FR2484413B1 - Analogues et intermediaires de carbacycline, leur preparation et leur utilisation - Google Patents

Analogues et intermediaires de carbacycline, leur preparation et leur utilisation

Info

Publication number
FR2484413B1
FR2484413B1 FR8103965A FR8103965A FR2484413B1 FR 2484413 B1 FR2484413 B1 FR 2484413B1 FR 8103965 A FR8103965 A FR 8103965A FR 8103965 A FR8103965 A FR 8103965A FR 2484413 B1 FR2484413 B1 FR 2484413B1
Authority
FR
France
Prior art keywords
intermediates
preparation
carbacycline
analogs
carbacycline analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8103965A
Other languages
English (en)
Other versions
FR2484413A1 (fr
Inventor
Paul Adrian Aristoff
Robert Charles Kelly
Norman Allan Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/125,608 external-priority patent/US4338457A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2484413A1 publication Critical patent/FR2484413A1/fr
Application granted granted Critical
Publication of FR2484413B1 publication Critical patent/FR2484413B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
FR8103965A 1980-02-28 1981-02-27 Analogues et intermediaires de carbacycline, leur preparation et leur utilisation Expired FR2484413B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/125,608 US4338457A (en) 1980-02-28 1980-02-28 Composition and process
US13505580A 1980-03-28 1980-03-28
US14054680A 1980-04-15 1980-04-15
US14295380A 1980-04-23 1980-04-23

Publications (2)

Publication Number Publication Date
FR2484413A1 FR2484413A1 (fr) 1981-12-18
FR2484413B1 true FR2484413B1 (fr) 1986-05-23

Family

ID=27494588

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8103965A Expired FR2484413B1 (fr) 1980-02-28 1981-02-27 Analogues et intermediaires de carbacycline, leur preparation et leur utilisation

Country Status (12)

Country Link
JP (2) JPH02167248A (fr)
AU (2) AU542861B2 (fr)
CA (1) CA1201712A (fr)
CH (2) CH655308A5 (fr)
DE (4) DE3153460C2 (fr)
FR (1) FR2484413B1 (fr)
GB (1) GB2070596B (fr)
HK (1) HK6989A (fr)
IL (1) IL61936A (fr)
IT (1) IT1144901B (fr)
NL (1) NL8100959A (fr)
SE (6) SE453594B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237200A1 (de) * 1982-10-05 1984-04-05 Schering AG, 1000 Berlin und 4709 Bergkamen 5-fluorcarbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1201712A (fr) * 1980-02-28 1986-03-11 Paul A. Aristoff Analogues de la carbacycline
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3142733A1 (de) * 1981-10-23 1983-05-05 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3146278C2 (de) * 1981-11-21 1984-10-31 Grünenthal GmbH, 5190 Stolberg cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen
IL67332A (en) * 1981-12-01 1985-12-31 Chinoin Gyogyszer Es Vegyeszet Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
EP0175450B1 (fr) * 1984-07-18 1989-03-22 The Upjohn Company Composé d'interphénylène-carbacycline
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19722849A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Antagonisten, insbesondere 3-Oxa-Tetra-hydronaphthalin-LTB¶4¶-Antagonisten
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
EP2792353B1 (fr) 2003-05-22 2018-02-28 United Therapeutics Corporation Polymorphe du sel de diéthanolamine de Treprostinil
KR101161889B1 (ko) 2003-12-16 2012-07-02 유나이티드 쎄러퓨틱스 코포레이션 허혈성 병변의 치료 및 예방을 위한 트레프로스티닐의 용도
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
CA2710725C (fr) 2010-07-22 2017-08-01 Alphora Research Inc. Aldehydes proteges pour une utilisation comme intermediaires pour des syntheses chimiques, et procedes pour leur preparation
CA2726599C (fr) 2010-12-30 2017-07-25 Alphora Research Inc. Procede de preparation de sel a partir de treprostinil
CN105164098A (zh) 2013-03-14 2015-12-16 联合治疗公司 曲前列环素的固体形式
KR101830693B1 (ko) * 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
HU231212B1 (hu) 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
IT1113341B (it) * 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
US4192891A (en) * 1979-04-25 1980-03-11 E. R. Squibb & Sons, Inc. Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction
CA1201712A (fr) * 1980-02-28 1986-03-11 Paul A. Aristoff Analogues de la carbacycline
US4338457A (en) * 1980-02-28 1982-07-06 The Upjohn Company Composition and process
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
HK6989A (en) 1989-01-27
DE3153474C2 (fr) 1990-05-31
CH648017A5 (de) 1985-02-28
JPH06145085A (ja) 1994-05-24
IL61936A (en) 1986-08-31
JPH048427B2 (fr) 1992-02-17
FR2484413A1 (fr) 1981-12-18
SE8504616L (sv) 1985-10-04
SE453594B (sv) 1988-02-15
DE3105588C2 (fr) 1989-04-13
SE8504617L (sv) 1985-10-04
JPH02167248A (ja) 1990-06-27
SE8504617D0 (sv) 1985-10-04
IL61936A0 (en) 1981-02-27
CH655308A5 (de) 1986-04-15
AU6660681A (en) 1981-09-03
SE8504616D0 (sv) 1985-10-04
DE3153390C2 (fr) 1989-09-14
DE3153460C2 (fr) 1990-08-16
SE8504618L (sv) 1985-10-04
GB2070596A (en) 1981-09-09
CA1201712A (fr) 1986-03-11
DE3105588A1 (de) 1981-12-10
SE8504615D0 (sv) 1985-10-04
DE3153460A1 (fr) 1988-08-11
SE8504619L (sv) 1985-10-04
AU567392B2 (en) 1987-11-19
NL8100959A (nl) 1981-10-01
AU3820885A (en) 1985-06-20
IT1144901B (it) 1986-10-29
SE8100564L (sv) 1981-08-29
IT8120019A0 (it) 1981-02-26
SE8504619D0 (sv) 1985-10-04
SE8504618D0 (sv) 1985-10-04
GB2070596B (en) 1984-02-08
AU542861B2 (en) 1985-03-21
SE8504615L (sv) 1985-10-04

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