DE3227178C2 - 2'-Modifizierte Kanamycine, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel - Google Patents

2'-Modifizierte Kanamycine, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel

Info

Publication number
DE3227178C2
DE3227178C2 DE3227178A DE3227178A DE3227178C2 DE 3227178 C2 DE3227178 C2 DE 3227178C2 DE 3227178 A DE3227178 A DE 3227178A DE 3227178 A DE3227178 A DE 3227178A DE 3227178 C2 DE3227178 C2 DE 3227178C2
Authority
DE
Germany
Prior art keywords
nhr
kanamycin
formula
protected
tetra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3227178A
Other languages
German (de)
English (en)
Other versions
DE3227178A1 (de
Inventor
Shunzo Tokyo Fukatsu
Yoshiharu Chofu Tokyo Ishido
Hamao Umezawa
Sumio Tokyo Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of DE3227178A1 publication Critical patent/DE3227178A1/de
Application granted granted Critical
Publication of DE3227178C2 publication Critical patent/DE3227178C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3227178A 1981-07-22 1982-07-21 2'-Modifizierte Kanamycine, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel Expired DE3227178C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56113578A JPS5815994A (ja) 1981-07-22 1981-07-22 ２′位修飾カナマイシン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
DE3227178A1 DE3227178A1 (de) 1983-02-24
DE3227178C2 true DE3227178C2 (de) 1984-06-20

Family

ID=14615779

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3227178A Expired DE3227178C2 (de) 1981-07-22 1982-07-21 2'-Modifizierte Kanamycine, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel

Country Status (6)

Country Link
US (1) US4455419A (en, 2012)
JP (1) JPS5815994A (en, 2012)
DE (1) DE3227178C2 (en, 2012)
FR (1) FR2510574B1 (en, 2012)
GB (1) GB2104514B (en, 2012)
IT (2) IT1192483B (en, 2012)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
GB0411948D0 (en) * 2004-05-28 2004-06-30 Univ Leeds Compounds
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CA2654561A1 (en) * 2006-06-02 2007-12-13 Meiji Seika Kaisha, Ltd. Novel aminoglycoside antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868360A (en) * 1972-10-24 1975-02-25 Schering Corp Process for preparing 2-deroxy-3-desamino-2,3-epimino-aminoglycosides and intermediates useful therein
JPS5850235B2 (ja) * 1974-12-11 1983-11-09 明治製菓株式会社 ３′，４′−α−エポキシ−リボスタマイシン又は−カナマイシンＢの製造法
US4171356A (en) * 1976-10-28 1979-10-16 Schering Corporation 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor
JPS5663993A (en) * 1979-10-30 1981-05-30 Microbial Chem Res Found Novel preparation of tobramycin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
FR2510574A1 (fr) 1983-02-04
IT8209478A0 (it) 1982-07-22
FR2510574B1 (fr) 1985-06-28
IT1192483B (it) 1988-04-13
DE3227178A1 (de) 1983-02-24
JPS5815994A (ja) 1983-01-29
GB2104514B (en) 1985-04-11
US4455419A (en) 1984-06-19
IT8209478A1 (it) 1984-01-22
JPH0134231B2 (en, 2012) 1989-07-18
GB2104514A (en) 1983-03-09

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