DE3409612A1 - Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung - Google Patents

Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung

Info

Publication number
DE3409612A1
DE3409612A1 DE19843409612 DE3409612A DE3409612A1 DE 3409612 A1 DE3409612 A1 DE 3409612A1 DE 19843409612 DE19843409612 DE 19843409612 DE 3409612 A DE3409612 A DE 3409612A DE 3409612 A1 DE3409612 A1 DE 3409612A1
Authority
DE
Germany
Prior art keywords
group
atom
carbon atoms
hydrogen atom
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843409612
Other languages
German (de)
English (en)
Inventor
Wolfgang Dipl.-Chem. Dr. 6531 Waldalgesheim Abele
Franz Dipl.-Chem. Dr. Esser
Wolfram Dr. 6507 Ingelheim Gaida
Wolfgang Dr. 6200 Wiesbaden Hoefke
Herbert Dipl.-Chem. Dr. Köppe
Richard Dr. 6535 Gau-Algesheim Reichl
Ilse Dr. 6534 Stromberg Streller
Werner Dr. 6531 Münster-Sarmsheim Traunecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Priority to DE19843409612 priority Critical patent/DE3409612A1/de
Priority to EP85102518A priority patent/EP0157206A3/de
Priority to KR1019850001630A priority patent/KR850006397A/ko
Priority to FI851022A priority patent/FI851022A7/fi
Priority to GR850658A priority patent/GR850658B/el
Priority to DD85274121A priority patent/DD234421A5/de
Priority to CS851778A priority patent/CS247196B2/cs
Priority to PL25237585A priority patent/PL252375A1/xx
Priority to ZA851948A priority patent/ZA851948B/xx
Priority to HU85975A priority patent/HUT37419A/hu
Priority to NO851029A priority patent/NO851029L/no
Priority to ES541295A priority patent/ES8606324A1/es
Priority to DK120185A priority patent/DK120185A/da
Priority to IL74616A priority patent/IL74616A0/xx
Priority to PT80115A priority patent/PT80115B/pt
Priority to JP60050718A priority patent/JPS60209581A/ja
Priority to AU40017/85A priority patent/AU4001785A/en
Priority to PH31999A priority patent/PH20880A/en
Publication of DE3409612A1 publication Critical patent/DE3409612A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19843409612 1984-03-16 1984-03-16 Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung Withdrawn DE3409612A1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE19843409612 DE3409612A1 (de) 1984-03-16 1984-03-16 Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
EP85102518A EP0157206A3 (de) 1984-03-16 1985-03-06 Neue substituierte Isochromane und Oxepine, deren Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
KR1019850001630A KR850006397A (ko) 1984-03-16 1985-03-14 치환된 이소크로만 및 옥세핀의 제조방법
FI851022A FI851022A7 (fi) 1984-03-16 1985-03-14 Uudet substituoidut isokromaanit ja oksepiinit, niiden happoadditiosuolat, niitä sisältävät lääkeaineet janiiden valmistusmenetelmät.
GR850658A GR850658B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-03-16 1985-03-14
DD85274121A DD234421A5 (de) 1984-03-16 1985-03-14 Verfahren zur herstellung von substituierten isochromanen und oxepinen
CS851778A CS247196B2 (en) 1984-03-16 1985-03-14 Method of new substituted isochromates and oxopines production
PL25237585A PL252375A1 (en) 1984-03-16 1985-03-14 Method of obtaining novel substituted isochomates and oxepins and their addition salts with acids
ZA851948A ZA851948B (en) 1984-03-16 1985-03-15 New substituted isochromanes and oxpines,the acid addition salts thereof,pharmaceutical compositions containing them and processes for preparing them
HU85975A HUT37419A (en) 1984-03-16 1985-03-15 Process for producing new, substituted isochromanes,oxepines and their acid additional salts
NO851029A NO851029L (no) 1984-03-16 1985-03-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive isokroman- og oksepinderivater
ES541295A ES8606324A1 (es) 1984-03-16 1985-03-15 Procedimiento para preparar isocromanos y oxepinas, susti- tuidos
DK120185A DK120185A (da) 1984-03-16 1985-03-15 Substituerede isochroman- og oxepinforbindelser, deres syreadditionssalte, laegemidler indeholdende disse forbindelser og fremgangsmaader til deres fremstilling
IL74616A IL74616A0 (en) 1984-03-16 1985-03-15 Substituted isochromanes and benzoxepines,and acid addition salts thereof,their preparation and pharmaceutical compositions containing them
PT80115A PT80115B (de) 1984-03-16 1985-03-15 Neue substituierte isochromane and oxepine deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JP60050718A JPS60209581A (ja) 1984-03-16 1985-03-15 新規置換イソクロマンおよびオキセピン化合物
AU40017/85A AU4001785A (en) 1984-03-16 1985-03-15 Substituted isochromanes and oxepines
PH31999A PH20880A (en) 1984-03-16 1985-03-18 Substituted benzoxepines and isochromanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843409612 DE3409612A1 (de) 1984-03-16 1984-03-16 Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DE3409612A1 true DE3409612A1 (de) 1985-09-19

Family

ID=6230653

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843409612 Withdrawn DE3409612A1 (de) 1984-03-16 1984-03-16 Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung

Country Status (18)

Country Link
EP (1) EP0157206A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS60209581A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR850006397A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU4001785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS247196B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD234421A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3409612A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK120185A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8606324A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI851022A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR850658B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT37419A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL74616A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO851029L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH20880A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL252375A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT80115B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA851948B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128369A (en) * 1989-06-23 1992-07-07 Kyowa Hakko Kogyo Co., Ltd. Arylalkylamine derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
EP0450689A1 (en) * 1990-04-02 1991-10-09 Akzo Nobel N.V. New isochromane derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128369A (en) * 1989-06-23 1992-07-07 Kyowa Hakko Kogyo Co., Ltd. Arylalkylamine derivatives

Also Published As

Publication number Publication date
HUT37419A (en) 1985-12-28
ZA851948B (en) 1986-11-26
PH20880A (en) 1987-05-27
PT80115B (de) 1987-03-24
DK120185D0 (da) 1985-03-15
ES541295A0 (es) 1986-04-01
IL74616A0 (en) 1985-06-30
JPS60209581A (ja) 1985-10-22
DD234421A5 (de) 1986-04-02
KR850006397A (ko) 1985-10-05
FI851022A0 (fi) 1985-03-14
FI851022L (fi) 1985-09-17
PL252375A1 (en) 1985-10-22
DK120185A (da) 1985-09-17
EP0157206A2 (de) 1985-10-09
CS247196B2 (en) 1986-12-18
PT80115A (de) 1985-04-01
AU4001785A (en) 1985-09-19
EP0157206A3 (de) 1986-06-11
FI851022A7 (fi) 1985-09-17
NO851029L (no) 1985-09-17
ES8606324A1 (es) 1986-04-01
GR850658B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-07-11

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