DE3153460A1 - - Google Patents

Info

Publication number
DE3153460A1
DE3153460A1 DE19813153460 DE3153460A DE3153460A1 DE 3153460 A1 DE3153460 A1 DE 3153460A1 DE 19813153460 DE19813153460 DE 19813153460 DE 3153460 A DE3153460 A DE 3153460A DE 3153460 A1 DE3153460 A1 DE 3153460A1
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813153460
Other versions
DE3153460C2 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/125,608 external-priority patent/US4338457A/en
Application filed filed Critical
Publication of DE3153460A1 publication Critical patent/DE3153460A1/de
Application granted granted Critical
Publication of DE3153460C2 publication Critical patent/DE3153460C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
DE3153460A 1980-02-28 1981-02-16 Expired - Lifetime DE3153460C2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/125,608 US4338457A (en) 1980-02-28 1980-02-28 Composition and process
US13505580A 1980-03-28 1980-03-28
US14054680A 1980-04-15 1980-04-15
US14295380A 1980-04-23 1980-04-23

Publications (2)

Publication Number Publication Date
DE3153460A1 true DE3153460A1 (de) 1988-08-11
DE3153460C2 DE3153460C2 (de) 1990-08-16

Family

ID=27494588

Family Applications (4)

Application Number Title Priority Date Filing Date
DE3153460A Expired - Lifetime DE3153460C2 (de) 1980-02-28 1981-02-16
DE3153390A Expired DE3153390C2 (de) 1980-02-28 1981-02-16
DE3153474A Expired - Lifetime DE3153474C2 (de) 1980-02-28 1981-02-16
DE3105588A Granted DE3105588A1 (de) 1980-02-28 1981-02-16 Carbacyclin analoga

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE3153390A Expired DE3153390C2 (de) 1980-02-28 1981-02-16
DE3153474A Expired - Lifetime DE3153474C2 (de) 1980-02-28 1981-02-16
DE3105588A Granted DE3105588A1 (de) 1980-02-28 1981-02-16 Carbacyclin analoga

Country Status (12)

Country Link
JP (2) JPH02167248A (de)
AU (2) AU542861B2 (de)
CA (1) CA1201712A (de)
CH (2) CH655308A5 (de)
DE (4) DE3153460C2 (de)
FR (1) FR2484413B1 (de)
GB (1) GB2070596B (de)
HK (1) HK6989A (de)
IL (1) IL61936A (de)
IT (1) IT1144901B (de)
NL (1) NL8100959A (de)
SE (6) SE453594B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237200A1 (de) * 1982-10-05 1984-04-05 Schering AG, 1000 Berlin und 4709 Bergkamen 5-fluorcarbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3142733A1 (de) * 1981-10-23 1983-05-05 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3146278C2 (de) * 1981-11-21 1984-10-31 Grünenthal GmbH, 5190 Stolberg cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen
IL67332A (en) * 1981-12-01 1985-12-31 Chinoin Gyogyszer Es Vegyeszet Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
EP0175450B1 (de) * 1984-07-18 1989-03-22 The Upjohn Company Eine Interphenylen-Carbacyclin-Verbindung
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19722849A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Antagonisten, insbesondere 3-Oxa-Tetra-hydronaphthalin-LTB¶4¶-Antagonisten
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
CA2526534C (en) 2003-05-22 2011-07-12 United Therapeutics Corporation Compounds and methods for delivery of prostacyclin analogs
JP5190200B2 (ja) * 2003-12-16 2013-04-24 ユナイテッド セラピューティクス コーポレイション 虚血性病変の治療および予防のためのトレプロスチニルの用途
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
JP2016517410A (ja) 2013-03-14 2016-06-16 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの固体形態
KR101830693B1 (ko) * 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
HU231212B1 (hu) 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
US4192891A (en) * 1979-04-25 1980-03-11 E. R. Squibb & Sons, Inc. Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
DE2912409A1 (de) * 1978-03-31 1979-10-11 Ono Pharmaceutical Co 6,9-methano-pgi tief 2 -analoge
US4338457A (en) * 1980-02-28 1982-07-06 The Upjohn Company Composition and process
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
US4192891A (en) * 1979-04-25 1980-03-11 E. R. Squibb & Sons, Inc. Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Chem. Lett., 1979, S.1299-1300 *
Chem. Lett., 1979, S.1437-1440 *
J. Chem. Soc. Chem. Comm., 1978, S.1067-1068 *
J. Org. Chem. 44, 1979, S.2880 *
Tetrahedr. Lett., 1978, S.3743-3746 *
Tetrahedr. Lett., 1979, S.2607-2610 *
Tetrahedr. Lett., 1979, S.433-436 *

Also Published As

Publication number Publication date
SE8504618L (sv) 1985-10-04
IL61936A0 (en) 1981-02-27
FR2484413B1 (fr) 1986-05-23
SE8504616L (sv) 1985-10-04
IT1144901B (it) 1986-10-29
NL8100959A (nl) 1981-10-01
CH648017A5 (de) 1985-02-28
AU3820885A (en) 1985-06-20
SE8504617L (sv) 1985-10-04
JPH048427B2 (de) 1992-02-17
SE8504615D0 (sv) 1985-10-04
SE8504618D0 (sv) 1985-10-04
DE3153390C2 (de) 1989-09-14
SE8504615L (sv) 1985-10-04
SE8504619D0 (sv) 1985-10-04
JPH02167248A (ja) 1990-06-27
AU542861B2 (en) 1985-03-21
AU6660681A (en) 1981-09-03
SE453594B (sv) 1988-02-15
IL61936A (en) 1986-08-31
SE8504616D0 (sv) 1985-10-04
SE8504617D0 (sv) 1985-10-04
HK6989A (en) 1989-01-27
SE8504619L (sv) 1985-10-04
IT8120019A0 (it) 1981-02-26
GB2070596A (en) 1981-09-09
AU567392B2 (en) 1987-11-19
DE3105588A1 (de) 1981-12-10
CA1201712A (en) 1986-03-11
GB2070596B (en) 1984-02-08
SE8100564L (sv) 1981-08-29
DE3153474C2 (de) 1990-05-31
DE3105588C2 (de) 1989-04-13
DE3153460C2 (de) 1990-08-16
CH655308A5 (de) 1986-04-15
FR2484413A1 (fr) 1981-12-18
JPH06145085A (ja) 1994-05-24

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Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US