DE3327709A1 - Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung - Google Patents

Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung

Info

Publication number
DE3327709A1
DE3327709A1 DE19833327709 DE3327709A DE3327709A1 DE 3327709 A1 DE3327709 A1 DE 3327709A1 DE 19833327709 DE19833327709 DE 19833327709 DE 3327709 A DE3327709 A DE 3327709A DE 3327709 A1 DE3327709 A1 DE 3327709A1
Authority
DE
Germany
Prior art keywords
insulin
formula
arg
crystallization
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19833327709
Other languages
German (de)
English (en)
Inventor
Ulrich Dr. 6238 Hofheim Grau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19833327709 priority Critical patent/DE3327709A1/de
Priority to HU842841A priority patent/HU201096B/hu
Priority to DE8484108769T priority patent/DE3469535D1/de
Priority to AT84108769T priority patent/ATE32729T1/de
Priority to EP84108769A priority patent/EP0133285B1/de
Priority to IL72512A priority patent/IL72512A/xx
Priority to PT78980A priority patent/PT78980A/pt
Priority to FI842981A priority patent/FI80277C/fi
Priority to US06/635,257 priority patent/US4959351A/en
Priority to ES534684A priority patent/ES8601109A1/es
Priority to NO843048A priority patent/NO167207C/no
Priority to DK368884A priority patent/DK172241B1/da
Priority to GR75437A priority patent/GR82438B/el
Priority to IE1947/84A priority patent/IE57711B1/en
Priority to AU31272/84A priority patent/AU567360B2/en
Priority to NZ209041A priority patent/NZ209041A/xx
Priority to PH31042A priority patent/PH22649A/en
Priority to JP59155695A priority patent/JPH0764876B2/ja
Priority to ZA845819A priority patent/ZA845819B/xx
Priority to CA000459844A priority patent/CA1246549A/en
Priority to KR1019840004496A priority patent/KR910009344B1/ko
Publication of DE3327709A1 publication Critical patent/DE3327709A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/622—Insulins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE19833327709 1983-07-29 1983-07-29 Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung Withdrawn DE3327709A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19833327709 DE3327709A1 (de) 1983-07-29 1983-07-29 Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
HU842841A HU201096B (en) 1983-07-29 1984-07-23 Crystal suspensions of insulin derivatives, process for their preparation and their use
DE8484108769T DE3469535D1 (en) 1983-07-29 1984-07-25 Crystal suspensions of insulin derivatives, process for their preparation and their use
AT84108769T ATE32729T1 (de) 1983-07-29 1984-07-25 Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung.
EP84108769A EP0133285B1 (de) 1983-07-29 1984-07-25 Insulin-Derivat-Kristallsuspensionen, Verfahren zu deren Herstellung und deren Verwendung
IL72512A IL72512A (en) 1983-07-29 1984-07-26 Crystal suspensions of insulin derivatives,processes for their preparation and pharmaceutical compositions containing them
PT78980A PT78980A (de) 1983-07-29 1984-07-26 Insulin-derivat-kristallsuspensionen verfahren zu deren herstellung und deren verwendung
FI842981A FI80277C (fi) 1983-07-29 1984-07-26 Foerfarande foer framstaellning av en kristallsuspension av insulinderivat.
US06/635,257 US4959351A (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives, processes for their preparation and their use
ES534684A ES8601109A1 (es) 1983-07-29 1984-07-27 Procedimiento para preparar suspensiones de cristales de uno o mas derivados de insulina
NO843048A NO167207C (no) 1983-07-29 1984-07-27 Fremgangsmaate til fremstilling av insulinderivat-krystallsuspensjoner.
DK368884A DK172241B1 (da) 1983-07-29 1984-07-27 Fremgangsmåde til fremstilling af en krystalsuspension af et eller flere insulinderivater samt en sådan krystalsuspension
GR75437A GR82438B (da) 1983-07-29 1984-07-27
IE1947/84A IE57711B1 (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives,processes for their preparation and their use
AU31272/84A AU567360B2 (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives
NZ209041A NZ209041A (en) 1983-07-29 1984-07-27 Crystalline suspensions of insulin derivatives
PH31042A PH22649A (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives and process for their preparation
JP59155695A JPH0764876B2 (ja) 1983-07-29 1984-07-27 インシュリン誘導体結晶懸濁液
ZA845819A ZA845819B (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives,processes for their preparation and their use
CA000459844A CA1246549A (en) 1983-07-29 1984-07-27 Crystal suspensions of insulin derivatives, processes for their preparation and their use
KR1019840004496A KR910009344B1 (ko) 1983-07-29 1984-07-28 인슐린 유도체의 결정 현탁액의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833327709 DE3327709A1 (de) 1983-07-29 1983-07-29 Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
DE3327709A1 true DE3327709A1 (de) 1985-02-07

Family

ID=6205461

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19833327709 Withdrawn DE3327709A1 (de) 1983-07-29 1983-07-29 Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE8484108769T Expired DE3469535D1 (en) 1983-07-29 1984-07-25 Crystal suspensions of insulin derivatives, process for their preparation and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8484108769T Expired DE3469535D1 (en) 1983-07-29 1984-07-25 Crystal suspensions of insulin derivatives, process for their preparation and their use

Country Status (20)

Country Link
US (1) US4959351A (da)
EP (1) EP0133285B1 (da)
JP (1) JPH0764876B2 (da)
KR (1) KR910009344B1 (da)
AT (1) ATE32729T1 (da)
AU (1) AU567360B2 (da)
CA (1) CA1246549A (da)
DE (2) DE3327709A1 (da)
DK (1) DK172241B1 (da)
ES (1) ES8601109A1 (da)
FI (1) FI80277C (da)
GR (1) GR82438B (da)
HU (1) HU201096B (da)
IE (1) IE57711B1 (da)
IL (1) IL72512A (da)
NO (1) NO167207C (da)
NZ (1) NZ209041A (da)
PH (1) PH22649A (da)
PT (1) PT78980A (da)
ZA (1) ZA845819B (da)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
WO1995000550A1 (en) * 1993-06-21 1995-01-05 Novo Nordisk A/S Aspb28 insulin crystals
EP0821006A2 (de) * 1996-07-26 1998-01-28 Hoechst Aktiengesellschaft Insulinderivate mit erhöhter Zinkbindung
US5834422A (en) * 1993-06-21 1998-11-10 Novo Nordisk A/S AspB28 insulin compositions
DE19521753B4 (de) * 1994-06-16 2009-07-23 Eli Lilly And Co., Indianapolis Monomere Insulinanalogonformulierungen

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DE3604868A1 (de) * 1986-02-15 1987-08-20 Behringwerke Ag Insulinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
WO1997005166A1 (en) 1995-07-25 1997-02-13 Novartis Ag Transforming growth factor beta crystals
AU5749198A (en) * 1997-02-07 1998-08-26 Novo Nordisk A/S Crystallisation of proteins
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
EP1039920A4 (en) * 1997-10-24 2003-05-28 Lilly Co Eli INSULIN ANALOGS ACYLATED BY FATTY ACID
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
IL156618A0 (en) 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
HUP0500733A3 (en) * 2001-02-09 2010-01-28 Genentech Inc Crystallization of igf-1
DE10114178A1 (de) * 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
NZ530700A (en) * 2001-06-21 2009-02-28 Altus Pharmaceuticals Inc Spherical protein particles and methods of making and using them
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
PL373543A1 (pl) * 2005-03-10 2006-09-18 Instytut Biotechnologii i Antybiotyków Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
WO2008065138A1 (en) * 2006-11-29 2008-06-05 Novo Nordisk A/S Novel insulin crystal and method for preparing the crystal
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
WO2010043566A2 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem insulin und einem glp-1-agonisten
ES2855146T3 (es) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
US9707176B2 (en) 2009-11-13 2017-07-18 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist and methionine
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
CN102219851B (zh) * 2011-05-09 2012-05-30 甘李药业有限公司 甘精胰岛素结晶的制备方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PT2750699E (pt) 2011-08-29 2015-11-03 Sanofi Aventis Deutschland Acelerómetro pendular
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
AR095986A1 (es) * 2013-04-03 2015-11-25 Sanofi Sa Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
WO2015084694A2 (en) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB729670A (en) * 1951-11-15 1955-05-11 Novo Terapeutisk Labor As Improved process for the production of insulin in crystalline form and crystalline insulin produced thereby
DK78069C (da) * 1952-06-23 1954-09-06 Novo Terapeutisk Labor As Fremgangsmåde til fremstilling af krystallinsk insulin.
US3719655A (en) * 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
WO1995000550A1 (en) * 1993-06-21 1995-01-05 Novo Nordisk A/S Aspb28 insulin crystals
US5834422A (en) * 1993-06-21 1998-11-10 Novo Nordisk A/S AspB28 insulin compositions
US5840680A (en) * 1993-06-21 1998-11-24 Novo Nordisk A/S ASPB28 insulin crystals
DE19521753B4 (de) * 1994-06-16 2009-07-23 Eli Lilly And Co., Indianapolis Monomere Insulinanalogonformulierungen
EP0821006A2 (de) * 1996-07-26 1998-01-28 Hoechst Aktiengesellschaft Insulinderivate mit erhöhter Zinkbindung
EP0821006A3 (de) * 1996-07-26 2001-11-28 Hoechst Aktiengesellschaft Insulinderivate mit erhöhter Zinkbindung

Also Published As

Publication number Publication date
HU201096B (en) 1990-09-28
PT78980A (de) 1984-08-01
CA1246549A (en) 1988-12-13
ZA845819B (en) 1985-03-27
AU567360B2 (en) 1987-11-19
DE3469535D1 (en) 1988-04-07
FI80277C (fi) 1990-05-10
EP0133285A1 (de) 1985-02-20
ES534684A0 (es) 1985-10-16
AU3127284A (en) 1985-01-31
ATE32729T1 (de) 1988-03-15
DK172241B1 (da) 1998-02-02
IE841947L (en) 1985-01-29
NZ209041A (en) 1989-02-24
FI842981A (fi) 1985-01-30
PH22649A (en) 1988-10-28
FI80277B (fi) 1990-01-31
NO167207C (no) 1991-10-16
ES8601109A1 (es) 1985-10-16
IE57711B1 (en) 1993-03-10
JPS6051118A (ja) 1985-03-22
EP0133285B1 (de) 1988-03-02
US4959351A (en) 1990-09-25
DK368884D0 (da) 1984-07-27
KR910009344B1 (ko) 1991-11-12
IL72512A (en) 1989-08-15
HUT35001A (en) 1985-05-28
NO167207B (no) 1991-07-08
DK368884A (da) 1985-01-30
IL72512A0 (en) 1984-11-30
JPH0764876B2 (ja) 1995-07-12
NO843048L (no) 1985-01-30
FI842981A0 (fi) 1984-07-26
KR850000981A (ko) 1985-03-14
GR82438B (da) 1984-12-13

Similar Documents

Publication Publication Date Title
DE3327709A1 (de) Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
EP0132769B1 (de) Pharmazeutisches Mittel zur Behandlung des Diabetes mellitus
EP2229406B1 (de) Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
EP0885961B1 (de) Neue Insulinderivate mit schnellem Wirkungseintritt
EP0368187B1 (de) Neue Insulinderivate, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
DE69631996T2 (de) Verfahren zur Herstellung von acylierten Proteinpuder
EP0763061B1 (de) Verfahren zur herstellung von cardiodilatin-fragmenten, hochgereinigte cardiodilatin-fragmente und zwischenprodukte zu deren herstellung
EP0132770A1 (de) Neue Insulin-Derivate, Verfahren zu deren Herstellung und deren Verwendung sowie pharmazeutische Mittel zur Behandlung des Diabetes mellitus
EP0140084B1 (de) Verfahren zur Herstellung von Insulin-Derivaten, deren B-Kette C-terminal verlängert ist, neue basisch modifizierte Insulin-Derivate, diese enthaltende Mittel und ihre Verwendung
DE102008003566A1 (de) Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DD244345A5 (de) Neue peptide
EP0376156A2 (de) Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
DE69434909T3 (de) Herstellung von humaninsulin
EP0135720B1 (de) Verfahren zur Herstellung von Insulin-Derivaten
DE3936876A1 (de) Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE102008025008A1 (de) Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE69829953T2 (de) Kristallisation von proteinen
EP1735343B1 (de) Verfahren zur gewinnung von insulinen durch verbesserte luftbegasung der faltung
EP0137361B1 (de) In Position B 30 modifizierte Insulin-Derivate, Verfahren zu deren Herstellung und deren Verwendung sowie pharmazeutische Mittel zur Behandlung des Diabetes mellitus
DE102008025007A1 (de) Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE10250297A1 (de) Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee