1998-07-02 |
| CN1147203A (zh) | 1997-04-09 |
| WO1995028938A1 (en) | 1995-11-02 |
| TW350773B (en) | 1999-01-21 |
| DE69525620T2 (de) | 2002-10-17 |
| EP0759300A1 (de) | 1997-02-26 |
| MX9604994A (es) | 1998-05-31 |
| AU2224695A (en) | 1995-11-16 |
| EP0759300B1 (de) | 2002-02-27 |
| CN1081921C (zh) | 2002-04-03 |
| US5718923A (en) | 1998-02-17 |
| ES2173183T3 (es) | 2002-10-16 |
| CA2188785C (en) | 2004-05-11 |
| KR100264547B1 (ko) | 2000-12-01 |
| KR970702053A (ko) | 1997-05-13 |
| EP0759300A4 (de) | 1997-07-16 |
| CA2188785A1 (en) | 1995-11-02 |
| EP1110540A1 (de) | 2001-06-27 |
| BR9507533A (pt) | 1997-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |