DE3137875C2 - Gerät und Verfahren zur schrittweisen Durchführung von chemischen Prozessen - Google Patents
Gerät und Verfahren zur schrittweisen Durchführung von chemischen ProzessenInfo
- Publication number
- DE3137875C2 DE3137875C2 DE19813137875 DE3137875A DE3137875C2 DE 3137875 C2 DE3137875 C2 DE 3137875C2 DE 19813137875 DE19813137875 DE 19813137875 DE 3137875 A DE3137875 A DE 3137875A DE 3137875 C2 DE3137875 C2 DE 3137875C2
- Authority
- DE
- Germany
- Prior art keywords
- chamber
- fluids
- sample
- reaction chamber
- capillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 48
- 238000001311 chemical methods and process Methods 0.000 title claims description 15
- 238000006243 chemical reaction Methods 0.000 claims description 191
- 239000003153 chemical reaction reagent Substances 0.000 claims description 122
- 239000012530 fluid Substances 0.000 claims description 111
- 239000011159 matrix material Substances 0.000 claims description 82
- 239000007788 liquid Substances 0.000 claims description 63
- 239000007787 solid Substances 0.000 claims description 45
- 239000000463 material Substances 0.000 claims description 32
- 239000012528 membrane Substances 0.000 claims description 24
- 238000007789 sealing Methods 0.000 claims description 24
- 239000010409 thin film Substances 0.000 claims description 22
- 239000011521 glass Substances 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 20
- 230000008569 process Effects 0.000 claims description 13
- -1 quaternary ammonium salt poly (N, N-dimethyl-3,5- dimethylene piperidinium chloride Chemical class 0.000 claims description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 12
- 239000012858 resilient material Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 230000003993 interaction Effects 0.000 claims description 9
- 229920002313 fluoropolymer Polymers 0.000 claims description 8
- 239000003365 glass fiber Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 6
- 230000006870 function Effects 0.000 claims description 5
- LFVLUOAHQIVABZ-UHFFFAOYSA-N Iodofenphos Chemical compound COP(=S)(OC)OC1=CC(Cl)=C(I)C=C1Cl LFVLUOAHQIVABZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000013013 elastic material Substances 0.000 claims 4
- 230000005540 biological transmission Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 158
- 239000002904 solvent Substances 0.000 description 96
- 108090000623 proteins and genes Proteins 0.000 description 51
- 239000007789 gas Substances 0.000 description 49
- 235000018102 proteins Nutrition 0.000 description 48
- 102000004169 proteins and genes Human genes 0.000 description 48
- 108090000765 processed proteins & peptides Proteins 0.000 description 40
- 239000011261 inert gas Substances 0.000 description 38
- 238000006731 degradation reaction Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 22
- 230000015556 catabolic process Effects 0.000 description 21
- 239000010408 film Substances 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 17
- 229920000209 Hexadimethrine bromide Polymers 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 14
- 235000001014 amino acid Nutrition 0.000 description 14
- 229940024606 amino acid Drugs 0.000 description 14
- 239000000306 component Substances 0.000 description 11
- 239000002699 waste material Substances 0.000 description 11
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 102000014150 Interferons Human genes 0.000 description 8
- 108010050904 Interferons Proteins 0.000 description 8
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 229940079322 interferon Drugs 0.000 description 8
- 238000012163 sequencing technique Methods 0.000 description 8
- 150000003862 amino acid derivatives Chemical class 0.000 description 7
- 229910052786 argon Inorganic materials 0.000 description 7
- 239000011324 bead Substances 0.000 description 7
- 238000010276 construction Methods 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 230000000712 assembly Effects 0.000 description 5
- 238000000429 assembly Methods 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 238000009739 binding Methods 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 238000011109 contamination Methods 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 125000006850 spacer group Chemical group 0.000 description 5
- 101710196022 Cuticle protein Proteins 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- QKFJKGMPGYROCL-UHFFFAOYSA-N phenyl isothiocyanate Chemical compound S=C=NC1=CC=CC=C1 QKFJKGMPGYROCL-UHFFFAOYSA-N 0.000 description 4
- 230000007017 scission Effects 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
- 239000004473 Threonine Substances 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 108010062636 apomyoglobin Proteins 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 3
- 238000005065 mining Methods 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- WJWWDONJARAUPN-UHFFFAOYSA-N 4-anilino-5h-1,3-thiazol-2-one Chemical class O=C1SCC(NC=2C=CC=CC=2)=N1 WJWWDONJARAUPN-UHFFFAOYSA-N 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
- 102000015427 Angiotensins Human genes 0.000 description 2
- 108010064733 Angiotensins Proteins 0.000 description 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 2
- 241000255601 Drosophila melanogaster Species 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 108010008488 Glycylglycine Proteins 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
- 241000283222 Physeter catodon Species 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- DRBWRJPFNOBNIO-KOLCDFICSA-N [(2r)-1-[(2r)-2-(pyridine-4-carbonylamino)propanoyl]pyrrolidin-2-yl]boronic acid Chemical compound N([C@H](C)C(=O)N1[C@@H](CCC1)B(O)O)C(=O)C1=CC=NC=C1 DRBWRJPFNOBNIO-KOLCDFICSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000001427 coherent effect Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 229940043257 glycylglycine Drugs 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001418 larval effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 229940117953 phenylisothiocyanate Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- PQMRRAQXKWFYQN-UHFFFAOYSA-N 1-phenyl-2-sulfanylideneimidazolidin-4-one Chemical compound S=C1NC(=O)CN1C1=CC=CC=C1 PQMRRAQXKWFYQN-UHFFFAOYSA-N 0.000 description 1
- ULKNJYDXLYMGFB-UHFFFAOYSA-N 3-(5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl)propanoic acid Chemical compound O=C1C(CCC(=O)O)NC(=S)N1C1=CC=CC=C1 ULKNJYDXLYMGFB-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 101150100400 66 gene Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241001507939 Cormus domestica Species 0.000 description 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 description 1
- 208000032765 Device extrusion Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 102000002278 Ribosomal Proteins Human genes 0.000 description 1
- 108010000605 Ribosomal Proteins Proteins 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 241000534944 Thia Species 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000061 acid fraction Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- MTXSIJUGVMTTMU-UHFFFAOYSA-N anabasine Chemical compound N1CCCCC1C1=CC=CN=C1 MTXSIJUGVMTTMU-UHFFFAOYSA-N 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013098 chemical test method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 150000002332 glycine derivatives Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- YPJUNDFVDDCYIH-UHFFFAOYSA-N perfluorobutyric acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)F YPJUNDFVDDCYIH-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
- F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
- F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
- F16K7/17—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00396—Membrane valves
- B01J2219/00398—Membrane valves in multiple arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00695—Synthesis control routines, e.g. using computer programs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19010080A | 1980-09-23 | 1980-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3137875A1 DE3137875A1 (de) | 1982-05-06 |
| DE3137875C2 true DE3137875C2 (de) | 1995-11-02 |
Family
ID=22700018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813137875 Expired - Lifetime DE3137875C2 (de) | 1980-09-23 | 1981-09-23 | Gerät und Verfahren zur schrittweisen Durchführung von chemischen Prozessen |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS57110962A (enrdf_load_stackoverflow) |
| CA (1) | CA1163425A (enrdf_load_stackoverflow) |
| DE (1) | DE3137875C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2490505B1 (enrdf_load_stackoverflow) |
| GB (3) | GB2084899B (enrdf_load_stackoverflow) |
| SE (3) | SE466223B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19652823A1 (de) * | 1996-12-18 | 1998-03-26 | Guenter Prof Dr Fuhr | Strukturierter Polytetrafluorethylen-Spacer |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2544720B1 (fr) * | 1983-04-19 | 1987-11-27 | California Inst Of Techn | Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides |
| DE3425763A1 (de) * | 1983-07-13 | 1985-01-24 | Nippon Zeon Co., Ltd., Tokio/Tokyo | Verfahren zur synthese von polynukleotiden |
| JPS60105691A (ja) * | 1983-11-14 | 1985-06-11 | Nippon Zeon Co Ltd | ポリヌクレオチド合成装置 |
| CA1218930A (en) * | 1984-02-22 | 1987-03-10 | Allelix Biopharmaceuticals Inc. | Device for performing quantitative chemical and immunochemical assays |
| US4668476A (en) * | 1984-03-23 | 1987-05-26 | Applied Biosystems, Inc. | Automated polypeptide synthesis apparatus |
| DE3508162C1 (de) * | 1985-03-07 | 1986-06-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Leitungssystem fuer Laboratoriumszwecke |
| DE3750624T2 (de) * | 1986-08-15 | 1995-02-16 | Beckmann Research Inst Of The | Durchlaufreaktor für Peptidsequenatoren. |
| US4773446A (en) * | 1986-08-27 | 1988-09-27 | Porton Instruments, Inc. | Valve block assembly |
| DE3637869A1 (de) * | 1986-11-06 | 1988-05-19 | Draegerwerk Ag | Mehrfachhalterung fuer pruefroehrchen |
| US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| EP0388224A3 (en) * | 1989-03-17 | 1991-05-22 | Seiko Instruments Inc. | Method and apparatus for effecting chemical treatment |
| JPH02307059A (ja) * | 1989-05-23 | 1990-12-20 | Seiko Instr Inc | 反応容器 |
| US5605839A (en) * | 1990-04-11 | 1997-02-25 | Ludwig Institute For Cancer Research | Methods and apparatus for use in sequential chemical reactions |
| DE9109797U1 (de) * | 1991-08-07 | 1991-09-26 | Wissenschaftliche Gerätebau Dr.-Ing. Herbert Knauer GmbH, 1000 Berlin | Gerät zur Durchführung von chemischen Prozessen an einer Probe eines chemischen Materials |
| IT1255014B (it) * | 1992-03-27 | 1995-10-13 | Instrumentation Lab Spa | Dispositivi di movimentazione ed intercettazione di fluidi |
| US5203368A (en) * | 1992-07-29 | 1993-04-20 | Protein Technologies Inc. | Matrix of valves |
| US5641459A (en) * | 1995-08-17 | 1997-06-24 | Pharmacia Biotech Ab | Machine for synthesizing oligonucleotides |
| GB2409411A (en) * | 2003-12-22 | 2005-06-29 | William Thomas Dennis Bates | Blood collection system |
| AU2012315883A1 (en) * | 2011-09-30 | 2014-04-17 | Ge Healthcare Limited | Reactor for multi-step radiochemistry |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3077766A (en) | 1960-07-08 | 1963-02-19 | Phillips Petroleum Co | Shut off valve for chromatographic system |
| DE1227855B (de) * | 1960-07-12 | 1966-11-03 | Ichthyol Ges | Verfahren zur Herstellung von Enzymkoerpern fuer die Durchfuehrung enzymatischer Reaktionen |
| US3717436A (en) | 1971-01-25 | 1973-02-20 | Beckman Ind Inc | Process for the sequential degradation of peptide chains |
| BE786213A (fr) * | 1971-07-13 | 1973-01-15 | Technicon Instr | Procede et appareil pour l'analyse d'echantillons, notamment desang |
| US3725010A (en) | 1971-08-23 | 1973-04-03 | Beckman Instruments Inc | Apparatus for automatically performing chemical processes |
| BE795316A (fr) * | 1972-02-11 | 1973-05-29 | Nat Patent Dev Corp | Systeme catalytique presentant une activite enzymatique durable et de stabilite augmentee |
| JPS5117438B2 (enrdf_load_stackoverflow) * | 1972-05-26 | 1976-06-02 | ||
| GB1427192A (en) * | 1972-05-26 | 1976-03-10 | Kannegiesser M | Apparatus for manufacturing mouldings from expandable synthetic plastics more particularly polyurethane |
| DE2308088C2 (de) * | 1973-02-19 | 1983-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur automatisierten Bestimmung der Aminosäuresequenz und Vorrichtung zu ihrer Durchführung |
| US3892531A (en) * | 1973-07-05 | 1975-07-01 | Beckman Instruments Inc | Apparatus for sequencing peptides and proteins |
| US3959307A (en) | 1974-02-15 | 1976-05-25 | Wittmann Brigitte | Method to determine automatically the sequence of amino acids |
| US3951167A (en) | 1974-12-05 | 1976-04-20 | E. I. Du Pont De Nemours And Company | Fluid handling assembly |
| US4065412A (en) * | 1976-05-07 | 1977-12-27 | Durrum Instrument Corporation | Peptide or protein sequencing method and apparatus |
| US4119120A (en) | 1976-11-29 | 1978-10-10 | Beckman Instruments, Inc. | Fluid switch |
| US4252769A (en) * | 1979-12-26 | 1981-02-24 | California Institute Of Technology | Apparatus for the performance of chemical processes |
-
1981
- 1981-09-10 GB GB8127343A patent/GB2084899B/en not_active Expired
- 1981-09-22 FR FR8117856A patent/FR2490505B1/fr not_active Expired
- 1981-09-22 CA CA000386403A patent/CA1163425A/en not_active Expired
- 1981-09-22 JP JP14890381A patent/JPS57110962A/ja active Granted
- 1981-09-22 SE SE8105597A patent/SE466223B/sv not_active IP Right Cessation
- 1981-09-23 DE DE19813137875 patent/DE3137875C2/de not_active Expired - Lifetime
-
1983
- 1983-12-14 GB GB08333305A patent/GB2146741B/en not_active Expired
- 1983-12-14 GB GB08333306A patent/GB2146550B/en not_active Expired
-
1988
- 1988-06-07 SE SE8802124A patent/SE501968C2/sv not_active IP Right Cessation
- 1988-06-07 SE SE8802125A patent/SE8802125A0/sv not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19652823A1 (de) * | 1996-12-18 | 1998-03-26 | Guenter Prof Dr Fuhr | Strukturierter Polytetrafluorethylen-Spacer |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2084899A (en) | 1982-04-21 |
| JPH0256635B2 (enrdf_load_stackoverflow) | 1990-11-30 |
| SE501968C2 (sv) | 1995-07-03 |
| GB2146741B (en) | 1985-11-20 |
| SE466223B (sv) | 1992-01-13 |
| GB8333305D0 (en) | 1984-01-18 |
| GB8333306D0 (en) | 1984-01-18 |
| DE3137875A1 (de) | 1982-05-06 |
| CA1163425A (en) | 1984-03-13 |
| SE8802125D0 (sv) | 1988-06-07 |
| FR2490505B1 (fr) | 1986-01-03 |
| GB2146550A (en) | 1985-04-24 |
| SE8802124D0 (sv) | 1988-06-07 |
| SE8802124L (enrdf_load_stackoverflow) | 1988-06-07 |
| FR2490505A1 (fr) | 1982-03-26 |
| GB2146550B (en) | 1985-11-13 |
| GB2146741A (en) | 1985-04-24 |
| SE8802125A0 (sv) | 1988-06-07 |
| SE8105597L (sv) | 1982-05-06 |
| JPS57110962A (en) | 1982-07-10 |
| GB2084899B (en) | 1985-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3137875C2 (de) | Gerät und Verfahren zur schrittweisen Durchführung von chemischen Prozessen | |
| US4704256A (en) | Apparatus for the sequential performance of chemical processes | |
| US4603114A (en) | Method for the sequential performance of chemical processes | |
| DE3804430C2 (de) | Einrichtung zur Trennung molekularer Komponenten aus flüssigen Gemischen | |
| DE69627333T2 (de) | Automatisierte, kontinuierliche mehrdimensionale hochgeschwindigkeitsmolekularselektion und -analyse | |
| DE69836241T2 (de) | Verfahren zur Sichtung einer Bibliothek von chemischen Verbindungen | |
| DE1915113A1 (de) | Probeninjektionssystem | |
| DE69310372T2 (de) | Synthesereaktionssäule | |
| DE19634828A1 (de) | Vorrichtung und Verfahren zur Zentrifugal-Adsorptionsprobenpräparation | |
| DE69701534T2 (de) | Laborreaktor zur automatisierten Peptidesynthese | |
| EP1697736B1 (de) | Vorrichtung zur probenvorbereitung | |
| DE112004000250T5 (de) | Probenaufbereitungsplatte für die Massenspektrometrie | |
| US4610847A (en) | Conversion flask for sequential performance apparatus | |
| EP0776374A1 (de) | Verfahren und vorrichtung zur bestimmung der aktivität von enzymen in flüssigkeiten, beziehungsweise der konzentration und/oder aktivität von inhibitoren in flüssigkeiten | |
| EP0664724B1 (de) | Verfahren für die gewinnung und die umpufferung und/oder einengung von gelösten makromolekülen eines makromolekülgemisches | |
| US5482862A (en) | Methods for the on-line analysis of fluid streams | |
| EP1353752A1 (de) | Vorrichtung und verfahren zum transferieren von fluidproben | |
| DE3929021A1 (de) | Verfahren zur gaschromatografischen analyse von stoffgemischen und einrichtung zu dessen verwirklichung | |
| DE1598237A1 (de) | Verfahren und Einrichtung zum automatischen Einbringen von Proben in die Kolonnen bei der Saeulen-Chromatographie | |
| EP0820804B1 (de) | Verfahren und Vorrichtung zur Probenvorbereitung | |
| EP1521635A1 (de) | Vorrichtung zur handhabung von flüssigkeiten in einer mehrzahl von kanälen | |
| WO2005007882A2 (de) | Probenzubereitungseinheit | |
| CA1178030A (en) | Apparatus for the sequential performance of chemical process | |
| DE3508162C1 (de) | Leitungssystem fuer Laboratoriumszwecke | |
| CA1188197A (en) | Selectively controlled multiple outlet valve |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8172 | Supplementary division/partition in: |
Ref country code: DE Ref document number: 3153759 Format of ref document f/p: P |
|
| Q171 | Divided out to: |
Ref country code: DE Ref document number: 3153759 |
|
| 8127 | New person/name/address of the applicant |
Owner name: PERKIN-ELMER CORP., FOSTER CITY, CALIF., US |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |