DE3260282D1 - 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions - Google Patents

2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions

Info

Publication number
DE3260282D1
DE3260282D1 DE8282870006T DE3260282T DE3260282D1 DE 3260282 D1 DE3260282 D1 DE 3260282D1 DE 8282870006 T DE8282870006 T DE 8282870006T DE 3260282 T DE3260282 T DE 3260282T DE 3260282 D1 DE3260282 D1 DE 3260282D1
Authority
DE
Germany
Prior art keywords
diphenylmethyl
piperazinyl
amides
acetic acids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282870006T
Other languages
German (de)
English (en)
Inventor
Eugene Baltes
Jean De Lannoy
Ludovic Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Application granted granted Critical
Publication of DE3260282D1 publication Critical patent/DE3260282D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8282870006T 1981-02-06 1982-02-05 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions Expired DE3260282D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8103768 1981-02-06
GB8110990 1981-04-08

Publications (1)

Publication Number Publication Date
DE3260282D1 true DE3260282D1 (en) 1984-08-02

Family

ID=26278356

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8282870006T Expired DE3260282D1 (en) 1981-02-06 1982-02-05 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions
DE2001199021 Active DE10199021I2 (de) 1981-02-06 1982-02-05 2-(4-Diphenylmethyl)-1-piperazinyl)-essigsaeure und ihre Amide Verfahren zu ihrer Bereitung und pharmazeutische Zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2001199021 Active DE10199021I2 (de) 1981-02-06 1982-02-05 2-(4-Diphenylmethyl)-1-piperazinyl)-essigsaeure und ihre Amide Verfahren zu ihrer Bereitung und pharmazeutische Zusammensetzungen

Country Status (24)

Country Link
US (1) US4525358A (enExample)
EP (1) EP0058146B1 (enExample)
AT (1) ATE8140T1 (enExample)
AU (1) AU544066B2 (enExample)
BA (2) BA97198B1 (enExample)
CA (1) CA1199918A (enExample)
CY (1) CY1307A (enExample)
DE (2) DE3260282D1 (enExample)
DK (2) DK154078C (enExample)
ES (2) ES8307776A1 (enExample)
FI (1) FI75816C (enExample)
GE (1) GEP20001996B (enExample)
GR (1) GR75407B (enExample)
HK (1) HK86485A (enExample)
HU (1) HU184989B (enExample)
LU (1) LU90870I2 (enExample)
MY (1) MY8700279A (enExample)
NL (1) NL300074I2 (enExample)
NO (2) NO155805C (enExample)
NZ (1) NZ199650A (enExample)
PL (2) PL134969B1 (enExample)
PT (1) PT74390B (enExample)
SU (2) SU1227113A3 (enExample)
YU (2) YU43511B (enExample)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202665A (en) * 1981-12-02 1986-04-11 Ferrosan Ab Diphenylbutyl-1-piperazinocarboxylate derivatives and pharmaceutical compositions
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5057524A (en) * 1990-02-08 1991-10-15 A. H. Robins Company Incorporated 4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
DK0661975T3 (da) * 1992-09-24 1999-09-27 Sepracor Inc Transdermal behandling af nældefeber ved anvendelse af optisk rent (+)-cetirizin
JPH08501561A (ja) * 1992-09-24 1996-02-20 セプラコア，インコーポレイテッド （−）セチリジンを用いたアレルギー疾患の治療のための組成物
TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
JP3338913B2 (ja) * 1993-06-29 2002-10-28 大鵬薬品工業株式会社 テトラゾール誘導体
DK0711289T3 (da) * 1993-07-30 2000-11-06 Delta Pharmaceuticals Inc Piperazinforbindelser til anvendelse i terapi
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
CA2180190A1 (en) * 1995-07-10 1997-01-11 Kazumi Ogata Benzylpiperazine derivatives
US6469009B1 (en) * 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
PE107598A1 (es) * 1996-09-11 1999-01-29 Ucb Sa Cetirizina util para el tratamiento de enfermedades de tipo virico
BE1011251A3 (fr) * 1997-07-03 1999-06-01 Ucb Sa Compositions pharmaceutiques administrables par voie orale, comprenant une substance active et une cyclodextrine.
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
ATE283709T1 (de) 1998-03-06 2004-12-15 Biosepra Medical Inc Implantierbare partikel zur erhöhung des gewebevolumens und zur behandlung von gastroösophagalreflux, inkontinenz und hautfalten
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
DE19814256A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Feste, schnellzerfallende Cetirizin-Formulierungen
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
EP1098644A1 (en) 1998-07-20 2001-05-16 Bristol-Myers Squibb Company Substituted benzimidazole antiviral agents
US6432961B1 (en) * 1998-08-18 2002-08-13 Ucb S.A. Method for preventing the onset of asthma
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) * 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6894059B1 (en) 1999-03-26 2005-05-17 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
EP1196408B1 (en) 1999-06-28 2004-09-15 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US6239277B1 (en) * 1999-10-20 2001-05-29 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
SK285641B6 (sk) * 1999-11-30 2007-05-03 Egis Gy�Gyszergy�R Rt. Spôsob prípravy {2-[4-(alfa-fenyl-p-chlórbenzyl)piperazin-1- yl]etoxy}octovej kyseliny a nové medziprodukty
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
CA2454564A1 (en) * 2001-07-26 2003-02-06 Ucb, S.A. Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
JP4454314B2 (ja) 2002-03-27 2010-04-21 サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド ４−（ジアリールメチル）−１−ピペラジニル誘導体
ATE388693T1 (de) 2002-04-04 2008-03-15 Pfizer Prod Inc Wohlschmeckende kautablette
AU2003237394A1 (en) * 2002-06-05 2003-12-22 Dr. Reddy's Laboratories Limited Crystalline (2-(4-((4-chlorophenyl)-phenyl methyl)-1-piperazinyl) ethoxy) acetic acid dihydrochloride
CN1692105A (zh) * 2002-12-04 2005-11-02 雷迪实验室有限公司 西替利嗪二盐酸盐多晶型物及其制备方法
US20050020608A1 (en) * 2003-03-25 2005-01-27 Dr. Reddy's Laboratories Limited Crystalline cetirizine monohydrochloride
US20060258684A1 (en) * 2003-05-21 2006-11-16 Singh Prasad S 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
KR100503443B1 (ko) * 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
KR100698400B1 (ko) * 2004-04-14 2007-03-23 이은주 탈모증 및 전립선비대증 치료를 위한 약제학적 조성물
JP4592748B2 (ja) * 2004-04-14 2010-12-08 ウンジュ イ 脱毛症及び前立腺肥大症治療のための薬剤学的組成物
PE20060484A1 (es) 2004-07-14 2006-07-06 Ucb Farchim Sa Preparaciones farmaceuticas liquidas que comprenden un compuesto de benzhidril piperizina
US20060127479A1 (en) * 2004-10-08 2006-06-15 Natrajan Kumaraperumal Solvent free taste masked pharmaceutical compositions
WO2006050909A1 (en) * 2004-11-10 2006-05-18 Ucb Farchim Sa Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them
AU2006264407B2 (en) 2005-07-04 2012-08-30 Ramu Krishnan Improved drug or pharmaceutical compounds and a preparation thereof
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
CA2653953C (en) 2006-06-01 2015-12-08 Schering-Plough Healthcare Products, Inc. Phenylephrine pharmaceutical formulations and compositions for colonic absorption
PL2041088T3 (pl) 2006-06-28 2014-07-31 Amgen Inc Inhibitory transportera-1 glicyny
KR100913850B1 (ko) * 2006-12-29 2009-08-26 우석대학교 산학협력단 고소하고 풍부한 버터향을 가지며 트랜스 지방산 함량이 낮은 가공 식용유의 제조방법 및 이 방법에 의해 제조된 가공 식용유
EP2121031B1 (en) 2007-03-12 2013-10-16 Nektar Therapeutics Oligomer-antihistamine conjugates
WO2009057133A2 (en) * 2007-07-24 2009-05-07 Glenmark Generics Limited A process for the synthesis of 2-[2-[4-[(4-chlorophenyl)phenyl methyl]-1-piperazinyl] ethoxy acetic acid
KR20100059836A (ko) * 2007-08-15 2010-06-04 케마지스 리미티드 고순도 레보세티리진 및 이의 염을 제조하기 위한 신규한 방법
US20090062305A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched cetirizine
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
DE602007012725D1 (de) 2007-11-21 2011-04-07 Synthon Bv Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen
CN101951886A (zh) * 2007-12-21 2011-01-19 先灵-普劳健康护理产品公司 增强羟甲唑啉的光稳定性
CN102046612A (zh) * 2008-06-02 2011-05-04 希普拉有限公司 合成左旋西替利嗪的方法和其中所用的中间体
US20110172425A1 (en) * 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
US20100145049A1 (en) * 2008-11-21 2010-06-10 Jie Zhu Process for making n-(diphenylmethyl)piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
US8569273B2 (en) 2009-03-17 2013-10-29 Aciex Therapeutics, Inc. Ophthalmic formulations of cetirizine and methods of use
US9254286B2 (en) 2009-03-17 2016-02-09 Aciex Therapeutics, Inc. Ophthalmic formulations of cetirizine and methods of use
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
US8513259B2 (en) 2009-07-03 2013-08-20 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
WO2011110939A2 (en) 2010-03-11 2011-09-15 Rubicon Research Private Limited Pharmaceutical compositions of substituted benzhydrylpiperazines
WO2011146032A2 (en) 2010-05-18 2011-11-24 Mahmut Bilgic Effervescent formulations
CN101928263A (zh) * 2010-07-06 2010-12-29 四川大学 一种制备盐酸乙氟利嗪的方法
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009398A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Fiziksel özellikleri geliştirilmiş tablet formülasyonları
TW201318624A (zh) 2011-09-29 2013-05-16 Shionogi & Co 包含ｐｇｄ２拮抗劑及組織胺拮抗劑之過敏性鼻炎治療用醫藥
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN103508879B (zh) * 2013-09-22 2015-10-21 江苏德峰药业有限公司 一种卤代烷氧基乙酸的合成方法
CN106029060A (zh) * 2013-11-27 2016-10-12 美国卫生和人力服务部 哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途
CN105793265B (zh) 2013-12-10 2018-02-13 山东丹红制药有限公司 作为抗病毒剂的咪唑衍生物及其制药用途
EP3305790B1 (en) 2015-06-08 2020-08-05 Shangdong Danhong Pharmaceutical Co., Ltd. Method for preparing imidazole derivative and intermediate thereof and crystal form
HK1258050A1 (zh) 2015-10-23 2019-11-01 Lyndra Therapeutics, Inc. 用於治疗剂缓释的胃驻留系统及其使用方法
WO2017100367A1 (en) 2015-12-08 2017-06-15 Lyndra, Inc. Geometric configurations for gastric residence systems
BR112018072511A2 (pt) * 2016-05-09 2019-03-12 Biogaia Ab métodos para selecionar uma cepa bacteriana e para profilaxia, inibição e/ou tratamento de uma alergia, cepa, e, composição antialérgica
AU2017268840B2 (en) 2016-05-27 2022-02-10 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
WO2018064630A1 (en) 2016-09-30 2018-04-05 Lyndra, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
CA3066658A1 (en) 2017-06-09 2018-12-13 Lyndra, Inc. Gastric residence systems with release rate-modulating films
CN115209874A (zh) 2020-02-03 2022-10-18 强生消费者公司 包含西替利嗪的单层咀嚼片
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CN113861131B (zh) * 2021-11-08 2024-04-19 深圳菲斯生物科技有限公司 一种西替利嗪杂质c的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2899436A (en) * 1959-08-11 chjch
US2630435A (en) * 1948-09-09 1953-03-03 Burroughs Wellcome Co N-benzohydryl-n-methyl piperazines and process of preparing same
US2636032A (en) * 1949-04-12 1953-04-21 Abbott Lab N, n'-disubstituted piperazines and process of preparing same
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
US3244718A (en) * 1964-02-17 1966-04-05 Biel John Hans Piperazine derivatives
NL137318C (enExample) * 1964-06-09
FR2082168A5 (en) * 1970-03-05 1971-12-10 Aries Robert (-1-benzhydryl-4-piperazinyl)-alkoxy-alkyl esters of benzoic - or phenyl-alkanoic acids - analgesic, antipyretic, sympathomimetic,
FR2081579B1 (enExample) * 1970-03-18 1973-04-06 Delalande Sa
BE794804A (fr) * 1972-02-01 1973-05-16 Crc Ricerca Chim Procede de preparation de derives de piperazine, et produits obtenus

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Publication number Publication date
NO2001022I2 (no) 2005-10-10
FI820318L (fi) 1982-08-07
YU42911B (en) 1988-12-31
DK5388A (da) 1988-01-07
US4525358A (en) 1985-06-25
BA97199B1 (bs) 1999-08-02
MY8700279A (en) 1987-12-31
NO155805B (no) 1987-02-23
PL134969B1 (en) 1985-09-30
ES509358A0 (es) 1983-08-01
DE10199021I2 (de) 2002-07-04
NL300074I1 (nl) 2002-02-01
SU1227113A3 (ru) 1986-04-23
NZ199650A (en) 1984-07-06
CA1199918A (en) 1986-01-28
FI75816C (fi) 1988-08-08
PL134903B1 (en) 1985-09-30
NO155805C (no) 1987-06-10
PL234935A1 (en) 1983-05-09
HK86485A (en) 1985-11-15
DE10199021I1 (de) 2001-06-21
DK155796C (da) 1989-10-09
EP0058146A1 (fr) 1982-08-18
DK44082A (da) 1982-08-07
PT74390B (fr) 1983-07-05
YU223584A (en) 1985-06-30
PT74390A (fr) 1982-03-01
SU1287749A3 (ru) 1987-01-30
YU23782A (en) 1985-06-30
GR75407B (enExample) 1984-07-13
YU43511B (en) 1989-08-31
DK5388D0 (da) 1988-01-07
EP0058146B1 (fr) 1984-06-27
ES8307776A1 (es) 1983-08-01
GEP20001996B (en) 2000-02-10
NL300074I2 (nl) 2002-03-01
FI75816B (fi) 1988-04-29
DK155796B (da) 1989-05-16
BA97198B1 (bs) 1999-08-02
ES521548A0 (es) 1984-08-01
CY1307A (en) 1985-12-06
LU90870I2 (en) 2002-03-01
AU8023182A (en) 1982-08-12
PL239687A1 (en) 1983-07-18
ES8406455A1 (es) 1984-08-01
DK154078B (da) 1988-10-10
HU184989B (en) 1987-06-30
AU544066B2 (en) 1985-05-16
NO820297L (no) 1982-08-09
DK154078C (da) 1989-05-22
ATE8140T1 (de) 1984-07-15

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