DE3209127A1 - Verfahren und system zur herstellung von durch lebende zellen erzeugten substanzen - Google Patents
Verfahren und system zur herstellung von durch lebende zellen erzeugten substanzenInfo
- Publication number
- DE3209127A1 DE3209127A1 DE19823209127 DE3209127A DE3209127A1 DE 3209127 A1 DE3209127 A1 DE 3209127A1 DE 19823209127 DE19823209127 DE 19823209127 DE 3209127 A DE3209127 A DE 3209127A DE 3209127 A1 DE3209127 A1 DE 3209127A1
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- 230000035931 haemagglutination Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24358381A | 1981-03-13 | 1981-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3209127A1 true DE3209127A1 (de) | 1982-12-09 |
| DE3209127C2 DE3209127C2 (enrdf_load_stackoverflow) | 1988-02-04 |
Family
ID=22919321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19823209127 Granted DE3209127A1 (de) | 1981-03-13 | 1982-03-12 | Verfahren und system zur herstellung von durch lebende zellen erzeugten substanzen |
Country Status (11)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0246469A1 (de) * | 1986-05-03 | 1987-11-25 | Hoechst Aktiengesellschaft | Verfahren zur Verkapselung von biologisch aktivem Material |
| DE3590071C2 (de) * | 1984-02-23 | 1988-05-05 | Snow Brand Milk Products Co Ltd | Verfahren zur Herstellung von Kapseln |
| DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
| US4582799A (en) * | 1983-04-15 | 1986-04-15 | Damon Biotech, Inc. | Process for recovering nonsecreted substances produced by cells |
| CA1196862A (en) * | 1983-06-01 | 1985-11-19 | Anthony M.F. Sun | Microencapsulation of living tissue and cells |
| JPS6025929A (ja) * | 1983-07-20 | 1985-02-08 | ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン | カプセル化細胞、その製造方法および用途 |
| JPS60141281A (ja) * | 1983-12-28 | 1985-07-26 | Meiji Milk Prod Co Ltd | 菌体顆粒の製造方法及び装置 |
| DE3575375D1 (de) * | 1984-02-15 | 1990-02-22 | Massachusetts Inst Technology | Verfahren zur verkapselung und systeme mit verkapseltem aktivmaterial. |
| US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| GR851626B (enrdf_load_stackoverflow) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| CA1241598A (en) * | 1984-07-11 | 1988-09-06 | Connaught Laboratories Limited | Droplet generation |
| EP0199362A3 (en) * | 1985-04-26 | 1987-10-07 | Massachusetts Institute Of Technology | System and apparatus for delayed and pulsed release of biologically active substances |
| CA1265443A (en) * | 1985-09-18 | 1990-02-06 | Elieser Gorelik | Assays for chemotherapeutic agents |
| DE3534983A1 (de) * | 1985-10-01 | 1987-04-02 | Sturge John & E Ltd | Komplexe immobilisierte biokatalysatoren sowie ihre herstellung und anwendung |
| JPS62166891A (ja) * | 1986-01-20 | 1987-07-23 | Snow Brand Milk Prod Co Ltd | 細胞培養による有用物質の製造方法 |
| EP0259365A1 (en) * | 1986-01-23 | 1988-03-16 | Ltl Associates | Covalent membranes |
| IL79052A0 (en) * | 1986-06-06 | 1986-11-30 | Univ Ramot | Device and process for production of alginate-shell beads containing biologically active material |
| JP2530690Y2 (ja) * | 1986-08-28 | 1997-03-26 | カシオ計算機株式会社 | 電子楽器 |
| US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| EP0604706A1 (en) | 1986-10-22 | 1994-07-06 | GAUTVIK, Kaare M., Dr. | Production of human parathyroid hormone from microorganisms |
| US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
| WO1988008448A2 (en) * | 1987-04-22 | 1988-11-03 | Michael Bay | Cell culture processes, materials and products |
| JPS6414225U (enrdf_load_stackoverflow) * | 1987-07-15 | 1989-01-25 | ||
| JPH025797U (enrdf_load_stackoverflow) * | 1988-06-23 | 1990-01-16 | ||
| WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
| SG47470A1 (en) * | 1991-04-25 | 1998-04-17 | Univ Brown Res Found | Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products |
| US5800829A (en) * | 1991-04-25 | 1998-09-01 | Brown University Research Foundation | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
| DE4229526B4 (de) * | 1992-09-07 | 2006-02-16 | Schrezenmeir, Jürgen, Dr. | Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper |
| US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| EP0802800B1 (en) * | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biocompatible immunoisolatory capsules containing genetically altered cells for the delivery of biologically active molecules |
| US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
| SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| EP2778221B1 (en) * | 2011-02-07 | 2017-07-26 | Life Technologies Corporation | Compositions and methods for stabilizing susceptible compounds |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2645730A1 (de) * | 1975-08-20 | 1978-04-13 | Damon Corp | Verfahren zur verkapselung von chemisch-aktiven substanzen |
| DE3012233A1 (de) * | 1979-03-28 | 1980-11-20 | Damon Corp | Verfahren zum einkapseln von lebensfaehigem gewebe in eine membran |
| DE3209045C2 (de) * | 1981-03-13 | 1986-06-19 | Damon Biotech, Inc., Needham Heights, Mass. | Verfahren zum selektiven Aufbrechen permeabler Membranen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
-
1982
- 1982-03-11 NO NO820794A patent/NO163060C/no unknown
- 1982-03-12 CA CA000398218A patent/CA1172961A/en not_active Expired
- 1982-03-12 JP JP57038238A patent/JPS5816693A/ja active Granted
- 1982-03-12 BE BE0/207559A patent/BE892479A/fr not_active IP Right Cessation
- 1982-03-12 SE SE8201554A patent/SE454780B/sv not_active IP Right Cessation
- 1982-03-12 DK DK112282A patent/DK112282A/da not_active Application Discontinuation
- 1982-03-12 FR FR8204242A patent/FR2503183B1/fr not_active Expired
- 1982-03-12 GB GB8207309A patent/GB2094833B/en not_active Expired
- 1982-03-12 IT IT20140/82A patent/IT1150682B/it active
- 1982-03-12 CH CH1575/82A patent/CH654328A5/de not_active IP Right Cessation
- 1982-03-12 DE DE19823209127 patent/DE3209127A1/de active Granted
-
1985
- 1985-08-22 JP JP60184995A patent/JPS6188893A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2645730A1 (de) * | 1975-08-20 | 1978-04-13 | Damon Corp | Verfahren zur verkapselung von chemisch-aktiven substanzen |
| DE3012233A1 (de) * | 1979-03-28 | 1980-11-20 | Damon Corp | Verfahren zum einkapseln von lebensfaehigem gewebe in eine membran |
| DE3209045C2 (de) * | 1981-03-13 | 1986-06-19 | Damon Biotech, Inc., Needham Heights, Mass. | Verfahren zum selektiven Aufbrechen permeabler Membranen |
Non-Patent Citations (1)
| Title |
|---|
| CHIBATA et al.: Microbial Technology, Vol. II, Herausgeber Peppler H.J. und Perlmann D.S., 433-461, 1979 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3590071C2 (de) * | 1984-02-23 | 1988-05-05 | Snow Brand Milk Products Co Ltd | Verfahren zur Herstellung von Kapseln |
| EP0246469A1 (de) * | 1986-05-03 | 1987-11-25 | Hoechst Aktiengesellschaft | Verfahren zur Verkapselung von biologisch aktivem Material |
| DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5816693A (ja) | 1983-01-31 |
| SE454780B (sv) | 1988-05-30 |
| GB2094833A (en) | 1982-09-22 |
| GB2094833B (en) | 1984-06-20 |
| NO163060C (no) | 1990-03-28 |
| JPS6244919B2 (enrdf_load_stackoverflow) | 1987-09-24 |
| SE8201554L (sv) | 1982-09-14 |
| JPS6157288B2 (enrdf_load_stackoverflow) | 1986-12-06 |
| DE3209127C2 (enrdf_load_stackoverflow) | 1988-02-04 |
| JPS6188893A (ja) | 1986-05-07 |
| DK112282A (da) | 1982-09-14 |
| IT8220140A0 (it) | 1982-03-12 |
| FR2503183B1 (fr) | 1985-11-08 |
| NO820794L (no) | 1982-09-14 |
| CA1172961A (en) | 1984-08-21 |
| CH654328A5 (de) | 1986-02-14 |
| IT1150682B (it) | 1986-12-17 |
| NO163060B (no) | 1989-12-18 |
| BE892479A (fr) | 1982-07-01 |
| FR2503183A1 (fr) | 1982-10-08 |
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Free format text: BEETZ JUN., R., DIPL.-ING. DR.-ING. TIMPE, W., DR.-ING. SIEGFRIED, J., DIPL.-ING. SCHMITT-FUMIAN, W., PROF. DIPL.-CHEM. DR.RER.NAT. MAYR, C., DIPL.-PHYS.DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN |
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