JPS6244919B2 - - Google Patents

Info

Publication number
JPS6244919B2
JPS6244919B2 JP60184995A JP18499585A JPS6244919B2 JP S6244919 B2 JPS6244919 B2 JP S6244919B2 JP 60184995 A JP60184995 A JP 60184995A JP 18499585 A JP18499585 A JP 18499585A JP S6244919 B2 JPS6244919 B2 JP S6244919B2
Authority
JP
Japan
Prior art keywords
cells
culture medium
capsule
membrane
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP60184995A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6188893A (ja
Inventor
Rimu Furankurin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Biotech Inc
Original Assignee
Damon Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc
Publication of JPS6188893A publication Critical patent/JPS6188893A/ja
Publication of JPS6244919B2 publication Critical patent/JPS6244919B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP60184995A 1981-03-13 1985-08-22 細胞により産生される物質の製造方法 Granted JPS6188893A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24358381A 1981-03-13 1981-03-13
US243583 1981-03-13

Publications (2)

Publication Number Publication Date
JPS6188893A JPS6188893A (ja) 1986-05-07
JPS6244919B2 true JPS6244919B2 (enrdf_load_stackoverflow) 1987-09-24

Family

ID=22919321

Family Applications (2)

Application Number Title Priority Date Filing Date
JP57038238A Granted JPS5816693A (ja) 1981-03-13 1982-03-12 細胞により産生される物質の製造方法
JP60184995A Granted JPS6188893A (ja) 1981-03-13 1985-08-22 細胞により産生される物質の製造方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP57038238A Granted JPS5816693A (ja) 1981-03-13 1982-03-12 細胞により産生される物質の製造方法

Country Status (11)

Country Link
JP (2) JPS5816693A (enrdf_load_stackoverflow)
BE (1) BE892479A (enrdf_load_stackoverflow)
CA (1) CA1172961A (enrdf_load_stackoverflow)
CH (1) CH654328A5 (enrdf_load_stackoverflow)
DE (1) DE3209127A1 (enrdf_load_stackoverflow)
DK (1) DK112282A (enrdf_load_stackoverflow)
FR (1) FR2503183B1 (enrdf_load_stackoverflow)
GB (1) GB2094833B (enrdf_load_stackoverflow)
IT (1) IT1150682B (enrdf_load_stackoverflow)
NO (1) NO163060C (enrdf_load_stackoverflow)
SE (1) SE454780B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6414225U (enrdf_load_stackoverflow) * 1987-07-15 1989-01-25

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
JPS6025929A (ja) * 1983-07-20 1985-02-08 ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン カプセル化細胞、その製造方法および用途
JPS60141281A (ja) * 1983-12-28 1985-07-26 Meiji Milk Prod Co Ltd 菌体顆粒の製造方法及び装置
EP0152898B1 (en) * 1984-02-15 1990-01-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system(
JPS60175539A (ja) * 1984-02-23 1985-09-09 Snow Brand Milk Prod Co Ltd カプセル体およびその製造法
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
GR851626B (enrdf_load_stackoverflow) * 1984-07-05 1985-11-26 Genentech Inc
CA1241598A (en) * 1984-07-11 1988-09-06 Connaught Laboratories Limited Droplet generation
EP0199362A3 (en) * 1985-04-26 1987-10-07 Massachusetts Institute Of Technology System and apparatus for delayed and pulsed release of biologically active substances
CA1265443A (en) * 1985-09-18 1990-02-06 Elieser Gorelik Assays for chemotherapeutic agents
DE3534983A1 (de) * 1985-10-01 1987-04-02 Sturge John & E Ltd Komplexe immobilisierte biokatalysatoren sowie ihre herstellung und anwendung
JPS62166891A (ja) * 1986-01-20 1987-07-23 Snow Brand Milk Prod Co Ltd 細胞培養による有用物質の製造方法
AU6940087A (en) * 1986-01-23 1987-08-14 Ltl Associates Covalent membranes
DE3615043A1 (de) * 1986-05-03 1987-11-05 Hoechst Ag Verfahren zur verkapselung von biologisch aktivem material
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
JP2530690Y2 (ja) * 1986-08-28 1997-03-26 カシオ計算機株式会社 電子楽器
US5010010A (en) * 1986-10-22 1991-04-23 Selmer-Sande, A.S. Production of human parathyroid hormone from microorganisms
US5420242A (en) * 1986-10-22 1995-05-30 Kaare M. Gautvik Production of human parathyroid hormone from microorganisms
EP0383751B1 (en) 1986-10-22 1994-03-09 GAUTVIK, Kaare M., Dr. Production of human parathyroid hormone from microorganisms
FI894998A7 (fi) * 1987-04-22 1989-10-20 Michael Bay Soluviljelmämenetelmiä, aineita ja tuotteita
JPH025797U (enrdf_load_stackoverflow) * 1988-06-23 1990-01-16
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
SG47470A1 (en) 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
DE4229526B4 (de) * 1992-09-07 2006-02-16 Schrezenmeir, Jürgen, Dr. Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
ATE218893T1 (de) * 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
WO2012109279A2 (en) * 2011-02-07 2012-08-16 Life Technologies Corporation Compositions and methods for stabilizing susceptible compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324683A (en) * 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6414225U (enrdf_load_stackoverflow) * 1987-07-15 1989-01-25

Also Published As

Publication number Publication date
JPS5816693A (ja) 1983-01-31
CH654328A5 (de) 1986-02-14
DK112282A (da) 1982-09-14
JPS6157288B2 (enrdf_load_stackoverflow) 1986-12-06
CA1172961A (en) 1984-08-21
GB2094833A (en) 1982-09-22
SE454780B (sv) 1988-05-30
FR2503183A1 (fr) 1982-10-08
SE8201554L (sv) 1982-09-14
NO163060C (no) 1990-03-28
IT1150682B (it) 1986-12-17
GB2094833B (en) 1984-06-20
NO820794L (no) 1982-09-14
BE892479A (fr) 1982-07-01
JPS6188893A (ja) 1986-05-07
FR2503183B1 (fr) 1985-11-08
IT8220140A0 (it) 1982-03-12
DE3209127C2 (enrdf_load_stackoverflow) 1988-02-04
DE3209127A1 (de) 1982-12-09
NO163060B (no) 1989-12-18

Similar Documents

Publication Publication Date Title
JPS6244919B2 (enrdf_load_stackoverflow)
US4409331A (en) Preparation of substances with encapsulated cells
US4407957A (en) Reversible microencapsulation of a core material
US4495288A (en) Method of culturing anchorage dependent cells
US4352883A (en) Encapsulation of biological material
US4391909A (en) Microcapsules containing viable tissue cells
US4673566A (en) Microencapsulation of living tissue and cells
CA1215922A (en) Microencapsulation of living tissue and cells
JPS6152737B2 (enrdf_load_stackoverflow)
CN1087779C (zh) 大胶囊化的分泌细胞
Lim Microencapsulation of living cells and tissues—theory and practice
JPS6038111B2 (ja) 固定依存性細胞の培養法
EP0127989A2 (en) Microencapsulation of living tissue and cells
JPS61189218A (ja) カプセル封入方法
US4582799A (en) Process for recovering nonsecreted substances produced by cells
US4927761A (en) Immobilization of cells with alginate and agarose
EP0259365A1 (en) Covalent membranes
CA1280381C (en) Entrapment of anchorage-dependent cells
JP3204675B2 (ja) ハイブリッド型人工膵臓の製造方法
JPH0685711B2 (ja) 細胞の繁殖方法
JPH0533981B2 (enrdf_load_stackoverflow)
JPH048034B2 (enrdf_load_stackoverflow)